DE69920697D1 - Adenosinderivate - Google Patents

Adenosinderivate

Info

Publication number: DE69920697D1
Authority: DE; Germany
Prior art keywords: adenosine derivatives; adenosine; derivatives
Prior art date: 1998-06-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69920697T

Other languages

English (en)

Other versions

DE69920697T2 (de

Inventor

David Edmund Bays

Richard Peter Charles Cousins

Hazel Joan Dyke

Colin David Eldred

Brian David Judkins

Martin Pass

Andrew Michael K Pennell

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-23

Filing date

1999-06-21

Publication date

2004-11-04

1999-06-21 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2004-11-04 Publication of DE69920697D1 publication Critical patent/DE69920697D1/de

2005-02-24 Application granted granted Critical

2005-02-24 Publication of DE69920697T2 publication Critical patent/DE69920697T2/de

2019-06-22 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000003835 adenosine derivatives Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Hematology (AREA)
Obesity (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DE69920697T 1998-06-23 1999-06-21 Adenosinderivate Expired - Lifetime DE69920697T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9813554.4A GB9813554D0 (en)	1998-06-23	1998-06-23	Chemical compounds
GB9813554		1998-06-23
PCT/EP1999/004182 WO1999067262A1 (en)	1998-06-23	1999-06-21	Adenosine derivatives

Publications (2)

Publication Number	Publication Date
DE69920697D1 true DE69920697D1 (de)	2004-11-04
DE69920697T2 DE69920697T2 (de)	2005-02-24

Family

ID=10834247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69920697T Expired - Lifetime DE69920697T2 (de)	1998-06-23	1999-06-21	Adenosinderivate

Country Status (39)

Country	Link
US (2)	US6492348B1 (de)
EP (2)	EP1447407A1 (de)
JP (2)	JP3378240B2 (de)
KR (1)	KR100612797B1 (de)
CN (2)	CN1202118C (de)
AP (1)	AP2000002014A0 (de)
AR (1)	AR018917A1 (de)
AT (1)	ATE277941T1 (de)
AU (1)	AU758018B2 (de)
BG (1)	BG65064B1 (de)
BR (1)	BR9911498A (de)
CA (1)	CA2335520C (de)
CO (1)	CO5040216A1 (de)
DE (1)	DE69920697T2 (de)
EA (1)	EA003828B1 (de)
EE (1)	EE04853B1 (de)
ES (1)	ES2226399T3 (de)
GB (1)	GB9813554D0 (de)
GE (1)	GEP20032958B (de)
HR (1)	HRP20000896B1 (de)
HU (1)	HUP0102453A3 (de)
ID (1)	ID27484A (de)
IL (2)	IL140284A0 (de)
IS (1)	IS5773A (de)
MY (1)	MY122481A (de)
NO (1)	NO318788B1 (de)
NZ (1)	NZ508915A (de)
OA (1)	OA11574A (de)
PE (1)	PE20000704A1 (de)
PL (1)	PL194087B1 (de)
PT (1)	PT1090019E (de)
RS (1)	RS50042B (de)
SI (1)	SI1090019T1 (de)
SK (1)	SK19582000A3 (de)
TR (1)	TR200100449T2 (de)
TW (1)	TW541312B (de)
UA (1)	UA64794C2 (de)
WO (1)	WO1999067262A1 (de)
ZA (1)	ZA200007514B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9813554D0 (en) *	1998-06-23	1998-08-19	Glaxo Group Ltd	Chemical compounds
WO2001064202A2 (en) *	2000-03-01	2001-09-07	Euro-Celtique S.A.	Tramadol for the treatment of functional gastrointestinal disorders
GB0106867D0 (en) *	2001-03-20	2001-05-09	Glaxo Group Ltd	Process
US20040162422A1 (en) *	2001-03-20	2004-08-19	Adrian Hall	Chemical compounds
GB0115182D0 (en) *	2001-06-20	2001-08-15	Glaxo Group Ltd	Medicaments
GB0115178D0 (en) *	2001-06-20	2001-08-15	Glaxo Group Ltd	Compounds
US6946449B2 (en)	2001-07-13	2005-09-20	Cv Therapeutics, Inc.	Partial and full agonists of A1 adenosine receptors
US7713946B2 (en)	2002-07-11	2010-05-11	Cv Therapeutics, Inc.	Partial and full agonists A1 adenosine receptors
US7157440B2 (en)	2001-07-13	2007-01-02	Cv Therapeutics, Inc.	Partial and full agonists of A1 adenosine receptors
CA2476683C (en)	2002-02-19	2011-11-01	Cv Therapeutics, Inc.	Partial and full agonists of a1 adenosine receptors
US20050222178A1 (en) *	2002-06-17	2005-10-06	Mark Shipton	Process
WO2004016635A2 (en) *	2002-08-15	2004-02-26	Cv Therapeutics, Inc.	Partial and full agonists of a1 adenosine receptors
WO2004055032A1 (en) *	2002-12-18	2004-07-01	Glaxo Group Limited	Adenosine derivative in polymorph v form
AU2003292255A1 (en) *	2002-12-18	2004-07-09	Glaxo Group Limited	Polymorph
WO2004055033A1 (en) *	2002-12-18	2004-07-01	Glaxo Group Limited	Adenosine derivative in polymorph iv form
NZ541651A (en)	2003-02-03	2009-01-31	Cv Therapeutics Inc	Partial and full agonists of A1 adenosine receptors
WO2005053712A1 (en) *	2003-12-02	2005-06-16	Glaxo Group Limited	Use of adenonsine derivatives for treating dyslipidemia, obesity, cardiovascular risk factors, metabolic syndrome, polycystic ovary syndrome, niddm
GT200500281A (es) *	2004-10-22	2006-04-24	Novartis Ag	Compuestos organicos.
GB0500785D0 (en) *	2005-01-14	2005-02-23	Novartis Ag	Organic compounds
GB0607954D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607944D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
ATE549337T1 (de)	2006-04-21	2012-03-15	Novartis Ag	Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten
GB0607953D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607948D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607950D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
EP1889846A1 (de)	2006-07-13	2008-02-20	Novartis AG	Purinderivate als A2a Agonisten
EP1903044A1 (de) *	2006-09-14	2008-03-26	Novartis AG	Adenosinderivate als Agonisten des A2A-Rezeptors
JP2010508835A (ja) *	2006-11-10	2010-03-25	ノバルティスアーゲー	シクロペンテンジオールモノアセテート誘導体
US20090088403A1 (en) *	2007-05-07	2009-04-02	Randy Blakely	A3 adenosine receptors as targets for the modulation of central serotonergic signaling
CN101712709A (zh) *	2008-10-06	2010-05-26	中国医学科学院药物研究所	三乙酰基-3-羟基苯基腺苷及其调血脂的用途
CN104363757B (zh) *	2012-02-11	2017-05-24	中央研究院	治疗疼痛的方法及组合物
EA031895B1 (ru)	2015-02-24	2019-03-29	Пфайзер Инк.	Замещенные нуклеозидные производные, полезные в качестве агентов против рака
CN108864099A (zh) *	2018-09-08	2018-11-23	湖北荆洪生物科技股份有限公司	一种高纯6-糠氨基嘌呤的合成方法
KR20250121114A (ko)	2022-12-16	2025-08-11	아스트라제네카 아베	2,6,9-삼치환된 퓨린

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US4962194A (en) *	1987-04-02	1990-10-09	Warner-Lambert Company	Method of preparing 51,N6-disubstituted adenosines from inosines
US5646128A (en) *	1989-09-15	1997-07-08	Gensia, Inc.	Methods for treating adenosine kinase related conditions
US5244896A (en) *	1990-09-14	1993-09-14	Marion Merrell Dow Inc.	Carbocyclic adenosine analogs useful as immunosuppressants
DK62592D0 (de) *	1992-05-14	1992-05-14	Novo Nordisk As
GB9301000D0 (en) *	1993-01-20	1993-03-10	Glaxo Group Ltd	Chemical compounds
JP3696882B2 (ja) *	1993-07-23	2005-09-21	メレルファーマス−ティカルズインコーポレイテッド	プロ炎症性サイトカインの選択的抑制剤として有用な新規な９−ｎ−二環式ヌクレオシド剤
AU3255097A (en) *	1996-07-05	1998-02-02	Novo Nordisk A/S	Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors
UA51716C2 (uk) *	1996-07-08	2002-12-16	Авентіс Фармасьютікалз Продактс Інк.	Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
AU4377397A (en) *	1996-10-14	1998-05-11	Novo Nordisk A/S	Novel therapeutically active adenosine derivatives
TW528755B (en) *	1996-12-24	2003-04-21	Glaxo Group Ltd	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh)	1998-01-31	2003-01-31	Glaxo Group Limited	Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
AR017457A1 (es)	1998-02-14	2001-09-05	Glaxo Group Ltd	Compuestos derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol, procesos para su preparacion, composiciones que los contienen y su uso en terapia para el tratamiento de enfermedades inflamatorias.
GB9813554D0 (en) *	1998-06-23	1998-08-19	Glaxo Group Ltd	Chemical compounds

1998
- 1998-06-23 GB GBGB9813554.4A patent/GB9813554D0/en not_active Ceased
1999
- 1999-06-21 AU AU45146/99A patent/AU758018B2/en not_active Ceased
- 1999-06-21 AT AT99927999T patent/ATE277941T1/de not_active IP Right Cessation
- 1999-06-21 PT PT99927999T patent/PT1090019E/pt unknown
- 1999-06-21 EP EP04076465A patent/EP1447407A1/de not_active Withdrawn
- 1999-06-21 TR TR2001/00449T patent/TR200100449T2/xx unknown
- 1999-06-21 DE DE69920697T patent/DE69920697T2/de not_active Expired - Lifetime
- 1999-06-21 CN CNB998098957A patent/CN1202118C/zh not_active Expired - Fee Related
- 1999-06-21 WO PCT/EP1999/004182 patent/WO1999067262A1/en not_active Ceased
- 1999-06-21 AP APAP/P/2000/002014A patent/AP2000002014A0/en unknown
- 1999-06-21 PL PL99345089A patent/PL194087B1/pl unknown
- 1999-06-21 ID IDW20010186A patent/ID27484A/id unknown
- 1999-06-21 BR BR9911498-4A patent/BR9911498A/pt not_active Application Discontinuation
- 1999-06-21 KR KR1020007014749A patent/KR100612797B1/ko not_active Expired - Fee Related
- 1999-06-21 HR HR20000896A patent/HRP20000896B1/xx not_active IP Right Cessation
- 1999-06-21 CO CO99038539A patent/CO5040216A1/es unknown
- 1999-06-21 PE PE1999000547A patent/PE20000704A1/es not_active Application Discontinuation
- 1999-06-21 OA OA1200000352A patent/OA11574A/en unknown
- 1999-06-21 RS YUP-828/00A patent/RS50042B/sr unknown
- 1999-06-21 NZ NZ508915A patent/NZ508915A/en unknown
- 1999-06-21 EE EEP200000784A patent/EE04853B1/xx not_active IP Right Cessation
- 1999-06-21 CN CNA2004100119394A patent/CN1616459A/zh active Pending
- 1999-06-21 GE GEAP19995692A patent/GEP20032958B/en unknown
- 1999-06-21 JP JP2000555913A patent/JP3378240B2/ja not_active Expired - Lifetime
- 1999-06-21 US US09/736,018 patent/US6492348B1/en not_active Expired - Lifetime
- 1999-06-21 ES ES99927999T patent/ES2226399T3/es not_active Expired - Lifetime
- 1999-06-21 SK SK1958-2000A patent/SK19582000A3/sk unknown
- 1999-06-21 UA UA2000127404A patent/UA64794C2/uk unknown
- 1999-06-21 EA EA200001222A patent/EA003828B1/ru not_active IP Right Cessation
- 1999-06-21 IL IL14028499A patent/IL140284A0/xx active IP Right Grant
- 1999-06-21 MY MYPI99002543A patent/MY122481A/en unknown
- 1999-06-21 EP EP99927999A patent/EP1090019B1/de not_active Expired - Lifetime
- 1999-06-21 HU HU0102453A patent/HUP0102453A3/hu unknown
- 1999-06-21 SI SI9930674T patent/SI1090019T1/xx unknown
- 1999-06-21 CA CA002335520A patent/CA2335520C/en not_active Expired - Fee Related
- 1999-06-22 AR ARP990102993A patent/AR018917A1/es unknown
- 1999-07-01 TW TW088111178A patent/TW541312B/zh not_active IP Right Cessation
2000
- 2000-12-13 IL IL140284A patent/IL140284A/en not_active IP Right Cessation
- 2000-12-14 ZA ZA200007514A patent/ZA200007514B/en unknown
- 2000-12-15 IS IS5773A patent/IS5773A/is unknown
- 2000-12-20 NO NO20006520A patent/NO318788B1/no unknown
2001
- 2001-01-15 BG BG105155A patent/BG65064B1/bg unknown
2002
- 2002-06-11 JP JP2002170486A patent/JP2003040891A/ja active Pending
- 2002-08-13 US US10/217,107 patent/US6677316B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EE04853B1 (et)	2007-06-15
HRP20000896A2 (en)	2001-12-31
EE200000784A (et)	2002-04-15
ZA200007514B (en)	2002-01-23
GB9813554D0 (en)	1998-08-19
TW541312B (en)	2003-07-11
PL194087B1 (pl)	2007-04-30
ATE277941T1 (de)	2004-10-15
HUP0102453A2 (hu)	2002-04-29
JP2003040891A (ja)	2003-02-13
CN1616459A (zh)	2005-05-18
PL345089A1 (en)	2001-12-03
UA64794C2 (en)	2004-03-15
RS50042B (sr)	2008-11-28
TR200100449T2 (tr)	2001-08-21
HRP20000896B1 (en)	2006-03-31
GEP20032958B (en)	2003-04-25
CA2335520C (en)	2007-02-20
BR9911498A (pt)	2001-03-20
EP1447407A1 (de)	2004-08-18
EP1090019A1 (de)	2001-04-11
AP2000002014A0 (en)	2000-12-31
KR20010083067A (ko)	2001-08-31
NO20006520D0 (no)	2000-12-20
US20030096788A1 (en)	2003-05-22
ES2226399T3 (es)	2005-03-16
CN1314910A (zh)	2001-09-26
NO20006520L (no)	2001-02-14
IL140284A0 (en)	2002-02-10
AU758018B2 (en)	2003-03-13
BG105155A (en)	2001-09-28
BG65064B1 (bg)	2007-01-31
AR018917A1 (es)	2001-12-12
ID27484A (id)	2001-04-12
IS5773A (is)	2000-12-15
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IL140284A (en)	2006-04-10
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EA200001222A1 (ru)	2001-08-27
SK19582000A3 (sk)	2001-11-06
PT1090019E (pt)	2005-01-31
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US6677316B2 (en)	2004-01-13
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Legal Events

Date	Code	Title	Description
2005-10-27	8364	No opposition during term of opposition

Publication	Publication Date	Title
ATE277941T1 (de)	2004-10-15	Adenosinderivate
NO20010193D0 (no)	2001-01-12	Tiobenzimidazol-derivater
ATE236136T1 (de)	2003-04-15	Benzosulfonderivate
DK1117669T3 (da)	2003-05-26	Antiviruspurinderivater
ATE256123T1 (de)	2003-12-15	Pyrimidonderivate
NO20010514D0 (no)	2001-01-30	Aminometylkarboksylsyre-derivater
ATE259810T1 (de)	2004-03-15	Phenyl-xanthinderivate
ATE310742T1 (de)	2005-12-15	C-4ß-SUBSTITUTIERTE MACROLID-DERIVATE
NO20006267D0 (no)	2000-12-11	Imidazolyl-derivater
ATE377018T1 (de)	2007-11-15	Erythromycinderivate
PT928790E (pt)	2003-07-31	Derivados de tiazolo
ATE231508T1 (de)	2003-02-15	Azyklische nukleosidderivate
PT1089964E (pt)	2004-03-31	Derivados de hidrazina
DK1115716T3 (da)	2003-02-24	2-phenylpyran-4-on-derivater
PT1056716E (pt)	2003-04-30	Derivados de ciclo-hexanodiolo
ATE233253T1 (de)	2003-03-15	Chromanderivate
DK1134219T3 (da)	2005-10-17	Cucloalkylsubstituerede aminomethylpyrrolidinderivater
DK1060183T3 (da)	2003-08-11	5-deoxycytidinderivater
PT1123283E (pt)	2004-09-30	Derivados de tiazole
PT928793E (pt)	2002-10-31	Derivados de tiazol
FI964468L (fi)	1996-11-06	Adenosiinijohdannaisia
DE59907635D1 (de)	2003-12-11	Pyrazolyldioxothiochromanoyl-derivate
PT1133471E (pt)	2004-02-27	Derivados de hidrazina
DK1090019T3 (da)	2005-02-07	Adenosinderivater
NO993562L (no)	1999-09-17	Gemcitabine derivater