TW233300B - - Google Patents

Info

Publication number: TW233300B
Authority: TW; Taiwan
Prior art keywords: anomeric mixture; countersolvent; ribofuranosyl; alkylsulfonates; deoxy
Prior art date: 1992-06-22

Application number

TW082104993A

Other languages

English (en)

Chinese (zh)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-22

Filing date

1993-06-22

Publication date

1994-11-01

1993-06-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-11-01 Application granted granted Critical

1994-11-01 Publication of TW233300B publication Critical patent/TW233300B/zh

Links

239000000203 mixture Substances 0.000 abstract 2
229940045714 alkyl sulfonate alkylating agent Drugs 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

TW082104993A 1992-06-22 1993-06-22 TW233300B (2)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/902,303 US5256797A (en)	1992-06-22	1992-06-22	Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number	Publication Date
TW233300B true TW233300B (2)	1994-11-01

Family

ID=25415647

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW082104993A TW233300B (2)	1992-06-22	1993-06-22

Country Status (17)

Country	Link
US (1)	US5256797A (2)
EP (1)	EP0576232B1 (2)
JP (1)	JPH0656867A (2)
KR (1)	KR100302087B1 (2)
AT (1)	ATE149505T1 (2)
BR (1)	BR9302426A (2)
CA (1)	CA2098888C (2)
CY (1)	CY2091B1 (2)
DE (1)	DE69308391T2 (2)
DK (1)	DK0576232T3 (2)
ES (1)	ES2100462T3 (2)
GR (1)	GR3023060T3 (2)
HK (1)	HK1006022A1 (2)
HU (1)	HU217976B (2)
IL (1)	IL106074A (2)
MX (1)	MX9303714A (2)
TW (1)	TW233300B (2)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR940000475A (ko) *	1992-06-22	1994-01-03	리로이 휘테커	알파-아노머가 풍부한 1-할로-2-데옥시-2, 2-디플루오로-d-리보푸라노실 유도체의 제조방법
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
KR20080021797A (ko)	2000-05-26	2008-03-07	이데닉스(케이만)리미티드	플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
PL374781A1 (en)	2002-06-28	2005-10-31	Idenix (Cayman) Limited	2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
HUE033832T2 (en)	2002-11-15	2018-01-29	Idenix Pharmaceuticals Llc	2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
RU2005121904A (ru)	2002-12-12	2006-01-20	Айденикс (Кайман) Лимитед (Ky)	Способ получения 2`-разветвленных нуклеозидов
EP1912643A2 (en) *	2004-06-23	2008-04-23	Idenix (Cayman) Limited	5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) *	2004-07-01	2007-05-08	Shenzhen Hande Technology Co., Ltd.	Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) *	2005-07-20	2007-02-15	Pharmacon Forschung & Beratung Gmbh	Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
EP1976382B1 (en)	2005-12-23	2013-04-24	IDENIX Pharmaceuticals, Inc.	Process for preparing a synthetic intermediate for preparation of branched nucleosides
JP2009526782A (ja) *	2006-02-07	2009-07-23	ケマジス・リミテッド	ゲムシタビンおよび関連中間体の製造方法
US20070249823A1 (en) *	2006-04-20	2007-10-25	Chemagis Ltd.	Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) *	2007-04-23	2008-10-23	Chemagis Ltd.	Gemcitabine production process
GB0812895D0 (en)	2008-07-15	2008-08-20	Glycom As	Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
US4965374A (en) *	1987-08-28	1990-10-23	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
CA1324128C (en) *	1987-08-28	1993-11-09	Ta-Sen Chou	2', 2'-difluoronucleosides

1992
- 1992-06-22 US US07/902,303 patent/US5256797A/en not_active Expired - Lifetime
1993
- 1993-06-21 EP EP93304821A patent/EP0576232B1/en not_active Expired - Lifetime
- 1993-06-21 AT AT93304821T patent/ATE149505T1/de active
- 1993-06-21 DK DK93304821.7T patent/DK0576232T3/da active
- 1993-06-21 CA CA002098888A patent/CA2098888C/en not_active Expired - Lifetime
- 1993-06-21 JP JP5149152A patent/JPH0656867A/ja active Pending
- 1993-06-21 IL IL106074A patent/IL106074A/en not_active IP Right Cessation
- 1993-06-21 ES ES93304821T patent/ES2100462T3/es not_active Expired - Lifetime
- 1993-06-21 MX MX9303714A patent/MX9303714A/es unknown
- 1993-06-21 KR KR1019930011306A patent/KR100302087B1/ko not_active Expired - Fee Related
- 1993-06-21 DE DE69308391T patent/DE69308391T2/de not_active Expired - Lifetime
- 1993-06-21 BR BR9302426A patent/BR9302426A/pt not_active Application Discontinuation
- 1993-06-21 HU HU9301826A patent/HU217976B/hu not_active IP Right Cessation
- 1993-06-22 TW TW082104993A patent/TW233300B/zh not_active IP Right Cessation
1997
- 1997-04-08 GR GR970400728T patent/GR3023060T3/el unknown
1998
- 1998-06-12 HK HK98105211A patent/HK1006022A1/en not_active IP Right Cessation
- 1998-06-18 CY CY9800012A patent/CY2091B1/xx unknown

Also Published As

Publication number	Publication date
BR9302426A (pt)	1994-01-11
EP0576232A1 (en)	1993-12-29
IL106074A0 (en)	1993-10-20
IL106074A (en)	1998-02-22
DE69308391T2 (de)	1997-07-17
HU9301826D0 (en)	1993-09-28
CY2091B1 (en)	2002-04-05
EP0576232B1 (en)	1997-03-05
KR100302087B1 (ko)	2001-10-22
HU217976B (hu)	2000-05-28
HK1006022A1 (en)	1999-02-05
JPH0656867A (ja)	1994-03-01
KR940000473A (ko)	1994-01-03
CA2098888A1 (en)	1993-12-23
ES2100462T3 (es)	1997-06-16
CA2098888C (en)	2003-07-29
DK0576232T3 (da)	1997-07-21
ATE149505T1 (de)	1997-03-15
HUT64551A (en)	1994-01-28
GR3023060T3 (en)	1997-07-30
DE69308391D1 (de)	1997-04-10
MX9303714A (es)	1994-01-31
US5256797A (en)	1993-10-26

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Legal Events

Date	Code	Title	Description
2012-08-01	MM4A	Annulment or lapse of patent due to non-payment of fees