DK0484094T3 - Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse - Google Patents

Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse

Info

Publication number: DK0484094T3
Authority: DK; Denmark
Prior art keywords: alkyl group; substituted alkyl; carbon; preparation; treatment
Prior art date: 1990-10-29

Application number

DK91309967.7T

Other languages

Danish (da)

English (en)

Inventor

Koichi Kojima

Hitoshi Kurata

Hiroyoshi Horikoshi

Takakazu Hamada

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-29

Filing date

1991-10-29

Publication date

1996-10-28

1991-10-29 Application filed by Sankyo Co filed Critical Sankyo Co

1996-10-28 Application granted granted Critical

1996-10-28 Publication of DK0484094T3 publication Critical patent/DK0484094T3/da

Links

238000011282 treatment Methods 0.000 title abstract 2
-1 Azasteroid compounds Chemical class 0.000 title 1
206010020880 Hypertrophy Diseases 0.000 title 1
210000002307 prostate Anatomy 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004986 diarylamino group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
201000004240 prostatic hypertrophy Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK91309967.7T 1990-10-29 1991-10-29 Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse DK0484094T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP29140190		1990-10-29

Publications (1)

Publication Number	Publication Date
DK0484094T3 true DK0484094T3 (da)	1996-10-28

Family

ID=17768420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91309967.7T DK0484094T3 (da)	1990-10-29	1991-10-29	Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse

Country Status (19)

Country	Link
US (1)	US5302621A (es)
EP (1)	EP0484094B1 (es)
JP (1)	JPH0819151B2 (es)
KR (1)	KR0134570B1 (es)
CN (2)	CN1053672C (es)
AT (1)	ATE139783T1 (es)
AU (1)	AU640279B2 (es)
CA (1)	CA2054368C (es)
CZ (1)	CZ279312B6 (es)
DE (1)	DE69120500T2 (es)
DK (1)	DK0484094T3 (es)
ES (1)	ES2091299T3 (es)
GR (1)	GR3020483T3 (es)
HU (2)	HU218667B (es)
IE (1)	IE76452B1 (es)
IL (1)	IL99889A (es)
PT (1)	PT99371B (es)
RU (1)	RU2070204C1 (es)
ZA (1)	ZA918570B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5304562A (en) *	1991-10-09	1994-04-19	Ciba-Geigy Corporation	17β-substituted Aza-androstane derivatives
CA2084799C (en)	1991-12-17	2003-01-28	Glenn J. Gormley	Method of prevention of prostatic carcinoma with 17 beta-n-monosubstituted-carbamoyl-4-aza-5 alpha-androst-1 -en-3-ones
ATE165368T1 (de) *	1991-12-20	1998-05-15	Glaxo Wellcome Inc	Inhibitoren von testosteron-5-alpha reductase.
US5698720A (en) *	1992-04-20	1997-12-16	Sankyo Company, Limited	Steroid derivatives
EP0725074A3 (en) *	1992-04-20	1996-11-20	Sankyo Co	Intermediate compounds for the preparation of androst-3,5-diene-3-carboxy derivatives
US5710275A (en) *	1992-05-20	1998-01-20	Merck & Co., Inc.	7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
AU674145B2 (en) *	1992-05-20	1996-12-12	Merck & Co., Inc.	New 17-ester, amide, and ketone derivatives of 3-oxo-4-azasteroids as 5a-reductase inhibitors
GB9216329D0 (en) *	1992-07-31	1992-09-16	Erba Carlo Spa	17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9216284D0 (en) *	1992-07-31	1992-09-16	Erba Carlo Spa	Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
US5302589A (en) *	1992-08-07	1994-04-12	Glaxo, Inc.	Heterocyclic inhibitors of 5-α-testosterone reductase
HU212459B (en) *	1992-10-02	1996-06-28	Richter Gedeon Vegyeszet	Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
EP0663924B1 (en) *	1992-10-06	2001-02-14	Merck & Co. Inc.	17-beta-carboxanilides of 4-aza-5-alpha-androstan-3-ones as 5-alpha-reductase inhibitors
WO1994022900A1 (en) *	1993-04-02	1994-10-13	Ciba-Geigy Ag	AZA-ANDROSTANE-17β-CARBOXAMIDES
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
TW408127B (en) *	1993-09-17	2000-10-11	Glaxo Inc	Androstenones
JPH09504553A (ja) *	1993-11-04	1997-05-06	メルクエンドカンパニーインコーポレーテッド	５α−レダクターゼ阻害薬としての７−置換−４−アザ−ステロイド誘導体
US5817818A (en) *	1994-09-16	1998-10-06	Glaxo Wellcome Inc.	Androstenones
US5578724A (en) *	1994-09-20	1996-11-26	Eli Lilly And Company	Process for preparation of benzo[f]quinolinones
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
IT1271325B (it) *	1994-12-23	1997-05-27	Poli Ind Chimica Spa	Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
US5656613A (en) *	1995-01-04	1997-08-12	Merck & Co., Inc.	Treatment of hyperandrogenic conditions
CN1072679C (zh) *	1995-07-30	2001-10-10	重庆医科大学	一种氮杂甾体化合物、制备及其用途
US6001844A (en) *	1995-09-15	1999-12-14	Merck & Co., Inc.	4-Azasteroids for treatment of hyperandrogenic conditions
EP0859761A4 (en) *	1995-09-15	2000-01-26	Merck & Co Inc	4-AZASTEROIDS FOR TREATING HYPERANDROGEN STATES
PT923942E (pt) *	1996-02-05	2002-03-28	Sankyo Co	Preparacao inibidora de 5alfa-reductase para administracao oral um processo para producao da mesma e sua utilizacao
PT963998E (pt) *	1997-02-26	2004-07-30	Sankyo Co	Composicoes para tratar ou prevenir cancro prostatico
US6093722A (en)	1997-02-26	2000-07-25	Sankyo Company, Limited	Method for treating prostate cancer
IL134199A0 (en)	1997-07-29	2001-04-30	Sankyo Co	MEDICAMENTS CONTAINING 5α-ANDROST-1-ENE-17β-CARBOXAMIDE DERIVATIVES
US6187925B1 (en) *	1997-12-23	2001-02-13	Merck & Co., Inc.	Intermediates and process for the synthesis of azasteroids
US5998427A (en) *	1998-05-14	1999-12-07	Glaxo Wellcome Inc.	Androstenones
US6645974B2 (en)	2001-07-31	2003-11-11	Merck & Co., Inc.	Androgen receptor modulators and methods for use thereof
HRP20040822A2 (en) *	2002-03-13	2005-06-30	Merck & Co. Inc.	Fluorinated 4-azasteroid derivatives as androgen receptor modulators
CA2524409C (en) *	2003-05-07	2011-12-20	Merck & Co., Inc.	Androgen receptor modulators and methods of use thereof
AU2004255749B2 (en) *	2003-06-30	2008-12-18	Merck Sharp & Dohme Corp.	17-acetamido-4-azasteroid derivatives as androgen receptor modulators
US7329750B2 (en) *	2003-06-30	2008-02-12	Merck & Co., Inc.	17-Acetamido-4-azasteroid derivatives as androgen receptor modulators
CA2530025A1 (en) *	2003-06-30	2005-01-20	William P. Dankulich	17-acetamido-4-azasteroid derivatives as androgen receptor modulators
US20080125403A1 (en) *	2004-04-02	2008-05-29	Merck & Co., Inc.	Method of Treating Men with Metabolic and Anthropometric Disorders
CN101146535A (zh) *	2005-03-25	2008-03-19	默克公司	用睾酮补充剂和5α-还原酶抑制剂治疗男性病人的方法
CN116621913B (zh) *	2022-08-12	2026-03-27	湖南科益新生物医药有限公司	一种4-氮杂甾体化合物及其制备方法、用途及药物组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU527030B2 (en) *	1978-04-13	1983-02-10	Merck & Co., Inc.	4-aza-17-substituted-5a-androstan-3-ones
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4179453A (en)	1978-04-13	1979-12-18	Merck & Co., Inc.	Process for preparing 17β-carboxy-5-androsten-3-ones
US4220775A (en) *	1979-03-15	1980-09-02	Merck & Co., Inc.	Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
US4760071A (en)	1984-02-27	1988-07-26	Merck & Co., Inc.	17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
IL74365A (en) *	1984-02-27	1990-07-26	Merck & Co Inc	17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it
GB8505862D0 (en) *	1985-03-07	1985-04-11	Erba Farmitalia	Steroidic 5alpha-reductase inhibitors
US5021575A (en) *	1989-11-13	1991-06-04	Merck & Co., Inc.	Method for introducing a 1,2 double bond into azasteroids

1991
- 1991-10-25 IE IE374791A patent/IE76452B1/en not_active IP Right Cessation
- 1991-10-28 RU SU5010339/04A patent/RU2070204C1/ru not_active IP Right Cessation
- 1991-10-28 CA CA002054368A patent/CA2054368C/en not_active Expired - Fee Related
- 1991-10-28 JP JP3281484A patent/JPH0819151B2/ja not_active Expired - Fee Related
- 1991-10-28 ZA ZA918570A patent/ZA918570B/xx unknown
- 1991-10-29 AU AU86821/91A patent/AU640279B2/en not_active Ceased
- 1991-10-29 DE DE69120500T patent/DE69120500T2/de not_active Expired - Fee Related
- 1991-10-29 PT PT99371A patent/PT99371B/pt not_active IP Right Cessation
- 1991-10-29 IL IL9988991A patent/IL99889A/en not_active IP Right Cessation
- 1991-10-29 HU HU396/91A patent/HU218667B/hu not_active IP Right Cessation
- 1991-10-29 KR KR1019910019062A patent/KR0134570B1/ko not_active Expired - Fee Related
- 1991-10-29 CZ CS913269A patent/CZ279312B6/cs not_active IP Right Cessation
- 1991-10-29 CN CN91111440A patent/CN1053672C/zh not_active Expired - Fee Related
- 1991-10-29 ES ES91309967T patent/ES2091299T3/es not_active Expired - Lifetime
- 1991-10-29 EP EP91309967A patent/EP0484094B1/en not_active Expired - Lifetime
- 1991-10-29 DK DK91309967.7T patent/DK0484094T3/da active
- 1991-10-29 AT AT91309967T patent/ATE139783T1/de not_active IP Right Cessation
1993
- 1993-02-26 US US08/023,871 patent/US5302621A/en not_active Expired - Fee Related
1995
- 1995-06-29 HU HU95P/P00567P patent/HU211642A9/hu unknown
1996
- 1996-07-09 GR GR960401851T patent/GR3020483T3/el unknown
1997
- 1997-01-24 CN CN97102330A patent/CN1072935C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUT59417A (en)	1992-05-28
HU913396D0 (en)	1992-01-28
US5302621A (en)	1994-04-12
GR3020483T3 (en)	1996-10-31
HU218667B (hu)	2000-10-28
AU8682191A (en)	1992-04-30
DE69120500T2 (de)	1997-02-27
DE69120500D1 (de)	1996-08-01
IE913747A1 (en)	1992-05-22
HK1005456A1 (en)	1999-01-08
JPH0819151B2 (ja)	1996-02-28
ZA918570B (en)	1992-08-26
AU640279B2 (en)	1993-08-19
EP0484094B1 (en)	1996-06-26
RU2070204C1 (ru)	1996-12-10
PT99371B (pt)	1999-04-30
CA2054368C (en)	2001-10-02
IE76452B1 (en)	1997-10-22
HU211642A9 (en)	1995-12-28
CZ279312B6 (cs)	1995-04-12
IL99889A (en)	1995-06-29
ES2091299T3 (es)	1996-11-01
CN1053672C (zh)	2000-06-21
KR920008063A (ko)	1992-05-27
CA2054368A1 (en)	1992-04-30
CN1062145A (zh)	1992-06-24
ATE139783T1 (de)	1996-07-15
CN1072935C (zh)	2001-10-17
CN1209319A (zh)	1999-03-03
PT99371A (pt)	1992-09-30
EP0484094A2 (en)	1992-05-06
IL99889A0 (en)	1992-08-18
HK1017274A1 (en)	1999-11-19
CS326991A3 (en)	1992-05-13
JPH0532693A (ja)	1993-02-09
KR0134570B1 (ko)	1998-04-14
EP0484094A3 (en)	1993-07-14

Publication	Publication Date	Title
DK0484094T3 (da)	1996-10-28	Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse
DK0567271T3 (da)	1998-02-16	Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
DK98787A (da)	1987-08-28	1,2,5,6-tetrahydropyridin-3-carboxaldehydoximderivater og praeparater med indhold deraf samt fremgangsmaade til deres fremstilling
ATE114465T1 (de)	1994-12-15	Pharmazeutische zusammensetzung zur inhibierung der knochenresorption.
DK0763024T3 (da)	2002-12-02	Fremgangmåde og mellemprodukter til fremstilling af piperazinderivater
EP0347815A3 (en)	1990-03-28	Cleaner for thermostatic water bath
FI103887B1 (fi)	1999-10-15	Menetelmä terapeuttisesti käyttökelpoisten imidatsolyylimetyyli-pyridiinien valmistamiseksi
ATE131061T1 (de)	1995-12-15	Förderung der osteogenese durch verwendung von vitamin d-derivaten.
DK397487D0 (da)	1987-07-30	3-aryl-3-cycloalkyl-piperidin-2,6-dion-derivater, deres fremstilling og anvendelse
SE8505369D0 (sv)	1985-11-13	New thienopyridine derivatives, a process of preparation thereof and therapeutic compositions containing the same
TW225989B (es)	1994-07-01
EP0802179A4 (en)	2000-04-05	DERIVATE SUBSTITUTED AMIDINONAPHTHYLESTER
DK0764443T3 (da)	2002-10-07	Midler tl behandling af med tumorer forbundet kakeksi
DK401779A (da)	1980-03-28	Fremgangsmaade til isomerisering af 3-azabicyclo-(3.1.0) hexanderivater
DK0627419T3 (da)	2000-04-25	Optisk aktive derivater af 1-phenylpyrrolidon og fremgangsmåde til fremstilling deraf
TH919A (th)	1983-04-22	การเตรียมอนุพันธ์ 1-แอลคิล-2-อะมิโน-เททราลิน