HK1002811A1 - 1,4,7,10-tetraazacyclododecane-butyltriols, process for their preparation, and pharmaceutical agents containing these compounds - Google Patents

1,4,7,10-tetraazacyclododecane-butyltriols, process for their preparation, and pharmaceutical agents containing these compounds Download PDF

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Publication number
HK1002811A1
HK1002811A1 HK98101937A HK98101937A HK1002811A1 HK 1002811 A1 HK1002811 A1 HK 1002811A1 HK 98101937 A HK98101937 A HK 98101937A HK 98101937 A HK98101937 A HK 98101937A HK 1002811 A1 HK1002811 A1 HK 1002811A1
Authority
HK
Hong Kong
Prior art keywords
general formula
metal
compounds
substituents
tetraazacyclododecane
Prior art date
Application number
HK98101937A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1002811B (en
Inventor
Platzek Johannes
Gries Heinz
Weinmann Hanns-Joachim
Schuhmann-Giampieri Gabriele
Press Wolf-Rudiger
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of HK1002811B publication Critical patent/HK1002811B/xx
Publication of HK1002811A1 publication Critical patent/HK1002811A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK98101937A 1990-03-19 1998-03-10 1,4,7,10-tetraazacyclododecane-butyltriols, process for their preparation, and pharmaceutical agents containing these compounds HK1002811A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4009119A DE4009119A1 (de) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4009119 1990-03-19

Publications (2)

Publication Number Publication Date
HK1002811B HK1002811B (en) 1998-09-18
HK1002811A1 true HK1002811A1 (en) 1998-09-18

Family

ID=6402765

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98101937A HK1002811A1 (en) 1990-03-19 1998-03-10 1,4,7,10-tetraazacyclododecane-butyltriols, process for their preparation, and pharmaceutical agents containing these compounds

Country Status (17)

Country Link
US (4) US5980864A (da)
EP (1) EP0448191B1 (da)
JP (1) JP2968367B2 (da)
AT (1) ATE124405T1 (da)
AU (1) AU647091B2 (da)
CA (1) CA2038493C (da)
DE (3) DE4009119A1 (da)
DK (1) DK0448191T3 (da)
ES (1) ES2074219T3 (da)
FI (1) FI109695B (da)
HK (1) HK1002811A1 (da)
HU (1) HU215964B (da)
IE (1) IE67643B1 (da)
IL (1) IL97592A (da)
NO (2) NO179610C (da)
NZ (1) NZ237461A (da)
PT (1) PT97065B (da)

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WO2018069179A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
EP3551614B1 (en) 2016-12-12 2021-08-25 Bracco Imaging SpA Dimeric contrast agents
EP3392254A1 (en) * 2017-04-20 2018-10-24 Koninklijke Philips N.V. Compounds for use in the diagnosis of a disease
KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
US12227527B2 (en) 2018-07-10 2025-02-18 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of 2,2′,2″-(10-((2R,3S)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR102167614B1 (ko) 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
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Also Published As

Publication number Publication date
ATE124405T1 (de) 1995-07-15
CA2038493C (en) 2002-07-02
US20020176823A1 (en) 2002-11-28
DE4009119A1 (de) 1991-09-26
JP2968367B2 (ja) 1999-10-25
FI911330L (fi) 1991-09-20
JPH05320146A (ja) 1993-12-03
DE59105815D1 (de) 1995-08-03
US20060078503A1 (en) 2006-04-13
US5980864A (en) 1999-11-09
NO2001003I1 (no) 2001-03-05
IL97592A (en) 1995-10-31
CA2038493A1 (en) 1991-09-20
AU7361091A (en) 1991-09-19
US6951639B2 (en) 2005-10-04
US6399043B1 (en) 2002-06-04
ES2074219T3 (es) 1995-09-01
IE67643B1 (en) 1996-04-17
FI109695B (fi) 2002-09-30
NZ237461A (en) 1993-12-23
FI911330A0 (fi) 1991-03-19
NO179610B (no) 1996-08-05
HUT60478A (en) 1992-09-28
PT97065B (pt) 1998-07-31
EP0448191A1 (de) 1991-09-25
HU215964B (hu) 1999-03-29
IL97592A0 (en) 1992-06-21
PT97065A (pt) 1991-10-31
IE910902A1 (en) 1991-09-25
NO179610C (no) 1996-11-13
EP0448191B1 (de) 1995-06-28
AU647091B2 (en) 1994-03-17
NO911063L (no) 1991-09-20
DK0448191T3 (da) 1995-11-20
DE10075007I2 (de) 2003-06-12
HU910874D0 (en) 1991-09-30
NO911063D0 (no) 1991-03-18

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Effective date: 20110317