DK0489767T3 - CCK-antagonister - Google Patents

CCK-antagonister

Info

Publication number
DK0489767T3
DK0489767T3 DK90912437.2T DK90912437T DK0489767T3 DK 0489767 T3 DK0489767 T3 DK 0489767T3 DK 90912437 T DK90912437 T DK 90912437T DK 0489767 T3 DK0489767 T3 DK 0489767T3
Authority
DK
Denmark
Prior art keywords
inclusive
carbon atoms
group
alkyl group
hydroxy
Prior art date
Application number
DK90912437.2T
Other languages
English (en)
Inventor
Sun Hyuk Kim
Sylviane Moreau
Original Assignee
Biomeasure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomeasure Inc filed Critical Biomeasure Inc
Application granted granted Critical
Publication of DK0489767T3 publication Critical patent/DK0489767T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK90912437.2T 1989-08-21 1990-08-20 CCK-antagonister DK0489767T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/396,567 US5010089A (en) 1988-08-12 1989-08-21 CCK antagonists and their use in treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
DK0489767T3 true DK0489767T3 (da) 1996-12-09

Family

ID=23567756

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90912437.2T DK0489767T3 (da) 1989-08-21 1990-08-20 CCK-antagonister

Country Status (13)

Country Link
US (1) US5010089A (da)
EP (1) EP0489767B1 (da)
JP (1) JPH05500049A (da)
AT (1) ATE145405T1 (da)
CA (1) CA2064897A1 (da)
DE (1) DE69029198T2 (da)
DK (1) DK0489767T3 (da)
ES (1) ES2095878T3 (da)
GR (1) GR1001001B (da)
IE (1) IE903009A1 (da)
NO (1) NO920677L (da)
PT (1) PT95059B (da)
WO (1) WO1991002719A2 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
JP3361100B2 (ja) * 1994-03-10 2003-01-07 ワーナー−ランバート・コンパニー Cck受容体アンタゴニストとしてのインドール誘導体
FI974437A7 (fi) 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogee nifosforylaasi-inhibiittoreina
MY114711A (en) 1995-06-06 2002-12-31 Pfizer Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents
DE69523182T2 (de) * 1995-06-06 2002-02-07 Pfizer Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
US4757151A (en) * 1985-11-14 1988-07-12 Warner-Lambert Company 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US4803284A (en) * 1987-08-19 1989-02-07 Centro De Investigacion Y De Estudios Avanzados Del Instituto Politecnico Nacional Processes for the preparation of 3-amino-2-(5-methoxy-1H-indol-3-yl) propionic acid monohydrate

Also Published As

Publication number Publication date
WO1991002719A2 (en) 1991-03-07
IE903009A1 (en) 1991-02-27
WO1991002719A3 (en) 1991-04-04
JPH05500049A (ja) 1993-01-14
EP0489767A4 (en) 1992-07-08
ES2095878T3 (es) 1997-03-01
DE69029198D1 (de) 1997-01-02
PT95059B (pt) 1997-12-31
EP0489767B1 (en) 1996-11-20
PT95059A (pt) 1991-05-22
US5010089A (en) 1991-04-23
NO920677D0 (no) 1992-02-20
CA2064897A1 (en) 1991-02-22
NO920677L (no) 1992-04-07
DE69029198T2 (de) 1997-04-24
EP0489767A1 (en) 1992-06-17
ATE145405T1 (de) 1996-12-15
GR1001001B (el) 1993-03-31
GR900100625A (en) 1991-12-30

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