MX9303714A - Proceso para la separacion de anomeros de 2-desoxi-2,2-difluoro-d-riboforanosil alquilsulfonato. - Google Patents

Proceso para la separacion de anomeros de 2-desoxi-2,2-difluoro-d-riboforanosil alquilsulfonato.

Info

Publication number
MX9303714A
MX9303714A MX9303714A MX9303714A MX9303714A MX 9303714 A MX9303714 A MX 9303714A MX 9303714 A MX9303714 A MX 9303714A MX 9303714 A MX9303714 A MX 9303714A MX 9303714 A MX9303714 A MX 9303714A
Authority
MX
Mexico
Prior art keywords
difluoro
riboforanosil
anomeres
alquilsulfonato
desoxi
Prior art date
Application number
MX9303714A
Other languages
English (en)
Spanish (es)
Inventor
Ta-Sen Chou
Timothy James Mccarthy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX9303714A publication Critical patent/MX9303714A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX9303714A 1992-06-22 1993-06-21 Proceso para la separacion de anomeros de 2-desoxi-2,2-difluoro-d-riboforanosil alquilsulfonato. MX9303714A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
MX9303714A true MX9303714A (es) 1994-01-31

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9303714A MX9303714A (es) 1992-06-22 1993-06-21 Proceso para la separacion de anomeros de 2-desoxi-2,2-difluoro-d-riboforanosil alquilsulfonato.

Country Status (17)

Country Link
US (1) US5256797A (2)
EP (1) EP0576232B1 (2)
JP (1) JPH0656867A (2)
KR (1) KR100302087B1 (2)
AT (1) ATE149505T1 (2)
BR (1) BR9302426A (2)
CA (1) CA2098888C (2)
CY (1) CY2091B1 (2)
DE (1) DE69308391T2 (2)
DK (1) DK0576232T3 (2)
ES (1) ES2100462T3 (2)
GR (1) GR3023060T3 (2)
HK (1) HK1006022A1 (2)
HU (1) HU217976B (2)
IL (1) IL106074A (2)
MX (1) MX9303714A (2)
TW (1) TW233300B (2)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR940000475A (ko) * 1992-06-22 1994-01-03 리로이 휘테커 알파-아노머가 풍부한 1-할로-2-데옥시-2, 2-디플루오로-d-리보푸라노실 유도체의 제조방법
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20080021797A (ko) 2000-05-26 2008-03-07 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
PL374781A1 (en) 2002-06-28 2005-10-31 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
EP1912643A2 (en) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
EP1976382B1 (en) 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
JP2009526782A (ja) * 2006-02-07 2009-07-23 ケマジス・リミテッド ゲムシタビンおよび関連中間体の製造方法
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
CA1324128C (en) * 1987-08-28 1993-11-09 Ta-Sen Chou 2', 2'-difluoronucleosides

Also Published As

Publication number Publication date
TW233300B (2) 1994-11-01
BR9302426A (pt) 1994-01-11
EP0576232A1 (en) 1993-12-29
IL106074A0 (en) 1993-10-20
IL106074A (en) 1998-02-22
DE69308391T2 (de) 1997-07-17
HU9301826D0 (en) 1993-09-28
CY2091B1 (en) 2002-04-05
EP0576232B1 (en) 1997-03-05
KR100302087B1 (ko) 2001-10-22
HU217976B (hu) 2000-05-28
HK1006022A1 (en) 1999-02-05
JPH0656867A (ja) 1994-03-01
KR940000473A (ko) 1994-01-03
CA2098888A1 (en) 1993-12-23
ES2100462T3 (es) 1997-06-16
CA2098888C (en) 2003-07-29
DK0576232T3 (da) 1997-07-21
ATE149505T1 (de) 1997-03-15
HUT64551A (en) 1994-01-28
GR3023060T3 (en) 1997-07-30
DE69308391D1 (de) 1997-04-10
US5256797A (en) 1993-10-26

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