DK0388054T3 - Pyrrolidin-derivater - Google Patents

Pyrrolidin-derivater

Info

Publication number: DK0388054T3
Authority: DK; Denmark
Prior art keywords: chem; formula; pyrrolidine derivatives; pyrrolidine; ch2s
Prior art date: 1989-03-17

Application number

DK90302269.7T

Other languages

Danish (da)

English (en)

Inventor

Peter Edward Dr Cross

Alexander Roderick D Mackenzie

Original Assignee

Pfizer

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-17

Filing date

1990-03-02

Publication date

1993-12-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10653525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0388054(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-03-02 Application filed by Pfizer, Pfizer Ltd filed Critical Pfizer

1993-12-06 Application granted granted Critical

1993-12-06 Publication of DK0388054T3 publication Critical patent/DK0388054T3/da

Links

150000003235 pyrrolidines Chemical class 0.000 title 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

DK90302269.7T 1989-03-17 1990-03-02 Pyrrolidin-derivater DK0388054T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898906166A GB8906166D0 (en)	1989-03-17	1989-03-17	Therapeutic agents

Publications (1)

Publication Number	Publication Date
DK0388054T3 true DK0388054T3 (da)	1993-12-06

Family

ID=10653525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90302269.7T DK0388054T3 (da)	1989-03-17	1990-03-02	Pyrrolidin-derivater

Country Status (37)

Country	Link
US (1)	US5096890B1 (de)
EP (1)	EP0388054B1 (de)
JP (2)	JPH0764809B2 (de)
KR (2)	KR920008166B1 (de)
CN (1)	CN1023007C (de)
AT (1)	ATE96783T1 (de)
AU (1)	AU614224B2 (de)
BA (1)	BA98300A (de)
CA (1)	CA2012295C (de)
CL (1)	CL2003002756A1 (de)
CY (2)	CY1812A (de)
CZ (1)	CZ280053B6 (de)
DD (1)	DD292911A5 (de)
DE (2)	DE122005000022I2 (de)
DK (1)	DK0388054T3 (de)
EG (1)	EG18951A (de)
ES (1)	ES2060020T3 (de)
FI (1)	FI95573C (de)
GB (1)	GB8906166D0 (de)
HK (1)	HK130294A (de)
HU (2)	HU217433B (de)
IE (1)	IE62515B1 (de)
IL (1)	IL93694A (de)
LU (1)	LU91161I2 (de)
MX (1)	MX9319890A (de)
MY (1)	MY105527A (de)
NL (1)	NL300191I2 (de)
NO (2)	NO176316C (de)
NZ (1)	NZ232958A (de)
PL (1)	PL164136B1 (de)
PT (1)	PT93443B (de)
RU (2)	RU1833374C (de)
SG (1)	SG143394G (de)
SK (1)	SK129590A3 (de)
UA (1)	UA18263A (de)
YU (1)	YU47587B (de)
ZA (1)	ZA901982B (de)

Families Citing this family (68)

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GB8825505D0 (en) *	1988-11-01	1988-12-07	Pfizer Ltd	Therapeutic agents
US5932594A (en) *	1988-11-01	1999-08-03	Pfizer, Inc.	Muscarinic receptor antagonists
GB8928042D0 (en) *	1989-12-12	1990-02-14	Pfizer Ltd	Muscarinic receptor antagonists
US5607950A (en) *	1990-01-06	1997-03-04	Pfizer Inc.	Muscarinic receptor antagonists
US5486527A (en) *	1990-01-06	1996-01-23	Pfizer Inc.	Anticholinergic agents
CA2134077C (en) *	1992-04-23	2002-05-21	Thaddeus R. Nieduzak	4-imidomethyl-1-[2'phenyl-2'oxoethyl-]piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy
GB9400600D0 (en) *	1994-01-14	1994-03-09	Pfizer Ltd	Treatment of motion seckness
US5639763A (en) *	1994-03-01	1997-06-17	Fmc Corporation	Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US6017931A (en) *	1994-03-01	2000-01-25	Fmc Corporation	Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5674891A (en) *	1994-07-27	1997-10-07	The Procter & Gamble Company	Dihydrobenzothiophene compounds useful as anti-inflammatory agents
JPH10506615A (ja) *	1994-07-27	1998-06-30	ザ、プロクター、エンド、ギャンブル、カンパニー	抗炎症剤として有用なジヒドロベンゾフラン及び関連化合物
GB9518953D0 (en) *	1995-09-15	1995-11-15	Pfizer Ltd	Pharmaceutical formulations
US5684031A (en) *	1996-02-01	1997-11-04	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) *	1996-02-01	1997-09-30	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
JP4167302B2 (ja) *	1996-12-02	2008-10-15	杏林製薬株式会社	新規ｎ―置換ピロリジン誘導体及びその製造法
US6131129A (en) *	1997-07-30	2000-10-10	Sony Corporation Of Japan	Computer system within an AV/C based media changer subunit providing a standarized command set
US6693202B1 (en)	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
IL141235A (en) *	2000-02-09	2012-04-30	Novartis Int Pharm Ltd	Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia
US6653339B2 (en)	2001-08-15	2003-11-25	Pfizer Inc.	Method of treating irritable bowel syndrome
PT1461306E (pt) *	2001-10-26	2009-04-01	Pharmacia & Upjohn Co Llc	Compostos de amónio quaternário
SE0103668D0 (sv) *	2001-11-02	2001-11-02	Astrazeneca Ab	Method for the treatment of overactive blader
MXPA04003806A (es) *	2001-11-05	2005-04-08	Upjohn Co	Aerosol antimuscarinico.
GB0129962D0 (en) *	2001-12-14	2002-02-06	Pfizer Ltd	Method of treatment
GB0207104D0 (en) *	2002-03-26	2002-05-08	Pfizer Ltd	Stable hydrate of a muscarinic receptor antagonist
AU2002345266B2 (en)	2002-07-08	2009-07-02	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
HK1079787A1 (zh)	2002-07-31	2006-04-13	Ranbaxy Laboratories Limited	用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物
WO2004014363A1 (en)	2002-08-09	2004-02-19	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist
EP1534675B1 (de)	2002-08-23	2009-02-25	Ranbaxy Laboratories, Ltd.	Fluor- und sulfonylaminohaltige, 3,6-disubstituierte azabicyclo¬3.1.0 hexanderivate als muscarinrezeptorantagonisten
TW200412945A (en) *	2002-10-25	2004-08-01	Upjohn Co	Quaternary ammonium compounds
TWI295669B (en) *	2002-10-30	2008-04-11	Theravance Inc	Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
ATE400553T1 (de)	2002-12-10	2008-07-15	Ranbaxy Lab Ltd	3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
AU2002347552A1 (en)	2002-12-23	2004-07-14	Ranbaxy Laboratories Limited	1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
DE60225195T2 (de)	2002-12-23	2009-02-26	Ranbaxy Laboratories, Ltd.	Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en)	2003-01-28	2009-02-10	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP4767842B2 (ja)	2003-04-01	2011-09-07	セラヴァンス，インコーポレーテッド	β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
EP1618091A1 (de)	2003-04-09	2006-01-25	Ranbaxy Laboratories, Ltd.	Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren
AU2003223010A1 (en)	2003-04-10	2004-11-01	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EA009059B1 (ru)	2003-04-10	2007-10-26	Рэнбакси Лабораториз Лимитед	Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
JP2006522787A (ja)	2003-04-11	2006-10-05	ランバクシーラボラトリーズリミテッド	ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
JP2006523676A (ja) *	2003-04-15	2006-10-19	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	第四級アンモニウム化合物と、その抗ムスカリン性剤としての使用
WO2004091597A2 (en) *	2003-04-15	2004-10-28	Pharmacia & Upjohn Company Llc	Method of treating irritable bowel syndrome (ibs)
CA2522666A1 (en) *	2003-04-18	2004-10-28	Pharmacia & Upjohn Company Llc	Combination therapies for chronic obstructive pulmonary disease (copd)
TW200510298A (en) *	2003-06-13	2005-03-16	Theravance Inc	Substituted pyrrolidine and related compounds
WO2005007645A1 (en)	2003-07-11	2005-01-27	Theravance, Inc.	Substituted 4-amino-1-benzylpiperidine compounds
EP1725525A1 (de) *	2004-03-11	2006-11-29	Theravance, Inc.	Als muscarinrezeptorantagonisten geeignete diphenylmethylverbindungen
JP2007528418A (ja) *	2004-03-11	2007-10-11	セラヴァンス，インコーポレーテッド	ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
WO2005092341A1 (en) *	2004-03-22	2005-10-06	Ranbaxy Laboratories Limited	Combination therapy for lower urinary tract symptoms
AU2006305619A1 (en)	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Pharmaceutical compositions of muscarinic receptor antagonists
US20070203221A1 (en)	2005-12-27	2007-08-30	Valeriano Merli	Processes for preparing darifenacin hydrobromide
AR062676A1 (es) *	2006-09-07	2008-11-26	Medichem Sa	Procedimiento mejorado para preparar compuestos de pirrolidina 1,3-disustituidas
JP2010513277A (ja) *	2006-12-13	2010-04-30	ギリード・サイエンシズ・インコーポレーテッド	ＣＯＰＤおよび慢性気管支炎の治療のためのムスカリン受容体アンタゴニストおよびβ−アゴニストの共通プロドラッグとしてのモノホスフェート
EP2109601A2 (de) *	2007-01-05	2009-10-21	Dr. Reddy's Laboratories Ltd.	Zubereitung von darifenacin und seinen salzen
CA2675942C (en) *	2007-02-23	2016-04-12	Theravance, Inc.	Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2008126106A2 (en) *	2007-04-16	2008-10-23	Manne Satyanarayana Reddy	Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts
US20100204296A1 (en) *	2007-06-08	2010-08-12	Actavis Group Ptc Ehf	Novel Polymorphs of Darifenacin Free Base and its Hydrobromide Salt
CA2691239A1 (en) *	2007-06-15	2008-12-18	Medichem, S.A.	Method for determining enantiomeric purity of darifenacin and intermediates
WO2009006413A1 (en) *	2007-06-30	2009-01-08	Auspex Pharmaceuticals, Inc.	Substituted pyrrolidines
WO2009010846A2 (en) *	2007-07-13	2009-01-22	Medichem, S.A.	Amorphous form of darifenacin hydrobromide and processes for the preparation thereof
CZ300895B6 (cs)	2008-01-28	2009-09-02	Zentiva, A. S.	Zpusob prípravy Darifenacinu
WO2009125430A2 (en) *	2008-03-17	2009-10-15	Matrix Laboratoires Limited	Improved process for producing darifenacin
WO2009122997A1 (ja) *	2008-04-02	2009-10-08	株式会社カネカ	（ｓ）－３－（１－シアノ－１，１－ジフェニルメチル）－ピロリジンの製造法
WO2010032225A2 (en) *	2008-09-22	2010-03-25	Watson Pharma Private Limited	Process for preparation of darifenacin and intermediates used in the process
EP2236509A1 (de)	2009-04-01	2010-10-06	Ragactives, S.L.	Methode zur Herstellung von 1,3-difunktionalisierten Pyrrolidin-Derivaten
NZ610978A (en)	2009-05-15	2014-11-28	Redx Pharma Ltd	Redox drug derivatives
WO2011070419A1 (en)	2009-12-10	2011-06-16	Aurobindo Pharma Limited	An improved process for the preparation of darifenacin hydrobromide
WO2011137054A1 (en)	2010-04-30	2011-11-03	Merck Sharp & Dohme Corp.	Novel beta 3 adrenergic receptor agonists
CN101857581A (zh) *	2010-06-22	2010-10-13	浙江美诺华药物化学有限公司	一种制备达非那新中间体5-(2-溴乙基)-2,3-二氢-1-苯并呋喃的方法
WO2011161504A1 (en)	2010-06-23	2011-12-29	Micro Labs Limited	Extended release formulations containing darifenacin or pharmaceutically acceptable salts thereof

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US4002766A (en) *	1974-12-26	1977-01-11	A. H. Robins Company, Incorporated	Antiarrhythmia methods
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EP0228893A3 (de) *	1985-12-20	1990-01-03	A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)	Durch Aryloxyalkyl-Gruppen N-substituierte Arylalkyl heterozyklische Amine in Allergieheilverfahren
IL78939A (en) *	1986-01-17	1990-04-29	Robins Co Inc A H	Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds

1989
- 1989-03-17 GB GB898906166A patent/GB8906166D0/en active Pending
1990
- 1990-03-02 EP EP90302269A patent/EP0388054B1/de not_active Expired - Lifetime
- 1990-03-02 ES ES90302269T patent/ES2060020T3/es not_active Expired - Lifetime
- 1990-03-02 DE DE200512000022 patent/DE122005000022I2/de active Active
- 1990-03-02 DE DE90302269T patent/DE69004302T2/de not_active Expired - Lifetime
- 1990-03-02 DK DK90302269.7T patent/DK0388054T3/da active
- 1990-03-02 AT AT90302269T patent/ATE96783T1/de active
- 1990-03-09 IL IL9369490A patent/IL93694A/en not_active IP Right Cessation
- 1990-03-13 US US07493068 patent/US5096890B1/en not_active Expired - Lifetime
- 1990-03-14 HU HU580/90A patent/HU217433B/hu unknown
- 1990-03-14 MX MX1989090A patent/MX9319890A/es unknown
- 1990-03-15 PT PT93443A patent/PT93443B/pt not_active IP Right Cessation
- 1990-03-15 ZA ZA901982A patent/ZA901982B/xx unknown
- 1990-03-15 JP JP2065521A patent/JPH0764809B2/ja not_active Expired - Lifetime
- 1990-03-15 KR KR1019900003453A patent/KR920008166B1/ko not_active Expired
- 1990-03-15 CA CA002012295A patent/CA2012295C/en not_active Expired - Lifetime
- 1990-03-15 EG EG17090A patent/EG18951A/xx active
- 1990-03-16 NO NO901241A patent/NO176316C/no not_active IP Right Cessation
- 1990-03-16 RU SU904743599A patent/RU1833374C/ru active
- 1990-03-16 AU AU51402/90A patent/AU614224B2/en not_active Expired
- 1990-03-16 PL PL90284342A patent/PL164136B1/pl unknown
- 1990-03-16 IE IE95590A patent/IE62515B1/en not_active IP Right Cessation
- 1990-03-16 CZ CS901295A patent/CZ280053B6/cs not_active IP Right Cessation
- 1990-03-16 NZ NZ232958A patent/NZ232958A/en unknown
- 1990-03-16 SK SK1295-90A patent/SK129590A3/sk not_active IP Right Cessation
- 1990-03-16 UA UA4743599A patent/UA18263A/uk unknown
- 1990-03-16 DD DD90338829A patent/DD292911A5/de not_active IP Right Cessation
- 1990-03-16 FI FI901333A patent/FI95573C/fi active Protection Beyond IP Right Term
- 1990-03-16 YU YU52790A patent/YU47587B/sh unknown
- 1990-03-16 MY MYPI90000416A patent/MY105527A/en unknown
- 1990-03-17 CN CN90101543A patent/CN1023007C/zh not_active Expired - Lifetime
1991
- 1991-03-13 RU SU914894696A patent/RU2015965C1/ru active
1992
- 1992-08-12 KR KR1019920014485A patent/KR960015142B1/ko not_active Expired - Lifetime
1994
- 1994-09-26 JP JP6229807A patent/JPH07149640A/ja active Pending
- 1994-10-03 SG SG143394A patent/SG143394G/en unknown
- 1994-11-24 HK HK130294A patent/HK130294A/en not_active IP Right Cessation
1995
- 1995-06-28 HU HU95P/P00505P patent/HU211640A9/hu active Protection Beyond IP Right Term
- 1995-10-20 CY CY181295A patent/CY1812A/xx unknown
1998
- 1998-03-30 BA BA980300A patent/BA98300A/bs unknown
2003
- 2003-12-26 CL CL200302756A patent/CL2003002756A1/es unknown
2005
- 2005-04-01 NO NO2005008C patent/NO2005008I2/no unknown
- 2005-04-04 CY CY2005005C patent/CY2005005I1/el unknown
- 2005-04-08 NL NL300191C patent/NL300191I2/nl unknown
- 2005-04-11 LU LU91161C patent/LU91161I2/fr unknown

Also Published As

Publication number	Publication date
US5096890A (en)	1992-03-17
KR960015142B1 (ko)	1996-11-01
CY2005005I2 (el)	2010-07-28
EG18951A (en)	1994-03-30
NO2005008I1 (en)	2005-04-11
LU91161I2 (fr)	2005-06-13
DE69004302T2 (de)	1994-02-24
FI901333A0 (fi)	1990-03-16
US5096890B1 (en)	1995-03-28
PL164136B1 (pl)	1994-06-30
NO176316C (no)	1995-03-15
DE122005000022I1 (de)	2005-08-04
IL93694A (en)	1994-08-26
JPH02282360A (ja)	1990-11-19
UA18263A (uk)	1997-12-25
NL300191I1 (nl)	2005-07-01
ATE96783T1 (de)	1993-11-15
DE69004302D1 (de)	1993-12-09
SG143394G (en)	1995-01-13
PT93443A (pt)	1990-11-07
SK278434B6 (en)	1997-05-07
BA98300A (bs)	2001-09-14
NL300191I2 (nl)	2005-08-01
HU217433B (hu)	2000-01-28
JPH07149640A (ja)	1995-06-13
IE62515B1 (en)	1995-02-08
EP0388054B1 (de)	1993-11-03
CZ280053B6 (cs)	1995-10-18
JPH0764809B2 (ja)	1995-07-12
CN1023007C (zh)	1993-12-08
HU211640A9 (en)	1995-12-28
EP0388054A1 (de)	1990-09-19
ES2060020T3 (es)	1994-11-16
NO2005008I2 (no)	2006-11-27
IL93694A0 (en)	1990-12-23
AU614224B2 (en)	1991-08-22
CY2005005I1 (el)	2010-07-28
MX9319890A (es)	1993-08-01
KR920008166B1 (ko)	1992-09-24
FI95573B (fi)	1995-11-15
RU2015965C1 (ru)	1994-07-15
CA2012295A1 (en)	1990-09-17
IE900955L (en)	1990-09-17
HU901580D0 (en)	1990-06-28
FI95573C (fi)	1996-02-26
NO901241D0 (no)	1990-03-16
KR900014367A (ko)	1990-10-23
CZ129590A3 (en)	1995-05-17
CN1045580A (zh)	1990-09-26
DE122005000022I2 (de)	2006-02-02
GB8906166D0 (en)	1989-05-04
CY1812A (en)	1995-10-20
YU47587B (sh)	1995-10-24
NZ232958A (en)	1992-05-26
MY105527A (en)	1994-10-31
NO176316B (no)	1994-12-05
YU52790A (sh)	1992-07-20
HK130294A (en)	1994-12-02
NO901241L (no)	1990-09-18
DD292911A5 (de)	1991-08-14
AU5140290A (en)	1990-09-20
ZA901982B (en)	1991-10-30
HUT58313A (en)	1992-02-28
SK129590A3 (en)	1997-05-07
CA2012295C (en)	1996-11-12
PT93443B (pt)	1996-02-29
CL2003002756A1 (es)	2005-02-11
RU1833374C (ru)	1993-08-07

Publication	Publication Date	Title
US5096890B1 (en)	1995-03-28	Pyrrolidine derivatives
NO932607D0 (no)	1993-07-19	Piperidinderivater og anvendelse av disse
DE69007126D1 (de)	1994-04-07	Muscarin-rezeptor-antagonisten.
FI97468B (fi)	1996-09-13	Menetelmä terapeuttisesti aktiivisten piperidiinijohdannaisten valmistamiseksi
FI922835A0 (fi)	1992-06-17	Menetelmä terapeuttisesti aktiivisten piperidiinijohdannaisten valmistamiseksi
DE69006745D1 (de)	1994-03-24	Muscarin-rezeptor-antagonisten.