DD208989A5 - Verfahren zur synthetisierung von menschlichem insulin - Google Patents

Verfahren zur synthetisierung von menschlichem insulin Download PDF

Info

Publication number: DD208989A5
Authority: DD; German Democratic Republic
Prior art keywords: sequence; proinsulin; human; insulin; encoding
Prior art date: 1979-09-12

Application number

DD80238563A

Other languages

German (de)

English (en)

Inventor

Graeme Bell

Raymond L Pictet

Howard M Goodmann

William J Rutter

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-09-12

Filing date

1980-09-12

Publication date

1984-04-18

1980-09-12 Application filed by Univ California filed Critical Univ California

1984-04-18 Publication of DD208989A5 publication Critical patent/DD208989A5/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Tropical Medicine & Parasitology (AREA)
Plant Pathology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)

DD80238563A 1979-09-12 1980-09-12 Verfahren zur synthetisierung von menschlichem insulin DD208989A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US7519279A	1979-09-12	1979-09-12

Publications (1)

Publication Number	Publication Date
DD208989A5 true DD208989A5 (de)	1984-04-18

Family

ID=22124154

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DD80238563A DD208989A5 (de)	1979-09-12	1980-09-12	Verfahren zur synthetisierung von menschlichem insulin
DD80238569A DD201693A5 (de)	1979-09-12	1980-09-12	Verfahren zur synthetisierung von menschlichem proinsulin
DD80223873A DD155004A5 (de)	1979-09-12	1980-09-12	Verfahren zur herstellung eines dns-transfervektors

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DD80238569A DD201693A5 (de)	1979-09-12	1980-09-12	Verfahren zur synthetisierung von menschlichem proinsulin
DD80223873A DD155004A5 (de)	1979-09-12	1980-09-12	Verfahren zur herstellung eines dns-transfervektors

Country Status (28)

Country	Link
EP (1)	EP0026598A1 (cs)
JP (1)	JP2637393B2 (cs)
KR (1)	KR870000501B1 (cs)
AT (1)	AT377003B (cs)
AU (1)	AU538154B2 (cs)
BE (1)	BE885196A (cs)
BG (2)	BG41136A3 (cs)
CA (1)	CA1180289A (cs)
CZ (2)	CZ278883B6 (cs)
DD (3)	DD208989A5 (cs)
DK (1)	DK385980A (cs)
ES (3)	ES8107307A1 (cs)
FI (1)	FI802837A7 (cs)
FR (1)	FR2464997B1 (cs)
GR (1)	GR70279B (cs)
IE (1)	IE52781B1 (cs)
IL (1)	IL61041A (cs)
IT (1)	IT1129250B (cs)
LU (1)	LU82757A1 (cs)
NZ (1)	NZ194786A (cs)
PH (1)	PH26475A (cs)
PL (1)	PL226725A1 (cs)
PT (1)	PT71790B (cs)
RO (1)	RO80005A (cs)
SK (1)	SK621580A3 (cs)
SU (1)	SU1491345A3 (cs)
YU (1)	YU233480A (cs)
ZA (1)	ZA805341B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4342832A (en) *	1979-07-05	1982-08-03	Genentech, Inc.	Method of constructing a replicable cloning vehicle having quasi-synthetic genes
DE3001928A1 (de) *	1980-01-19	1981-08-06	Hoechst Ag, 6000 Frankfurt	Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
US4249952A (en) *	1980-03-03	1981-02-10	Pennsylvania Engineering Corporation	Method for producing cement clinker from cement kiln waste dust
AU545912B2 (en) *	1980-03-10	1985-08-08	Cetus Corporation	Cloned heterologous jive products in bacillies
US4338397A (en) *	1980-04-11	1982-07-06	President And Fellows Of Harvard College	Mature protein synthesis
NZ199391A (en) *	1981-01-02	1985-12-13	Genentech Inc	Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
ZA824218B (en)	1981-06-29	1983-04-27	Cetus Corp	Plasmid for producing human insulin
EP0090433A1 (en) *	1982-03-31	1983-10-05	Genetics Institute, Inc.	Creation of DNA sequences encoding modified proinsulin precursors
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US5023321A (en) *	1982-12-13	1991-06-11	Howard Florey Institute Of Experimental Physiology & Medicine	Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL71991A (en) *	1983-06-06	1994-05-30	Genentech Inc	Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
DE3752347T2 (de) *	1986-05-20	2002-09-26	The General Hospital Corp., Boston	Verfahren zur pharmakokinetischen Studie der Insulin-Expression mit nicht-menschlichem Transgen-Säugetier
ES2301178T3 (es)	1996-04-05	2008-06-16	Novartis Vaccines & Diagnostic	Vectores basados en alfavirus recombinantes con inhibicion reducida de la sintesis macromolecular celular.
AUPP655698A0 (en) *	1998-10-16	1998-11-05	Commonwealth Scientific And Industrial Research Organisation	Delivery system for porcine somatotropin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ187300A (en) *	1977-05-27	1982-08-17	Univ California	Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
AT373281B (de) *	1977-11-08	1984-01-10	Genentech Inc	Verfahren zur herstellung eines strukturgens
JPS54163600A (en) *	1977-11-08	1979-12-26	Genentech Inc	Microbiological polypeptide expression method and means
US4411994A (en) *	1978-06-08	1983-10-25	The President And Fellows Of Harvard College	Protein synthesis
FI792481A7 (fi) *	1978-08-11	1981-01-01	The Regents Of The Univ Of	Enkaroyyttisen proteiinin synteesi mikro-organismia käyttäen.

1980
- 1980-08-25 GR GR62740A patent/GR70279B/el unknown
- 1980-08-27 NZ NZ194786A patent/NZ194786A/en unknown
- 1980-08-28 ZA ZA00805341A patent/ZA805341B/xx unknown
- 1980-09-09 FR FR8019399A patent/FR2464997B1/fr not_active Expired
- 1980-09-10 LU LU82757A patent/LU82757A1/fr unknown
- 1980-09-10 PT PT71790A patent/PT71790B/pt unknown
- 1980-09-10 IL IL61041A patent/IL61041A/xx not_active IP Right Cessation
- 1980-09-10 FI FI802837A patent/FI802837A7/fi not_active Application Discontinuation
- 1980-09-11 AU AU62324/80A patent/AU538154B2/en not_active Expired
- 1980-09-11 PH PH24566A patent/PH26475A/en unknown
- 1980-09-11 CA CA000360565A patent/CA1180289A/en not_active Expired
- 1980-09-11 BE BE0/202074A patent/BE885196A/fr not_active IP Right Cessation
- 1980-09-11 IT IT68405/80A patent/IT1129250B/it active
- 1980-09-11 EP EP80303195A patent/EP0026598A1/en not_active Ceased
- 1980-09-11 SU SU802994154A patent/SU1491345A3/ru active
- 1980-09-11 DK DK385980A patent/DK385980A/da not_active Application Discontinuation
- 1980-09-11 AT AT0458580A patent/AT377003B/de not_active IP Right Cessation
- 1980-09-12 ES ES495030A patent/ES8107307A1/es not_active Expired
- 1980-09-12 CZ CS806215A patent/CZ278883B6/cs unknown
- 1980-09-12 YU YU02334/80A patent/YU233480A/xx unknown
- 1980-09-12 SK SK6215-80A patent/SK621580A3/sk unknown
- 1980-09-12 PL PL22672580A patent/PL226725A1/xx unknown
- 1980-09-12 DD DD80238563A patent/DD208989A5/de unknown
- 1980-09-12 RO RO80102151A patent/RO80005A/ro unknown
- 1980-09-12 BG BG049043A patent/BG41136A3/xx unknown
- 1980-09-12 DD DD80238569A patent/DD201693A5/de unknown
- 1980-09-12 KR KR1019800003590A patent/KR870000501B1/ko not_active Expired
- 1980-09-12 JP JP55127043A patent/JP2637393B2/ja not_active Expired - Lifetime
- 1980-09-12 DD DD80223873A patent/DD155004A5/de unknown
- 1980-09-12 BG BG057337A patent/BG41137A3/xx unknown
- 1980-09-12 IE IE1912/80A patent/IE52781B1/en unknown
1981
- 1981-06-30 ES ES503567A patent/ES503567A0/es active Granted
- 1981-06-30 ES ES503568A patent/ES503568A0/es active Granted
1984
- 1984-07-16 CZ CS845488A patent/CZ548884A3/cs unknown

Also Published As

Publication number	Publication date
JP2637393B2 (ja)	1997-08-06
GR70279B (cs)	1982-09-03
DD201693A5 (de)	1983-08-03
YU233480A (en)	1984-02-29
PT71790A (en)	1980-10-01
IT8068405A0 (it)	1980-09-11
JPS5695199A (en)	1981-08-01
PH26475A (en)	1992-07-27
FR2464997B1 (fr)	1985-05-24
SK278191B6 (en)	1996-03-06
ES8300857A1 (es)	1982-11-16
ES8305420A1 (es)	1983-04-01
IE52781B1 (en)	1988-03-02
FI802837A7 (fi)	1981-03-12
AU6232480A (en)	1981-03-19
FR2464997A1 (fr)	1981-03-20
SK621580A3 (en)	1996-03-06
CZ548884A3 (en)	1996-08-14
LU82757A1 (fr)	1981-02-02
ZA805341B (en)	1982-01-27
RO80005A (ro)	1983-07-07
DD155004A5 (de)	1982-05-05
SU1491345A3 (ru)	1989-06-30
CZ278883B6 (en)	1994-08-17
BE885196A (fr)	1980-12-31
BG41136A3 (bg)	1987-04-15
ES495030A0 (es)	1981-10-01
CZ621580A3 (en)	1994-03-16
KR830003576A (ko)	1983-06-21
IE801912L (en)	1981-03-12
IL61041A0 (en)	1980-11-30
AT377003B (de)	1985-01-25
KR870000501B1 (ko)	1987-03-12
EP0026598A1 (en)	1981-04-08
ES8107307A1 (es)	1981-10-01
ES503567A0 (es)	1983-04-01
BG41137A3 (bg)	1987-04-15
IL61041A (en)	1984-02-29
DK385980A (da)	1981-03-13
AU538154B2 (en)	1984-08-02
NZ194786A (en)	1984-02-03
PT71790B (en)	1981-07-07
ES503568A0 (es)	1982-11-16
ATA458580A (de)	1984-06-15
IT1129250B (it)	1986-06-04
CA1180289A (en)	1985-01-02
PL226725A1 (en)	1983-07-18
RO80005B (ro)	1983-06-30

Publication	Publication Date	Title
DE2858357C2 (cs)	1990-03-15
DE69521752T2 (de)	2001-11-08	Verfahren für die Herstellung von Proteinen
DE3050722C2 (cs)	1987-09-24
DE69021335T2 (de)	1996-04-11	Wachstumshormonfusionsproteine.
DE3280422T2 (de)	1993-05-27	Verfahren und produkte zur leichten mikrobiologischen expression von dns-sequenzen.
EP0513073B1 (de)	1995-06-28	VERFAHREN ZUR ENZYMATISCHEN SPALTUNG REKOMBINANTER PROTEINE UNTER VERWENDUNG VON IgA-PROTEASEN
DE3153606C2 (cs)	1991-04-25
DE3650553T2 (de)	1997-02-27	Verfahren zur Herstellung biologisch aktiver Rinder- und Schweine-Wachstumshormone und Mischung mit biologisch aktivem Schweine-Wachstumshormon
DD216044A5 (de)	1984-11-28	Verfahren zur herstellung eines rekombinierenden dna-klonierungsvektors
DD147369A5 (de)	1981-04-01	Verfahren zur synthese eines eukaryontischen proteins durch mikroorganismen
DE69434909T3 (de)	2012-02-09	Herstellung von humaninsulin
DD212403A5 (de)	1984-08-15	Verfahren zur synthetisierung von rinderwachstumshormon
DD154022A5 (de)	1982-02-17	Verfahren zur herstellung von menschlichem pre-wachstumshormon
DD155004A5 (de)	1982-05-05	Verfahren zur herstellung eines dns-transfervektors
DE60209883T2 (de)	2006-09-07	Übersekretierte peptide, deren herstellung, und gleichzeitige verbesserung der sekretierten form eines oder mehrerer anderer polypeptide
DE3751081T2 (de)	1995-10-19	[Leu 13] Motilin, dessen kodierende DNS-Moleküle und Verfahren zu dessen Herstellung.
DE3587205T2 (de)	1993-08-26	Verfahren zur herstellung eines proteins und dafuer zu verwendender vektor, rekombinante dns und transformierte zelle.
DE69630630T2 (de)	2004-09-23	Staphylococcus aureus V8 Protease Mutanten
DE3786870T2 (de)	1993-11-11	Methode zur Herstellung von Proteinen.
DE3884241T2 (de)	1994-01-13	Analoge des Porcin-Wachstumshormones.
EP0495398A1 (de)	1992-07-22	Rekombinante IgA-Protease
AT389891B (de)	1990-02-12	Verfahren zur herstellung von menschlichem proinsulin
AT389890B (de)	1990-02-12	Verfahren zur herstellung von humaninsulin
WO1986001540A1 (en)	1986-03-13	Modified insulin precursors products and processes
AT386607B (de)	1988-09-26	Verfahren zum herstellen eines dns-transfer-vektors