DK0576232T3 - Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer - Google Patents

Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer

Info

Publication number
DK0576232T3
DK0576232T3 DK93304821.7T DK93304821T DK0576232T3 DK 0576232 T3 DK0576232 T3 DK 0576232T3 DK 93304821 T DK93304821 T DK 93304821T DK 0576232 T3 DK0576232 T3 DK 0576232T3
Authority
DK
Denmark
Prior art keywords
deoxy
difluoro
ribofyranosylalkyl
separation
sulfon atoms
Prior art date
Application number
DK93304821.7T
Other languages
Danish (da)
English (en)
Inventor
Ta-Sen Chou
Timothy James Mccarthy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0576232T3 publication Critical patent/DK0576232T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK93304821.7T 1992-06-22 1993-06-21 Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer DK0576232T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
DK0576232T3 true DK0576232T3 (da) 1997-07-21

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93304821.7T DK0576232T3 (da) 1992-06-22 1993-06-21 Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer

Country Status (17)

Country Link
US (1) US5256797A (2)
EP (1) EP0576232B1 (2)
JP (1) JPH0656867A (2)
KR (1) KR100302087B1 (2)
AT (1) ATE149505T1 (2)
BR (1) BR9302426A (2)
CA (1) CA2098888C (2)
CY (1) CY2091B1 (2)
DE (1) DE69308391T2 (2)
DK (1) DK0576232T3 (2)
ES (1) ES2100462T3 (2)
GR (1) GR3023060T3 (2)
HK (1) HK1006022A1 (2)
HU (1) HU217976B (2)
IL (1) IL106074A (2)
MX (1) MX9303714A (2)
TW (1) TW233300B (2)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR940000475A (ko) * 1992-06-22 1994-01-03 리로이 휘테커 알파-아노머가 풍부한 1-할로-2-데옥시-2, 2-디플루오로-d-리보푸라노실 유도체의 제조방법
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20080021797A (ko) 2000-05-26 2008-03-07 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
PL374781A1 (en) 2002-06-28 2005-10-31 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
EP1912643A2 (en) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
EP1976382B1 (en) 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
JP2009526782A (ja) * 2006-02-07 2009-07-23 ケマジス・リミテッド ゲムシタビンおよび関連中間体の製造方法
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
CA1324128C (en) * 1987-08-28 1993-11-09 Ta-Sen Chou 2', 2'-difluoronucleosides

Also Published As

Publication number Publication date
TW233300B (2) 1994-11-01
BR9302426A (pt) 1994-01-11
EP0576232A1 (en) 1993-12-29
IL106074A0 (en) 1993-10-20
IL106074A (en) 1998-02-22
DE69308391T2 (de) 1997-07-17
HU9301826D0 (en) 1993-09-28
CY2091B1 (en) 2002-04-05
EP0576232B1 (en) 1997-03-05
KR100302087B1 (ko) 2001-10-22
HU217976B (hu) 2000-05-28
HK1006022A1 (en) 1999-02-05
JPH0656867A (ja) 1994-03-01
KR940000473A (ko) 1994-01-03
CA2098888A1 (en) 1993-12-23
ES2100462T3 (es) 1997-06-16
CA2098888C (en) 2003-07-29
ATE149505T1 (de) 1997-03-15
HUT64551A (en) 1994-01-28
GR3023060T3 (en) 1997-07-30
DE69308391D1 (de) 1997-04-10
MX9303714A (es) 1994-01-31
US5256797A (en) 1993-10-26

Similar Documents

Publication Publication Date Title
DK0576232T3 (da) Fremgangsmåde til separation af 2-deoxy-2, 2-difluor-D-ribofyranosylalkylsulfonatomerer
DK0587364T3 (da) Fremgangsmåde til anomerisering af nukleosider
DZ1708A1 (fr) Procédé de préparation de combustibles hydrocarbones.
NO155789C (no) Fremgangsmaate til fremstilling av gjenstander av karbonfibre som er bundet sammen ved hjelp av harpiks.
DK41085A (da) Fremgangsmaade ved og anlaeg til detektering af fejlbehaeftede genstande, saasom beholdere
DE3578646D1 (de) Integriertes gastrennungsverfahren.
DK53087D0 (da) Fremgangsmaade til fremstilling af carbonfilm
DK0576229T3 (da) Lavtemperatur fremgangsmåde til fremstilling af alphaanomerberigede 2-deoxy-2,2-difluor-D-ribofuranosylsulfonater
ES2011810B3 (es) Dispositivo para el temple de laminas de vidrio.
DE68919170D1 (de) Hochtemperaturflammdüse für Gaschromatographie.
IT7828461A0 (it) Processo per la separazione dicomposti aromatici da miscele di idrocarburi.
DK0638068T3 (da) Fremgangsmåde til fremstilling af (S)-3-amino-1-substitueret-pyrrolidiner
DK0600536T3 (da) Fremgangsmåde til oprensning af 1,1-diflourethan
DK406187D0 (da) Apparat til traekning af glasstang
IT8522600A0 (it) Procedimento di separazione di diclorotolueni tramite adsorbimento su zeoliti.
IT8722594A0 (it) Dispositivo di frizione per il processo di temporizzazione su spolette di proiettili.
DK0462673T3 (da) Fremgangsmåde til fremstilling af benzinkomponenter
DK192890D0 (da) 24r-scumnol, fremgangsmaade til fremstilling heraf samt anvendelse af samme
ATE177090T1 (de) Glycidylderivate von 2,6-dibromo-3,5-dialkyl-4- hydroxybenzylethern
DE3568420D1 (en) Process for the pretreatment of 1,2-dichloroethane before its pyrolysis
ES1017471Y (es) Casquillo de soporte para sujetador de panel.
FR2385676B1 (2)
TR24604A (tr) Sicak,gaz halinde veya sivi vasatlardan kati madde zerrelerinin separasyonuna ma
ES270945Y (es) Soporte aislate universal para componentes semiconductores de alto voltaje.
DK93884D0 (da) Fremgangsmade til fremstilling af 1,5-dibeskyttede-1,5,10-triazadecaner, mellemprodukter derfor samt disses fremstilling