DK0487410T3 - Endothelinantagonister. - Google Patents

Endothelinantagonister.

Info

Publication number: DK0487410T3
Authority: DK; Denmark
Prior art keywords: representing; residue; leucine; valine; image
Prior art date: 1990-11-21

Application number

DK91403118T

Other languages

Danish (da)

English (en)

Inventor

Gilles Hamon

Eve Mahe

Dung Le-Nguyen

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-21

Filing date

1991-11-20

Publication date

2000-03-27

1991-11-20 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

2000-03-27 Application granted granted Critical

2000-03-27 Publication of DK0487410T3 publication Critical patent/DK0487410T3/da

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 5
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 5
229960003136 leucine Drugs 0.000 abstract 5
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 3
229960004295 valine Drugs 0.000 abstract 3
239000004474 valine Substances 0.000 abstract 3
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 2
229960003767 alanine Drugs 0.000 abstract 2
235000004279 alanine Nutrition 0.000 abstract 2
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 2
125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 abstract 2
229960000310 isoleucine Drugs 0.000 abstract 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 2
239000004475 Arginine Substances 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
229940000635 beta-alanine Drugs 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
229960005190 phenylalanine Drugs 0.000 abstract 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Toxicology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Dental Preparations (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

DK91403118T 1990-11-21 1991-11-20 Endothelinantagonister. DK0487410T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9014498A FR2669339B1 (fr)	1990-11-21	1990-11-21	Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.

Publications (1)

Publication Number	Publication Date
DK0487410T3 true DK0487410T3 (da)	2000-03-27

Family

ID=9402414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91403118T DK0487410T3 (da)	1990-11-21	1991-11-20	Endothelinantagonister.

Country Status (10)

Country	Link
US (1)	US5510331A (de)
EP (1)	EP0487410B1 (de)
JP (1)	JP3373217B2 (de)
AT (1)	ATE183203T1 (de)
CA (1)	CA2055902A1 (de)
DE (1)	DE69131518T2 (de)
DK (1)	DK0487410T3 (de)
ES (1)	ES2135389T3 (de)
FR (1)	FR2669339B1 (de)
GR (1)	GR3031331T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6087324A (en) *	1993-06-24	2000-07-11	Takeda Chemical Industries, Ltd.	Sustained-release preparation
EP0679658A4 (de) *	1993-06-25	1997-06-04	Kyowa Hakko Kogyo Kk	Endothelinantagonisierendes peptid.
EP0698613B1 (de) *	1994-07-25	1999-03-24	Kyowa Hakko Kogyo Co., Ltd.	Endothelin-antagonisierendes Peptid
JP2002538135A (ja)	1999-03-01	2002-11-12	エランファーマシューティカルズ，インコーポレイテッド	α４β７レセプターアンタゴニストとして有用なα−アミノ酢酸誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE90108T1 (de) *	1987-10-09	1993-06-15	Takeda Chemical Industries Ltd	Vasokonstriktor-peptid.
GB8913089D0 (en) *	1989-06-07	1989-07-26	Ciba Geigy Japan Ltd	Novel endothelin derivative
WO1992002237A1 (en) *	1990-08-08	1992-02-20	The Rockefeller University	Analogs of endothelin

1990
- 1990-11-21 FR FR9014498A patent/FR2669339B1/fr not_active Expired - Fee Related
1991
- 1991-11-20 DE DE69131518T patent/DE69131518T2/de not_active Expired - Fee Related
- 1991-11-20 ES ES91403118T patent/ES2135389T3/es not_active Expired - Lifetime
- 1991-11-20 EP EP91403118A patent/EP0487410B1/de not_active Expired - Lifetime
- 1991-11-20 DK DK91403118T patent/DK0487410T3/da active
- 1991-11-20 AT AT91403118T patent/ATE183203T1/de not_active IP Right Cessation
- 1991-11-20 CA CA002055902A patent/CA2055902A1/fr not_active Abandoned
- 1991-11-20 JP JP32971791A patent/JP3373217B2/ja not_active Expired - Fee Related
1994
- 1994-10-13 US US08/322,707 patent/US5510331A/en not_active Expired - Fee Related
1999
- 1999-09-24 GR GR990402433T patent/GR3031331T3/el unknown

Also Published As

Publication number	Publication date
EP0487410B1 (de)	1999-08-11
FR2669339B1 (fr)	1995-03-03
CA2055902A1 (fr)	1992-05-22
FR2669339A1 (fr)	1992-05-22
DE69131518D1 (de)	1999-09-16
ES2135389T3 (es)	1999-11-01
JP3373217B2 (ja)	2003-02-04
US5510331A (en)	1996-04-23
EP0487410A2 (de)	1992-05-27
EP0487410A3 (en)	1992-09-30
ATE183203T1 (de)	1999-08-15
GR3031331T3 (en)	1999-12-31
DE69131518T2 (de)	2000-01-13
JPH04283600A (ja)	1992-10-08

Publication	Publication Date	Title
DK1310558T3 (da)	2007-10-08	Stabile produkter af det baktericide/permeabilitetsforögende protein og farmaceutiske sammensætninger, der indeholder disse
DK0776209T3 (da)	2008-11-24	Polynukleinsyrer og proteiner fra et porcin reproduktiv og respiratorisk syndrom-virus og anvendelser deraf
IL109585A0 (en)	1994-08-26	Peptidic ketones as interleukin-1 beta protease activity inhibitors and pharmaceutical compositions containing them
WO2000012541A3 (en)	2000-06-08	Cytotoxic peptides modified by bulky or lipophilic moieties
FI860153A0 (fi)	1986-01-13	Oligopeptider, deras mellanprodukter och foerfarande foer deras framstaellning.
ATE241014T2 (de)	2003-06-15	Hiv-2 varianten
KR910700062A (ko)	1991-03-13	마가이닌 펩타이드의 결실 동족체
HU9201470D0 (en)	1992-07-28	Process for the production of new polypeptides that show affininty towards lipoposaccharides
ES2176456T3 (es)	2002-12-01	Procedimiento de preparacion de un compuesto inhibidor del vih proteasa.
FR2647677B1 (fr)	1991-09-27	Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
ATE213499T1 (de)	2002-03-15	Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
ES2081442T3 (es)	1996-03-16	Proteasa de bacillus licheniformis.
AU2001284419A1 (en)	2002-03-22	Novel polypeptides and anti-hiv drugs containing the same
NO971621D0 (no)	1997-04-09	Keratinocyttvekstfaktoranaloger
DK0487410T3 (da)	2000-03-27	Endothelinantagonister.
DK0556124T3 (da)	1996-07-29	Hidtil ukendte peptidderivater deres fremstilling og anvendelse som lægemidler
DE3751398D1 (de)	1995-08-17	Substrat-Peptide.
DK0732339T3 (da)	2002-08-19	Peptider fra HIV-gag-proteinet, fremstilling og anvendelse deraf
IL95166A0 (en)	1991-06-10	Renin-inhibiting amino oligohydroxy derivatives
ES8401320A1 (es)	1983-12-16	"un procedimiento para preparar composiciones farmaceuticas a base de sales de teofilina y aminoacidos basicos".
ES2052447A1 (es)	1994-07-01	Peptidos hemorreguladores.
JPS5283738A (en)	1977-07-12	Novel dipeptide derivatives and their salts