ATE258050T1 - Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen - Google Patents
Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungenInfo
- Publication number
- ATE258050T1 ATE258050T1 AT97946578T AT97946578T ATE258050T1 AT E258050 T1 ATE258050 T1 AT E258050T1 AT 97946578 T AT97946578 T AT 97946578T AT 97946578 T AT97946578 T AT 97946578T AT E258050 T1 ATE258050 T1 AT E258050T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- bis
- indole
- compositions
- inflammatory compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001272 neurogenic effect Effects 0.000 title 1
- TYGUTURXHKSOBP-UHFFFAOYSA-N 10-bromo-5,12-dihydroindolo[2,3-g]carbazole-2,3-diol Chemical class C1=C(Br)C=C2NC3=C(C4=C(C=C(C(=C4)O)O)N4)C4=CC=C3C2=C1 TYGUTURXHKSOBP-UHFFFAOYSA-N 0.000 abstract 1
- WBSVEUIXHWCPBI-UHFFFAOYSA-N CCN.C1=CC=C2NC=CC2=C1.C1=CC=C2NC=CC2=C1 Chemical class CCN.C1=CC=C2NC=CC2=C1.C1=CC=C2NC=CC2=C1 WBSVEUIXHWCPBI-UHFFFAOYSA-N 0.000 abstract 1
- AUJKXAIGSXKZBR-UHFFFAOYSA-N Dragmacidin Natural products BrC1=CC(O)=C2C(C3CN(C(CN3)C=3C4=CC=C(Br)C=C4NC=3)C)=CNC2=C1Br AUJKXAIGSXKZBR-UHFFFAOYSA-N 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 229930186849 nortopsentin Natural products 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- ONYVJPZNVCOAFF-UHFFFAOYSA-N topsentin Natural products Oc1ccc2cc([nH]c2c1)C(=O)c3ncc([nH]3)c4c[nH]c5ccccc45 ONYVJPZNVCOAFF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3026196P | 1996-10-31 | 1996-10-31 | |
| PCT/US1997/020300 WO1998018466A2 (en) | 1996-10-31 | 1997-10-31 | Anti-neurogenic inflammatory compounds and compositions and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258050T1 true ATE258050T1 (de) | 2004-02-15 |
Family
ID=21853343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97946578T ATE258050T1 (de) | 1996-10-31 | 1997-10-31 | Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5955462A (de) |
| EP (1) | EP0935463B1 (de) |
| JP (1) | JP2001503414A (de) |
| AT (1) | ATE258050T1 (de) |
| CA (1) | CA2268399C (de) |
| DE (1) | DE69727305T2 (de) |
| ES (1) | ES2212814T3 (de) |
| WO (1) | WO1998018466A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999042092A2 (en) * | 1998-02-20 | 1999-08-26 | Harbor Branch Oceanographic Institution, Inc. | Compounds and methods of use for treatment of neurogenic inflammation |
| ATE277010T1 (de) * | 1998-07-08 | 2004-10-15 | Harbor Branch Oceanographic | Bis-indolederivate und ihre verwendung als entzündungshemmende mittel |
| US6589975B2 (en) | 1998-07-08 | 2003-07-08 | The Regents Of The University Of California | Synthetic compounds for treatment of inflammation |
| CA2460345A1 (en) | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| JP2005507882A (ja) * | 2001-09-17 | 2005-03-24 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 皮膚不調の治療方法 |
| WO2014152788A1 (en) * | 2013-03-14 | 2014-09-25 | The Coca-Cola-Company | Gas barrier enhancing additives and methods |
| US9522168B2 (en) | 2014-05-29 | 2016-12-20 | Johnson & Johnson Consumer Inc. | Topical compositions comprising Acmella oleracea extracts and uses thereof |
| EP3927702A4 (de) | 2019-04-11 | 2022-05-11 | Angion Biomedica Corp. | Feste formen von (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazol |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| BR112022015379A2 (pt) | 2020-02-04 | 2022-09-27 | Mindset Pharma Inc | Derivados de 3-pirrolidino-indol como agentes psicodélicos serotonérgicos para o tratamento de distúrbios do snc |
| JP2023542921A (ja) | 2020-09-21 | 2023-10-12 | ランドス バイオファーマ インコーポレイテッド | Ｎｌｒｘ１リガンド |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| CN113480524B (zh) * | 2021-08-10 | 2022-08-30 | 河北工业大学 | 生物碱hamacanthins系列衍生物及其制备方法和用途 |
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CN121135694A (zh) * | 2025-09-22 | 2025-12-16 | 湖南中医药大学 | 一种双吲哚生物碱(S)-6’’-Debromohamacanthin A的不对称制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4895844A (en) * | 1987-03-25 | 1990-01-23 | Harbor Branch Oceanographic Institution, Inc. | Indole alkaloid compositions and their methods of use |
| US4866084A (en) * | 1987-07-17 | 1989-09-12 | Harbor Branch Oceanographic Institution, Inc. | Topsentin compounds effective against viruses and certain tumors |
| NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| US4970226A (en) * | 1989-10-03 | 1990-11-13 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents |
| CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
| AU687754B2 (en) * | 1990-08-31 | 1998-03-05 | Warner-Lambert Company | Tachykinin antagonists |
| US5290777A (en) * | 1993-02-24 | 1994-03-01 | Regents Of The Univ. Of California | Use for topsentin compounds and pharmaceutical compositions containing same |
| DE69521895T2 (de) * | 1994-06-01 | 2002-04-04 | Astrazeneca Ab, Soedertaelje | Indolderivate als prodrugs von "5-ht1-like" rezeptor agonisten |
| ES2165915T3 (es) * | 1994-06-06 | 2002-04-01 | Warner Lambert Co | Antagonistas del receptor de la taquiquinina (nk 1). |
| FR2731224B1 (fr) * | 1995-03-02 | 1997-05-30 | Pf Medicament | Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments |
| WO1997013512A1 (en) * | 1995-10-10 | 1997-04-17 | Eli Lilly And Company | N-[2-substituted-3-(2-aminoethyl)-1h-indol-5-yl]-amides: new 5-ht1f agonists |
| WO1997038692A1 (en) * | 1996-04-12 | 1997-10-23 | Eli Lilly And Company | Bisindoles for treating pain or nociception |
-
1997
- 1997-10-31 CA CA002268399A patent/CA2268399C/en not_active Expired - Fee Related
- 1997-10-31 US US08/961,475 patent/US5955462A/en not_active Expired - Lifetime
- 1997-10-31 JP JP52082898A patent/JP2001503414A/ja active Pending
- 1997-10-31 EP EP97946578A patent/EP0935463B1/de not_active Expired - Lifetime
- 1997-10-31 ES ES97946578T patent/ES2212814T3/es not_active Expired - Lifetime
- 1997-10-31 AT AT97946578T patent/ATE258050T1/de not_active IP Right Cessation
- 1997-10-31 WO PCT/US1997/020300 patent/WO1998018466A2/en not_active Ceased
- 1997-10-31 DE DE69727305T patent/DE69727305T2/de not_active Expired - Lifetime
-
1999
- 1999-07-16 US US09/356,282 patent/US6090811A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69727305D1 (de) | 2004-02-26 |
| US5955462A (en) | 1999-09-21 |
| ES2212814T3 (es) | 2004-08-01 |
| JP2001503414A (ja) | 2001-03-13 |
| EP0935463B1 (de) | 2004-01-21 |
| DE69727305T2 (de) | 2004-06-24 |
| CA2268399A1 (en) | 1998-05-07 |
| US6090811A (en) | 2000-07-18 |
| EP0935463A2 (de) | 1999-08-18 |
| WO1998018466A2 (en) | 1998-05-07 |
| WO1998018466A3 (en) | 1998-08-13 |
| CA2268399C (en) | 2008-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |