DD292138A5 - Vernetzte hydrogele und ihre verwendung als wundauflage - Google Patents

Vernetzte hydrogele und ihre verwendung als wundauflage Download PDF

Info

Publication number: DD292138A5
Authority: DD; German Democratic Republic
Prior art keywords: acid; crosslinked; parts; weight; wound
Prior art date: 1989-02-08

Application number

DD90337639A

Other languages

German (de)

English (en)

Inventor

Zbigniew Dipl-Chem Dr Czech

Kurt Dipl-Chem Dr Seeger

Original Assignee

Lohmann Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-08

Filing date

1990-02-06

Publication date

1991-07-25

1990-02-06 Application filed by Lohmann Gmbh & Co Kg filed Critical Lohmann Gmbh & Co Kg

1991-07-25 Publication of DD292138A5 publication Critical patent/DD292138A5/de

Links

239000000017 hydrogel Substances 0.000 claims abstract description 34
229920001222 biopolymer Polymers 0.000 claims abstract description 19
208000027418 Wounds and injury Diseases 0.000 claims abstract description 18
206010048629 Wound secretion Diseases 0.000 claims abstract description 16
229920001059 synthetic polymer Polymers 0.000 claims abstract description 16
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 14
239000000203 mixture Substances 0.000 claims abstract description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
229920001577 copolymer Polymers 0.000 claims abstract description 12
150000005846 sugar alcohols Polymers 0.000 claims abstract description 12
239000003431 cross linking reagent Substances 0.000 claims abstract description 10
238000000034 method Methods 0.000 claims abstract description 7
239000003349 gelling agent Substances 0.000 claims abstract description 6
150000003839 salts Chemical class 0.000 claims abstract description 6
239000002504 physiological saline solution Substances 0.000 claims abstract description 4
230000008569 process Effects 0.000 claims abstract description 4
238000002360 preparation method Methods 0.000 claims abstract description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
108010010803 Gelatin Proteins 0.000 claims description 11
239000008273 gelatin Substances 0.000 claims description 11
229920000159 gelatin Polymers 0.000 claims description 11
235000019322 gelatine Nutrition 0.000 claims description 11
235000011852 gelatine desserts Nutrition 0.000 claims description 11
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 6
239000002253 acid Substances 0.000 claims description 5
235000011187 glycerol Nutrition 0.000 claims description 5
229920000642 polymer Polymers 0.000 claims description 5
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims description 4
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims description 4
238000003756 stirring Methods 0.000 claims description 4
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 3
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
229920000877 Melamine resin Polymers 0.000 claims description 3
150000001541 aziridines Chemical class 0.000 claims description 3
238000010438 heat treatment Methods 0.000 claims description 3
229910052751 metal Inorganic materials 0.000 claims description 3
239000002184 metal Substances 0.000 claims description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 3
239000001814 pectin Substances 0.000 claims description 3
235000010987 pectin Nutrition 0.000 claims description 3
229920001277 pectin Polymers 0.000 claims description 3
235000013772 propylene glycol Nutrition 0.000 claims description 3
DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
239000001124 (E)-prop-1-ene-1,2,3-tricarboxylic acid Substances 0.000 claims description 2
YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims description 2
CYUZOYPRAQASLN-UHFFFAOYSA-N 3-prop-2-enoyloxypropanoic acid Chemical compound OC(=O)CCOC(=O)C=C CYUZOYPRAQASLN-UHFFFAOYSA-N 0.000 claims description 2
102000008186 Collagen Human genes 0.000 claims description 2
108010035532 Collagen Proteins 0.000 claims description 2
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
229940091181 aconitic acid Drugs 0.000 claims description 2
150000001298 alcohols Chemical class 0.000 claims description 2
229910052783 alkali metal Inorganic materials 0.000 claims description 2
150000001340 alkali metals Chemical class 0.000 claims description 2
150000003863 ammonium salts Chemical class 0.000 claims description 2
PVEOYINWKBTPIZ-UHFFFAOYSA-N but-3-enoic acid Chemical compound OC(=O)CC=C PVEOYINWKBTPIZ-UHFFFAOYSA-N 0.000 claims description 2
BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 claims description 2
OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 2
GTZCVFVGUGFEME-IWQZZHSRSA-N cis-aconitic acid Chemical compound OC(=O)C\C(C(O)=O)=C\C(O)=O GTZCVFVGUGFEME-IWQZZHSRSA-N 0.000 claims description 2
229920001436 collagen Polymers 0.000 claims description 2
239000000470 constituent Substances 0.000 claims description 2
LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims description 2
238000001035 drying Methods 0.000 claims description 2
150000002118 epoxides Chemical class 0.000 claims description 2
239000001530 fumaric acid Substances 0.000 claims description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
239000011976 maleic acid Substances 0.000 claims description 2
LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 2
229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
239000000661 sodium alginate Substances 0.000 claims description 2
235000010413 sodium alginate Nutrition 0.000 claims description 2
229940005550 sodium alginate Drugs 0.000 claims description 2
LLZRNZOLAXHGLL-UHFFFAOYSA-J titanic acid Chemical class O[Ti](O)(O)O LLZRNZOLAXHGLL-UHFFFAOYSA-J 0.000 claims description 2
GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 claims description 2
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims description 2
150000003918 triazines Chemical class 0.000 claims description 2
230000000694 effects Effects 0.000 abstract description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
239000002250 absorbent Substances 0.000 abstract 1
230000002745 absorbent Effects 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1
206010052428 Wound Diseases 0.000 description 15
238000010521 absorption reaction Methods 0.000 description 8
239000000243 solution Substances 0.000 description 4
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
238000004132 cross linking Methods 0.000 description 3
230000003248 secreting effect Effects 0.000 description 3
QAXCWBIVFCEYGG-UHFFFAOYSA-N 1-methylquinazolin-4-one Chemical compound C1=CC=C2N(C)C=NC(=O)C2=C1 QAXCWBIVFCEYGG-UHFFFAOYSA-N 0.000 description 2
235000010443 alginic acid Nutrition 0.000 description 2
229920000615 alginic acid Polymers 0.000 description 2
239000002585 base Substances 0.000 description 2
239000000178 monomer Substances 0.000 description 2
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 2
230000035699 permeability Effects 0.000 description 2
239000005020 polyethylene terephthalate Substances 0.000 description 2
229920000139 polyethylene terephthalate Polymers 0.000 description 2
-1 polyoxyethylene Polymers 0.000 description 2
230000029663 wound healing Effects 0.000 description 2
RYSXWUYLAWPLES-MTOQALJVSA-N (Z)-4-hydroxypent-3-en-2-one titanium Chemical compound [Ti].C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O RYSXWUYLAWPLES-MTOQALJVSA-N 0.000 description 1
YOBOXHGSEJBUPB-MTOQALJVSA-N (z)-4-hydroxypent-3-en-2-one;zirconium Chemical compound [Zr].C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O YOBOXHGSEJBUPB-MTOQALJVSA-N 0.000 description 1
PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
239000004971 Cross linker Substances 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
239000006096 absorbing agent Substances 0.000 description 1
125000005595 acetylacetonate group Chemical group 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
150000003926 acrylamides Chemical class 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
230000006399 behavior Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
230000008859 change Effects 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000010959 commercial synthesis reaction Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
230000035876 healing Effects 0.000 description 1
235000015110 jellies Nutrition 0.000 description 1
239000008274 jelly Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
150000002482 oligosaccharides Chemical class 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
230000028327 secretion Effects 0.000 description 1
229940047670 sodium acrylate Drugs 0.000 description 1
229910052719 titanium Inorganic materials 0.000 description 1
239000010936 titanium Substances 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Materials Engineering (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Dispersion Chemistry (AREA)
Hematology (AREA)
Materials For Medical Uses (AREA)
Compositions Of Macromolecular Compounds (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Medicinal Preparation (AREA)
Colloid Chemistry (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)

DD90337639A 1989-02-08 1990-02-06 Vernetzte hydrogele und ihre verwendung als wundauflage DD292138A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3903672A DE3903672C1 (fr)	1989-02-08	1989-02-08

Publications (1)

Publication Number	Publication Date
DD292138A5 true DD292138A5 (de)	1991-07-25

Family

ID=6373623

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD90337639A DD292138A5 (de)	1989-02-08	1990-02-06	Vernetzte hydrogele und ihre verwendung als wundauflage

Country Status (23)

Country	Link
US (2)	US5135755A (fr)
EP (1)	EP0382128B1 (fr)
JP (1)	JPH082368B2 (fr)
KR (1)	KR950003695B1 (fr)
AT (1)	ATE126070T1 (fr)
BG (1)	BG60006B2 (fr)
BR (1)	BR9000531A (fr)
CA (1)	CA2009475A1 (fr)
CS (1)	CS276925B6 (fr)
DD (1)	DD292138A5 (fr)
DE (2)	DE3903672C1 (fr)
DK (1)	DK0382128T3 (fr)
ES (1)	ES2078915T3 (fr)
FI (1)	FI102725B1 (fr)
GR (1)	GR3017878T3 (fr)
HU (1)	HU204189B (fr)
IE (1)	IE72218B1 (fr)
IL (1)	IL93166A (fr)
NO (1)	NO180668C (fr)
PL (1)	PL163801B1 (fr)
PT (1)	PT93078A (fr)
RO (1)	RO105547B1 (fr)
RU (1)	RU2086234C1 (fr)

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DE4007668A1 (de) *	1990-03-10	1991-09-12	Beiersdorf Ag	Hydrogelschaeume und verfahren zu deren herstellung
US5847023A (en) *	1990-10-26	1998-12-08	Mdv Technologies, Inc.	Thermal irreversible gel corneal contact lens formed in situ
US5762620A (en) *	1992-04-02	1998-06-09	Ndm Acquisition Corp.	Wound dressing containing a partially dehydrated hydrogel
GB9208731D0 (en) *	1992-04-22	1992-06-10	Squibb & Sons Inc	Hydrocolloid wound gel
US5549914A (en) *	1992-12-14	1996-08-27	Sween Corporation	Heat stable wound care gel
DE4336301C2 (de) *	1993-10-25	1997-05-07	Arbo Tec Sensor Technologie Gm	Elektrisch leitfähige Hydrogelzusammensetzung, Verfahren zur Herstellung eines Hydrogels und deren Verwendung
GB2284606A (en) *	1993-11-24	1995-06-14	Aspid S A De C V	Polymerised collagen-based anti-fibroid composition
US5614586A (en) *	1994-04-06	1997-03-25	Graphic Controls Corporation	Polyacrylate and Polymethacrylate ester based hydrogel adhesives
US5674275A (en) *	1994-04-06	1997-10-07	Graphic Controls Corporation	Polyacrylate and polymethacrylate ester based hydrogel adhesives
GB2291348B (en) *	1994-07-18	1999-01-20	Johnson & Johnson Medical	Sterile gel composition for wound treatment comprising alginate and polyhydric alcohol
US5502042A (en) *	1994-07-22	1996-03-26	United States Surgical Corporation	Methods and compositions for treating wounds
US5905092A (en) *	1994-09-27	1999-05-18	Virotex Corporation Reel/Frame	Topical antibiotic composition providing optimal moisture environment for rapid wound healing that reduces skin contraction
US5631301A (en) *	1994-09-27	1997-05-20	Virotex Corporation	Topical antibiotic composition providing optimal moisture environment
US5676967A (en) *	1995-04-18	1997-10-14	Brennen Medical, Inc.	Mesh matrix wound dressing
WO1997022371A1 (fr)	1995-12-18	1997-06-26	Collagen Corporation	Composition a base de polymeres reticules et leur procede d'utilisation
US7883693B2 (en)	1995-12-18	2011-02-08	Angiodevice International Gmbh	Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
US6833408B2 (en)	1995-12-18	2004-12-21	Cohesion Technologies, Inc.	Methods for tissue repair using adhesive materials
US7435425B2 (en) *	2001-07-17	2008-10-14	Baxter International, Inc.	Dry hemostatic compositions and methods for their preparation
US8603511B2 (en)	1996-08-27	2013-12-10	Baxter International, Inc.	Fragmented polymeric compositions and methods for their use
US8303981B2 (en)	1996-08-27	2012-11-06	Baxter International Inc.	Fragmented polymeric compositions and methods for their use
US6066325A (en)	1996-08-27	2000-05-23	Fusion Medical Technologies, Inc.	Fragmented polymeric compositions and methods for their use
US5851229A (en) *	1996-09-13	1998-12-22	Meadox Medicals, Inc.	Bioresorbable sealants for porous vascular grafts
US6090915A (en) *	1996-10-18	2000-07-18	Hormel Foods Corporation	Collagen or gelatin crumble composition and uses
US20020086423A1 (en) *	1997-09-09	2002-07-04	Toshiaki Takezawa	Hydrogel thin film containing extracellular matrix components
JPH11158026A (ja) *	1997-12-01	1999-06-15	Shiseido Co Ltd	保湿剤及び皮膚外用剤
US6121375A (en)	1999-02-11	2000-09-19	Hydromer, Inc.	Gels formed by the interaction of poly(aldehyde) with various substances
AU3615700A (en)	1999-03-04	2000-09-21	United States Surgical Corporation	Scar reduction
RU2157159C1 (ru) *	1999-04-26	2000-10-10	Тарутта Елена Петровна	Комбинированный трансплантат для склеропластики
RU2198684C2 (ru) *	2001-04-06	2003-02-20	Российский научно-исследовательский институт гематологии и трансфузиологии	Гемостатическая губка и способ ее получения
US20040235791A1 (en) *	2002-01-25	2004-11-25	Gruskin Elliott A.	Scar reduction
CN1272071C (zh) *	2002-03-14	2006-08-30	美德阿利克斯株式会社	创伤用外用剂
GB0300625D0 (en) *	2003-01-10	2003-02-12	Bristol Myers Squibb Co	Wound dressing
ITMI20030414A1 (it) *	2003-03-06	2004-09-07	Biofarm S R L Ora Biofarmitalia S P A	Tampone con strato di gel con attivita' cosmetica o terapeutica.
RU2326893C2 (ru) *	2003-04-16	2008-06-20	Кориум Интернэшнл	Ковалентное и нековалентное сшивание гидрофильных полимеров и адгезивные композиции, полученные с ними
US8834864B2 (en) *	2003-06-05	2014-09-16	Baxter International Inc.	Methods for repairing and regenerating human dura mater
US7927626B2 (en) *	2003-08-07	2011-04-19	Ethicon, Inc.	Process of making flowable hemostatic compositions and devices containing such compositions
KR100506543B1 (ko) *	2003-08-14	2005-08-05	주식회사 제닉	온도 감응성 상태변화 하이드로겔 조성물 및 그 제조방법
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1989
- 1989-02-08 DE DE3903672A patent/DE3903672C1/de not_active Expired - Fee Related
1990
- 1990-01-24 IL IL9316690A patent/IL93166A/en not_active IP Right Cessation
- 1990-02-02 BG BG091103A patent/BG60006B2/bg unknown
- 1990-02-03 ES ES90102173T patent/ES2078915T3/es not_active Expired - Lifetime
- 1990-02-03 EP EP90102173A patent/EP0382128B1/fr not_active Expired - Lifetime
- 1990-02-03 DE DE59009486T patent/DE59009486D1/de not_active Expired - Fee Related
- 1990-02-03 RO RO144064A patent/RO105547B1/ro unknown
- 1990-02-03 DK DK90102173.3T patent/DK0382128T3/da active
- 1990-02-03 AT AT90102173T patent/ATE126070T1/de not_active IP Right Cessation
- 1990-02-05 RU SU904742980A patent/RU2086234C1/ru active
- 1990-02-06 DD DD90337639A patent/DD292138A5/de not_active IP Right Cessation
- 1990-02-06 US US07/475,608 patent/US5135755A/en not_active Expired - Fee Related
- 1990-02-07 PL PL90283669A patent/PL163801B1/pl unknown
- 1990-02-07 NO NO900581A patent/NO180668C/no unknown
- 1990-02-07 JP JP2026212A patent/JPH082368B2/ja not_active Expired - Lifetime
- 1990-02-07 BR BR909000531A patent/BR9000531A/pt not_active Application Discontinuation
- 1990-02-07 KR KR1019900001447A patent/KR950003695B1/ko not_active Expired - Fee Related
- 1990-02-07 IE IE43590A patent/IE72218B1/en not_active IP Right Cessation
- 1990-02-07 PT PT93078A patent/PT93078A/pt not_active Application Discontinuation
- 1990-02-07 CS CS90593A patent/CS276925B6/cs not_active IP Right Cessation
- 1990-02-07 CA CA002009475A patent/CA2009475A1/fr not_active Abandoned
- 1990-02-08 HU HU90719A patent/HU204189B/hu not_active IP Right Cessation
- 1990-02-08 FI FI900629A patent/FI102725B1/fi not_active IP Right Cessation
1992
- 1992-04-29 US US07/875,488 patent/US5336501A/en not_active Expired - Fee Related
1995
- 1995-10-25 GR GR950402983T patent/GR3017878T3/el unknown

Also Published As

Publication number	Publication date
FI102725B (fi)	1999-02-15
RU2086234C1 (ru)	1997-08-10
EP0382128A2 (fr)	1990-08-16
ES2078915T3 (es)	1996-01-01
US5135755A (en)	1992-08-04
IE72218B1 (en)	1997-04-09
GR3017878T3 (en)	1996-01-31
IL93166A0 (en)	1990-11-05
NO900581D0 (no)	1990-02-07
HU900719D0 (en)	1990-04-28
JPH02265560A (ja)	1990-10-30
NO900581L (no)	1990-08-09
RO105547B1 (ro)	1992-09-25
AU621187B2 (en)	1992-03-05
HUT53798A (en)	1990-12-28
AU4876990A (en)	1990-08-16
DE3903672C1 (fr)	1990-02-01
HU204189B (en)	1991-12-30
JPH082368B2 (ja)	1996-01-17
KR900012633A (ko)	1990-09-01
US5336501A (en)	1994-08-09
CA2009475A1 (fr)	1990-08-08
NO180668C (no)	1997-05-28
NO180668B (no)	1997-02-17
DK0382128T3 (da)	1995-08-09
PT93078A (pt)	1990-08-31
FI900629A0 (fi)	1990-02-08
EP0382128B1 (fr)	1995-08-09
ATE126070T1 (de)	1995-08-15
IL93166A (en)	1994-05-30
FI102725B1 (fi)	1999-02-15
BG60006B2 (bg)	1993-06-30
IE900435L (en)	1990-08-08
CS276925B6 (en)	1992-09-16
BR9000531A (pt)	1991-01-15
DE59009486D1 (de)	1995-09-14
CS5939290A2 (en)	1991-10-15
EP0382128A3 (en)	1990-12-12
PL163801B1 (pl)	1994-05-31
KR950003695B1 (ko)	1995-04-17

Legal Events

Date	Code	Title	Description
1991-07-25	A5	Published as prov. exclusive patent
1995-07-06	ENJ	Ceased due to non-payment of renewal fee

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DD145062A5 (de)	1980-11-19	Transparentes fluessigkeitsverbandsmaterial
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DE69620513T2 (de)	2002-11-14	Zelluloseesterwundverband