DE3584183D1 - Octahydrothiazolo(4,5-g)chinoline. - Google Patents

Octahydrothiazolo(4,5-g)chinoline.

Info

Publication number: DE3584183D1
Authority: DE; Germany
Prior art keywords: sub; alkyl; octahydrothiazolo; nhc; sup
Prior art date: 1984-04-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE8585302852T

Other languages

English (en)

Inventor

Edmund Carl Kornfeld

Robert Daniel Titus

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-27

Filing date

1985-04-24

Publication date

1991-10-31

1985-04-24 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1991-10-31 Application granted granted Critical

1991-10-31 Publication of DE3584183D1 publication Critical patent/DE3584183D1/de

2005-04-25 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
150000003839 salts Chemical group 0.000 abstract 2
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229940052760 dopamine agonists Drugs 0.000 abstract 1
239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
-1 substituted-octahydrothiazolo [4,5-g]quinolines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/30—Metal salts; Chelates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DE8585302852T 1984-04-27 1985-04-24 Octahydrothiazolo(4,5-g)chinoline. Expired - Lifetime DE3584183D1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/604,687 US4537893A (en)	1984-04-27	1984-04-27	Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors

Publications (1)

Publication Number	Publication Date
DE3584183D1 true DE3584183D1 (de)	1991-10-31

Family

ID=24420601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE8585302852T Expired - Lifetime DE3584183D1 (de)	1984-04-27	1985-04-24	Octahydrothiazolo(4,5-g)chinoline.

Country Status (19)

Country	Link
US (1)	US4537893A (de)
EP (1)	EP0160502B1 (de)
JP (1)	JPH0631262B2 (de)
KR (1)	KR870001072B1 (de)
CN (1)	CN85101547A (de)
AT (1)	ATE67767T1 (de)
AU (1)	AU564946B2 (de)
CA (1)	CA1287356C (de)
DE (1)	DE3584183D1 (de)
DK (1)	DK185485A (de)
ES (1)	ES8704177A1 (de)
GR (1)	GR850989B (de)
HU (1)	HU193113B (de)
IL (1)	IL74988A0 (de)
NZ (1)	NZ211863A (de)
PH (1)	PH21951A (de)
PT (1)	PT80339B (de)
SU (1)	SU1414318A3 (de)
ZA (1)	ZA852999B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4778894A (en) *	1983-09-26	1988-10-18	Eli Lilly And Company	6 oxo-decahydroquinolines
US4977160A (en) *	1986-06-16	1990-12-11	Eli Lilly And Company	BCD tricyclic ergoline part-structure analogues
US5134143A (en) *	1986-06-16	1992-07-28	Eli Lilly And Company	BCD tricyclic ergoline part-structure analogues
US4826986A (en) *	1986-06-16	1989-05-02	Eli Lilly And Company	6-Oxo-trans-octa- and decahydroquinolines
DE3624607A1 (de) *	1986-07-21	1988-01-28	Boehringer Ingelheim Kg	Neue tetrahydrobenzothiazolo-chinoline ihre herstellung und verwendung
US4762843A (en) *	1986-09-15	1988-08-09	Warner-Lambert Company	Hetero [f] fused carbocyclic pyridines as dopaminergic agents
US4939259A (en) *	1989-07-24	1990-07-03	Eli Lilly And Company	2-oxo-pyrido[2,3-g]quinoline derivatives
US5006525A (en) *	1989-07-24	1991-04-09	Eli Lilly And Company	Dopamine agonists method
US4977149A (en) *	1989-07-24	1990-12-11	Eli Lilly And Company	Pyridoquinoline dopamine agonists, compositions and use
US5057515A (en) *	1989-07-24	1991-10-15	Eli Lilly And Company	Method for agonizing a dopamine receptor
US5416090A (en) *	1991-01-31	1995-05-16	Eli Lilly And Company	Method of treating inflammation
CA2144669A1 (en) *	1994-03-29	1995-09-30	Kozo Akasaka	Biphenyl derivatives
EP0816406B1 (de) *	1996-06-26	2000-09-06	Bayer Ag	Verfahren zur Herstellung salzarmer Präparationen von Kondensationsprodukten
WO2009139855A2 (en) *	2008-05-14	2009-11-19	Ipsen Pharma S.A.S.	Pharmaceutical compositions of somatostatin-dopamine conjugates
TWI537274B (zh) *	2011-03-14	2016-06-11	橘生藥品工業股份有限公司	新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2056224A1 (de) *	1969-11-17	1971-06-03	Danchi Seiyaku Co , Ltd , Tokio	Neue Thiazolochinohnderivate und Ver fahren zu ihrer Herstellung
US4198415A (en) *	1979-01-22	1980-04-15	Eli Lilly And Company	Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines
US4258049A (en) *	1979-07-02	1981-03-24	Smithkline Corporation	Inhibiting phenylethanolamine N-methyltransferase with thiadiazolo and oxadiazolotetrahydroisoquinolines
US4367231A (en) *	1979-09-14	1983-01-04	Eli Lilly And Company	Method of using octahydro pyrazolo[3,4-g]quinolines

1984
- 1984-04-27 US US06/604,687 patent/US4537893A/en not_active Expired - Fee Related
1985
- 1985-04-01 CN CN198585101547A patent/CN85101547A/zh active Pending
- 1985-04-22 CA CA000479702A patent/CA1287356C/en not_active Expired - Lifetime
- 1985-04-22 NZ NZ211863A patent/NZ211863A/en unknown
- 1985-04-22 ZA ZA852999A patent/ZA852999B/xx unknown
- 1985-04-22 SU SU853883101A patent/SU1414318A3/ru active
- 1985-04-23 IL IL74988A patent/IL74988A0/xx unknown
- 1985-04-23 GR GR850989A patent/GR850989B/el unknown
- 1985-04-23 PT PT80339A patent/PT80339B/pt not_active IP Right Cessation
- 1985-04-24 EP EP85302852A patent/EP0160502B1/de not_active Expired - Lifetime
- 1985-04-24 AU AU41666/85A patent/AU564946B2/en not_active Ceased
- 1985-04-24 DE DE8585302852T patent/DE3584183D1/de not_active Expired - Lifetime
- 1985-04-24 AT AT85302852T patent/ATE67767T1/de not_active IP Right Cessation
- 1985-04-25 PH PH32196A patent/PH21951A/en unknown
- 1985-04-25 KR KR1019850002803A patent/KR870001072B1/ko not_active Expired
- 1985-04-25 ES ES542565A patent/ES8704177A1/es not_active Expired
- 1985-04-25 DK DK185485A patent/DK185485A/da not_active Application Discontinuation
- 1985-04-26 HU HU851624A patent/HU193113B/hu unknown
- 1985-04-26 JP JP60092157A patent/JPH0631262B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0160502A2 (de)	1985-11-06
HU193113B (en)	1987-08-28
DK185485D0 (da)	1985-04-25
CA1287356C (en)	1991-08-06
JPH0631262B2 (ja)	1994-04-27
PT80339A (en)	1985-05-01
EP0160502B1 (de)	1991-09-25
ZA852999B (en)	1986-11-26
AU4166685A (en)	1985-10-31
CN85101547A (zh)	1987-01-24
JPS60233091A (ja)	1985-11-19
PH21951A (en)	1988-04-15
ES542565A0 (es)	1987-03-16
NZ211863A (en)	1987-10-30
IL74988A0 (en)	1985-08-30
HUT37624A (en)	1986-01-23
GR850989B (de)	1985-11-25
SU1414318A3 (ru)	1988-07-30
ES8704177A1 (es)	1987-03-16
PT80339B (en)	1987-02-16
DK185485A (da)	1985-10-28
AU564946B2 (en)	1987-09-03
EP0160502A3 (en)	1987-03-11
KR870001072B1 (ko)	1987-05-27
KR850007261A (ko)	1985-12-02
ATE67767T1 (de)	1991-10-15
US4537893A (en)	1985-08-27

Legal Events

Date	Code	Title	Description
1992-10-22	8364	No opposition during term of opposition
1996-04-11	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE3584183D1 (de)	1991-10-31	Octahydrothiazolo(4,5-g)chinoline.
GB1423006A (en)	1976-01-28	Herbicidal compositions containing 4-phenoxy-phenoxy-propionic acid derivatives
KR850001171A (ko)	1985-03-16	퀴놀린 화합물의 제조방법
SE8804586D0 (sv)	1988-12-20	1,4-dihydro-4-oxonaftyridinderivat och salter daerav foerfarande foer framstaellning av dessa jaemte antibakteriella medel innefattande dessa
IT1171880B (it)	1987-06-10	Derivati di 2-ammino-3-acilammino-6-benzilammino-piridina aventi azione antiepilettica e procedimento per la loro produzione
SE8204237L (sv)	1982-07-08	Karbostyrilforeningar, kompositioner innehallande dessa samt forfaranden for framstellning derav
ES8601201A1 (es)	1985-10-16	Procedimiento para preparar derivados de imidazolina
ES543368A0 (es)	1986-08-01	Procedimiento para la obtencion de derivados de 1-fluoro-1- -azolil-2,2-diaril-etano
DK67384A (da)	1984-08-16	N-iminopyridiniumbetainderivater
ES533320A0 (es)	1985-08-01	Procedimiento para preparar 1-acetonil-2-(fenilimino)-imidazolidinas
KR860001815A (ko)	1986-03-22	옥타하이드로-옥사졸로[4,5-g]퀴놀린의 제조방법
RU93004729A (ru)	1996-02-27	Новые производные имидазола
AU2508584A (en)	1984-09-06	N-arylpiperazine derivatives
YU47949B (sh)	1996-07-24	3,4-DI-(HIDRO)-2H,6H-PIRIMIDO (2,1-b)(1,3) TIAZIN DERIVATII1,2,3,4-TETRA-(HIDRO)-PIRIMIDIN.2.TIONI I POSTUPCI ZA NJIHOVO DOBIJANJE
KR850004760A (ko)	1985-07-27	이미다조 퀴놀린 유도체의 제조방법
DK165586D0 (da)	1986-04-11	Heterocycliske amidderivater, deres fremstilling og anvendelse som fungicider
IT1161216B (it)	1987-03-18	Composizioni farmaceutiche contenenti composti a scheletro flavanonico, procedimento per la preparazione di detti composti e nuovi composti ottenuti
RU95117134A (ru)	1997-09-27	Производное морфолина или его фармацевтически приемлемая соль и фармацевтическая композиция на его основе
DK0763516T3 (da)	2001-09-17	Fremstilling og anvendelse af rene enantiomerer af 8-halogen-6-hydroxyoctansyrer, deres alkylestere og deres salte med rene enantiomerer af alfa-methylbenzylamin
ATE30675T1 (de)	1987-11-15	Benzobicyclononanamin-derivate mit antikonvulsiven eigenschaften.
BR8400237A (pt)	1984-08-28	Derivados de sulfenil nitrometano,processo para a preparacao de derivados de sulfenil nitrometano,composicoes pesticidas e metodo para combater pragas
ES8607331A1 (es)	1986-05-16	Procedimiento para preparar derivados de oxazafosforina