JPH0656867A - ２−デオキシ−２，２−ジフルオロ−ｄ−リボフラノシルアルキルスルホネートアノマーを分離する方法 - Google Patents

２−デオキシ−２，２−ジフルオロ−ｄ−リボフラノシルアルキルスルホネートアノマーを分離する方法

Info

Publication number
JPH0656867A
JPH0656867A JP5149152A JP14915293A JPH0656867A JP H0656867 A JPH0656867 A JP H0656867A JP 5149152 A JP5149152 A JP 5149152A JP 14915293 A JP14915293 A JP 14915293A JP H0656867 A JPH0656867 A JP H0656867A
Authority
JP
Japan
Prior art keywords
deoxy
difluoro
ribofuranosyl
benzoyl
anomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5149152A
Other languages
English (en)
Japanese (ja)
Inventor
Ta-Sen Chou
タ−セン・チョウ
Timothy J Mccarthy
ティモシー・ジェイムズ・マッカーシー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH0656867A publication Critical patent/JPH0656867A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP5149152A 1992-06-22 1993-06-21 ２−デオキシ−２，２−ジフルオロ−ｄ−リボフラノシルアルキルスルホネートアノマーを分離する方法 Pending JPH0656867A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers
US902303 1992-06-22

Publications (1)

Publication Number Publication Date
JPH0656867A true JPH0656867A (ja) 1994-03-01

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5149152A Pending JPH0656867A (ja) 1992-06-22 1993-06-21 ２−デオキシ−２，２−ジフルオロ−ｄ−リボフラノシルアルキルスルホネートアノマーを分離する方法

Country Status (16)

Country Link
US (1) US5256797A (2)
EP (1) EP0576232B1 (2)
JP (1) JPH0656867A (2)
KR (1) KR100302087B1 (2)
AT (1) ATE149505T1 (2)
BR (1) BR9302426A (2)
CA (1) CA2098888C (2)
CY (1) CY2091B1 (2)
DE (1) DE69308391T2 (2)
DK (1) DK0576232T3 (2)
ES (1) ES2100462T3 (2)
GR (1) GR3023060T3 (2)
HU (1) HU217976B (2)
IL (1) IL106074A (2)
MX (1) MX9303714A (2)
TW (1) TW233300B (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011528023A (ja) * 2008-07-15 2011-11-10 グリコム アクティエセルスカブ 結晶性炭化水素誘導体

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0576231B1 (en) * 1992-06-22 1997-05-28 Eli Lilly And Company Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2, 2-difluoro-D-ribofuranosyl derivatives
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
PL359169A1 (en) 2000-05-26 2004-08-23 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses
KR20050035194A (ko) 2002-06-28 2005-04-15 이데닉스 (케이만) 리미티드 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AU2003298658A1 (en) 2002-11-15 2004-06-15 Idenix (Cayman) Limited 2'-branched nucleosides and flaviviridae mutation
US7598373B2 (en) 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
US20060040944A1 (en) * 2004-06-23 2006-02-23 Gilles Gosselin 5-Aza-7-deazapurine derivatives for treating Flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
CA2641719A1 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
DE3856158T2 (de) * 1987-08-28 1998-08-20 Lilly Co Eli Verfahren zur Herstellung von Zwischenverbindungen verwendbar in der Herstellung von 2',2'-Difluoronucleosiden

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011528023A (ja) * 2008-07-15 2011-11-10 グリコム アクティエセルスカブ 結晶性炭化水素誘導体
US8796434B2 (en) 2008-07-15 2014-08-05 Glycom A/S Crystalline carbohydrate derivative

Also Published As

Publication number Publication date
MX9303714A (es) 1994-01-31
TW233300B (2) 1994-11-01
ATE149505T1 (de) 1997-03-15
BR9302426A (pt) 1994-01-11
CA2098888C (en) 2003-07-29
KR100302087B1 (ko) 2001-10-22
ES2100462T3 (es) 1997-06-16
HK1006022A1 (en) 1999-02-05
KR940000473A (ko) 1994-01-03
DE69308391T2 (de) 1997-07-17
DE69308391D1 (de) 1997-04-10
IL106074A (en) 1998-02-22
GR3023060T3 (en) 1997-07-30
EP0576232A1 (en) 1993-12-29
IL106074A0 (en) 1993-10-20
US5256797A (en) 1993-10-26
HU9301826D0 (en) 1993-09-28
HUT64551A (en) 1994-01-28
CA2098888A1 (en) 1993-12-23
DK0576232T3 (da) 1997-07-21
EP0576232B1 (en) 1997-03-05
CY2091B1 (en) 2002-04-05
HU217976B (hu) 2000-05-28

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