DD263771A5 - Verfahren zur herstellung von 2-oxo-5-phenyl-2,5-dihydrofuron-3-ylaminen - Google Patents
Verfahren zur herstellung von 2-oxo-5-phenyl-2,5-dihydrofuron-3-ylaminen Download PDFInfo
- Publication number
- DD263771A5 DD263771A5 DD30316087A DD30316087A DD263771A5 DD 263771 A5 DD263771 A5 DD 263771A5 DD 30316087 A DD30316087 A DD 30316087A DD 30316087 A DD30316087 A DD 30316087A DD 263771 A5 DD263771 A5 DD 263771A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- oxo
- phenyl
- formula
- carboxy
- preparation
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- YQOUMBVFEWZLME-VOTSOKGWSA-N (e)-2-oxo-4-phenylbut-3-enoic acid Chemical compound OC(=O)C(=O)\C=C\C1=CC=CC=C1 YQOUMBVFEWZLME-VOTSOKGWSA-N 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 2
- JNSNWRLASLHOPB-UHFFFAOYSA-N 4-amino-2-phenyl-2h-furan-5-one Chemical class O1C(=O)C(N)=CC1C1=CC=CC=C1 JNSNWRLASLHOPB-UHFFFAOYSA-N 0.000 abstract description 4
- BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical compound CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 abstract 1
- 239000005541 ACE inhibitor Substances 0.000 description 3
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 1
- 102100030988 Angiotensin-converting enzyme Human genes 0.000 description 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 1
- 150000001448 anilines Chemical class 0.000 description 1
- 125000004744 butyloxycarbonyl group Chemical group 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000004742 propyloxycarbonyl group Chemical group 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86822786A | 1986-05-28 | 1986-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD263771A5 true DD263771A5 (de) | 1989-01-11 |
Family
ID=25351280
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD30316087A DD263771A5 (de) | 1986-05-28 | 1987-05-26 | Verfahren zur herstellung von 2-oxo-5-phenyl-2,5-dihydrofuron-3-ylaminen |
| DD32522387A DD278787A5 (de) | 1986-05-28 | 1987-05-26 | Verfahren zur herstellung von ace-inhibitoren aus 2-oxo-5-phenyl-2,5-dihydro-furan-3-ylaminen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD32522387A DD278787A5 (de) | 1986-05-28 | 1987-05-26 | Verfahren zur herstellung von ace-inhibitoren aus 2-oxo-5-phenyl-2,5-dihydro-furan-3-ylaminen |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT395008B (fr) |
| CA (1) | CA1284499C (fr) |
| DD (2) | DD263771A5 (fr) |
| DK (2) | DK167018B1 (fr) |
| ES (1) | ES2005880A6 (fr) |
| FI (1) | FI88723C (fr) |
| GR (1) | GR870819B (fr) |
| HU (2) | HU199807B (fr) |
| NO (1) | NO170489C (fr) |
| PT (1) | PT84947B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010043558A (ko) | 1998-05-13 | 2001-05-25 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 감수분열 조절 화합물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
-
1987
- 1987-05-25 GR GR870819A patent/GR870819B/el unknown
- 1987-05-25 FI FI872306A patent/FI88723C/fi not_active IP Right Cessation
- 1987-05-26 PT PT8494787A patent/PT84947B/pt unknown
- 1987-05-26 DD DD30316087A patent/DD263771A5/de not_active IP Right Cessation
- 1987-05-26 CA CA000537949A patent/CA1284499C/fr not_active Expired - Lifetime
- 1987-05-26 DD DD32522387A patent/DD278787A5/de not_active IP Right Cessation
- 1987-05-27 HU HU657987A patent/HU199807B/hu unknown
- 1987-05-27 DK DK271087A patent/DK167018B1/da active IP Right Grant
- 1987-05-27 NO NO872226A patent/NO170489C/no unknown
- 1987-05-27 AT AT135787A patent/AT395008B/de not_active IP Right Cessation
- 1987-05-27 HU HU244487A patent/HU199832B/hu unknown
- 1987-05-28 ES ES8701572A patent/ES2005880A6/es not_active Expired
-
1992
- 1992-10-27 DK DK130992A patent/DK169322B1/da active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PT84947A (en) | 1987-06-01 |
| DK271087A (da) | 1987-11-29 |
| FI872306A0 (fi) | 1987-05-25 |
| NO170489B (no) | 1992-07-13 |
| HU199832B (en) | 1990-03-28 |
| DK271087D0 (da) | 1987-05-27 |
| HU199807B (en) | 1990-03-28 |
| NO872226L (no) | 1987-11-30 |
| ATA135787A (de) | 1992-01-15 |
| AT395008B (de) | 1992-08-25 |
| DK169322B1 (da) | 1994-10-10 |
| HUT44534A (en) | 1988-03-28 |
| CA1284499C (fr) | 1991-05-28 |
| DK130992D0 (da) | 1992-10-27 |
| FI872306L (fi) | 1987-11-29 |
| GR870819B (en) | 1987-09-25 |
| DK130992A (da) | 1992-10-27 |
| PT84947B (pt) | 1990-02-08 |
| NO170489C (no) | 1992-10-21 |
| FI88723B (fi) | 1993-03-15 |
| DD278787A5 (de) | 1990-05-16 |
| DK167018B1 (da) | 1993-08-16 |
| FI88723C (fi) | 1993-06-28 |
| NO872226D0 (no) | 1987-05-27 |
| ES2005880A6 (es) | 1989-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |