DE69801459T2 - Beschichteter endovaskulärer Stent - Google Patents

Beschichteter endovaskulärer Stent

Info

Publication number
DE69801459T2
DE69801459T2 DE69801459T DE69801459T DE69801459T2 DE 69801459 T2 DE69801459 T2 DE 69801459T2 DE 69801459 T DE69801459 T DE 69801459T DE 69801459 T DE69801459 T DE 69801459T DE 69801459 T2 DE69801459 T2 DE 69801459T2
Authority
DE
Germany
Prior art keywords
heparin
support structure
coating
endovascular stent
functional groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69801459T
Other languages
English (en)
Other versions
DE69801459D1 (de
Inventor
Randy Chan
John J. Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Cardiovascular Systems Inc
Original Assignee
Advanced Cardiovascular Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25301436&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69801459(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Advanced Cardiovascular Systems Inc filed Critical Advanced Cardiovascular Systems Inc
Application granted granted Critical
Publication of DE69801459D1 publication Critical patent/DE69801459D1/de
Publication of DE69801459T2 publication Critical patent/DE69801459T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/92—Stents in the form of a rolled-up sheet expanding after insertion into the vessel, e.g. with a spiral shape in cross-section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
    • Y10S623/921—Blood vessel

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Description

  • Die vorliegende Erfindung betrifft endovaskuläre Stents und bezieht sich insbesondere auf Beschichtungen, die auf Stents aufgetragen sind, um die Thrombogenizität nach der Implantation zu reduzieren.
  • Stents werden in Blutgefäße implantiert, mit dem Ziel, die Blutgefäße durchgängig zu halten, durch Verhindern eines Kollapses des Lumens und/oder durch Erschweren einer Restenose, einer erneuten Blockage des Gefäßes, wie sie etwa einer angioplastischen Behandlung folgen könnte, die durchgeführt wird, um eine vorherige Blockage aufzubrechen oder zu dilatieren. Unglücklicherweise könnte die Gegenwart eines Fremdkörpers in dem Blutflussweg einen thrombogenen Effekt haben. Daher erwies es sich als wünschenswert, verschiedene antikoagulante Medikamente mit dem Ziel zu verwenden, einen antithrombogenen Effekt vorzusehen und die Wahrscheinlichkeit der Entwicklung von Restenose zu reduzieren.
  • Ein Medikament, das sich für solche Zwecke als besonders wirkungsvoll erwies, ist Heparin. Indem man die wirkungsvolle Konzentration des Medikaments in und um den Implantationsort beibehält, bis der Stent durch neues Körpergewebe umschlossen ist, kann das Thromboserisiko wesentlich gelindert werden. Hierzu wurden verschiedene Ansätze bei der Verabreichung von Heparin in Verbindung mit der Entfaltung der Stents angewendet.
  • Während die systemische Verabreichung von Heparin bewirken kann, dass der Implantationsort einem effektiven Heparinpegel ausgesetzt wird, wäre ein solcher Heparinpegel notwendigerweise auch in gleicher Konzentration im gesamten Rest des Körpers des Patienten vorhanden, was zuunerwünschten Nebeneffekten führen kann, wie etwa schwer zu steuernden Blutungen. Es ist daher erkannt worden, dass ein Regime, in dem das Heparin weitgehend auf den Implantationsort beschränkt ist, viel wünschenswerter ist. Ein Ansatz, der zum derartigen Einschränken des Medikaments entwickelt wurde, beinhaltet das Beschichten oder Imprägnieren des Stents mit Heparin. Das Heparin wird hierdurch dort konzentriert, wo es am meisten benötigt wird, wobei aber die Konzentration des Medikaments und entsprechend die Einwirkung des Medikaments auf das System des Patienten lokalisiert ist.
  • Beispielsweise offenbart die US-A-5,356,433 eine medizinische Vorrichtung oder Komponenten medizinischer Vorrichtungen, die metallische Oberflächen aufweisen, die verbesserte Biokompatibilitätseigenschaften haben. Die Oberflächen werden durch eine zweistufige Behandlung hergestellt, einschließlich dem kovalenten Koppeln eines Organosilans, das Amin-reaktive Stellen aufweist, mit der Oberfläche des metallischen Elements, typischerweise durch ein Metalloxid davon. Danach wird das biologisch aktive Mittel, wie etwa Heparin, kovalent mit der Organosilanbeschichtung gekoppelt. Der zweistufige Prozess soll besonders vorteilhaft zur Herstellung medizinischer Vorrichtungen in der Form von Stents sein, die während der Implantationsprozeduren gebogen und gebeugt werden müssen.
  • Nachteile, die bei bisher bekannten heparinisierten Stents auftreten, beinhalten die begrenzte Lagerbeständigkeit solcher Vorrichtungen, die Tatsache, dass sich das Heparin zersetzt, wenn der Stent einer Vor- Entfaltungs-Sterilisation unterzogen wird (entweder durch Hitze oder durch eine chemische Lösung, wie etwa Ethylendioxid), die Unfähigkeit, die Dosierung zu ändern, der der Patient ausgesetzt wird, und die Unfähigkeit, etwaiges Heparin nachzufüllen, das verlorengegangen sein könnte, während sich der Stent in dem Entfaltungsprozess befindet. Zusätzlich waren die Kosten bisher bekannter heparinisierter Stentvorrichtungen sehr hoch, da solche Fälle notwendigerweise die Aufwendungen beinhalten, die aufgrund stringenter Regulationsanforderungen auftreten, die häufig mit dem Vorsehen einer medikamentenhaltigen Vorrichtung einhergehen.
  • Die bisherige Technik war daher nicht in der Lage; diese Nachteile und Mängel zu überwinden, und es ist ein neuer Ansatz erforderlich, um Heparin sicher, effektiv und ökonomisch zu einem Implantationsort auszugeben.
  • Die vorliegende Erfindung gibt eine Beschichtung einer implantierbaren endovaskulären Vorrichtung an, um das anschließende Auftragen von Heparin auf deren Oberfläche zu erleichtern. Das Auftragen des Heparins wird in vitro kurz vor dem Implantieren erreicht. Als Ergebnis dieses Timings des Beschichtungsprozesses hat die beschichtete Vorrichtung eine Lagerbeständigkeit, die beträchtlich länger ist als die Lagerbeständigkeit von vorbeschichteten heparinhaltigen Vorrichtungen, ist der Bedarf nach speziellen Handhabungs- und Sterilisationsprozeduren, die vorbeschichteten heparinhaltigen Vorrichtungen zugeordnet sind, überflüssig, und kann die Dosierung des Heparins leicht auf die Anforderungen eines Individuums zugeschnitten werden.
  • Ein zusätzlicher Vorteil, der durch die erfindungsgemäße Vorrichtung erreicht wird, ist, dass die Vorrichtung keinen Anforderungen unterliegt, die medikamentenhaltigen Vorrichtungen häufig von Regierungsstellen auferlegt werden.
  • Insbesondere sieht die vorliegende Erfindung einen verpackten, heparinlosen Stent vor, umfassend: eine Trägerstruktur, die in dem Gefäßsystem eines Patienten implantierbar ist; und eine Beschichtung, die auf die Trägerstruktur aufgetragen ist, wobei die Beschichtung aus einem oder mehreren Materialien gebildet ist, die an der Stentstruktur anhaften und die funktionelle Gruppen vorsehen, die in der Lage sind, Heparin anzuziehen, und mit denen Heparin Bindungen bildet, wenn dieses Material einer heparinhaltigen Lösung ausgesetzt wird.
  • Bevorzugt bilden die Beschichtungsmaterialien Ionenbindungen mit den Stentoberflächen. Die in der Beschichtung enthaltenen funktionellen Gruppen können primäre, sekundäre und/oder tertiäre Amine oder andere Funktionalitäten aufweisen, wie etwa Carboxylgruppen.
  • Die heparinanziehende Beschichtung kann aufgetragen werden, um den gesamten Stent zu umschließen, oder alternativ, nur gewählte Oberflächen davon zu bedecken. Durch Beschränken der Abdeckung auf nur die Innenfläche des Stents, d. h. die Oberfläche, die nach der Stententfaltung direkt dem Blutfluss ausgesetzt wird, kann ein viel höherer Heparinpegel auf den Stent aufgetragen werden, als er als sicher betrachtet werden könnte, wenn der gleiche Pegel indirektem Kontakt mit der Gefäßwand stünde. Somit wird ein toxischer Effekt auf die Gefäßwand vermieden, wobei jedoch das Blut in der Nähe der Vorrichtung nichtsdestoweniger einer effektiven Heparinkonzentration ausgesetzt wird. Alternativ könnte man es als ausreichend ansehen, nur die Enden des Stents zu beschichten, d. h. an den Nach-Entfaltungsstellen, an denen die Störung des Blutflusses am größten ist und wo Thrombosen am wahrscheinlichsten auftreten.
  • Die Beschichtung kann durch verschiedene Prozesse aufgetragen werden, wie etwa durch Tauchen, Sprühen oder Formgießen. Das bevorzugte Verfahren ist eine Plasmaabscheidung, wobei eine Basisschicht, die nach ihrer Fähigkeit, an der Stentoberfläche anzuhaften, gewählt ist, zuerst auf den Stent aufgetragen wird, wonach eine Deckschicht darauf aufgetragen wird, die nach ihrer Fähigkeit zur Bindung an der Basisschicht und als Beitrag zu den geeigneten funktionellen Gruppen zur Bindung an dem Heparin gewählt ist.
  • Die vorliegende Erfindung gibt auch ein in vitro-Verfahren zur Herstellung eines endovaskulären Stents an, der zur Ausgabe von Heparin zu einer bestimmten Stelle innerhalb des Gefäßsystems eines Patienten geeignet ist, das die Schritte aufweist: Vorsehen einer implantierbaren Trägerstruktur; Auftragen einer Beschichtung darauf, die an der Trägerstruktur anhaftet und die funktionelle Gruppen enthält, die in der Lage sind, Heparin anzuziehen und mit denen Heparin Bindungen bildet, wenn die Beschichtung einer heparinhaltigen Lösung ausgesetzt wird; Sterilisieren und Verpacken der Trägerstruktur mit der darauf aufgetragenen Beschichtung; Entfernen der beschichteten. Trägerstruktur aus ihrer Verpackung; und Aussetzen der beschichteten Trägerstruktur einer heparinhaltigen Lösung.
  • Andere Merkmale und Vorteile von Ausführungen der Erfindung werden aus der folgenden detaillierten Beschreibung ersichtlich, die in Verbindung mit den beigefügten Zeichnungen Beispiele der Prinzipien der Erfindung erläutert.
    • KURZBESCHREIBUNG DER ZEICHNUNG
  • Fig. 1 ist einen Perspektivansicht eines implantierbaren Stents.
    • DETAILBESCHREIBUNG DER BEVORZUGTEN AUSFÜHRUNGEN
  • Es sind eine weite Vielzahl verschiedener Stentkonfigurationen erdacht worden, die auf verschiedene Problemstellungen abzielen, die durch den beabsichtigten Gebrauch und die gewünschte Funktion der Vorrichtungen impliziert sind. Es wurden verschiedene Materialien bei der Konstruktion von Stents benutzt, die Metalle und Polymere einschließen. Sowohl der Turbulenzgrad, der durch eine bestimmte Stentkonfiguration verursacht wird, wenn sie dem Blutfluss ausgesetzt wird, als auch das Material, aus dem der Stent aufgebaut ist, beeinflussen beide den Grad an Thrombogenizität, der nach der Entfaltung erwartet werden kann. Die vorliegende Ausführung sieht eine Beschichtung für Stents vor, an denen Heparin angebracht wird und hierdurch die Tendenz hat, eine Thrombosebildung zu reduzieren oder zu beseitigen. Ferner ist die Eigenschaft der Beschichtung so, dass in sie das Heparin unmittelbar vor der Implantationsprozedur eingebracht werden kann.
  • Eine Stentbeschichtung nach der vorliegenden Erfindung haftet auf der Stentoberfläche und besitzt funktionelle Gruppen, die Heparin anziehen und an die Heparin bindet. Funktionelle Gruppen, von denen bekannt ist, dass sie die erforderliche Affintität für Heparin besitzen, beinhalten primäre, sekundäre und tertiäre Amine. Primäre Amine sind aufgrund der außerordentlichen Affinität derselben für Heparin bevorzugt. Alternativ könnten Carboxylgruppen verwendet werden. Die funktionellen Gruppen müssen positiv geladene Ionen enthalten, die dazu dienen, die negativ geladenen Ionen anzuziehen, die dem Heparin zugeordnet sind. Diese Anziehung erleichtert die Bildung einer Ionenbindung.
  • Die Beschichtung kann durch verschiedene Prozesse aufgetragen werden, wie etwa durch Tauchen, Sprühen, Formgießen oder durch Plasmaabscheidung. Plasmaabscheidung ist bevorzugt. In einem ersten Schritt der Plasmaabscheidung wird eine Basisschicht oder eine Grundierung auf der Stentoberfläche abgelegt, die die Oberfläche zur Aufnahme der Substanz vorbereitet, die die heparinanziehenden funktionellen Gruppen enthält. In der bevorzugten Ausführung wird ein metallischer Stent zuerst mit Methangasplasma behandelt, das einen Film auf der Oberfläche des Stents hinterlässt. Die Methanmoleküle in dem Film sind mit den Kohlenstoffatomen gegen den Stent hin orientiert, und die Wasserstoffatome liegen frei. Dann wird eine Deckschicht, die die gewünschten funktionellen Gruppen enthält, auf die Basisschicht aufgetragen. Die zweite Schicht kann durch die Plasmaabscheidung von Ammoniakgas gebildet werden, sodass die funktionellen primären Amingruppen verbleiben, die von der Stentoberfläche abstehen. Es können auch andere Chemikalien, wie etwa Alkylamin, Nitrilverbindungen oder aminhaltige Monomere verwendet werden, um aminfunktionelle Gruppen auf die Oberfläche plasmaabzuscheiden. Wenn ein Gemisch von primären, sekundären und tertiären Aminen durch solche Verfahren abgeschieden wird, ist es bevorzugt, dass die primären Amine einen größeren Prozentsatz des Gemisches bilden als die sekundären und tertiären Amine, und zwar aufgrund der größeren Affinität der primären Amine für Heparin. Alternativ kann die Abscheidung carboxylfunktioneller Gruppen durch die Plasmaabscheidung von Monomeren erreicht werden, wie etwa Methylmethacrylat oder Acrylsäure.
  • Die Dicke der sich ergebenden Stentbeschichtung sollte 0,0254 mm (0,001 Zoll) oder weniger betragen, während eine Dicke von weniger als 1 Mikron bevorzugt ist. Obwohl eine gleichmäßige Konzentration funktioneller Gruppen erwünscht sein kann, die von der beschichteten Oberfläche absteht, ist dies für die gewünschte Funktion der Beschichtung nicht kritisch. Andererseits muss eine Konzentration von mindestens 54 Picamol/Stent erreicht werden, um sicherzustellen, dass das Heparin an der Beschichtung mit einem ausreichenden Pegel anhaftet.
  • Die Beschichtung kann auf den gesamten Stent aufgetragen werden oder nur auf gewählte Oberflächen davon. Fig. 1 zeigt allgemein einen Stent 12 in einem entfalteten Zustand und dient zum Identifizieren der Oberfläche 14, die zur Wand des Gefäßes weist, in das der Stent implantiert wird, der Oberfläche 16, die zu dem Blutfluss durch den Stent freiliegt, des "stromaufwärtigen" Rands des Stents 18 sowie des "stromabwärtigen" Rands 20, die nacheinander zum Blut freiliegen, wenn es durch das betreffende Gefäß strömt. Indem man nur diejenigen Flächen beschichtet, die zu dem Blutfluss weisen, kann eine Heparinkonzentration darauf aufgetragen werden, die anderenfalls für das Gefäßwandgewebe toxisch wäre; wenn sie sich auf denjenigen Oberflächen befände, die nach der Entfaltung in direktem Kontakt mit der Gefäßwand stehen. Alternativ könnte es für eine in einem bestimmten Patienten implantierte bestimmte Stentkonfiguration ausreichen, ausschließlich die stromaufwärtigen und/oder stromabwärtigen Ränder des Stents zu beschichten, da aufgrund der Turbulenz, die durch das Vorhandensein des Stents in dem Blutflussweg induziert wird, die Thrombose am wahrscheinlichsten an diesen Grenzen entsteht.
  • Nachdem der Beschichtungsprozess abgeschlossen ist, kann der beschichtete Stent gereinigt und sterilisiert und zur langfristigen Aufbewahrung geeignet verpackt werden. Wegen des Fehlens jeglicher abbaubarer Medikamente oder Substanzen an dem Stent kann eine ziemlich verlängerte nutzbare Lagerbeständigkeit erwartet werden.
  • Bei Gebrauch behandelt der Arzt den Stent vor dem Implantieren durch Spülen mit beispielsweise einer heparinisierten Salzlösung vor. Auf diese Weise kann der Arzt leicht und präzise den Heparinpegel einstellen, indem er die Konzentration des Heparins in der Salzlösung steuert und/oder die Zeit steuert, über die der Stent und dessen Beschichtung dem Heparin ausgesetzt werden.
  • Während eine bestimmte Ausführung der Erfindung dargestellt und beschrieben wurde, versteht es sich für den Fachmann, dass zahlreiche Modifikationen vorgenommen werden können, ohne vom Umfang der Erfindung abzuweichen, wie er in den beigefügten Ansprüchen definiert ist.

Claims (24)

1. Verpackter, heparinloser Stent, umfassend:
eine Trägerstruktur, die in dem Gefäßsystem eines Patienten implantierbar ist; und
eine Beschichtung, die auf die Trägerstruktur aufgetragen ist, wobei die Beschichtung aus einem oder mehreren Materialien gebildet ist, die an der Stentstruktur anhaften und die funktionelle Gruppen vorsehen, die in der Lage sind, Heparin anzuziehen, und mit denen Heparin Bindungen bildet, wenn dieses Material einer heparinhaltigen Lösung ausgesetzt wird.
2. Endovaskulärer Stent nach Anspruch 1, worin die heparinhaltige Lösung heparinisiertes Blut aufweist.
3. Endovaskulärer Stent nach Anspruch 1, worin die heparinhaltige Lösung heparinisierte Salzlösung aufweist.
4. Endovaskulärer Stent nach Anspruch 1, worin die Beschichtung auf die gesamte Trägerstruktur aufgetragen ist.
5. Endovaskulärer Stent nach Anspruch 1, wobei die Trägerstruktur derart konfiguriert ist, dass beim Implantieren in ein Blutgefäß diese Trägerstruktur Oberflächen aufweist, die zu den Gefäßwänden weisen, Oberflächen, die zu dem Blutfluss weisen, und einen stromaufwärtigen Rand und einen stromabwärtigen Rand aufweist, wobei die Beschichtung ausschließlich auf die zu dem Blutfluss weisende Oberfläche aufgetragen ist.
6. Endovaskulärer Stent nach Anspruch 1, wobei die Trägerstruktur derart konfiguriert ist, dass beim Implantieren in ein Blutgefäß diese Trägerstruktur Oberflächen aufweist, die zu den Gefäßwänden weisen, Oberflächen, die zu dem Blutfluss weisen, und einen stromaufwärtigen Rand und einen stromabwärtigen Rand aufweist, wobei die Beschichtung ausschließlich auf den stromaufwärtigen und den stromabwärtigen Rand aufgetragen ist.
7. Endovaskulärer Stent nach Anspruch 1, worin die Bindungen, die in der Lage sind, die heparinanziehenden funktionellen Gruppen mit Heparin zu bilden, Ionenbindungen sind:
8. Endovaskulärer Stent nach Anspruch 7, worin die funktionellen Gruppen ein primäres Amin aufweisen.
9. Endovaskulärer Stent nach Anspruch 7, worin die funktionellen Gruppen ein sekundäres Amin aufweisen.
10. Endovaskulärer Stent nach Anspruch 7, worin die funktionellen Gruppen ein tertiäres Amin aufweisen.
11. Endovaskulärer Stent nach Anspruch 7, worin die funktionellen Gruppen Carboxylgruppen aufweisen.
12. Endovaskulärer Stent nach Anspruch 1, worin die Beschichtung eine Basisschicht aufweist, wobei die Basisschicht nach ihrer Fähigkeit zur Anhaftung an der Trägerstruktur ausgewählt ist, sowie eine Deckschicht, wobei die Deckschicht nach ihrer Fähigkeit zur Bindung an der Basisschicht ausgewählt ist und die funktionellen Gruppen enthält, die in der Lage sind, Heparin anzuziehen, und mit denen Heparin Bindungen bildet, wenn dieses Material einer heparinhaltigen Lösung ausgesetzt wird.
13. Endovaskulärer Stent nach Anspruch 12, worin die Bindungen, die in der Lage sind, die heparinanziehenden funktionellen Gruppen mit dem Heparin zu bilden, Ionenbindungen sind.
14. Endovaskulärer Stent nach Anspruch 12, worin die Basisschicht an der Trägerstruktur hydrophob angebracht ist.
15. Endovaskulärer Stent nach Anspruch 12, worin die Deckschicht mit der Basisschicht kovalent gebunden ist.
16. In vitro-Verfahren zur Herstellung eines endovaskulären Stents, der zur Ausgabe von Heparin zu einer bestimmten Stelle innerhalb des Gefäßsystems eines Patienten geeignet ist, das die Schritte aufweist:
Vorsehen einer implantierbaren Trägerstruktur;
Auftragen einer Beschichtung darauf, die an der Trägerstruktur anhaftet und die funktionelle Gruppen enthält, die in der Lage sind, Heparin anzuziehen, und mit denen Heparin Bindungen bildet, wenn die Beschichtung einer heparinhaltigen Lösung ausgesetzt wird;
Sterilisieren und Verpacken der Trägerstruktur mit der darauf aufgetragenen Beschichtung;
Entfernen der beschichteten Trägerstruktur aus ihrer Verpackung; und Aussetzen der beschichteten Trägerstruktur einer heparinhaltigen Lösung.
17. Verfahren nach Anspruch 16, worin die Beschichtung auf die gesamte Trägerstruktur aufgetragen ist.
18. Verfahren nach Anspruch 16, worin die Trägerstruktur derart konfiguriert ist, dass beim Implantieren in ein Blutgefäß die Trägerstruktur Oberflächen aufweist, die zu den Gefäßwänden weisen, Oberflächen, die zu dem Blutfluss weisen, sowie einen stromaufwärtigen Rand und einen stromabwärtigen Rand, wobei die Beschichtung ausschließlich auf die Oberflächen aufgetragen ist, die zu dem Blutfluss weisen.
19. Verfahren nach Anspruch 16, worin die Trägerstruktur derart konfiguriert ist, dass beim Implantieren in ein Blutgefäß diese Trägerstruktur Oberflächen aufweist, die zu den Gefäßwänden weisen, Oberflächen, die zu dem Blutfluss weisen, sowie einen tromaufwärtigen Rand und einen stromabwärtigen Rand, wobei die Beschichtung ausschließlich auf den stromaufwärtigen und den stromabwärtigen Rand aufgetragen ist.
20. Verfahren nach Anspruch 16, worin die Beschichtung durch Tauchen auf die Trägerstruktur aufgetragen ist.
21. Verfahren nach Anspruch 16, worin die Beschichtung durch Sprühen auf die Struktur aufgetragen ist.
22. Verfahren nach Anspruch 16, worin die Beschichtung durch Formgießen auf die Trägerstruktur aufgetragen ist.
23. Verfahren nach Anspruch 16, worin die Beschichtung durch Plasmaabscheidung auf die Trägerstruktur aufgetragen ist.
24. Verfahren nach. Anspruch 16, worin die Beschichtung aufgetragen ist durch zuerst Auftragen einer Basisschicht, die nach ihrer Fähigkeit, auf der Trägerstruktur zu haften, gewählt ist, und dann Auftragen einer Deckschicht darauf, die nach ihrer Fähigkeit gewählt ist, an der Basisschicht zu binden, und die die funkionellen Gruppen enthält, die in der Lage sind, Heparin anzuziehen, und mit denen Heparin Bindungen bildet, wenn die Beschichtung einer heparinhaltigen Lösung ausgesetzt wird.
DE69801459T 1997-04-24 1998-04-24 Beschichteter endovaskulärer Stent Revoked DE69801459T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/847,763 US6776792B1 (en) 1997-04-24 1997-04-24 Coated endovascular stent

Publications (2)

Publication Number Publication Date
DE69801459D1 DE69801459D1 (de) 2001-10-04
DE69801459T2 true DE69801459T2 (de) 2002-04-11

Family

ID=25301436

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69801459T Revoked DE69801459T2 (de) 1997-04-24 1998-04-24 Beschichteter endovaskulärer Stent

Country Status (4)

Country Link
US (4) US6776792B1 (de)
EP (1) EP0873732B1 (de)
JP (1) JP3000076B2 (de)
DE (1) DE69801459T2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004018255A1 (de) * 2004-04-15 2005-11-10 Universitätsklinikum Schleswig-Holstein Gefäßprothese

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174326B1 (en) 1996-09-25 2001-01-16 Terumo Kabushiki Kaisha Radiopaque, antithrombogenic stent and method for its production
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US20090239940A1 (en) * 1997-07-22 2009-09-24 Del Monte Federica Treating heart failure and ventricular arrhythmias
US6560461B1 (en) 1997-08-04 2003-05-06 Mundi Fomukong Authorized location reporting paging system
JP2002524196A (ja) 1998-09-10 2002-08-06 パーカーディア，インコーポレイティド 左心室血管再生用の経心筋シャントおよびその取付機構
FR2785812B1 (fr) * 1998-11-16 2002-11-29 Commissariat Energie Atomique Protheses bioactives, notamment a proprietes immunosuppressives, antistenose et antithrombose, et leur fabrication
KR100336508B1 (ko) * 1999-03-06 2002-05-15 정명호 혈관용 맥 스텐트의 헤타린 코팅방법
GB2347861B (en) * 1999-03-13 2003-11-26 Biointeractions Ltd Biocompatible endoprostheses
IT1307263B1 (it) 1999-08-05 2001-10-30 Sorin Biomedica Cardio Spa Stent per angioplastica con azione antagonista della restenosi,relativo corredo e componenti.
DE69934990T2 (de) 1999-11-23 2007-11-15 Sorin Biomedica Cardio S.R.L., Saluggia Verfahren zur Übertragung radioaktiver Stoffe auf Stents in der Angioplastie und Bausatz
US6746686B2 (en) 2000-01-24 2004-06-08 Biocompatibles Uk Limited Coated implants
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
KR100371008B1 (ko) * 2000-08-05 2003-02-06 조동련 혈소판 응집 억제제 부착 스텐트의 그 제조 방법
US6783793B1 (en) 2000-10-26 2004-08-31 Advanced Cardiovascular Systems, Inc. Selective coating of medical devices
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US6565659B1 (en) 2001-06-28 2003-05-20 Advanced Cardiovascular Systems, Inc. Stent mounting assembly and a method of using the same to coat a stent
US6656216B1 (en) 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
DE60236093D1 (de) 2001-07-26 2010-06-02 Merit Medical Systems Inc Entfernbarer stent
US7682669B1 (en) * 2001-07-30 2010-03-23 Advanced Cardiovascular Systems, Inc. Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
US7223282B1 (en) 2001-09-27 2007-05-29 Advanced Cardiovascular Systems, Inc. Remote activation of an implantable device
US8123799B1 (en) 2001-11-30 2012-02-28 Advanced Cardiovascular Systems, Inc. Modified implantable device surface and a method of making the same
US8470019B1 (en) * 2001-11-30 2013-06-25 Advanced Cardiovascular Systems, Inc. TiNxOy modified surface for an implantable device and a method of producing the same
US7465298B2 (en) * 2002-06-28 2008-12-16 Mercator Medsystems, Inc. Methods and systems for delivering liquid substances to tissues surrounding body lumens
AU2003286660A1 (en) * 2002-10-25 2004-05-13 Essentia Biosystems, Inc. Implantable medical devices using zinc
US20040093056A1 (en) 2002-10-26 2004-05-13 Johnson Lianw M. Medical appliance delivery apparatus and method of use
GB0225197D0 (en) * 2002-10-30 2002-12-11 Univ Sheffield Surface
US7637942B2 (en) 2002-11-05 2009-12-29 Merit Medical Systems, Inc. Coated stent with geometry determinated functionality and method of making the same
US7875068B2 (en) 2002-11-05 2011-01-25 Merit Medical Systems, Inc. Removable biliary stent
US7959671B2 (en) 2002-11-05 2011-06-14 Merit Medical Systems, Inc. Differential covering and coating methods
US7527644B2 (en) 2002-11-05 2009-05-05 Alveolus Inc. Stent with geometry determinated functionality and method of making the same
WO2004078065A2 (en) * 2003-03-03 2004-09-16 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
US8281737B2 (en) 2003-03-10 2012-10-09 Boston Scientific Scimed, Inc. Coated medical device and method for manufacturing the same
US7637934B2 (en) 2003-03-31 2009-12-29 Merit Medical Systems, Inc. Medical appliance optical delivery and deployment apparatus and method
WO2005023292A1 (en) * 2003-09-03 2005-03-17 The General Hospital Corporation Methods of treating restenosis
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
SE526861C2 (sv) * 2003-11-17 2005-11-15 Syntach Ag Vävnadslesionsskapande anordning samt en uppsättning av anordningar för behandling av störningar i hjärtrytmregleringssystemet
US7563324B1 (en) 2003-12-29 2009-07-21 Advanced Cardiovascular Systems Inc. System and method for coating an implantable medical device
US9398967B2 (en) * 2004-03-02 2016-07-26 Syntach Ag Electrical conduction block implant device
US7553377B1 (en) 2004-04-27 2009-06-30 Advanced Cardiovascular Systems, Inc. Apparatus and method for electrostatic coating of an abluminal stent surface
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
US7763065B2 (en) 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
US11207457B2 (en) * 2004-08-27 2021-12-28 Edwards Lifesciences Corporation Device and method for establishing an artificial arterio-venous fistula
CN101035481A (zh) * 2004-10-08 2007-09-12 赛恩泰克公司 用于治疗心房颤动的两步疤痕形成法
US7632307B2 (en) 2004-12-16 2009-12-15 Advanced Cardiovascular Systems, Inc. Abluminal, multilayer coating constructs for drug-delivery stents
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
KR100759130B1 (ko) 2005-02-12 2007-09-19 휴메드 주식회사 항 인테그린 항체 코팅스텐트 및 그의 제조방법
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
US7914574B2 (en) 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
US9101949B2 (en) 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US7896539B2 (en) 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US20070073377A1 (en) * 2005-09-27 2007-03-29 Mcdonald Michael B Method for placing a stent through a constricted lumen, and medical device
US20070083252A1 (en) * 2005-09-27 2007-04-12 Mcdonald Michael B Method for placing a stent through a constricted lumen, and medical device
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US9155641B2 (en) * 2006-03-09 2015-10-13 Cook Medical Technologies Llc Expandable stent grafts
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8535368B2 (en) * 2006-05-19 2013-09-17 Boston Scientific Scimed, Inc. Apparatus for loading and delivering a stent
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US8177798B2 (en) 2006-12-05 2012-05-15 Tyco Healthcare Group Lp Adhesive coated stent and insertion instrument
US7704275B2 (en) 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US20090011117A1 (en) * 2007-07-03 2009-01-08 Endotronix, Inc. Methods for texturing a surface of an endovascular implant
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US20100003828A1 (en) * 2007-11-28 2010-01-07 Guowen Ding Methods for adjusting critical dimension uniformity in an etch process with a highly concentrated unsaturated hydrocarbon gas
EP2211773A4 (de) 2007-11-30 2015-07-29 Reva Medical Inc Axial-radial verschachtelte expandierbare vorrichtung
CN103948460B (zh) 2008-10-10 2016-05-25 雷瓦医药公司 可扩展的滑动和锁定支架
US20100106234A1 (en) * 2008-10-23 2010-04-29 Medtronic Vascular, Inc. Medical Devices With Extended Drug Diffusion Pathway
AU2010239605B2 (en) * 2009-04-20 2014-06-26 Rox Medical, Inc. Device and method for establishing an artificial arterio-venous fistula
WO2011011433A1 (en) * 2009-07-20 2011-01-27 Boston Scientific Scimed, Inc. Medical device coating system
JP5809237B2 (ja) 2010-04-10 2015-11-10 レヴァ メディカル、 インコーポレイテッドＲｅｖａ Ｍｅｄｉｃａｌ， Ｉｎｃ． 拡張可能なスライドロックステント
PL217879B1 (pl) 2010-07-06 2014-08-29 Univ Jagielloński Wielowarstwowa powłoka ochronna do zabezpieczania powierzchni metalowych materiałów implantacyjnych i jej zastosowanie
WO2014159337A1 (en) 2013-03-14 2014-10-02 Reva Medical, Inc. Reduced - profile slide and lock stent
US9320592B2 (en) 2013-03-15 2016-04-26 Covidien Lp Coated medical devices and methods of making and using same
US9545301B2 (en) 2013-03-15 2017-01-17 Covidien Lp Coated medical devices and methods of making and using same
US9668890B2 (en) 2013-11-22 2017-06-06 Covidien Lp Anti-thrombogenic medical devices and methods
WO2016012179A1 (en) * 2014-07-22 2016-01-28 Biotronik Ag Biodegradable metal stent and methods
US9789228B2 (en) 2014-12-11 2017-10-17 Covidien Lp Antimicrobial coatings for medical devices and processes for preparing such coatings
EP4017384A1 (de) 2019-08-22 2022-06-29 Edwards Lifesciences Corporation Punktionsnadeln
CN121694847A (zh) 2019-11-14 2026-03-20 爱德华兹生命科学公司 经导管的医疗植入物递送
US12527942B2 (en) 2021-02-01 2026-01-20 Edwards Lifesciences Corporation Pulmonary vein shunting

Family Cites Families (913)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR732895A (fr) 1932-10-18 1932-09-25 Consortium Elektrochem Ind Objets filés en alcool polyvinylique
US2386454A (en) 1940-11-22 1945-10-09 Bell Telephone Labor Inc High molecular weight linear polyester-amides
US2647017A (en) 1951-04-19 1953-07-28 Ind Res Inst Nozzle
US2701559A (en) * 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US3288728A (en) 1966-02-18 1966-11-29 Union Carbide Corp Para-xylylene copolymers
US3849514A (en) 1967-11-17 1974-11-19 Eastman Kodak Co Block polyester-polyamide copolymers
GB1237035A (en) 1969-08-20 1971-06-30 Tsi Travmatologii I Ortopedii Magnesium-base alloy for use in bone surgery
US3900632A (en) 1970-02-27 1975-08-19 Kimberly Clark Co Laminate of tissue and random laid continuous filament web
US3773737A (en) 1971-06-09 1973-11-20 Sutures Inc Hydrolyzable polymers of amino acid and hydroxy acids
US3839743A (en) 1972-04-21 1974-10-08 A Schwarcz Method for maintaining the normal integrity of blood
US3753615A (en) 1972-04-26 1973-08-21 Dyk Res Corp Van Scanning apparatus
US4104410A (en) 1973-12-21 1978-08-01 Malecki George J Processing of green vegetables for color retention in canning
US4164524A (en) * 1974-05-31 1979-08-14 Ward Charles A Treatment of blood containing vessels
US4075045A (en) * 1976-02-09 1978-02-21 International Business Machines Corporation Method for fabricating FET one-device memory cells with two layers of polycrystalline silicon and fabrication of integrated circuits containing arrays of the memory cells charge storage capacitors utilizing five basic pattern deliberating steps
US4132357A (en) * 1976-06-23 1979-01-02 Inmont Corporation Apparatus and method for spray application of solvent-thinned coating compositions
US4110497A (en) 1976-07-02 1978-08-29 Snyder Manufacturing Co., Ltd. Striped laminate and method and apparatus for making same
JPS5418317A (en) 1977-07-11 1979-02-10 Ricoh Kk Tape feeder
US4323071A (en) 1978-04-24 1982-04-06 Advanced Catheter Systems, Inc. Vascular guiding catheter assembly and vascular dilating catheter assembly and a combination thereof and methods of making the same
JPS6037735B2 (ja) 1978-10-18 1985-08-28 住友電気工業株式会社 人工血管
GB2041377B (en) * 1979-01-22 1983-09-28 Woodroof Lab Inc Bio compatible and blood compatible materials and methods
DE2928007A1 (de) 1979-07-11 1981-01-15 Riess Guido Dr Knochen-implantatkoerper fuer prothesen und knochenverbindungsstuecke sowie verfahren zu seiner herstellung
US4329383A (en) 1979-07-24 1982-05-11 Nippon Zeon Co., Ltd. Non-thrombogenic material comprising substrate which has been reacted with heparin
US4226243A (en) 1979-07-27 1980-10-07 Ethicon, Inc. Surgical devices of polyesteramides derived from bis-oxamidodiols and dicarboxylic acids
SU790725A1 (ru) 1979-07-27 1983-01-23 Ордена Ленина Институт Элементоорганических Соединений Ан Ссср Способ получени алкилароматических полиимидов
SU872531A1 (ru) 1979-08-07 1981-10-15 Институт Физиологии Им.И.С.Бериташвили Ан Гсср Способ получени полуретанов
SU811750A1 (ru) 1979-08-07 1983-09-23 Институт Физиологии Им.С.И.Бериташвили Бис-карбонаты алифатических диолов-мономеры дл полиуретанов и поликарбонатов и способ их получени
SU876663A1 (ru) 1979-11-11 1981-10-30 Институт Физиологии Им. Академика И.С.Бериташвили Ан Гсср Способ получени полиарилатов
US4346028A (en) 1979-12-14 1982-08-24 Monsanto Company Asbestiform crystalline calcium sodium or lithium phosphate, preparation and compositions
US4343931A (en) 1979-12-17 1982-08-10 Minnesota Mining And Manufacturing Company Synthetic absorbable surgical devices of poly(esteramides)
US4529792A (en) 1979-12-17 1985-07-16 Minnesota Mining And Manufacturing Company Process for preparing synthetic absorbable poly(esteramides)
SU1016314A1 (ru) 1979-12-17 1983-05-07 Институт Физиологии Им.И.С.Бериташвили Способ получени полиэфируретанов
SU905228A1 (ru) 1980-03-06 1982-02-15 Институт Физиологии Им. Акад.И.С. Бериташвили Ан Гсср Способ получени полимочевины
US4629563B1 (en) 1980-03-14 1997-06-03 Memtec North America Asymmetric membranes
US4774039A (en) 1980-03-14 1988-09-27 Brunswick Corporation Dispersing casting of integral skinned highly asymmetric polymer membranes
DE3019996A1 (de) 1980-05-24 1981-12-03 Institute für Textil- und Faserforschung Stuttgart, 7410 Reutlingen Hohlorgan
US4608984A (en) 1980-10-17 1986-09-02 Fogarty Thomas J Self-retracting dilatation catheter
US4338942A (en) 1980-10-20 1982-07-13 Fogarty Thomas J Dilatation catherter apparatus
US4439185A (en) 1981-10-21 1984-03-27 Advanced Cardiovascular Systems, Inc. Inflating and deflating device for vascular dilating catheter assembly
US4880683A (en) 1981-12-28 1989-11-14 Minnesota Mining And Manufacturing Company Hot-tackifying adhesive tape
US4516972A (en) 1982-01-28 1985-05-14 Advanced Cardiovascular Systems, Inc. Guiding catheter and method of manufacture
US4894662A (en) 1982-03-01 1990-01-16 Western Atlas International, Inc. Method and system for determining position on a moving platform, such as a ship, using signals from GPS satellites
US5619212A (en) 1982-03-01 1997-04-08 Western Atlas International, Inc. System for determining position from suppressed carrier radio waves
US4902289A (en) * 1982-04-19 1990-02-20 Massachusetts Institute Of Technology Multilayer bioreplaceable blood vessel prosthesis
US4517687A (en) 1982-09-15 1985-05-21 Meadox Medicals, Inc. Synthetic woven double-velour graft
US4489670A (en) 1983-05-16 1984-12-25 Sermetel Fixture for centrifugal apparatus
FR2547704B1 (fr) 1983-06-24 1985-11-29 Morin Claude Casque de protection perfectionne
US4554929A (en) 1983-07-13 1985-11-26 Advanced Cardiovascular Systems, Inc. Catheter guide wire with short spring tip and method of using the same
US4656083A (en) 1983-08-01 1987-04-07 Washington Research Foundation Plasma gas discharge treatment for improving the biocompatibility of biomaterials
US4594407A (en) 1983-09-20 1986-06-10 Allied Corporation Prosthetic devices derived from krebs-cycle dicarboxylic acids and diols
US4702252A (en) 1983-10-13 1987-10-27 Smiths Industries Public Limited Company Catheters
US4616652A (en) 1983-10-19 1986-10-14 Advanced Cardiovascular Systems, Inc. Dilatation catheter positioning apparatus
US4538622A (en) 1983-11-10 1985-09-03 Advanced Cardiovascular Systems, Inc. Guide wire for catheters
US5669936A (en) 1983-12-09 1997-09-23 Endovascular Technologies, Inc. Endovascular grafting system and method for use therewith
US5197977A (en) 1984-01-30 1993-03-30 Meadox Medicals, Inc. Drug delivery collagen-impregnated synthetic vascular graft
US4633873A (en) 1984-04-26 1987-01-06 American Cyanamid Company Surgical repair mesh
US4596574A (en) 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4573470A (en) 1984-05-30 1986-03-04 Advanced Cardiovascular Systems, Inc. Low-profile steerable intraoperative balloon dilitation catheter
CH671337A5 (de) 1984-06-19 1989-08-31 Ceskoslovenska Akademie Ved
US4879135A (en) 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
US4965586A (en) 1984-08-16 1990-10-23 Geostar Corporation Position determination and message transfer system employing satellites and stored terrain map
JPS6174668A (ja) 1984-09-19 1986-04-16 Yoshida Kogyo Kk <Ykk> 回転塗装機の塗料別供給装置
IT1186142B (it) 1984-12-05 1987-11-18 Medinvent Sa Dispositivo di impiantazione transluminale
SU1293518A1 (ru) 1985-04-11 1987-02-28 Тбилисский зональный научно-исследовательский и проектный институт типового и экспериментального проектирования жилых и общественных зданий Установка дл испытаний образца крестообразной строительной конструкции
US4699611A (en) 1985-04-19 1987-10-13 C. R. Bard, Inc. Biliary stent introducer
US5628781A (en) 1985-06-06 1997-05-13 Thomas Jefferson University Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves
US4656242A (en) 1985-06-07 1987-04-07 Henkel Corporation Poly(ester-amide) compositions
US4718907A (en) 1985-06-20 1988-01-12 Atrium Medical Corporation Vascular prosthesis having fluorinated coating with varying F/C ratio
US4638805A (en) * 1985-07-30 1987-01-27 Advanced Cardiovascular Systems, Inc. Self-venting balloon dilatation catheter and method
US4818559A (en) 1985-08-08 1989-04-04 Sumitomo Chemical Company, Limited Method for producing endosseous implants
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4807256A (en) 1985-12-23 1989-02-21 Texas Instruments Incorporated Global position system receiver
US4611051A (en) 1985-12-31 1986-09-09 Union Camp Corporation Novel poly(ester-amide) hot-melt adhesives
US4743252A (en) 1986-01-13 1988-05-10 Corvita Corporation Composite grafts
SU1477423A1 (ru) 1986-01-16 1989-05-07 Особое конструкторско-технологическое бюро Физико-технического института низких температур АН УССР Баллонный катетер
EP0556940A1 (de) 1986-02-24 1993-08-25 Robert E. Fischell Intravaskulärer Stent
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
EP0241838B1 (de) 1986-04-07 1992-04-15 Agency Of Industrial Science And Technology Antithrombogenisches Material
US5350395A (en) 1986-04-15 1994-09-27 Yock Paul G Angioplasty apparatus facilitating rapid exchanges
US5040548A (en) 1989-06-01 1991-08-20 Yock Paul G Angioplasty mehtod
US4882168A (en) 1986-09-05 1989-11-21 American Cyanamid Company Polyesters containing alkylene oxide blocks as drug delivery systems
US4740207A (en) 1986-09-10 1988-04-26 Kreamer Jeffry W Intralumenal graft
US4723549A (en) 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
US4722335A (en) 1986-10-20 1988-02-02 Vilasi Joseph A Expandable endotracheal tube
DE3736386A1 (de) 1986-10-27 1988-07-14 Pioneer Electronic Corp Fahrzeugpeilverfahren
JPH0696023B2 (ja) 1986-11-10 1994-11-30 宇部日東化成株式会社 人工血管およびその製造方法
IT1196836B (it) 1986-12-12 1988-11-25 Sorin Biomedica Spa Protesi in materiale polimerico con rivestimento di carbonio biocompatibile
US4748982A (en) 1987-01-06 1988-06-07 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
IT1202558B (it) 1987-02-17 1989-02-09 Alberto Arpesani Protesi interna per la sostituzione di una parte del corpo umano particolarmente nelle operazioni vascolari
US4988356A (en) * 1987-02-27 1991-01-29 C. R. Bard, Inc. Catheter and guidewire exchange system
US5721131A (en) 1987-03-06 1998-02-24 United States Of America As Represented By The Secretary Of The Navy Surface modification of polymers with self-assembled monolayers that promote adhesion, outgrowth and differentiation of biological cells
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
CA1336319C (en) 1987-03-13 1995-07-18 Cesare Gianturco Endovascular stent
JPS63238872A (ja) 1987-03-25 1988-10-04 テルモ株式会社 管状器官内腔の内径確保用器具
US6387379B1 (en) 1987-04-10 2002-05-14 University Of Florida Biofunctional surface modified ocular implants, surgical instruments, medical devices, prostheses, contact lenses and the like
US4816339A (en) 1987-04-28 1989-03-28 Baxter International Inc. Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation
US4871542A (en) 1987-04-30 1989-10-03 Ferring Service Center, N.V. Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US5059211A (en) 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US4894231A (en) 1987-07-28 1990-01-16 Biomeasure, Inc. Therapeutic agent delivery system
KR920001501B1 (ko) * 1987-09-01 1992-02-15 가부시기가이샤 히다찌세이사구쇼 블랙매트릭스 컬러브라운관 및 그 제조방법
DE3855725T2 (de) 1987-10-08 1997-04-17 Terumo Corp Instrument und vorrichtung zum aufrechterhalten des inneren lumendurchmessers eines schlauchförmigen organs
DK530787D0 (da) 1987-10-09 1987-10-09 Bukh Meditec Indretning til indfoering i en legemshulhed
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4906423A (en) 1987-10-23 1990-03-06 Dow Corning Wright Methods for forming porous-surfaced polymeric bodies
US4932353A (en) 1987-12-18 1990-06-12 Mitsubishi Denki Kabushiki Kaisha Chemical coating apparatus
US4877030A (en) 1988-02-02 1989-10-31 Andreas Beck Device for the widening of blood vessels
US5019096A (en) 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
JP2561309B2 (ja) 1988-03-28 1996-12-04 テルモ株式会社 医療用材料およびその製造方法
US5192311A (en) 1988-04-25 1993-03-09 Angeion Corporation Medical implant and method of making
US5109344A (en) 1988-04-28 1992-04-28 Mazda Motor Corporation Vehicle navigation apparatus employing node selection, comparison and elimination techniques
US4967606A (en) 1988-04-29 1990-11-06 Caveo Scientific Instruments, Inc. Method and apparatus for pipetting liquids
US4994298A (en) 1988-06-07 1991-02-19 Biogold Inc. Method of making a biocompatible prosthesis
US4931287A (en) 1988-06-14 1990-06-05 University Of Utah Heterogeneous interpenetrating polymer networks for the controlled release of drugs
DE3821544C2 (de) 1988-06-25 1994-04-28 H Prof Dr Med Just Dilatationskatheter
US4865870A (en) * 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
DE68920925T2 (de) 1988-07-11 1995-06-22 Terumo Corp Medizinisches Material und Gerät.
US5502158A (en) 1988-08-08 1996-03-26 Ecopol, Llc Degradable polymer composition
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
WO1990001969A1 (en) 1988-08-24 1990-03-08 Slepian Marvin J Biodegradable polymeric endoluminal sealing
US5019090A (en) 1988-09-01 1991-05-28 Corvita Corporation Radially expandable endoprosthesis and the like
US5226913A (en) 1988-09-01 1993-07-13 Corvita Corporation Method of making a radially expandable prosthesis
US5053048A (en) 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US5511726A (en) 1988-09-23 1996-04-30 Battelle Memorial Institute Nebulizer device
US4943346A (en) 1988-09-29 1990-07-24 Siemens Aktiengesellschaft Method for manufacturing printed circuit boards
CA1322628C (en) 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
US5085629A (en) 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US4950227A (en) 1988-11-07 1990-08-21 Boston Scientific Corporation Stent delivery system
FI85223C (fi) 1988-11-10 1992-03-25 Biocon Oy Biodegraderande kirurgiska implant och medel.
US4977901A (en) 1988-11-23 1990-12-18 Minnesota Mining And Manufacturing Company Article having non-crosslinked crystallized polymer coatings
CA2004833A1 (en) 1988-12-08 1990-06-08 Leonard Armand Trudell Prosthesis of foam polyurethane and collagen and uses thereof
CH678393A5 (de) 1989-01-26 1991-09-13 Ulrich Prof Dr Med Sigwart
ES2102364T3 (es) 1989-01-27 1997-08-01 Au Membrane & Biotech Res Inst Membranas receptoras y control del paso a su traves por medio de ionoforos.
US5087244A (en) * 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
US5163958A (en) 1989-02-02 1992-11-17 Cordis Corporation Carbon coated tubular endoprosthesis
US5289831A (en) 1989-03-09 1994-03-01 Vance Products Incorporated Surface-treated stent, catheter, cannula, and the like
NZ228382A (en) 1989-03-17 1992-08-26 Carter Holt Harvey Plastic Pro Drug administering coil-like device for insertion in body cavity of animal
US5146471A (en) 1989-03-23 1992-09-08 Echelon Systems Corporation Correlator for spread spectrum communications systems
JP3133750B2 (ja) 1989-03-24 2001-02-13 キヤノン株式会社 インクジェットカートリッジおよびそれを用いるインクジェット記録装置
US5972505A (en) 1989-04-04 1999-10-26 Eastman Chemical Company Fibers capable of spontaneously transporting fluids
US5108755A (en) 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US5100429A (en) 1989-04-28 1992-03-31 C. R. Bard, Inc. Endovascular stent and delivery system
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US4990158A (en) 1989-05-10 1991-02-05 United States Surgical Corporation Synthetic semiabsorbable tubular prosthesis
WO1990013420A1 (en) * 1989-05-11 1990-11-15 Landec Labs, Inc. Temperature-activated adhesive assemblies
US5156911A (en) 1989-05-11 1992-10-20 Landec Labs Inc. Skin-activated temperature-sensitive adhesive assemblies
KR0138097B1 (ko) 1989-05-22 1998-06-15 고다까 토시오 도포장치
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US4955899A (en) 1989-05-26 1990-09-11 Impra, Inc. Longitudinally compliant vascular graft
US5116318A (en) 1989-06-06 1992-05-26 Cordis Corporation Dilatation balloon within an elastic sleeve
US5037392A (en) 1989-06-06 1991-08-06 Cordis Corporation Stent-implanting balloon assembly
US5620420A (en) 1989-06-16 1997-04-15 Kriesel; Marshall S. Fluid delivery apparatus
US5272012A (en) 1989-06-23 1993-12-21 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
US5258419A (en) 1989-06-26 1993-11-02 Minnesota Mining And Manufacturing Company Methods of preparing radiation resistant heat sealable polymer blends
US5059169A (en) 1989-07-07 1991-10-22 C. R. Bard, Inc. High-friction prostatic stent
US5084065A (en) * 1989-07-10 1992-01-28 Corvita Corporation Reinforced graft assembly
US5611347A (en) 1989-07-25 1997-03-18 Smith & Nephew, Inc. Zirconium oxide and zirconium nitride coated percutaneous devices
US5015505A (en) 1989-09-25 1991-05-14 Bridgestone/Firestone, Inc. Method and apparatus for striping a tire sidewall
JPH0648975B2 (ja) 1989-10-02 1994-06-29 俊郎 樋口 微小インジェクション装置及びそのインジェクション制御方法
US5035706A (en) 1989-10-17 1991-07-30 Cook Incorporated Percutaneous stent and method for retrieval thereof
US5087394A (en) * 1989-11-09 1992-02-11 Scimed Life Systems, Inc. Method for forming an inflatable balloon for use in a catheter
US5059166A (en) 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5610815A (en) 1989-12-11 1997-03-11 Caterpillar Inc. Integrated vehicle positioning and navigation system, apparatus and method
US5049132A (en) 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5971954A (en) 1990-01-10 1999-10-26 Rochester Medical Corporation Method of making catheter
US5460610A (en) 1990-01-12 1995-10-24 Don Michael; T. Anthony Treatment of obstructions in body passages
US5176638A (en) * 1990-01-12 1993-01-05 Don Michael T Anthony Regional perfusion catheter with improved drug delivery control
JPH05503934A (ja) 1990-01-30 1993-06-24 アクゾ・エヌ・ヴエー 壁により完全に包囲され、１種以上の活性物質で全部又は一部を充填した中空空間から成る、活性物質の調節送達のための物品
ES2071207T3 (es) 1990-02-08 1995-06-16 Howmedica Dilatador hinchable.
US5108416A (en) 1990-02-13 1992-04-28 C. R. Bard, Inc. Stent introducer system
NL194941C (nl) * 1990-02-15 2003-08-04 Cordis Corp Werkwijze voor het aanbrengen van een fysiologisch actieve verbinding op een substraatoppervlak.
EP0518940A4 (en) 1990-02-26 1993-05-12 Marvin J. Slepian Method and apparatus for treatment of tubular organs
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5156623A (en) 1990-04-16 1992-10-20 Olympus Optical Co., Ltd. Sustained release material and method of manufacturing the same
US5344426A (en) 1990-04-25 1994-09-06 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5158548A (en) 1990-04-25 1992-10-27 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5242399A (en) 1990-04-25 1993-09-07 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5123917A (en) 1990-04-27 1992-06-23 Lee Peter Y Expandable intraluminal vascular graft
US5292516A (en) 1990-05-01 1994-03-08 Mediventures, Inc. Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers
US5300295A (en) 1990-05-01 1994-04-05 Mediventures, Inc. Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
US5298260A (en) 1990-05-01 1994-03-29 Mediventures, Inc. Topical drug delivery with polyoxyalkylene polymer thermoreversible gels adjustable for pH and osmolality
US5306501A (en) 1990-05-01 1994-04-26 Mediventures, Inc. Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers
US5078720A (en) * 1990-05-02 1992-01-07 American Medical Systems, Inc. Stent placement instrument and method
EP0527969A1 (de) 1990-05-11 1993-02-24 SAAB, Mark, A. Hochfeste, dünnwandige, einstückige katheter
US5290271A (en) 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
EP0528971B1 (de) 1990-05-14 1999-09-01 JERNBERG, Gary R. Chirurgisches implantat und verfahren zum einbetten von chemotherapeutika
WO1991017724A1 (en) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
EP0737453A3 (de) 1990-05-18 1997-02-05 Richard S Stack Intravaskulärer Stent
US5279594A (en) 1990-05-23 1994-01-18 Jackson Richard R Intubation devices with local anesthetic effect for medical use
US5360443A (en) 1990-06-11 1994-11-01 Barone Hector D Aortic graft for repairing an abdominal aortic aneurysm
CA2038605C (en) 1990-06-15 2000-06-27 Leonard Pinchuk Crack-resistant polycarbonate urethane polymer prostheses and the like
CA2081896A1 (en) 1990-06-15 1991-12-16 James E. Shapland Drug delivery apparatus and method
US6060451A (en) 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
GB2245445A (en) 1990-06-18 1992-01-02 Philips Electronic Associated Method of and apparatus for obtaining vehicle heading information
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5236447A (en) 1990-06-29 1993-08-17 Nissho Corporation Artificial tubular organ
US5342395A (en) 1990-07-06 1994-08-30 American Cyanamid Co. Absorbable surgical repair devices
US5112457A (en) 1990-07-23 1992-05-12 Case Western Reserve University Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants
US5455040A (en) * 1990-07-26 1995-10-03 Case Western Reserve University Anticoagulant plasma polymer-modified substrate
IT9084979A1 (it) 1990-07-30 1992-01-30 Imad Sheiban Catetere per angioplastica coronarica transluminale percutanea con due palloncini alla sua estremita' distale uno di diametro piccolo (1, 5mm. seguito da un altro palloncino di diametro maggiore variabile da 2, 5 a 4 mm il palloncino piccolo ha la fu
US5342283A (en) 1990-08-13 1994-08-30 Good Roger R Endocurietherapy
DE69114505T2 (de) * 1990-08-28 1996-04-18 Meadox Medicals, Inc., Oakland, N.J. Selbsttragendes gewebtes gefässtransplantat.
SE9102448D0 (sv) 1990-08-28 1991-08-26 Meadox Medicals Inc Ravel-resistant, self-supporting woven graft
US5213561A (en) 1990-09-06 1993-05-25 Weinstein Joseph S Method and devices for preventing restenosis after angioplasty
US6248129B1 (en) 1990-09-14 2001-06-19 Quanam Medical Corporation Expandable polymeric stent with memory and delivery apparatus and method
US5108417A (en) 1990-09-14 1992-04-28 Interface Biomedical Laboratories Corp. Anti-turbulent, anti-thrombogenic intravascular stent
US5163952A (en) 1990-09-14 1992-11-17 Michael Froix Expandable polymeric stent with memory and delivery apparatus and method
US5258020A (en) 1990-09-14 1993-11-02 Michael Froix Method of using expandable polymeric stent with memory
US5222971A (en) 1990-10-09 1993-06-29 Scimed Life Systems, Inc. Temporary stent and methods for use and manufacture
US5462990A (en) 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
DE69116130T2 (de) 1990-10-18 1996-05-15 Ho Young Song Selbstexpandierender, endovaskulärer dilatator
US5104410A (en) 1990-10-22 1992-04-14 Intermedics Orthopedics, Inc Surgical implant having multiple layers of sintered porous coating and method
JP2657581B2 (ja) 1990-11-28 1997-09-24 本田技研工業株式会社 移動体の現在位置表示装置
US5390207A (en) 1990-11-28 1995-02-14 Novatel Communications Ltd. Pseudorandom noise ranging receiver which compensates for multipath distortion by dynamically adjusting the time delay spacing between early and late correlators
WO1992010218A1 (en) 1990-12-06 1992-06-25 W.L. Gore & Associates, Inc. Implantable bioabsorbable article
GB9027793D0 (en) 1990-12-21 1991-02-13 Ucb Sa Polyester-amides containing terminal carboxyl groups
US5163951A (en) 1990-12-27 1992-11-17 Corvita Corporation Mesh composite graft
CS277367B6 (en) 1990-12-29 1993-01-13 Krajicek Milan Three-layered vascular prosthesis
US5893840A (en) 1991-01-04 1999-04-13 Medtronic, Inc. Releasable microcapsules on balloon catheters
US5102402A (en) 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5254091A (en) 1991-01-08 1993-10-19 Applied Medical Resources Corporation Low profile balloon catheter and method for making same
CA2060067A1 (en) 1991-01-28 1992-07-29 Lilip Lau Stent delivery system
CA2101629A1 (en) 1991-02-12 1992-08-13 Edward E. Schmitt Temperature zone specific pressure-sensitive adhesive compositions, and adhesive assemblies and methods of use associated therewith
WO1992014422A1 (fr) * 1991-02-20 1992-09-03 Tdk Corporation Bio-implant composite et methode de production
GB2253164B (en) 1991-02-22 1994-10-05 Hoechst Uk Ltd Improvements in or relating to electrostatic coating of substrates of medicinal products
US5116365A (en) 1991-02-22 1992-05-26 Cordis Corporation Stent apparatus and method for making
US5347284A (en) 1991-02-28 1994-09-13 Texas Instruments Incorporated System and method for a digital navigation satellite receiver
JP2842943B2 (ja) 1991-03-08 1999-01-06 敬二 伊垣 脈管ステントとその保持構造体および脈管ステント挿着装置
US5383925A (en) * 1992-09-14 1995-01-24 Meadox Medicals, Inc. Three-dimensional braided soft tissue prosthesis
US5188734A (en) * 1991-03-26 1993-02-23 Memtec America Corporation Ultraporous and microporous integral membranes
US5171445A (en) 1991-03-26 1992-12-15 Memtec America Corporation Ultraporous and microporous membranes and method of making membranes
JP2939893B2 (ja) 1991-04-24 1999-08-25 バクスター インターナショナル インコーポレーテッド 交換可能な一体式−ワイヤーバルーンカテーテル
US5225842A (en) 1991-05-09 1993-07-06 Navsys Corporation Vehicle tracking system employing global positioning system (gps) satellites
EP0514887B1 (de) 1991-05-21 1997-04-16 Matsushita Electric Industrial Co., Ltd. Fahrzeugpositionsbestimmungsvorrichtung
US5304200A (en) 1991-05-29 1994-04-19 Cordis Corporation Welded radially expandable endoprosthesis and the like
US5234416A (en) 1991-06-06 1993-08-10 Advanced Cardiovascular Systems, Inc. Intravascular catheter with a nontraumatic distal tip
US5205822A (en) 1991-06-10 1993-04-27 Cordis Corporation Replaceable dilatation catheter
US5318531A (en) 1991-06-11 1994-06-07 Cordis Corporation Infusion balloon catheter
US5213576A (en) 1991-06-11 1993-05-25 Cordis Corporation Therapeutic porous balloon catheter
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
JPH04369492A (ja) 1991-06-18 1992-12-22 Pioneer Electron Corp Ｇｐｓ測位装置
US5314472A (en) 1991-10-01 1994-05-24 Cook Incorporated Vascular stent
US5330768A (en) 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
CA2074304C (en) 1991-08-02 1996-11-26 Cyril J. Schweich, Jr. Drug delivery catheter
US5356433A (en) 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
US5302168A (en) 1991-09-05 1994-04-12 Hess Robert L Method and apparatus for restenosis treatment
US5269802A (en) 1991-09-10 1993-12-14 Garber Bruce B Prostatic stent
WO1993004720A1 (en) 1991-09-12 1993-03-18 THE UNITED STATES, as represented by SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES Apparatus for and method of making ultra thin walled wire reinforced endotracheal tubing and product thereof
US5229045A (en) 1991-09-18 1993-07-20 Kontron Instruments Inc. Process for making porous membranes
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
WO1993006792A1 (en) 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5366504A (en) 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
US5234457A (en) 1991-10-09 1993-08-10 Boston Scientific Corporation Impregnated stent
US5282860A (en) 1991-10-16 1994-02-01 Olympus Optical Co., Ltd. Stent tube for medical use
DE69230040T2 (de) 1991-10-21 2000-01-05 Peptech Ltd Biokompatibles implantat für die zeitliche abstimmung der ovulation von stuten
US5456713A (en) 1991-10-25 1995-10-10 Cook Incorporated Expandable transluminal graft prosthesis for repairs of aneurysm and method for implanting
CA2380683C (en) 1991-10-28 2006-08-08 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
US5167614A (en) 1991-10-29 1992-12-01 Medical Engineering Corporation Prostatic stent
US5756476A (en) 1992-01-14 1998-05-26 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell proliferation using antisense oligonucleotides
US5493588A (en) 1992-01-22 1996-02-20 Trimble Navigation Limited Multipath compensation for code phase signals
CA2087132A1 (en) * 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
DE69313312T2 (de) 1992-01-31 1998-01-02 Advanced Cardiovascular System Schützmembran für Stent-tragenden Ballonkatheter
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
EP0566245B1 (de) 1992-03-19 1999-10-06 Medtronic, Inc. Intraluminales Erweiterungsgerät
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5571166A (en) 1992-03-19 1996-11-05 Medtronic, Inc. Method of making an intraluminal stent
US5591224A (en) 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
US5599352A (en) * 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
ES2116406T3 (es) 1992-03-25 1998-07-16 Cook Inc Stent vascular.
GB9206736D0 (en) 1992-03-27 1992-05-13 Sandoz Ltd Improvements of organic compounds and their use in pharmaceutical compositions
JPH07505316A (ja) 1992-03-31 1995-06-15 ボストン　サイエンティフィック　コーポレーション 医療用ワイヤ
US5254089A (en) 1992-04-02 1993-10-19 Boston Scientific Corp. Medication dispensing balloon catheter
US5306250A (en) 1992-04-02 1994-04-26 Indiana University Foundation Method and apparatus for intravascular drug delivery
US5323152A (en) 1992-04-15 1994-06-21 Sumitomo Electric Industries, Ltd. Apparatus for detecting the position of a vehicle
US5219980A (en) 1992-04-16 1993-06-15 Sri International Polymers biodegradable or bioerodiable into amino acids
EP0568451B1 (de) 1992-04-28 1999-08-04 Terumo Kabushiki Kaisha Thermoplastische Polymerzusammensetzung und daraus hergestellte medizinische Vorrichtungen
US5383927A (en) 1992-05-07 1995-01-24 Intervascular Inc. Non-thromogenic vascular prosthesis
AU678350B2 (en) 1992-05-08 1997-05-29 Schneider (Usa) Inc. Esophageal stent and delivery tool
DE4222380A1 (de) 1992-07-08 1994-01-13 Ernst Peter Prof Dr M Strecker In den Körper eines Patienten perkutan implantierbare Endoprothese
JPH0638851A (ja) 1992-07-21 1994-02-15 Itoki Crebio Corp 椅 子
US5306294A (en) 1992-08-05 1994-04-26 Ultrasonic Sensing And Monitoring Systems, Inc. Stent construction of rolled configuration
JP3295454B2 (ja) 1992-08-05 2002-06-24 パイオニア株式会社 Ｇｐｓ受信機の信号処理方法
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5853408A (en) 1992-08-20 1998-12-29 Advanced Cardiovascular Systems, Inc. In-vivo modification of the mechanical properties of surgical devices
US5342621A (en) 1992-09-15 1994-08-30 Advanced Cardiovascular Systems, Inc. Antithrombogenic surface
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
EP0597593A1 (de) 1992-10-30 1994-05-18 Medtronic, Inc. Gerinnungsbeständige Gegenstände
US5344455A (en) 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5278200A (en) * 1992-10-30 1994-01-11 Medtronic, Inc. Thromboresistant material and articles
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
US5830461A (en) 1992-11-25 1998-11-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods for promoting wound healing and treating transplant-associated vasculopathy
US5390124A (en) 1992-12-01 1995-02-14 Caterpillar Inc. Method and apparatus for improving the accuracy of position estimates in a satellite based navigation system
US5342348A (en) 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
FR2699168B1 (fr) 1992-12-11 1995-01-13 Rhone Poulenc Chimie Procédé de traitement d'un matériau comprenant un polymère par hydrolyse.
US5336518A (en) * 1992-12-11 1994-08-09 Cordis Corporation Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents
DE4242476C1 (de) 1992-12-16 1994-08-11 Eppendorf Geraetebau Netheler Vorrichtung zum Zentrifugieren von Proben
EP0604022A1 (de) 1992-12-22 1994-06-29 Advanced Cardiovascular Systems, Inc. Mehrschichtiges resorbierbares Stent und Verfahren zu dessen Herstellung
US5443458A (en) 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
US5487730A (en) 1992-12-30 1996-01-30 Medtronic, Inc. Balloon catheter with balloon surface retention means
US5275012A (en) * 1993-01-07 1994-01-04 Ford Motor Company Climate control system for electric vehicle
US5423849A (en) 1993-01-15 1995-06-13 Target Therapeutics, Inc. Vasoocclusion device containing radiopaque fibers
US5350800A (en) 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces
US5229172A (en) 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization
US5308641A (en) 1993-01-19 1994-05-03 Medtronic, Inc. Biocompatibility of solid surfaces
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5360401A (en) 1993-02-18 1994-11-01 Advanced Cardiovascular Systems, Inc. Catheter for stent delivery
WO1994021320A1 (en) 1993-03-15 1994-09-29 Advanced Cardiovascular Systems, Inc. Fluid delivery catheter
US5347536A (en) 1993-03-17 1994-09-13 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Multipath noise reduction for spread spectrum signals
WO1994021196A2 (en) 1993-03-18 1994-09-29 C.R. Bard, Inc. Endovascular stents
US5368560A (en) 1993-03-29 1994-11-29 Medical Development Systems, Inc. Suction nozzle
FI92465C (fi) 1993-04-14 1994-11-25 Risto Tapani Lehtinen Menetelmä endo-osteaalisten materiaalien käsittelemiseksi
US5441515A (en) 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5464650A (en) * 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5824048A (en) * 1993-04-26 1998-10-20 Medtronic, Inc. Method for delivering a therapeutic substance to a body lumen
JP3595571B2 (ja) 1993-05-07 2004-12-02 日精エー・エス・ビー機械株式会社 二重壁ボトルとその成形方法及び装置
IT1276342B1 (it) 1993-06-04 1997-10-30 Ist Naz Stud Cura Dei Tumori Stent metallico rivestito con materiale polimerico biocompatibile
JPH0767895A (ja) 1993-06-25 1995-03-14 Sumitomo Electric Ind Ltd 抗菌性人工血管及び抗菌性手術用縫合糸
US5471218A (en) 1993-07-01 1995-11-28 Trimble Navigation Limited Integrated terrestrial survey and satellite positioning system
US5458615A (en) 1993-07-06 1995-10-17 Advanced Cardiovascular Systems, Inc. Stent delivery system
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
EG20321A (en) 1993-07-21 1998-10-31 Otsuka Pharma Co Ltd Medical material and process for producing the same
DE69330132T2 (de) 1993-07-23 2001-11-15 Cook Inc., Bloomington Flexibler stent mit einer aus einem materialbogen geformten konfiguration
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
DE4327024A1 (de) 1993-08-12 1995-02-16 Bayer Ag Thermoplastisch verarbeitbare und biologisch abbaubare aliphatische Polyesteramide
US5746745A (en) 1993-08-23 1998-05-05 Boston Scientific Corporation Balloon catheter
US5409495A (en) 1993-08-24 1995-04-25 Advanced Cardiovascular Systems, Inc. Apparatus for uniformly implanting a stent
EP1716864A1 (de) 1993-08-26 2006-11-02 Genetics Institute, LLC Neuronale Regeneration mit menschlichen morphogenischen Knochenproteinen
US5380299A (en) * 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5618298A (en) 1993-10-23 1997-04-08 Simon; Michael Vascular prosthesis made of resorbable material
US5545209A (en) 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
WO1995010989A1 (en) 1993-10-19 1995-04-27 Scimed Life Systems, Inc. Intravascular stent pump
DK0659389T3 (da) 1993-10-20 1999-02-15 Schneider Europ Ag Endoprotese
US5855598A (en) * 1993-10-21 1999-01-05 Corvita Corporation Expandable supportive branched endoluminal grafts
US5723004A (en) 1993-10-21 1998-03-03 Corvita Corporation Expandable supportive endoluminal grafts
US5445646A (en) 1993-10-22 1995-08-29 Scimed Lifesystems, Inc. Single layer hydraulic sheath stent delivery apparatus and method
US5571135A (en) 1993-10-22 1996-11-05 Scimed Life Systems Inc. Stent delivery apparatus and method
JP3758048B2 (ja) 1993-10-26 2006-03-22 帝国ピストンリング株式会社 リングの塗装方法及び塗装装置
DE4336705C2 (de) 1993-10-27 1996-11-28 Hoffmann Elektrokohle Schleifkontaktelement sowie Verfahren zur Verbindung eines elektrischen Anschlußleiters mit einem Schleifkontaktelement
US5389106A (en) 1993-10-29 1995-02-14 Numed, Inc. Impermeable expandable intravascular stent
US5493694A (en) 1993-11-08 1996-02-20 Trimble Navigation Limited Fast response system for a fleet of vehicles
US5599301A (en) * 1993-11-22 1997-02-04 Advanced Cardiovascular Systems, Inc. Motor control system for an automatic catheter inflation system
US5554673A (en) 1993-11-29 1996-09-10 Polygenex International, Inc. Dip molded polyurethane film compositions
SE501288C2 (sv) 1993-11-30 1995-01-09 Corimed Gmbh Förfarande för framställning av keramiskt implantatmaterial, företrädesvis hydroxylapatit uppvisande keramiskt implantatmaterial
JP2661534B2 (ja) 1993-12-28 1997-10-08 日本電気株式会社 スペクトラム拡散受信方法及び受信機
JP2703510B2 (ja) 1993-12-28 1998-01-26 アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド 拡大可能なステント及びその製造方法
EP0741585A1 (de) 1994-01-21 1996-11-13 Brown University Research Foundation Bioverträgliche implantate
US6051576A (en) 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
US5626611A (en) 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
US5470313A (en) 1994-02-24 1995-11-28 Cardiovascular Dynamics, Inc. Variable diameter balloon dilatation catheter
US5556413A (en) 1994-03-11 1996-09-17 Advanced Cardiovascular Systems, Inc. Coiled stent with locking ends
EP0804249A2 (de) 1994-03-15 1997-11-05 Brown University Research Foundation Polymeres system zur freisetzung von genen
US5599922A (en) * 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
CZ274596A3 (en) 1994-03-18 1997-03-12 Lynx Therapeutics Oligonucleotide n3 - p5 phosphoramidates and process of their synthesis and hybridization
US5726297A (en) 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
US5588962A (en) * 1994-03-29 1996-12-31 Boston Scientific Corporation Drug treatment of diseased sites deep within the body
US5485163A (en) 1994-03-30 1996-01-16 Motorola, Inc. Personal locator system
US5456661A (en) 1994-03-31 1995-10-10 Pdt Cardiovascular Catheter with thermally stable balloon
US5656082A (en) 1994-04-04 1997-08-12 Tatsumo Kabushiki Kaisha Liquid applying apparatus utilizing centrifugal force
US5399666A (en) 1994-04-21 1995-03-21 E. I. Du Pont De Nemours And Company Easily degradable star-block copolymers
US5479351A (en) 1994-04-22 1995-12-26 Trimble Navigation Limited Time-keeping system and method for synchronizing independent recordings of a live performance in post-recording editing
US5504491A (en) 1994-04-25 1996-04-02 Chapman; Robert W. Global status and position reporting system
US5693085A (en) 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
US5765418A (en) 1994-05-16 1998-06-16 Medtronic, Inc. Method for making an implantable medical device from a refractory metal
DK63894A (da) 1994-06-06 1996-01-08 Meadox Medicals Inc Kateter med stent samt fremgangsmåde til fremstilling af et sådant kateter med stent
US5728068A (en) 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5567410A (en) 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
US5629077A (en) 1994-06-27 1997-05-13 Advanced Cardiovascular Systems, Inc. Biodegradable mesh and film stent
US5857998A (en) * 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
US5670558A (en) 1994-07-07 1997-09-23 Terumo Kabushiki Kaisha Medical instruments that exhibit surface lubricity when wetted
US5495257A (en) 1994-07-19 1996-02-27 Trimble Navigation Limited Inverse differential corrections for SATPS mobile stations
US5788979A (en) 1994-07-22 1998-08-04 Inflow Dynamics Inc. Biodegradable coating with inhibitory properties for application to biocompatible materials
US5554120A (en) 1994-07-25 1996-09-10 Advanced Cardiovascular Systems, Inc. Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters
US5817327A (en) 1994-07-27 1998-10-06 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
US5541845A (en) 1994-08-02 1996-07-30 Trimble Navigation Limited Monitoring of route and schedule adherence
US5486834A (en) 1994-08-08 1996-01-23 Trimble Navigation Limited Global orbiting navigation satellite system receiver
US5516881A (en) 1994-08-10 1996-05-14 Cornell Research Foundation, Inc. Aminoxyl-containing radical spin labeling in polymers and copolymers
ES2138094T3 (es) 1994-09-07 2000-01-01 Synthes Ag Dispositivo medico para la implantacion en organismos vivientes.
US6015429A (en) 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US5490076A (en) 1994-09-12 1996-02-06 Itt Corporation Apparatus and method for autonavigation with one or more orbiting satellites and an anchor station
US5593403A (en) * 1994-09-14 1997-01-14 Scimed Life Systems Inc. Method for modifying a stent in an implanted site
US5578073A (en) 1994-09-16 1996-11-26 Ramot Of Tel Aviv University Thromboresistant surface treatment for biomaterials
US5649977A (en) 1994-09-22 1997-07-22 Advanced Cardiovascular Systems, Inc. Metal reinforced polymer stent
US5485496A (en) * 1994-09-22 1996-01-16 Cornell Research Foundation, Inc. Gamma irradiation sterilizing of biomaterial medical devices or products, with improved degradation and mechanical properties
FR2724938A1 (fr) 1994-09-28 1996-03-29 Lvmh Rech Polymeres fonctionnalises par des acides amines ou des derives d'acides amines, leur utilisation comme agents tensioactifs en particulier dans des compositions cosmetiques et notamment des vernis a ongles.
CA2202511A1 (en) 1994-10-12 1996-04-25 Laurence A. Roth Targeted delivery via biodegradable polymers
US5765682A (en) 1994-10-13 1998-06-16 Menlo Care, Inc. Restrictive package for expandable or shape memory medical devices and method of preventing premature change of same
AU699821B2 (en) 1994-10-17 1998-12-17 Kabushikikaisha Igaki Iryo Sekkei Stent for liberating drug
US5836965A (en) 1994-10-19 1998-11-17 Jendersee; Brad Stent delivery and deployment method
IL115755A0 (en) 1994-10-27 1996-01-19 Medinol Ltd X-ray visible stent
US5836964A (en) 1996-10-30 1998-11-17 Medinol Ltd. Stent fabrication method
US5707385A (en) * 1994-11-16 1998-01-13 Advanced Cardiovascular Systems, Inc. Drug loaded elastic membrane and method for delivery
US5485161A (en) 1994-11-21 1996-01-16 Trimble Navigation Limited Vehicle speed control based on GPS/MAP matching of posted speeds
CA2163824C (en) 1994-11-28 2000-06-20 Richard J. Saunders Method and apparatus for direct laser cutting of metal stents
US5628755A (en) 1995-02-20 1997-05-13 Schneider (Europe) A.G. Balloon catheter and stent delivery system
US6059752A (en) 1994-12-09 2000-05-09 Segal; Jerome Mechanical apparatus and method for dilating and irradiating a site of treatment
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5569198A (en) 1995-01-23 1996-10-29 Cortrak Medical Inc. Microporous catheter
US5919570A (en) 1995-02-01 1999-07-06 Schneider Inc. Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices
US6017577A (en) 1995-02-01 2000-01-25 Schneider (Usa) Inc. Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices
US5702754A (en) 1995-02-22 1997-12-30 Meadox Medicals, Inc. Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US5869127A (en) 1995-02-22 1999-02-09 Boston Scientific Corporation Method of providing a substrate with a bio-active/biocompatible coating
US6147168A (en) 1995-03-06 2000-11-14 Ethicon, Inc. Copolymers of absorbable polyoxaesters
US5854376A (en) 1995-03-09 1998-12-29 Sekisui Kaseihin Kogyo Kabushiki Kaisha Aliphatic ester-amide copolymer resins
JP3507503B2 (ja) 1995-03-10 2004-03-15 インプラ・インコーポレーテッド 体腔内用の封止型ステント及びその製造方法並びにその体腔内への導入方法
US5647857A (en) 1995-03-16 1997-07-15 Endotex Interventional Systems, Inc. Protective intraluminal sheath
WO1996029030A1 (en) 1995-03-17 1996-09-26 Smith & Nephew Richards Inc. Medical implants
US5876743A (en) 1995-03-21 1999-03-02 Den-Mat Corporation Biocompatible adhesion in tissue repair
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
WO1996030064A1 (en) * 1995-03-31 1996-10-03 Boston Scientific Corporation Multiple hole drug delivery balloon
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
SI9620067A (sl) 1995-04-19 1998-06-30 Kazunori Kataoka Heteroteleheličen blok-kopolimer in postopek za njegovo proizvodnjo
US20020091433A1 (en) 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US5537121A (en) 1995-04-28 1996-07-16 Trimble Navigation Limited Carrier phase multipath reduction technique
US5667523A (en) 1995-04-28 1997-09-16 Impra, Inc. Dual supported intraluminal graft
US5730698A (en) 1995-05-09 1998-03-24 Fischell; Robert E. Balloon expandable temporary radioisotope stent system
DK0824344T3 (da) 1995-05-09 2005-08-15 Phoqus Pharmaceuticals Ltd Pulverformig sammensætning til elektrostatisk coating af farmaceutiske substrater
GB2316342B (en) 1995-05-09 2000-01-12 Colorcon Ltd Electrostatic coating
US7008668B2 (en) 1995-05-09 2006-03-07 Phoqus Pharmaceuticals Limited Powder coating composition for electrostatic coating of pharmaceutical substrates
GB2333975B (en) 1995-05-09 2000-01-12 Colorcon Ltd Improvements in or relating to electrostatic coating of substrates
US6059810A (en) 1995-05-10 2000-05-09 Scimed Life Systems, Inc. Endovascular stent and method
JP2795824B2 (ja) * 1995-05-12 1998-09-10 オオタ株式会社 チタン系インプラントの表面処理方法及び生体親和性チタン系インプラント
US5628786A (en) 1995-05-12 1997-05-13 Impra, Inc. Radially expandable vascular graft with resistance to longitudinal compression and method of making same
US5674242A (en) 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
US5954744A (en) 1995-06-06 1999-09-21 Quanam Medical Corporation Intravascular stent
US5711812A (en) * 1995-06-06 1998-01-27 Varian Associates, Inc. Apparatus for obtaining dose uniformity in plasma doping (PLAD) ion implantation processes
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US5820917A (en) 1995-06-07 1998-10-13 Medtronic, Inc. Blood-contacting medical device and method
US5591199A (en) * 1995-06-07 1997-01-07 Porter; Christopher H. Curable fiber composite stent and delivery system
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7550005B2 (en) 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US6010530A (en) * 1995-06-07 2000-01-04 Boston Scientific Technology, Inc. Self-expanding endoluminal prosthesis
WO1998017331A1 (en) 1995-06-07 1998-04-30 Cook Incorporated Silver implantable medical device
EP0869804A4 (de) 1995-06-07 2001-08-16 American Nat Red Cross Supplementierte und nichtsupplementierte verdichtungsmittel, verfahren zu deren herstellung und verwendung
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US5693376A (en) 1995-06-23 1997-12-02 Wisconsin Alumni Research Foundation Method for plasma source ion implantation and deposition for cylindrical surfaces
US6209621B1 (en) 1995-07-07 2001-04-03 Depuy Orthopaedics, Inc. Implantable prostheses with metallic porous bead preforms applied during casting and method of forming the same
US5667767A (en) 1995-07-27 1997-09-16 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5877224A (en) 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
CA2179083A1 (en) 1995-08-01 1997-02-02 Michael S. Williams Composite metal and polymer locking stents for drug delivery
GB9611437D0 (en) 1995-08-03 1996-08-07 Secr Defence Biomaterial
US5962923A (en) 1995-08-07 1999-10-05 Applied Materials, Inc. Semiconductor device having a low thermal budget metal filling and planarization of contacts, vias and trenches
DE19533682A1 (de) * 1995-09-12 1997-03-13 Biotronik Mess & Therapieg Verfahren zum Anlagern und Immobilisieren von Heparin auf anorganischen Substratoberflächen von kardiovaskulären Implantanten
US5868704A (en) 1995-09-18 1999-02-09 W. L. Gore & Associates, Inc. Balloon catheter device
US5935135A (en) 1995-09-29 1999-08-10 United States Surgical Corporation Balloon delivery system for deploying stents
US5830879A (en) 1995-10-02 1998-11-03 St. Elizabeth's Medical Center Of Boston, Inc. Treatment of vascular injury using vascular endothelial growth factor
US5723219A (en) 1995-12-19 1998-03-03 Talison Research Plasma deposited film networks
US5804318A (en) * 1995-10-26 1998-09-08 Corvita Corporation Lubricious hydrogel surface modification
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5607442A (en) 1995-11-13 1997-03-04 Isostent, Inc. Stent with improved radiopacity and appearance characteristics
US5788626A (en) 1995-11-21 1998-08-04 Schneider (Usa) Inc Method of making a stent-graft covered with expanded polytetrafluoroethylene
US5658995A (en) 1995-11-27 1997-08-19 Rutgers, The State University Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide)
US5840009A (en) 1995-12-05 1998-11-24 Isostent, Inc. Radioisotope stent with increased radiation field strength at the ends of the stent
DE19545678A1 (de) 1995-12-07 1997-06-12 Goldschmidt Ag Th Copolymere Polyaminosäureester
US6048964A (en) 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
SG46752A1 (en) 1995-12-27 1998-02-20 Taiwan Semiconductor Mfg A method to prevent volcano effect in tungsten plug deposition
US5865723A (en) * 1995-12-29 1999-02-02 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
DE69732794T2 (de) 1996-01-05 2006-04-06 Medtronic, Inc., Minneapolis Expandierbare endoluminale prothesen
US6150630A (en) 1996-01-11 2000-11-21 The Regents Of The University Of California Laser machining of explosives
US5722984A (en) 1996-01-16 1998-03-03 Iso Stent, Inc. Antithrombogenic radioactive coating for an intravascular stent
US6033582A (en) 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
US6054553A (en) 1996-01-29 2000-04-25 Bayer Ag Process for the preparation of polymers having recurring agents
WO1997027959A1 (en) 1996-01-30 1997-08-07 Medtronic, Inc. Articles for and methods of making stents
US5772864A (en) 1996-02-23 1998-06-30 Meadox Medicals, Inc. Method for manufacturing implantable medical devices
US5695498A (en) 1996-02-28 1997-12-09 Numed, Inc. Stent implantation system
US5823996A (en) 1996-02-29 1998-10-20 Cordis Corporation Infusion balloon catheter
JP2000509014A (ja) 1996-03-11 2000-07-18 フォーカル，インコーポレイテッド 放射性核種および放射性医薬品のポリマー送達
CA2199890C (en) 1996-03-26 2002-02-05 Corvita Corporation Stents and stent-grafts having enhanced hoop strength and methods of making the same
US5713949A (en) 1996-08-06 1998-02-03 Jayaraman; Swaminathan Microporous covered stents and method of coating
US5830179A (en) 1996-04-09 1998-11-03 Endocare, Inc. Urological stent therapy system and method
NZ331269A (en) 1996-04-10 2000-01-28 Advanced Cardiovascular System Expandable stent, its structural strength varying along its length
US5932299A (en) 1996-04-23 1999-08-03 Katoot; Mohammad W. Method for modifying the surface of an object
US6033719A (en) 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
US5653691A (en) 1996-04-25 1997-08-05 Rupp; Garry Eugene Thickened inner lumen for uniform stent expansion and method of making
US5925552A (en) 1996-04-25 1999-07-20 Medtronic, Inc. Method for attachment of biomolecules to medical devices surfaces
US5928916A (en) 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
US6071266A (en) 1996-04-26 2000-06-06 Kelley; Donald W. Lubricious medical devices
US6241760B1 (en) 1996-04-26 2001-06-05 G. David Jang Intravascular stent
US6592617B2 (en) 1996-04-30 2003-07-15 Boston Scientific Scimed, Inc. Three-dimensional braided covered stent
US5955509A (en) 1996-05-01 1999-09-21 Board Of Regents, The University Of Texas System pH dependent polymer micelles
US5610241A (en) 1996-05-07 1997-03-11 Cornell Research Foundation, Inc. Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US5951881A (en) 1996-07-22 1999-09-14 President And Fellows Of Harvard College Fabrication of small-scale cylindrical articles
US5833644A (en) 1996-05-20 1998-11-10 Percusurge, Inc. Method for emboli containment
DE69734060T2 (de) 1996-05-24 2006-06-29 Angiotech Pharmaceuticals, Inc., Vancouver Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
US5733326A (en) 1996-05-28 1998-03-31 Cordis Corporation Composite material endoprosthesis
US5876433A (en) 1996-05-29 1999-03-02 Ethicon, Inc. Stent and method of varying amounts of heparin coated thereon to control treatment
US5811151A (en) 1996-05-31 1998-09-22 Medtronic, Inc. Method of modifying the surface of a medical device
US5914182A (en) 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
US5874165A (en) 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
US5876426A (en) 1996-06-13 1999-03-02 Scimed Life Systems, Inc. System and method of providing a blood-free interface for intravascular light delivery
US5769884A (en) 1996-06-27 1998-06-23 Cordis Corporation Controlled porosity endovascular implant
NL1003459C2 (nl) * 1996-06-28 1998-01-07 Univ Twente Copoly(ester-amides) en copoly(ester-urethanen).
US5833659A (en) 1996-07-10 1998-11-10 Cordis Corporation Infusion balloon catheter
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5871436A (en) 1996-07-19 1999-02-16 Advanced Cardiovascular Systems, Inc. Radiation therapy method and device
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5830178A (en) 1996-10-11 1998-11-03 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
US6120535A (en) * 1996-07-29 2000-09-19 Radiance Medical Systems, Inc. Microporous tubular prosthesis
GB9616032D0 (en) 1996-07-31 1996-09-11 Ici Plc Cassette casing for thermal transfer printing dye ribbon
US5800516A (en) 1996-08-08 1998-09-01 Cordis Corporation Deployable and retrievable shape memory stent/tube and method
US5830217A (en) 1996-08-09 1998-11-03 Thomas J. Fogarty Soluble fixation device and method for stent delivery catheters
US6060518A (en) 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
US6123712A (en) 1996-08-23 2000-09-26 Scimed Life Systems, Inc. Balloon catheter with stent securement means
WO1998007390A1 (en) 1996-08-23 1998-02-26 Scimed Life Systems, Inc. Stent delivery system having stent securement apparatus
WO1998007523A1 (en) 1996-08-23 1998-02-26 Pursley Matt D Apparatus and method for nonextrusion manufacturing of catheters
WO1998008463A1 (en) 1996-08-30 1998-03-05 Helix Medical Corporation Medical devices having microbial resistant material properties
US6344271B1 (en) 1998-11-06 2002-02-05 Nanoenergy Corporation Materials and products using nanostructured non-stoichiometric substances
US5855618A (en) * 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US5807404A (en) * 1996-09-19 1998-09-15 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
US5913871A (en) 1996-09-25 1999-06-22 Medtronic, Inc. Balloon modification for improved stent fixation and deployment
US6174326B1 (en) 1996-09-25 2001-01-16 Terumo Kabushiki Kaisha Radiopaque, antithrombogenic stent and method for its production
JP3938418B2 (ja) 1996-09-25 2007-06-27 テルモ株式会社 ステント
US5783657A (en) 1996-10-18 1998-07-21 Union Camp Corporation Ester-terminated polyamides of polymerized fatty acids useful in formulating transparent gels in low polarity liquids
NL1004162C2 (nl) 1996-10-01 1998-04-02 Cordis Europ Ballonkatheter voor stentplaatsing.
FR2753907B1 (fr) 1996-10-02 1999-07-16 Nycomed Lab Sa Ballon pour catheter de dilatation et son procede de fabrication
US6387121B1 (en) 1996-10-21 2002-05-14 Inflow Dynamics Inc. Vascular and endoluminal stents with improved coatings
US6099561A (en) 1996-10-21 2000-08-08 Inflow Dynamics, Inc. Vascular and endoluminal stents with improved coatings
US5868781A (en) 1996-10-22 1999-02-09 Scimed Life Systems, Inc. Locking stent
US6086610A (en) 1996-10-22 2000-07-11 Nitinol Devices & Components Composite self expanding stent device having a restraining element
US5843119A (en) 1996-10-23 1998-12-01 United States Surgical Corporation Apparatus and method for dilatation of a body lumen and delivery of a prothesis therein
US6530951B1 (en) 1996-10-24 2003-03-11 Cook Incorporated Silver implantable medical device
US5833651A (en) 1996-11-08 1998-11-10 Medtronic, Inc. Therapeutic intraluminal stents
GB9623634D0 (en) 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
GB2356585B (en) 1996-11-13 2001-07-11 Phoqus Ltd Method and apparatus for the coating of substrates for pharmaceutical use and intermediate products for use in producing solid dosage forms
GB2356586B (en) 1996-11-13 2001-07-11 Phoqus Ltd Method and apparatus for the coating of substrates for pharmaceutical use and products for use in producing solid dosage forms
US5807244A (en) 1996-11-15 1998-09-15 Barot; Jagdish Shantilal Single use disposable iris retractor
US5846247A (en) 1996-11-15 1998-12-08 Unsworth; John D. Shape memory tubular deployment system
US5695810A (en) 1996-11-20 1997-12-09 Cornell Research Foundation, Inc. Use of cobalt tungsten phosphide as a barrier material for copper metallization
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US5741881A (en) 1996-11-25 1998-04-21 Meadox Medicals, Inc. Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions
US5728751A (en) 1996-11-25 1998-03-17 Meadox Medicals, Inc. Bonding bio-active materials to substrate surfaces
US5877263A (en) 1996-11-25 1999-03-02 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
US6120491A (en) 1997-11-07 2000-09-19 The State University Rutgers Biodegradable, anionic polymers derived from the amino acid L-tyrosine
IT1289728B1 (it) 1996-12-10 1998-10-16 Sorin Biomedica Cardio Spa Dispositivo di impianto e corredo che lo comprende
JP2001505807A (ja) 1996-12-10 2001-05-08 パーデュー・リサーチ・ファウンデーション 人工血管弁
US5871437A (en) 1996-12-10 1999-02-16 Inflow Dynamics, Inc. Radioactive stent for treating blood vessels to prevent restenosis
US6045899A (en) 1996-12-12 2000-04-04 Usf Filtration & Separations Group, Inc. Highly assymetric, hydrophilic, microfiltration membranes having large pore diameters
US5980972A (en) 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US5906759A (en) 1996-12-26 1999-05-25 Medinol Ltd. Stent forming apparatus with stent deforming blades
IT1289815B1 (it) 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa Stent per angioplastica e relativo procedimento di produzione
IT1291001B1 (it) 1997-01-09 1998-12-14 Sorin Biomedica Cardio Spa Stent per angioplastica e suo procedimento di produzione
US5733330A (en) 1997-01-13 1998-03-31 Advanced Cardiovascular Systems, Inc. Balloon-expandable, crush-resistant locking stent
US6132809A (en) 1997-01-16 2000-10-17 Precision Valve & Automation, Inc. Conformal coating using multiple applications
US5858556A (en) * 1997-01-21 1999-01-12 Uti Corporation Multilayer composite tubular structure and method of making
JP3523765B2 (ja) 1997-01-24 2004-04-26 テルモ株式会社 生体器官拡張器具
US5997517A (en) * 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
AU6252298A (en) 1997-01-28 1998-08-18 United States Surgical Corporation Polyesteramides with amino acid-derived groups alternating with alpha-hydroxyacid-derived groups and surgical articles made therefrom
EP0967933B1 (de) 1997-01-28 2004-12-29 United States Surgical Corporation Polyesteramid, seine darstellung und daraus fabrizierte chirurgische artikel
DE69812903T2 (de) 1997-01-28 2003-12-04 United States Surgical Corp., Norwalk Polyesteramid,seine herstellung und damit hergestellte chirurgische vorrichtungen
US5782742A (en) 1997-01-31 1998-07-21 Cardiovascular Dynamics, Inc. Radiation delivery balloon
US6090330A (en) 1997-02-06 2000-07-18 Matsushita Electric Industrial Co., Ltd. Laser processing method
US6159951A (en) 1997-02-13 2000-12-12 Ribozyme Pharmaceuticals Inc. 2'-O-amino-containing nucleoside analogs and polynucleotides
AU737252B2 (en) 1997-02-20 2001-08-16 Cook Medical Technologies Llc Coated implantable medical device
US6582472B2 (en) 1997-02-26 2003-06-24 Applied Medical Resources Corporation Kinetic stent
US6140431A (en) 1997-02-27 2000-10-31 Rohm And Haas Company Process for preparing continuously variable-composition copolymers
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders
EP0916362B1 (de) 1997-03-31 2009-07-08 Kabushikikaisha Igaki Iryo Sekkei Stent für gefässe
AU6946198A (en) 1997-04-01 1998-10-22 Cap Biotechnology, Inc. Calcium phosphate microcarriers and microspheres
US5874101A (en) 1997-04-14 1999-02-23 Usbiomaterials Corp. Bioactive-gel compositions and methods
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
US5843172A (en) 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
FI103715B1 (fi) 1997-04-21 1999-08-31 Heimo Ylaenen Uusi komposiitti ja sen käyttö
US6019777A (en) 1997-04-21 2000-02-01 Advanced Cardiovascular Systems, Inc. Catheter and method for a stent delivery system
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US5810871A (en) 1997-04-29 1998-09-22 Medtronic, Inc. Stent delivery system
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US5741327A (en) 1997-05-06 1998-04-21 Global Therapeutics, Inc. Surgical stent featuring radiopaque markers
US5972029A (en) 1997-05-13 1999-10-26 Fuisz Technologies Ltd. Remotely operable stent
US5969422A (en) 1997-05-15 1999-10-19 Advanced Micro Devices, Inc. Plated copper interconnect structure
US6303901B1 (en) 1997-05-20 2001-10-16 The Regents Of The University Of California Method to reduce damage to backing plate
US5891192A (en) 1997-05-22 1999-04-06 The Regents Of The University Of California Ion-implanted protein-coated intralumenal implants
BE1011180A6 (fr) 1997-05-27 1999-06-01 Medicorp R & D Benelux Sa Endoprothese luminale auto expansible.
US6159978A (en) 1997-05-28 2000-12-12 Aventis Pharmaceuticals Product, Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6245760B1 (en) 1997-05-28 2001-06-12 Aventis Pharmaceuticals Products, Inc Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6180632B1 (en) 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6056993A (en) 1997-05-30 2000-05-02 Schneider (Usa) Inc. Porous protheses and methods for making the same wherein the protheses are formed by spraying water soluble and water insoluble fibers onto a rotating mandrel
US5902631A (en) 1997-06-03 1999-05-11 Wang; Lixiao Lubricity gradient for medical devices
US6106454A (en) 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US5883011A (en) 1997-06-18 1999-03-16 Vlsi Technology, Inc. Method of removing an inorganic antireflective coating from a semiconductor substrate
US6110483A (en) 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
WO1999001118A2 (en) 1997-07-01 1999-01-14 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US5898178A (en) 1997-07-02 1999-04-27 Implant Sciences Corporation Ion source for generation of radioactive ion beams
US6211249B1 (en) 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
US5810873A (en) 1997-07-15 1998-09-22 Advanced Cardiovascular Systems, Inc. Stent crimping tool and method of use
DE19731021A1 (de) 1997-07-18 1999-01-21 Meyer Joerg In vivo abbaubares metallisches Implantat
US5980928A (en) 1997-07-29 1999-11-09 Terry; Paul B. Implant for preventing conjunctivitis in cattle
US6245103B1 (en) 1997-08-01 2001-06-12 Schneider (Usa) Inc Bioabsorbable self-expanding stent
US6340367B1 (en) 1997-08-01 2002-01-22 Boston Scientific Scimed, Inc. Radiopaque markers and methods of using the same
US6174330B1 (en) 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US5980564A (en) 1997-08-01 1999-11-09 Schneider (Usa) Inc. Bioabsorbable implantable endoprosthesis with reservoir
CN1272873A (zh) 1997-08-08 2000-11-08 普罗格特-甘布尔公司 具有用于提供所洗织物外观和完整性益处的基于氨基酸的聚合物的洗衣用洗涤剂组合物
US5897911A (en) 1997-08-11 1999-04-27 Advanced Cardiovascular Systems, Inc. Polymer-coated stent structure
US6121027A (en) 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6117979A (en) 1997-08-18 2000-09-12 Medtronic, Inc. Process for making a bioprosthetic device and implants produced therefrom
US6143370A (en) 1997-08-27 2000-11-07 Northeastern University Process for producing polymer coatings with various porosities and surface areas
US6129928A (en) 1997-09-05 2000-10-10 Icet, Inc. Biomimetic calcium phosphate implant coatings and methods for making the same
US6284333B1 (en) 1997-09-10 2001-09-04 Scimed Life Systems, Inc. Medical devices made from polymer blends containing low melting temperature liquid crystal polymers
US6010445A (en) * 1997-09-11 2000-01-04 Implant Sciences Corporation Radioactive medical device and process
JP2001518292A (ja) 1997-09-22 2001-10-16 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ エンドヌクレアーゼ活性を有する核酸触媒
DE69838256T2 (de) 1997-09-24 2008-05-15 Med Institute, Inc., West Lafayette Radial aufweitbarer stent
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US6042606A (en) 1997-09-29 2000-03-28 Cook Incorporated Radially expandable non-axially contracting surgical stent
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US5976182A (en) 1997-10-03 1999-11-02 Advanced Cardiovascular Systems, Inc. Balloon-expandable, crush-resistant locking stent and method of loading the same
US6120788A (en) 1997-10-16 2000-09-19 Bioamide, Inc. Bioabsorbable triglycolic acid poly(ester-amide)s
US6273850B1 (en) 1997-10-29 2001-08-14 Medtronic Ave, Inc. Device for positioning a radiation source at a stenosis treatment site
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
WO1999024174A1 (en) 1997-11-10 1999-05-20 Katoot Mohammad W Method for modifying the surface of an object
US6007631A (en) 1997-11-10 1999-12-28 Speedline Technologies, Inc. Multiple head dispensing system and method
WO1999026674A2 (de) 1997-11-24 1999-06-03 Jennissen Herbert P Verfahren zur immobilisierung von mediatormolekülen auf anorganischen und metallischen implantatmaterialien
US6027510A (en) 1997-12-08 2000-02-22 Inflow Dynamics Inc. Stent delivery system
US6093463A (en) 1997-12-12 2000-07-25 Intella Interventional Systems, Inc. Medical devices made from improved polymer blends
US5957975A (en) 1997-12-15 1999-09-28 The Cleveland Clinic Foundation Stent having a programmed pattern of in vivo degradation
US6626939B1 (en) 1997-12-18 2003-09-30 Boston Scientific Scimed, Inc. Stent-graft with bioabsorbable structural support
US6149574A (en) 1997-12-19 2000-11-21 Radiance Medical Systems, Inc. Dual catheter radiation delivery system
US5986169A (en) 1997-12-31 1999-11-16 Biorthex Inc. Porous nickel-titanium alloy article
EP1045677A4 (de) * 1998-01-06 2005-01-12 Aderans Res Inst Inc Bioabsorbierbare fasern und damit hergestellte, verstärkte verbundelemente
EP0933814A1 (de) 1998-01-28 1999-08-04 Interuniversitair Micro-Elektronica Centrum Vzw Metallisierungsstruktur auf einem fluorhaltigen Dielektrikum und Herstellungsverfahren dafür
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6224626B1 (en) 1998-02-17 2001-05-01 Md3, Inc. Ultra-thin expandable stent
US6140127A (en) 1998-02-18 2000-10-31 Cordis Corporation Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
IL137878A0 (en) 1998-02-23 2001-10-31 Mnemoscience Gmbh Shape memory polymers
BR9907968B1 (pt) 1998-02-23 2009-12-01 composição de polìmeros com memória de formato biodegradáveis e artigos compreendendo a mesma.
US6488701B1 (en) 1998-03-31 2002-12-03 Medtronic Ave, Inc. Stent-graft assembly with thin-walled graft component and method of manufacture
US6024737A (en) 1998-02-25 2000-02-15 Advanced Cardiovascular Systems, Inc. Stent crimping device
US5938697A (en) 1998-03-04 1999-08-17 Scimed Life Systems, Inc. Stent having variable properties
US6110188A (en) 1998-03-09 2000-08-29 Corvascular, Inc. Anastomosis method
US6024918A (en) 1998-03-13 2000-02-15 Medtronic, Inc. Method for attachment of biomolecules to surfaces of medical devices
US6019789A (en) 1998-04-01 2000-02-01 Quanam Medical Corporation Expandable unit cell and intraluminal stent
US6258371B1 (en) 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
US6063092A (en) 1998-04-07 2000-05-16 Medtronic Inc. Heat set and crimping process to optimize stent retention
DE19916086B4 (de) 1998-04-11 2004-11-11 Inflow Dynamics Inc. Implantierbare Prothese, insbesondere Gefäßprothese (Stent)
US20030040790A1 (en) 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US20010029351A1 (en) 1998-04-16 2001-10-11 Robert Falotico Drug combinations and delivery devices for the prevention and treatment of vascular disease
US7658727B1 (en) 1998-04-20 2010-02-09 Medtronic, Inc Implantable medical device with enhanced biocompatibility and biostability
US20020188037A1 (en) 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
WO1999055396A1 (en) 1998-04-27 1999-11-04 Surmodics, Inc. Bioactive agent release coating
US5893852A (en) 1998-04-28 1999-04-13 Advanced Cardiovascular Systems, Inc. Stent crimping tool and method of use
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US6113629A (en) 1998-05-01 2000-09-05 Micrus Corporation Hydrogel for the therapeutic treatment of aneurysms
DE69935716T2 (de) 1998-05-05 2007-08-16 Boston Scientific Ltd., St. Michael Stent mit glatten enden
US6296603B1 (en) 1998-05-26 2001-10-02 Isostent, Inc. Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms
KR100314496B1 (ko) 1998-05-28 2001-11-22 윤동진 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도
US6174316B1 (en) * 1998-05-28 2001-01-16 Medtronic, Inc. Stent delivery system
US6083258A (en) 1998-05-28 2000-07-04 Yadav; Jay S. Locking stent
US6099559A (en) 1998-05-28 2000-08-08 Medtronic Ave, Inc. Endoluminal support assembly with capped ends
AU4435399A (en) 1998-06-11 1999-12-30 Cerus Corporation Inhibiting proliferation of arterial smooth muscle cells
US6106889A (en) 1998-06-11 2000-08-22 Biocoat Incorporated Method of selective coating of articles
DE59913189D1 (de) 1998-06-25 2006-05-04 Biotronik Ag Implantierbare, bioresorbierbare Gefässwandstütze, insbesondere Koronarstent
DE19856983A1 (de) 1998-06-25 1999-12-30 Biotronik Mess & Therapieg Implantierbare, bioresorbierbare Gefäßwandstütze, insbesondere Koronarstent
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
WO2000002243A1 (en) 1998-07-01 2000-01-13 Seiko Epson Corporation Semiconductor device, method of manufacture, circuit board, and electronic device
US6010573A (en) * 1998-07-01 2000-01-04 Virginia Commonwealth University Apparatus and method for endothelial cell seeding/transfection of intravascular stents
WO2000002599A1 (en) 1998-07-08 2000-01-20 Advanced Biocompatible Coatings Inc. Biocompatible metallic stents with hydroxy methacrylate coating
CA2337534C (en) 1998-07-21 2008-05-06 Biocompatibles Limited Coating
NL1009738C2 (nl) 1998-07-24 2000-01-25 Cordis Europ Ballonkatheter met vullichaam voor het plaatsen van een stent.
DE19834396C2 (de) 1998-07-30 2000-07-13 Daimlerchrysler Aerospace Ag Verfahren zur Oberflächenbeschichtung medizinischer Implantate
US6436816B1 (en) 1998-07-31 2002-08-20 Industrial Technology Research Institute Method of electroless plating copper on nitride barrier
US6093199A (en) 1998-08-05 2000-07-25 Endovascular Technologies, Inc. Intra-luminal device for treatment of body cavities and lumens and method of use
US6080099A (en) 1998-08-12 2000-06-27 Syntheon, Llc Radioactive therapeutic seeds
JP4898991B2 (ja) 1998-08-20 2012-03-21 クック メディカル テクノロジーズ エルエルシー 被覆付植込式医療装置
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
EP1119379A1 (de) 1998-09-02 2001-08-01 Boston Scientific Limited Arzneimittelabgabevorrichtung für stents
WO2000018446A1 (en) 1998-09-25 2000-04-06 Cathnet-Science S.A. Multi-layered sleeve for intravascular expandable device
US6011125A (en) * 1998-09-25 2000-01-04 General Electric Company Amide modified polyesters
US6245099B1 (en) 1998-09-30 2001-06-12 Impra, Inc. Selective adherence of stent-graft coverings, mandrel and method of making stent-graft device
US6168619B1 (en) * 1998-10-16 2001-01-02 Quanam Medical Corporation Intravascular stent having a coaxial polymer member and end sleeves
EP1123081B1 (de) 1998-10-19 2002-12-11 SYNTHES AG Chur Aushärtbarer keramischer hydraulischer zement
DE19855421C2 (de) 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
US6187024B1 (en) 1998-11-10 2001-02-13 Target Therapeutics, Inc. Bioactive coating for vaso-occlusive devices
EP1000958B1 (de) 1998-11-12 2004-03-17 Takiron Co. Ltd. Bioabbaubares, absorbierbares Formgedächtnismaterial
US6125523A (en) 1998-11-20 2000-10-03 Advanced Cardiovascular Systems, Inc. Stent crimping tool and method of use
US6099455A (en) 1998-11-25 2000-08-08 Isostent, Inc. Radioisotope stent with non-radioactive end sections
US6495200B1 (en) 1998-12-07 2002-12-17 Chartered Semiconductor Manufacturing Ltd. Method to deposit a seeding layer for electroless copper plating
US6294836B1 (en) 1998-12-22 2001-09-25 Cvc Products Inc. Semiconductor chip interconnect barrier material and fabrication method
US6100195A (en) 1998-12-28 2000-08-08 Chartered Semiconductor Manu. Ltd. Passivation of copper interconnect surfaces with a passivating metal layer
US6120847A (en) 1999-01-08 2000-09-19 Scimed Life Systems, Inc. Surface treatment method for stent coating
US6530950B1 (en) 1999-01-12 2003-03-11 Quanam Medical Corporation Intraluminal stent having coaxial polymer member
US6350277B1 (en) 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
CA2360938C (en) 1999-02-02 2008-01-08 Warren Oliver Haggard Controlled release composite
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
US6193727B1 (en) 1999-02-05 2001-02-27 Advanced Cardiovascular Systems, Inc. System for removably securing a stent on a catheter assembly and method of use
US6143354A (en) 1999-02-08 2000-11-07 Medtronic Inc. One-step method for attachment of biomolecules to substrate surfaces
US6187045B1 (en) 1999-02-10 2001-02-13 Thomas K. Fehring Enhanced biocompatible implants and alloys
US6488773B1 (en) 1999-02-19 2002-12-03 Plastic Stuff, Llc Apparatus and method for spraying polymer
US5976155A (en) 1999-03-05 1999-11-02 Advanced Cardiovascular Systems, Inc. System for removably securing a stent on a catheter assembly and method of use
US6362099B1 (en) 1999-03-09 2002-03-26 Applied Materials, Inc. Method for enhancing the adhesion of copper deposited by chemical vapor deposition
US6183505B1 (en) 1999-03-11 2001-02-06 Medtronic Ave, Inc. Method of stent retention to a delivery catheter balloon-braided retainers
US6066156A (en) 1999-03-11 2000-05-23 Advanced Cardiovascular Systems, Inc. Temperature activated adhesive for releasably attaching stents to balloons
US6364903B2 (en) 1999-03-19 2002-04-02 Meadox Medicals, Inc. Polymer coated stent
US6258099B1 (en) 1999-03-31 2001-07-10 Scimed Life Systems, Inc. Stent security balloon/balloon catheter
AU4975500A (en) 1999-04-23 2000-11-10 Agion Technologies, Llc Stent having antimicrobial agent
US6156373A (en) 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6375458B1 (en) 1999-05-17 2002-04-23 Memry Corporation Medical instruments and devices and parts thereof using shape memory alloys
WO2000071064A1 (en) 1999-05-21 2000-11-30 Micro Therapeutics, Inc. Methods for delivering in vivo uniform dispersed embolic compositions of high viscosity
US6168617B1 (en) * 1999-06-14 2001-01-02 Scimed Life Systems, Inc. Stent delivery system
US6667049B2 (en) 1999-06-14 2003-12-23 Ethicon, Inc. Relic process for producing bioresorbable ceramic tissue scaffolds
FR2795326B1 (fr) 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
US6312459B1 (en) 1999-06-30 2001-11-06 Advanced Cardiovascular Systems, Inc. Stent design for use in small vessels
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6494862B1 (en) 1999-07-13 2002-12-17 Advanced Cardiovascular Systems, Inc. Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway
US6283947B1 (en) 1999-07-13 2001-09-04 Advanced Cardiovascular Systems, Inc. Local drug delivery injection catheter
US6177523B1 (en) * 1999-07-14 2001-01-23 Cardiotech International, Inc. Functionalized polyurethanes
AUPQ170799A0 (en) 1999-07-20 1999-08-12 Cardiac Crc Nominees Pty Limited Shape memory polyurethane or polyurethane-urea polymers
US6569193B1 (en) 1999-07-22 2003-05-27 Advanced Cardiovascular Systems, Inc. Tapered self-expanding stent
AU6526100A (en) 1999-08-06 2001-03-05 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
DE19938704C1 (de) 1999-08-14 2001-10-31 Ivoclar Vivadent Ag Verfahren zur Herstellung von Reaktionssystemen zur Implantation in den menschlichen und tierischen Körper als Knochenersatz, die u.a. Calcium und Phosphor enthalten
US6479565B1 (en) 1999-08-16 2002-11-12 Harold R. Stanley Bioactive ceramic cement
US6322588B1 (en) 1999-08-17 2001-11-27 St. Jude Medical, Inc. Medical devices with metal/polymer composites
FI19991852A7 (fi) 1999-09-01 2001-03-02 Yli Urpo Antti Uusi monikerroksinen materiaali, joka käsittää vaikuttavan ainesosan, ja sen valmistus
US6287628B1 (en) 1999-09-03 2001-09-11 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
EP1214108B1 (de) 1999-09-03 2007-01-10 Advanced Cardiovascular Systems, Inc. Poröse prothese und verfahren zur abscheidung von substanzen in den poren
US6713119B2 (en) 1999-09-03 2004-03-30 Advanced Cardiovascular Systems, Inc. Biocompatible coating for a prosthesis and a method of forming the same
US6503556B2 (en) 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
US6749626B1 (en) 2000-03-31 2004-06-15 Advanced Cardiovascular Systems, Inc. Actinomycin D for the treatment of vascular disease
US6503954B1 (en) 2000-03-31 2003-01-07 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing actinomycin D and a method of forming the same
US6759054B2 (en) 1999-09-03 2004-07-06 Advanced Cardiovascular Systems, Inc. Ethylene vinyl alcohol composition and coating
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US6379381B1 (en) 1999-09-03 2002-04-30 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
US20040029952A1 (en) 1999-09-03 2004-02-12 Yung-Ming Chen Ethylene vinyl alcohol composition and coating
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
JP4172883B2 (ja) 1999-09-08 2008-10-29 Ｈｏｙａ株式会社 薬物徐放用担体および薬物徐放用担体の製造方法
AU7575800A (en) 1999-09-08 2001-04-10 Advanced Cardiovascular Systems Inc. System for removably securing a stent on a catheter assembly and method of use
US6582417B1 (en) 1999-09-22 2003-06-24 Advanced Cardiovascular Systems, Inc. Methods and apparatuses for radiation treatment
US6576191B1 (en) 1999-09-30 2003-06-10 Therox, Inc. Apparatus for blood oxygenation
US6203551B1 (en) 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
US6387123B1 (en) * 1999-10-13 2002-05-14 Advanced Cardiovascular Systems, Inc. Stent with radiopaque core
WO2001026584A1 (en) 1999-10-14 2001-04-19 United Stenting, Inc. Stents with multilayered struts
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6521284B1 (en) 1999-11-03 2003-02-18 Scimed Life Systems, Inc. Process for impregnating a porous material with a cross-linkable composition
US7226475B2 (en) 1999-11-09 2007-06-05 Boston Scientific Scimed, Inc. Stent with variable properties
DE19953771C1 (de) 1999-11-09 2001-06-13 Coripharm Medizinprodukte Gmbh Resorbierbares Knochen-Implantatmaterial sowie Verfahren zur Herstellung desselben
US6610087B1 (en) 1999-11-16 2003-08-26 Scimed Life Systems, Inc. Endoluminal stent having a matched stiffness region and/or a stiffness gradient and methods for providing stent kink resistance
EP2308522A3 (de) 1999-11-17 2012-02-29 Boston Scientific Limited Miniaturisierte Vorrichtungen zur Abgabe von Molekülen in einer Trägerflüssigkeit
DE69934990T2 (de) 1999-11-23 2007-11-15 Sorin Biomedica Cardio S.R.L., Saluggia Verfahren zur Übertragung radioaktiver Stoffe auf Stents in der Angioplastie und Bausatz
US7947069B2 (en) 1999-11-24 2011-05-24 University Of Washington Medical devices comprising small fiber biomaterials, and methods of use
US6251136B1 (en) 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US6554854B1 (en) 1999-12-10 2003-04-29 Scimed Life Systems, Inc. Process for laser joining dissimilar metals and endoluminal stent with radiopaque marker produced thereby
GB9929946D0 (en) 1999-12-17 2000-02-09 Phoqus Limited Electrostatic application of powder material to solid dosage forms
US6338739B1 (en) 1999-12-22 2002-01-15 Ethicon, Inc. Biodegradable stent
US6981987B2 (en) * 1999-12-22 2006-01-03 Ethicon, Inc. Removable stent for body lumens
US6494908B1 (en) 1999-12-22 2002-12-17 Ethicon, Inc. Removable stent for body lumens
US6613432B2 (en) * 1999-12-22 2003-09-02 Biosurface Engineering Technologies, Inc. Plasma-deposited coatings, devices and methods
US6908624B2 (en) 1999-12-23 2005-06-21 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6283949B1 (en) 1999-12-27 2001-09-04 Advanced Cardiovascular Systems, Inc. Refillable implantable drug delivery pump
US20010007083A1 (en) 1999-12-29 2001-07-05 Roorda Wouter E. Device and active component for inhibiting formation of thrombus-inflammatory cell matrix
US6481262B2 (en) 1999-12-30 2002-11-19 Advanced Cardiovascular Systems, Inc. Stent crimping tool
US6899731B2 (en) 1999-12-30 2005-05-31 Boston Scientific Scimed, Inc. Controlled delivery of therapeutic agents by insertable medical devices
US6444567B1 (en) 2000-01-05 2002-09-03 Advanced Micro Devices, Inc. Process for alloying damascene-type Cu interconnect lines
JP4473390B2 (ja) 2000-01-07 2010-06-02 川澄化学工業株式会社 ステント及びステントグラフト
ATE313341T1 (de) 2000-01-11 2006-01-15 Intralytix Inc Polymermischungen als bioabbaubare matrizen zur herstellung von biokompositen
WO2001052772A1 (en) 2000-01-19 2001-07-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health_Human Servicesthe National Institutes Of Health Method and apparatus for coating an endoprosthesis
GB0002305D0 (en) 2000-02-01 2000-03-22 Phoqus Limited Power material for electrostatic application
US6375826B1 (en) 2000-02-14 2002-04-23 Advanced Cardiovascular Systems, Inc. Electro-polishing fixture and electrolyte solution for polishing stents and method
US6447835B1 (en) 2000-02-15 2002-09-10 Scimed Life Systems, Inc. Method of coating polymeric tubes used in medical devices
KR100371559B1 (ko) 2000-04-03 2003-02-06 주식회사 경원메디칼 생체적합적 골재생을 촉진하는 골대체 및 재생소재용칼슘포스페이트 인조골
US6527801B1 (en) 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US6387118B1 (en) 2000-04-20 2002-05-14 Scimed Life Systems, Inc. Non-crimped stent delivery system
US6510722B1 (en) * 2000-05-10 2003-01-28 Advanced Cardiovascular Systems, Inc. Stent crimping tool for producing a grooved crimp
US6270779B1 (en) 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
US20020007215A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020005206A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Antiproliferative drug and delivery device
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
EP1153621A1 (de) 2000-05-12 2001-11-14 MERCK PATENT GmbH Biozemente auf TCP-PHA-Basismischung mit verbesserter Kompressionsfestigkeit
US20020007213A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020007214A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US6395325B1 (en) 2000-05-16 2002-05-28 Scimed Life Systems, Inc. Porous membranes
US6673385B1 (en) * 2000-05-31 2004-01-06 Advanced Cardiovascular Systems, Inc. Methods for polymeric coatings stents
US6395326B1 (en) * 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
AU2001265238A1 (en) 2000-05-31 2001-12-11 Advanced Cardiovascular Systems Inc. An apparatus and method for forming a coating onto a surface of a prosthesis
US6279368B1 (en) 2000-06-07 2001-08-28 Endovascular Technologies, Inc. Nitinol frame heating and setting mandrel
US6585765B1 (en) 2000-06-29 2003-07-01 Advanced Cardiovascular Systems, Inc. Implantable device having substances impregnated therein and a method of impregnating the same
IL137090A (en) 2000-06-29 2010-04-15 Pentech Medical Devices Ltd Polymeric stent
US20020077693A1 (en) 2000-12-19 2002-06-20 Barclay Bruce J. Covered, coiled drug delivery stent and method
AU2001279288A1 (en) 2000-07-06 2002-01-21 Biosurface Engineering Technologies, Inc. Drug diffusion coatings, applications and methods
US6555157B1 (en) 2000-07-25 2003-04-29 Advanced Cardiovascular Systems, Inc. Method for coating an implantable device and system for performing the method
US6569191B1 (en) 2000-07-27 2003-05-27 Bionx Implants, Inc. Self-expanding stent with enhanced radial expansion and shape memory
EP1309354A2 (de) 2000-07-27 2003-05-14 Rutgers, The State University Therapeutische polyester und polyamide
US6574851B1 (en) 2000-07-31 2003-06-10 Advanced Cardiovascular Systems, Inc. Stent made by rotational molding or centrifugal casting and method for making the same
US6451373B1 (en) 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
US6455424B1 (en) 2000-08-07 2002-09-24 Micron Technology, Inc. Selective cap layers over recessed polysilicon plugs
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US6903005B1 (en) 2000-08-30 2005-06-07 Micron Technology, Inc. Method for the formation of RuSixOy-containing barrier layers for high-k dielectrics
US6585926B1 (en) 2000-08-31 2003-07-01 Advanced Cardiovascular Systems, Inc. Method of manufacturing a porous balloon
US6562136B1 (en) 2000-09-08 2003-05-13 Surmodics, Inc. Coating apparatus and method
WO2002026162A2 (en) 2000-09-26 2002-04-04 Advanced Cardiovascular Systems, Inc. A method of loading a substance onto an implantable device
US6485512B1 (en) 2000-09-27 2002-11-26 Advanced Cardiovascular Systems, Inc. Two-stage light curable stent and delivery system
US6254632B1 (en) 2000-09-28 2001-07-03 Advanced Cardiovascular Systems, Inc. Implantable medical device having protruding surface structures for drug delivery and cover attachment
US6716444B1 (en) 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US7261735B2 (en) 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US6746773B2 (en) 2000-09-29 2004-06-08 Ethicon, Inc. Coatings for medical devices
US20020051730A1 (en) 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US6492615B1 (en) 2000-10-12 2002-12-10 Scimed Life Systems, Inc. Laser polishing of medical devices
US6506437B1 (en) * 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6783793B1 (en) 2000-10-26 2004-08-31 Advanced Cardiovascular Systems, Inc. Selective coating of medical devices
US6558733B1 (en) 2000-10-26 2003-05-06 Advanced Cardiovascular Systems, Inc. Method for etching a micropatterned microdepot prosthesis
US6758859B1 (en) 2000-10-30 2004-07-06 Kenny L. Dang Increased drug-loading and reduced stress drug delivery device
US6517888B1 (en) 2000-11-28 2003-02-11 Scimed Life Systems, Inc. Method for manufacturing a medical device having a coated portion by laser ablation
US6504307B1 (en) * 2000-11-30 2003-01-07 Advanced Cardiovascular Systems, Inc. Application of variable bias voltage on a cylindrical grid enclosing a target
US6664335B2 (en) 2000-11-30 2003-12-16 Cardiac Pacemakers, Inc. Polyurethane elastomer article with “shape memory” and medical devices therefrom
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
GB2370243B (en) 2000-12-21 2004-06-16 Phoqus Ltd Electrostatic application of powder material to solid dosage forms in an elect ric field
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
AU2002249826A1 (en) 2000-12-22 2002-07-30 Avantec Vascular Corporation Delivery of therapeutic capable agents
US20020082679A1 (en) 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
US6824559B2 (en) 2000-12-22 2004-11-30 Advanced Cardiovascular Systems, Inc. Ethylene-carboxyl copolymers as drug delivery matrices
US6524232B1 (en) 2000-12-22 2003-02-25 Advanced Cardiovascular Systems, Inc. Method for radioactive stent delivery
US6544543B1 (en) 2000-12-27 2003-04-08 Advanced Cardiovascular Systems, Inc. Periodic constriction of vessels to treat ischemic tissue
US6565599B1 (en) 2000-12-28 2003-05-20 Advanced Cardiovascular Systems, Inc. Hybrid stent
US6540776B2 (en) 2000-12-28 2003-04-01 Advanced Cardiovascular Systems, Inc. Sheath for a prosthesis and methods of forming the same
US6663662B2 (en) 2000-12-28 2003-12-16 Advanced Cardiovascular Systems, Inc. Diffusion barrier layer for implantable devices
US20020087123A1 (en) 2001-01-02 2002-07-04 Hossainy Syed F.A. Adhesion of heparin-containing coatings to blood-contacting surfaces of medical devices
US6645195B1 (en) 2001-01-05 2003-11-11 Advanced Cardiovascular Systems, Inc. Intraventricularly guided agent delivery system and method of use
US6544582B1 (en) 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Method and apparatus for coating an implantable device
US6544223B1 (en) 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Balloon catheter for delivering therapeutic agents
US6740040B1 (en) 2001-01-30 2004-05-25 Advanced Cardiovascular Systems, Inc. Ultrasound energy driven intraventricular catheter to treat ischemia
US20030032767A1 (en) 2001-02-05 2003-02-13 Yasuhiro Tada High-strength polyester-amide fiber and process for producing the same
AU2002238076B2 (en) 2001-02-09 2007-05-17 Endoluminal Therapeutics, Inc. Endomural therapy
US6540777B2 (en) 2001-02-15 2003-04-01 Scimed Life Systems, Inc. Locking stent
US6563080B2 (en) 2001-02-15 2003-05-13 Scimed Life Systems, Inc. Laser cutting of stents and other medical devices
ES2295153T3 (es) 2001-02-27 2008-04-16 Kabushikikaisha Igaki Iryo Sekkei Elemento de sujecion de stent y sistema de implante de un stent.
US20030004141A1 (en) * 2001-03-08 2003-01-02 Brown David L. Medical devices, compositions and methods for treating vulnerable plaque
US6613077B2 (en) 2001-03-27 2003-09-02 Scimed Life Systems, Inc. Stent with controlled expansion
US6623448B2 (en) 2001-03-30 2003-09-23 Advanced Cardiovascular Systems, Inc. Steerable drug delivery device
US6645135B1 (en) 2001-03-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Intravascular catheter device and method for simultaneous local delivery of radiation and a therapeutic substance
US6780424B2 (en) 2001-03-30 2004-08-24 Charles David Claude Controlled morphologies in polymer drug for release of drugs from polymer films
US6625486B2 (en) 2001-04-11 2003-09-23 Advanced Cardiovascular Systems, Inc. Method and apparatus for intracellular delivery of an agent
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US6712845B2 (en) 2001-04-24 2004-03-30 Advanced Cardiovascular Systems, Inc. Coating for a stent and a method of forming the same
NZ528994A (en) 2001-04-26 2006-02-24 Control Delivery Sys Inc Sustained release drug delivery system containing codrugs
US6420189B1 (en) 2001-04-27 2002-07-16 Advanced Micro Devices, Inc. Superconducting damascene interconnected for integrated circuit
US6660034B1 (en) 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
GB0110846D0 (en) 2001-05-02 2001-06-27 Phoqus Ltd Tablets with coloured patterns
US6656506B1 (en) 2001-05-09 2003-12-02 Advanced Cardiovascular Systems, Inc. Microparticle coated medical device
US7651695B2 (en) 2001-05-18 2010-01-26 Advanced Cardiovascular Systems, Inc. Medicated stents for the treatment of vascular disease
US6605154B1 (en) 2001-05-31 2003-08-12 Advanced Cardiovascular Systems, Inc. Stent mounting device
US6743462B1 (en) 2001-05-31 2004-06-01 Advanced Cardiovascular Systems, Inc. Apparatus and method for coating implantable devices
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US6679980B1 (en) * 2001-06-13 2004-01-20 Advanced Cardiovascular Systems, Inc. Apparatus for electropolishing a stent
US6666880B1 (en) 2001-06-19 2003-12-23 Advised Cardiovascular Systems, Inc. Method and system for securing a coated stent to a balloon catheter
US6695920B1 (en) 2001-06-27 2004-02-24 Advanced Cardiovascular Systems, Inc. Mandrel for supporting a stent and a method of using the mandrel to coat a stent
US6572644B1 (en) 2001-06-27 2003-06-03 Advanced Cardiovascular Systems, Inc. Stent mounting device and a method of using the same to coat a stent
US7247313B2 (en) 2001-06-27 2007-07-24 Advanced Cardiovascular Systems, Inc. Polyacrylates coatings for implantable medical devices
US6673154B1 (en) 2001-06-28 2004-01-06 Advanced Cardiovascular Systems, Inc. Stent mounting device to coat a stent
US6565659B1 (en) 2001-06-28 2003-05-20 Advanced Cardiovascular Systems, Inc. Stent mounting assembly and a method of using the same to coat a stent
US6706013B1 (en) 2001-06-29 2004-03-16 Advanced Cardiovascular Systems, Inc. Variable length drug delivery catheter
US6656216B1 (en) 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
US6585755B2 (en) 2001-06-29 2003-07-01 Advanced Cardiovascular Polymeric stent suitable for imaging by MRI and fluoroscopy
US6527863B1 (en) 2001-06-29 2003-03-04 Advanced Cardiovascular Systems, Inc. Support device for a stent and a method of using the same to coat a stent
US6682771B2 (en) * 2001-07-02 2004-01-27 Scimed Life Systems, Inc. Coating dispensing system and method using a solenoid head for coating medical devices
EP1273314A1 (de) 2001-07-06 2003-01-08 Terumo Kabushiki Kaisha Stent
GB0117618D0 (en) 2001-07-19 2001-09-12 Phoqus Ltd Pharmaceutical dosage form
GB0117619D0 (en) 2001-07-19 2001-09-12 Phoqus Ltd Pharmaceutical dosage form
US6641611B2 (en) 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
US8303651B1 (en) 2001-09-07 2012-11-06 Advanced Cardiovascular Systems, Inc. Polymeric coating for reducing the rate of release of a therapeutic substance from a stent
US6669980B2 (en) 2001-09-18 2003-12-30 Scimed Life Systems, Inc. Method for spray-coating medical devices
US6863683B2 (en) 2001-09-19 2005-03-08 Abbott Laboratoris Vascular Entities Limited Cold-molding process for loading a stent onto a stent delivery system
EP1429689A4 (de) 2001-09-24 2006-03-08 Medtronic Ave Inc Rationale arzneimitteltherapie-vorrichtung und verfahren
US7195640B2 (en) 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030059520A1 (en) 2001-09-27 2003-03-27 Yung-Ming Chen Apparatus for regulating temperature of a composition and a method of coating implantable devices
US6753071B1 (en) 2001-09-27 2004-06-22 Advanced Cardiovascular Systems, Inc. Rate-reducing membrane for release of an agent
US20030065377A1 (en) 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US20030073961A1 (en) 2001-09-28 2003-04-17 Happ Dorrie M. Medical device containing light-protected therapeutic agent and a method for fabricating thereof
AU2002356530A1 (en) 2001-09-28 2003-04-07 Boston Scientific Limited Medical devices comprising nanomaterials and therapeutic methods utilizing the same
US20030088307A1 (en) 2001-11-05 2003-05-08 Shulze John E. Potent coatings for stents
DE60221287D1 (de) 2001-11-08 2007-08-30 Atrium Medical Corp Intraluminale vorrichtung mit einer ein therapeutisches-mittel enthaltenden beschichtung
US7585516B2 (en) 2001-11-12 2009-09-08 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices
US6703307B2 (en) 2001-11-26 2004-03-09 Advanced Micro Devices, Inc. Method of implantation after copper seed deposition
US6517889B1 (en) 2001-11-26 2003-02-11 Swaminathan Jayaraman Process for coating a surface of a stent
US6663880B1 (en) 2001-11-30 2003-12-16 Advanced Cardiovascular Systems, Inc. Permeabilizing reagents to increase drug delivery and a method of local delivery
US20030105530A1 (en) 2001-12-04 2003-06-05 Inion Ltd. Biodegradable implant and method for manufacturing one
US6752826B2 (en) 2001-12-14 2004-06-22 Thoratec Corporation Layered stent-graft and methods of making the same
US6605874B2 (en) 2001-12-19 2003-08-12 Intel Corporation Method of making semiconductor device using an interconnect
US6709514B1 (en) 2001-12-28 2004-03-23 Advanced Cardiovascular Systems, Inc. Rotary coating apparatus for coating implantable medical devices
GB2384199B (en) 2002-01-17 2005-04-06 Phoqus Ltd Electrostatic application of powder material to solid dosage forms
US6887270B2 (en) 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
GB0204771D0 (en) 2002-02-28 2002-04-17 Phoqus Ltd Fast disintegrating tablets
GB0204772D0 (en) 2002-02-28 2002-04-17 Phoqus Ltd Pharmaceutical dosage forms
JP2005520640A (ja) 2002-03-20 2005-07-14 アドヴァンスド カーディオヴァスキュラー システムズ， インコーポレイテッド ステント用の生物分解性疎水性ポリマー
US6743463B2 (en) 2002-03-28 2004-06-01 Scimed Life Systems, Inc. Method for spray-coating a medical device having a tubular wall such as a stent
US20030187495A1 (en) 2002-04-01 2003-10-02 Cully Edward H. Endoluminal devices, embolic filters, methods of manufacture and use
US6664187B1 (en) 2002-04-03 2003-12-16 Advanced Micro Devices, Inc. Laser thermal annealing for Cu seedlayer enhancement
US6812143B2 (en) 2002-04-26 2004-11-02 International Business Machines Corporation Process of forming copper structures
US6645547B1 (en) 2002-05-02 2003-11-11 Labcoat Ltd. Stent coating device
US7270675B2 (en) 2002-05-10 2007-09-18 Cordis Corporation Method of forming a tubular membrane on a structural frame
US20030236565A1 (en) 2002-06-21 2003-12-25 Dimatteo Kristian Implantable prosthesis
US6865810B2 (en) 2002-06-27 2005-03-15 Scimed Life Systems, Inc. Methods of making medical devices
US7491233B1 (en) 2002-07-19 2009-02-17 Advanced Cardiovascular Systems Inc. Purified polymers for coatings of implantable medical devices
US7141063B2 (en) 2002-08-06 2006-11-28 Icon Medical Corp. Stent with micro-latching hinge joints
AU2003259336A1 (en) 2002-08-21 2004-03-11 Phoqus Pharmaceuticals Limited Use of an aqueous solution of citric acid and a water-soluble sugar like lactitol as granulation liquid in the manufacture of tablets
GB0219516D0 (en) 2002-08-21 2002-10-02 Phoqus Ltd Fast dissolving and taste masked oral dosage form comprising sildenafil
US20040054104A1 (en) 2002-09-05 2004-03-18 Pacetti Stephen D. Coatings for drug delivery devices comprising modified poly(ethylene-co-vinyl alcohol)
WO2004023985A2 (en) 2002-09-13 2004-03-25 Linvatec Corporation Drawn expanded stent
GB0221293D0 (en) 2002-09-13 2002-10-23 Phoqus Ltd Method and apparatus for applying powder in a pattern to a substrate
US20040063805A1 (en) 2002-09-19 2004-04-01 Pacetti Stephen D. Coatings for implantable medical devices and methods for fabrication thereof
US6818063B1 (en) 2002-09-24 2004-11-16 Advanced Cardiovascular Systems, Inc. Stent mandrel fixture and method for minimizing coating defects
US7087263B2 (en) 2002-10-09 2006-08-08 Advanced Cardiovascular Systems, Inc. Rare limiting barriers for implantable medical devices
US6846323B2 (en) * 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
US7563780B1 (en) * 2004-06-18 2009-07-21 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004018255A1 (de) * 2004-04-15 2005-11-10 Universitätsklinikum Schleswig-Holstein Gefäßprothese

Also Published As

Publication number Publication date
US20040236417A1 (en) 2004-11-25
EP0873732A1 (de) 1998-10-28
US6605114B1 (en) 2003-08-12
EP0873732B1 (de) 2001-08-29
JPH10309320A (ja) 1998-11-24
US7077860B2 (en) 2006-07-18
JP3000076B2 (ja) 2000-01-17
US6776792B1 (en) 2004-08-17
US20060178738A1 (en) 2006-08-10
DE69801459D1 (de) 2001-10-04

Similar Documents

Publication Publication Date Title
DE69801459T2 (de) Beschichteter endovaskulärer Stent
DE69623455T2 (de) Beschichteter dilatator zur abgabe eines arzneistoffs
DE69730475T2 (de) Beschichteter Stent und Verfahren zur Wirkstoffabgabe
DE60032912T2 (de) Poröse prothese und verfahren zur abscheidung von substanzen in den poren
DE69810986T2 (de) Medizinische Wirkstoffe freisetzende Beschichtungen für medizinische Vorrichtungen
DE602004011847T2 (de) Stent mit Phenoxyharz als Grundierung
DE69729778T2 (de) Stent zur Dilatation von stenotischen Schäden eines Blutgefässes
DE69637302T2 (de) Verfahren zur Beschichtung von Arzneimittel enthaltenden Stents
DE69721458T2 (de) Ausrüstung enthaltend eine implantierbare Vorrichtung
DE69932034T2 (de) Hydrophile beschichtung für eine intracorporale medizinische vorrichtung
DE60026065T2 (de) Elektropolymerisierbare monomere und polymerbeschichtungen auf implantierbaren geräten
DE69732439T2 (de) Ein Stent für Angioplastik und damit verbundenes Produktionsverfahren
DE69133445T2 (de) Arzneistoffabgabesystem
DE4334272C2 (de) Beschichtung für Biomaterial und seine Verwendung
DE69633012T2 (de) Stickstoffoxyd-freisetzende verbindungen sowie methoden und intravaskuläre vorrichtungen zu ihrem gebrauch zum vorbeugen von restenosen
DE60104396T2 (de) Medizinische vorrichtung
DE69906797T2 (de) Stent-transplantate mit bioaktiven beschichtungen
WO2002080996A1 (de) Medizinisches implantat und verfahren zu seiner herstellung
DE10237571A1 (de) Endovaskuläres Implantat mit aktiver Beschichtung
DE10237572A1 (de) Stent mit polymerer Beschichtung
DE102018110591A1 (de) Medizinische Vorrichtung und Beschichtung mit Haftvermittler
DE60002744T2 (de) Intraluminale vorrichtung, beschichtung für eine solche vorrichtung und verfahren zu deren herstellung
EP0652017B1 (de) Beschichtung für Biomaterial
CA2235909A1 (en) Coated endovascular stent
DE102007050668A1 (de) Stent mit einem Grundkörper aus einem bioinerten metallischen Implantatwerkstoff

Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee
8331 Complete revocation
8380 Miscellaneous part iii

Free format text: DIE ZURUECKNAHME VOM 12.02.2004 WURDE GELOESCHT.