DK0460917T3 - Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf - Google Patents

Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf

Info

Publication number: DK0460917T3
Authority: DK; Denmark
Prior art keywords: ester derivative; eicosapentaenoic acid; preparing; present; continuous distillation
Prior art date: 1990-06-04

Application number

DK91305044.9T

Other languages

Danish (da)

English (en)

Inventor

Kazuhiko Hata

Hideo Noda

Masahiro Makuta

Original Assignee

Kansai Chem Eng

Nippon Suisan Kaisha Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-04

Filing date

1991-06-04

Publication date

1997-01-20

1990-06-04 Priority claimed from JP2145617A external-priority patent/JP3040136B2/ja

1990-06-04 Priority claimed from JP2145618A external-priority patent/JP3005638B2/ja

1991-06-04 Application filed by Kansai Chem Eng, Nippon Suisan Kaisha Ltd filed Critical Kansai Chem Eng

1997-01-20 Application granted granted Critical

1997-01-20 Publication of DK0460917T3 publication Critical patent/DK0460917T3/da

Links

JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical class CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 title abstract 2
229960005135 eicosapentaenoic acid Drugs 0.000 title abstract 2
JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 title abstract 2
235000020673 eicosapentaenoic acid Nutrition 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 4
238000001944 continuous distillation Methods 0.000 abstract 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
238000010276 construction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
- C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
- C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Crystallography & Structural Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Fats And Perfumes (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK91305044.9T 1990-06-04 1991-06-04 Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf DK0460917T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2145617A JP3040136B2 (ja)	1990-06-04	1990-06-04	エイコサペンタエン酸またはそのエステルの製造方法
JP2145618A JP3005638B2 (ja)	1990-06-04	1990-06-04	高濃度エイコサペンタエン酸またはそのエステルの製造方法

Publications (1)

Publication Number	Publication Date
DK0460917T3 true DK0460917T3 (da)	1997-01-20

Family

ID=26476703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91305044.9T DK0460917T3 (da)	1990-06-04	1991-06-04	Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf

Country Status (11)

Country	Link
EP (1)	EP0460917B1 (fr)
JP (1)	JPH11236591A (fr)
KR (1)	KR100208701B1 (fr)
AT (1)	ATE147062T1 (fr)
AU (1)	AU641016B2 (fr)
CA (1)	CA2043615C (fr)
DE (1)	DE69123880T2 (fr)
DK (1)	DK0460917T3 (fr)
ES (1)	ES2095909T3 (fr)
GR (1)	GR3022660T3 (fr)
NO (1)	NO177699C (fr)

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JP3400466B2 (ja) *	1991-10-28	2003-04-28	日本水産株式会社	高純度エイコサペンタエン酸またはそのエステルの製造方法
NO322213B1 (no) *	1998-01-30	2006-08-28	Ube Industries	Fremgangsmåte for rensing av varmenedbrytbare aromatiske hydroksylforbindelser ved destillasjon hvor de varmenedbrytbare aromatiske hydroksylforbindelsene befinner seg i en flerkomponentholdig væskeblanding.
NZ332331A (en) *	1998-10-15	2000-03-27	Craig Nazzer	Continuous process for removing solids from miscible liquid mixture; lower boiling point liquid(s) removed by flashing or boiling
GB9901809D0 (en)	1999-01-27	1999-03-17	Scarista Limited	Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
JP4558870B2 (ja)	1999-11-08	2010-10-06	株式会社日本触媒	塔式処理方法および装置
FR2833006A1 (fr) *	2001-11-30	2003-06-06	Cognis France Sa	Procede de preparation d'ester methylique d'acide oleique industriel
WO2010028067A1 (fr)	2008-09-02	2010-03-11	Amarin Corporation Plc	Composition pharmaceutique comprenant de l'acide eïcosapentaénoïque et de l'acide nicotinique et ses procédés d'utilisation
KR101383006B1 (ko)	2009-02-10	2014-04-08	아마린 파마, 인크.	고중성지방혈증 치료 방법
PT3278665T (pt)	2009-04-29	2020-11-19	Amarin Pharmaceuticals Ie Ltd	Composição farmacêutica estável e métodos de utilização das mesmas
SG175390A1 (en)	2009-04-29	2011-12-29	Amarin Corp Plc	Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
CN106074486A (zh)	2009-06-15	2016-11-09	阿马里纳药物爱尔兰有限公司	在相伴他汀类疗法的对象中降低甘油三酯、没有增加ldl‑c水平的组合物和方法
US20110071176A1 (en)	2009-09-23	2011-03-24	Amarin Pharma, Inc.	Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
US11712429B2 (en)	2010-11-29	2023-08-01	Amarin Pharmaceuticals Ireland Limited	Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ778131A (en)	2010-11-29	2023-03-31	Amarin Pharmaceuticals Ie Ltd	Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
CN102417447B (zh) *	2011-10-31	2014-04-30	广西亿康药业股份有限公司	十一烯酸的生产方法
EP2775837A4 (fr)	2011-11-07	2015-10-28	Amarin Pharmaceuticals Ie Ltd	Méthodes de traitement de l'hypertriglycéridémie
US11291643B2 (en)	2011-11-07	2022-04-05	Amarin Pharmaceuticals Ireland Limited	Methods of treating hypertriglyceridemia
ES2891473T3 (es)	2012-01-06	2022-01-28	Amarin Pharmaceuticals Ie Ltd	Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto
KR20240096704A (ko)	2012-05-14	2024-06-26	가부시키가이샤 닛스이	환경 오염 물질을 저감시킨 고도 불포화 지방산 또는 고도 불포화 지방산 에틸에스테르 및 그 제조 방법
CN102776067A (zh) *	2012-05-31	2012-11-14	源华能源科技（福建）有限公司	一种分子蒸馏提纯粗脂肪酸甲酯工艺
EP4338805B1 (fr)	2012-06-29	2025-06-04	Amarin Pharmaceuticals Ireland Limited	Ester éthylique d'acide eicosapentaénoïque destiné à être utilisé dans la réduction du risque d'infarctus myocardique non fatal chez un sujet atteint d'une thérapie par statine
WO2014074552A2 (fr)	2012-11-06	2014-05-15	Amarin Pharmaceuticals Ireland Limited	Compositions et procédés pour diminuer les triglycérides sans augmenter les taux de ldl-c chez un sujet traité en même temps par la statine
US20140187633A1 (en)	2012-12-31	2014-07-03	Amarin Pharmaceuticals Ireland Limited	Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en)	2012-12-31	2017-11-14	A,arin Pharmaceuticals Ireland Limited	Compositions comprising EPA and obeticholic acid and methods of use thereof
US9452151B2 (en)	2013-02-06	2016-09-27	Amarin Pharmaceuticals Ireland Limited	Methods of reducing apolipoprotein C-III
US9624492B2 (en)	2013-02-13	2017-04-18	Amarin Pharmaceuticals Ireland Limited	Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en)	2013-02-19	2017-05-30	The Regents Of The University Of Colorado	Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en)	2013-03-14	2016-03-15	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en)	2013-03-15	2014-09-18	Amarin Pharmaceuticals Ireland Limited	Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en)	2013-06-06	2021-04-06	Amarin Pharmaceuticals Ireland Limited	Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en)	2013-09-04	2015-03-05	Amarin Pharmaceuticals Ireland Limited	Methods of treating or preventing prostate cancer
US9585859B2 (en)	2013-10-10	2017-03-07	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103570590B (zh) *	2013-10-30	2016-04-06	临沂远博化工有限公司	一种生产硫酸二甲酯的设备
EP3733857A3 (fr)	2013-12-04	2020-12-09	Nippon Suisan Kaisha, Ltd.	Huile microbienne contenant de l'acide dihomo-gamma-linolénique et biomasse microbienne contenant de l'acide dihomo-gamma-linolénique
US10561631B2 (en)	2014-06-11	2020-02-18	Amarin Pharmaceuticals Ireland Limited	Methods of reducing RLP-C
WO2015195662A1 (fr)	2014-06-16	2015-12-23	Amarin Pharmaceuticals Ireland Limited	Procédés de réduction ou de prévention de l'oxydation des ldl petites et denses ou des acides gras polyinsaturés membranaires
US9918953B2 (en)	2014-09-17	2018-03-20	Nippon Suisan Kaisha, Ltd.	Composition containing eicosapentaenoic acid alkyl ester, and method for producing same
US10406130B2 (en)	2016-03-15	2019-09-10	Amarin Pharmaceuticals Ireland Limited	Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
WO2018213663A1 (fr)	2017-05-19	2018-11-22	Amarin Pharmaceuticals Ireland Limited	Compositions et méthodes pour dimunuer les triglycérides chez un sujet ayant une fonction rénale réduite
US11058661B2 (en)	2018-03-02	2021-07-13	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
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US12427134B2 (en)	2019-11-12	2025-09-30	Amarin Pharmaceuticals Ireland Limited	Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter
AU2022263358A1 (en)	2021-04-21	2023-11-30	Amarin Pharmaceuticals Ireland Limited	Methods of reducing the risk of heart failure

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DE2055892C3 (de) *	1970-11-13	1979-08-16	Basf Ag, 6700 Ludwigshafen	Verfahren zur Reinigung von Butandiol
DE2220922C2 (de) *	1972-04-28	1985-06-20	Feld & Hahn Gmbh, 5413 Bendorf	Verfahren und Vorrichtung zur Abtrennung von Fettsäuren durch Destillation
US4377526A (en) *	1981-05-15	1983-03-22	Nippon Suisan Kaisha, Ltd.	Method of purifying eicosapentaenoic acid and its esters
DE3226116A1 (de) *	1981-07-16	1983-02-03	VEB Chemieanlagenbaukombinat Leipzig-Grimma, DDR 7240 Grimma	Verfahren und vorrichtung zur kontinuierlichen rektifikation von mehr- und vielstoffgemischen
GB2218984B (en) *	1988-05-27	1992-09-23	Renafield Limited	Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses

1991
- 1991-06-03 CA CA002043615A patent/CA2043615C/fr not_active Expired - Fee Related
- 1991-06-04 EP EP91305044A patent/EP0460917B1/fr not_active Expired - Lifetime
- 1991-06-04 NO NO912144A patent/NO177699C/no unknown
- 1991-06-04 KR KR1019910009345A patent/KR100208701B1/ko not_active Expired - Fee Related
- 1991-06-04 AU AU78186/91A patent/AU641016B2/en not_active Ceased
- 1991-06-04 DK DK91305044.9T patent/DK0460917T3/da active
- 1991-06-04 AT AT91305044T patent/ATE147062T1/de not_active IP Right Cessation
- 1991-06-04 ES ES91305044T patent/ES2095909T3/es not_active Expired - Lifetime
- 1991-06-04 DE DE69123880T patent/DE69123880T2/de not_active Expired - Fee Related
1997
- 1997-02-26 GR GR970400347T patent/GR3022660T3/el unknown
1998
- 1998-12-14 JP JP10354409A patent/JPH11236591A/ja active Pending

Also Published As

Publication number	Publication date
CA2043615C (fr)	2001-08-14
NO912144D0 (no)	1991-06-04
KR920000690A (ko)	1992-01-29
ATE147062T1 (de)	1997-01-15
JPH11236591A (ja)	1999-08-31
DE69123880D1 (de)	1997-02-13
DE69123880T2 (de)	1997-07-03
EP0460917A2 (fr)	1991-12-11
NO177699B (no)	1995-07-31
EP0460917A3 (en)	1993-07-07
NO912144L (no)	1991-12-05
ES2095909T3 (es)	1997-03-01
GR3022660T3 (en)	1997-05-31
CA2043615A1 (fr)	1991-12-05
KR100208701B1 (ko)	1999-07-15
EP0460917B1 (fr)	1997-01-02
NO177699C (no)	1995-11-08
AU7818691A (en)	1991-12-05
AU641016B2 (en)	1993-09-09

Publication	Publication Date	Title
DK0460917T3 (da)	1997-01-20	Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf
NO944644D0 (no)	1994-12-02	Fremstilling av 3,4,4-trisubstituert-piperidinyl-N-alkylkarboksylater og mellomprodukter
DK0535940T3 (da)	1998-04-27	Fremgangsmåde til fremstilling af dihomo-gamma-linolensyre og et lipid indeholdende samme
DK542785A (da)	1986-05-30	Fremgangsmaade til fremstilling af 7-halogen-7-deoxylincomycin eller dermed analoge forbindelser
ATE123482T1 (de)	1995-06-15	Verfahren zur umwandlung eines einsatzmaterials, das lineare olefine enthält.
DK0535939T3 (da)	1997-08-11	Fremgangsmåde til fremstilling af omega 9-type polyumættet fedtsyre
DK0655454T3 (da)	2001-10-08	Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere
BR8503211A (pt)	1987-02-10	Processo para produzir diol e furano e microorganismo capaz do mesmo
DE69425315D1 (de)	2000-08-24	Verfahren zum Produzieren von Kartoffelmikroknollen
DE59209181D1 (de)	1998-03-12	Verfahren zur Herstellung von Mikrostrukturkörpern
ATE104268T1 (de)	1994-04-15	Verfahren zur herstellung eines alphaketocarbons\|ureester.
ATE175957T1 (de)	1999-02-15	Verfahren zur herstellung von alkoxyiminoacetamid-verbindungen
DE69133494D1 (de)	2006-01-12	Microbiologische Herstellung von L-Ascorbinsäure
DK399681A (da)	1982-04-09	Fremgangsmaade til fremstilling af 5-methyl-4-imidazolcarboxylsyreestere
ATE207139T1 (de)	2001-11-15	Verfahren zur herstellung von butantetracarbonsäure
DK211189D0 (da)	1989-05-01	Fremgangsmaade til fremstilling af 5-chlor-3-chlorsulfonyl-2-thiophencarboxylsyreestere
ATE109446T1 (de)	1994-08-15	Verfahren zur herstellung von terpenketonen.
FI102083B1 (fi)	1998-10-15	Menetelmä L-karnitiinin valmistamiseksi epäjatkuvasti mikrobiologista tietä
DE59000677D1 (de)	1993-02-11	Verfahren zur herstellung von 2-cyan-3,3-diarylacrylsaeureestern.
ATE224901T1 (de)	2002-10-15	Verfahren zur herstellung von 5-brom-2- fluorbenzolboronsäure
ATE167674T1 (de)	1998-07-15	Verfahren zur herstellung von l-ascorbinsäure
ATE130608T1 (de)	1995-12-15	Verfahren zur herstellung von fluoromethyl substituierten pyridin-carbodithioaten.
ATE55769T1 (de)	1990-09-15	Substituierte dioxanone, verfahren zu deren herstellung und deren verwendung.
DK0454494T3 (da)	1995-12-04	Calicheamicinoner, derivater deraf og analoge dertil og fremgangsmåde til fremstilling af disse
ATE178093T1 (de)	1999-04-15	Verfahren zur herstellung von neuraminidase