DK0595111T4 - Carbazolonderivater og fremgangsmåde til deres fremstilling - Google Patents

Carbazolonderivater og fremgangsmåde til deres fremstilling

Info

Publication number: DK0595111T4
Authority: DK; Denmark
Prior art keywords: formula; methyl; group; chem; preparation
Prior art date: 1992-10-14

Application number

DK93116542T

Other languages

Danish (da)

English (en)

Other versions

DK0595111T3 (da

Inventor

Peter Dr Bod

Kalman Dr Harsanyi

Ferenc Dr Trischler

Eva Fekecs

Attila Csehi

Bela Dr Hegedus

Nee Donat Eva Mersich

Nee Komlosi Gyoergyi Szabo

Nee Sziki Erika Horvath

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-14

Filing date

1993-10-13

Publication date

2001-10-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26318102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0595111(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-10-14 Priority claimed from HU9203223A external-priority patent/HU212785B/hu

1992-10-14 Priority claimed from HU9203222A external-priority patent/HU212934B/hu

1993-10-13 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1998-04-14 Application granted granted Critical

1998-04-14 Publication of DK0595111T3 publication Critical patent/DK0595111T3/da

2001-10-22 Publication of DK0595111T4 publication Critical patent/DK0595111T4/da

Links

AMLYRCOEFHJSFS-UHFFFAOYSA-N carbazol-1-one Chemical class C1=CC=C2C3=CC=CC(=O)C3=NC2=C1 AMLYRCOEFHJSFS-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
-1 2-methyl-1H-imidazol-1-yl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229960005343 ondansetron Drugs 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Otolaryngology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Photoreceptors In Electrophotography (AREA)

DK93116542T 1992-10-14 1993-10-13 Carbazolonderivater og fremgangsmåde til deres fremstilling DK0595111T4 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9203223A HU212785B (en)	1992-10-14	1992-10-14	Process for producing of a carbazolone derivative
HU9203222A HU212934B (en)	1992-10-14	1992-10-14	Process for producing novel alkoxalylated carbazolone derivatives

Publications (2)

Publication Number	Publication Date
DK0595111T3 DK0595111T3 (da)	1998-04-14
DK0595111T4 true DK0595111T4 (da)	2001-10-22

Family

ID=26318102

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93116542T DK0595111T4 (da)	1992-10-14	1993-10-13	Carbazolonderivater og fremgangsmåde til deres fremstilling

Country Status (20)

Country	Link
US (2)	US5416221A (fr)
EP (1)	EP0595111B2 (fr)
JP (1)	JP3378315B2 (fr)
KR (1)	KR100289912B1 (fr)
CN (2)	CN1052979C (fr)
AT (1)	ATE157973T1 (fr)
CA (1)	CA2106642C (fr)
CZ (1)	CZ284223B6 (fr)
DE (1)	DE69313771T3 (fr)
DK (1)	DK0595111T4 (fr)
EE (1)	EE03071B1 (fr)
ES (1)	ES2106936T5 (fr)
GR (1)	GR3025599T3 (fr)
HR (1)	HRP931292B1 (fr)
PL (2)	PL174173B1 (fr)
RO (1)	RO115799B1 (fr)
RU (1)	RU2119914C1 (fr)
SI (1)	SI9300537B (fr)
SK (1)	SK281243B6 (fr)
UA (2)	UA26893C2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU226135B1 (en) *	2000-03-28	2008-05-28	Richter Gedeon Nyrt	Intermediate of ondansetron and process for its production
KR100368895B1 (ko) *	2000-03-30	2003-01-24	하나제약 주식회사	1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법
EP1339707A2 (fr) *	2000-10-30	2003-09-03	Teva Pharmaceutical Industries Ltd.	Nouvelles formes de cristaux et solvates de chlorhydrate d'ondansetron et leurs procedes de preparation
EP1207160A1 (fr) *	2000-11-20	2002-05-22	Hanmi Pharm. Co., Ltd.	Procédé de préparation de la 1,2,3,9-tétrahydro-9-méthyl-3-((2-méthyl-1H-imidazol-1-yl)-méthyl)-4H-carbazol-4-one
RU2207340C2 (ru) *	2001-08-10	2003-06-27	Ципла Лтд.	Способ получения 1,2,3,9-тетрагидро-9-метил-3-[(2-метил-1н-имидазол-1-ил)метил]-4н-карбазол -4-она или его фармацевтически приемлемых солей
PT1499623E (pt) *	2002-04-29	2007-08-10	Teva Gyogyszergyar Zartkoeruee	''processo papa a preparação de 1, 2, 3, 9-tetra-hidro-9-metil-3- [(2-metil-1h-imidazol-1-il) metil] -4h-carbazol-4-ona''
MXPA04010845A (es) *	2002-04-30	2005-01-25	Biogal Gyogyszergyar	Formas cristalinas novedosas de ondansetron, procesos para su preparacion, composiciones farmaceuticas que contienen las formas novedosas y metodos para tratar las nauseas utilizando las mismas.
US20050131045A1 (en) *	2002-04-30	2005-06-16	Judith Aronhime	Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
FI6164U1 (fi) *	2003-01-09	2004-03-15	Synthon Bv	Ondansetronmuotoja
KR20060017545A (ko) *	2003-06-10	2006-02-23	스미스클라인 비참 코포레이션	테트라하이드로카르바졸 유도체 및 이들의 약제학적 용도
US7390503B1 (en)	2003-08-22	2008-06-24	Barr Laboratories, Inc.	Ondansetron orally disintegrating tablets
JP2008505965A (ja) *	2004-07-12	2008-02-28	カディラヘルスケアリミティド	カンナビノイド受容体修飾因子としての三環式ピラゾール誘導体
US7696356B2 (en) *	2004-08-17	2010-04-13	Taro Pharmaceutical Industries Limited	Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (fr) *	2004-10-26	2006-05-04	Ipca Laboratories Limited	Procede monotope de preparation de l'agent antiemetique 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl-1h-imidazole-1-yl)methyl]-4h-carbazol-4-one
ES2369782T3 (es) *	2004-12-27	2011-12-05	Actelion Pharmaceuticals Ltd.	Derivados de 2,3,4,9-tetrahidro-1h-carbazol como antagonistas del receptor crth2.
CN115677561B (zh) *	2022-11-01	2024-04-05	常州兰陵制药有限公司	一种1,2,3,4-四氢-9-甲基-4h-咔唑酮及其合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3579534A (en) *	1969-05-09	1971-05-18	American Cyanamid Co	Tetrahydrocarbazolecarboxylates
LU88268I2 (fr) *	1984-01-25	1994-02-03
CN1011237B (zh) *	1984-01-25	1991-01-16	格拉克索公司	1，2，3，9-四氢-3-[(2-甲基-1h-咪唑-1-基)甲基]-4h-咔唑-4-酮类和其盐以及溶剂化物的制备
GB8518743D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8518742D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8617994D0 (en) *	1986-07-23	1986-08-28	Glaxo Group Ltd	Heterocyclic compounds
GB8628473D0 (en) *	1986-11-28	1987-01-07	Glaxo Group Ltd	Chemical compounds
JPH01258673A (ja) *	1987-10-22	1989-10-16	Glaxo Group Ltd	ケトン誘導体

1993
- 1993-09-21 CA CA002106642A patent/CA2106642C/fr not_active Expired - Fee Related
- 1993-10-08 HR HR3223/92A patent/HRP931292B1/xx not_active IP Right Cessation
- 1993-10-11 UA UA93002172A patent/UA26893C2/uk unknown
- 1993-10-13 US US08/135,407 patent/US5416221A/en not_active Expired - Lifetime
- 1993-10-13 SI SI9300537A patent/SI9300537B/sl not_active IP Right Cessation
- 1993-10-13 PL PL93300685A patent/PL174173B1/pl not_active IP Right Cessation
- 1993-10-13 ES ES93116542T patent/ES2106936T5/es not_active Expired - Lifetime
- 1993-10-13 DE DE69313771T patent/DE69313771T3/de not_active Expired - Fee Related
- 1993-10-13 CZ CZ932156A patent/CZ284223B6/cs not_active IP Right Cessation
- 1993-10-13 AT AT93116542T patent/ATE157973T1/de not_active IP Right Cessation
- 1993-10-13 KR KR1019930021223A patent/KR100289912B1/ko not_active Expired - Fee Related
- 1993-10-13 DK DK93116542T patent/DK0595111T4/da active
- 1993-10-13 RU RU93049416A patent/RU2119914C1/ru not_active IP Right Cessation
- 1993-10-13 PL PL93324329A patent/PL174526B1/pl not_active IP Right Cessation
- 1993-10-13 SK SK1110-93A patent/SK281243B6/sk unknown
- 1993-10-13 JP JP25588093A patent/JP3378315B2/ja not_active Expired - Fee Related
- 1993-10-13 RO RO93-01370A patent/RO115799B1/ro unknown
- 1993-10-13 EP EP93116542A patent/EP0595111B2/fr not_active Expired - Lifetime
- 1993-10-13 CN CN93119192A patent/CN1052979C/zh not_active Expired - Fee Related
1994
- 1994-07-19 EE EE9400092A patent/EE03071B1/xx not_active IP Right Cessation
- 1994-11-25 US US08/344,871 patent/US5478949A/en not_active Expired - Lifetime
1997
- 1997-12-04 GR GR970403244T patent/GR3025599T3/el unknown
1999
- 1999-05-11 CN CN99106445A patent/CN1083430C/zh not_active Expired - Fee Related
- 1999-05-24 UA UA99052847A patent/UA27022C2/uk unknown

Also Published As

Publication number	Publication date
ATE157973T1 (de)	1997-09-15
GR3025599T3 (en)	1998-03-31
HRP931292A2 (en)	1994-12-31
JP3378315B2 (ja)	2003-02-17
RU2119914C1 (ru)	1998-10-10
PL174173B1 (pl)	1998-06-30
CN1083430C (zh)	2002-04-24
PL300685A1 (en)	1994-04-18
EP0595111B2 (fr)	2001-08-16
US5416221A (en)	1995-05-16
KR100289912B1 (ko)	2001-09-17
SI9300537B (sl)	2003-02-28
UA26893C2 (uk)	1999-12-29
EP0595111B1 (fr)	1997-09-10
CN1235967A (zh)	1999-11-24
SK281243B6 (sk)	2001-01-18
EE03071B1 (et)	1998-02-16
CA2106642A1 (fr)	1994-04-15
DE69313771T3 (de)	2002-04-18
CN1089941A (zh)	1994-07-27
DE69313771D1 (de)	1997-10-16
DK0595111T3 (da)	1998-04-14
CZ215693A3 (en)	1994-05-18
SI9300537A (en)	1994-06-30
HRP931292B1 (en)	1999-08-31
DE69313771T2 (de)	1998-02-12
CN1052979C (zh)	2000-05-31
KR940009152A (ko)	1994-05-20
JPH06293734A (ja)	1994-10-21
ES2106936T5 (es)	2001-12-16
EP0595111A1 (fr)	1994-05-04
CA2106642C (fr)	2005-08-16
RO115799B1 (ro)	2000-06-30
SK111093A3 (en)	1994-11-09
ES2106936T3 (es)	1997-11-16
US5478949A (en)	1995-12-26
UA27022C2 (uk)	2000-02-28
PL174526B1 (pl)	1998-08-31
CZ284223B6 (cs)	1998-09-16

Publication	Publication Date	Title
DK0595111T4 (da)	2001-10-22	Carbazolonderivater og fremgangsmåde til deres fremstilling
HUT57722A (en)	1991-12-30	Process for producing azaspiran derivatives and pharmaceutical compositions comprising such compounds
CA2157117A1 (fr)	1994-09-15	Derives spirocycliques de la piperidine
IL101012A0 (en)	1992-11-15	Pyranyl cyanoguanadine derivatives,processes for the preparation thereof and cardioplegic solution containing the same
DK0625147T3 (da)	1996-11-11	Fremgangsmåde til fremstilling af taxanderivater
AU1120095A (en)	1995-06-27	Novel imidazole derivative and process for producing the same
DK0646570T3 (da)	1998-10-26	Fremgansmåde til fremstilling af lignanforbindelser
PL309874A1 (en)	1996-02-05	Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
NO172577C (no)	1993-08-11	Fremgangsmaate og mellomprodukter ved fremstilling av substituerte indolinonderivater
AU628521B2 (en)	1992-09-17	Improvements in or relating to organic compounds
DK0503453T3 (da)	2001-07-16	Fremgangsmåde til fremstilling af cephalosporiner og mellemprodukter i denne fremgangsmåde
HU9200172D0 (en)	1992-04-28	Substituted 1,2,3,4-tetrahydro-cyclopenta/b/indole-and 1,2,3,3a,4,8a-hexahydro-cyclopenta/b/indole derivatives, their intermediate products, process for their production and medical preparations containing them
MY109069A (en)	1996-11-30	Fungicidal derivatives of 2-alkoxy-2-imidazolin-5-ones
CA2275253A1 (fr)	1998-06-25	Procede pour la preparation de 3-hydroxypyrazols n-substitues
DK0811603T3 (da)	2002-12-16	Aminotetralonderivater og fremgangsmåder til fremstilling af samme
DK0613896T3 (da)	1999-04-26	Fremgangsmåde til fremstilling af sulfonylurinstofderivater
DK0841328T3 (da)	2001-10-22	Fremgangsmåde til fremstilling af 4-amino-1,2,4-triazoler
DK0842924T3 (da)	2003-12-08	Pyridine intermediates, useful in the synthesis ofbeta-adrenergic receptor agonists
CA2027542A1 (fr)	1990-08-24	Enaminocetones cycliques absorbant les uv
NZ332245A (en)	2000-03-27	Substituted benzo-oxazolol carboxylic acid derivatives, process for their production and medicaments containing them
AU2639999A (en)	1999-09-15	Intermediate compounds in the synthesis of the a ring moiety of 2-substituted vitamin d derivatives
ZA924888B (en)	1993-04-28	Process for the synthesis of enantiomers of 3-aminochroman compounds
EP0294828A3 (en)	1990-05-09	Mitomycin analogs, a process for preparing them and pharmaceutical compositions
ATE139767T1 (de)	1996-07-15	Verfahren zur herstellung 5-pyrazolomerkaptan- derivate und dessen zwischenprodukte
ES8502096A1 (es)	1984-12-16	Un procedimiento para la preparacion de 4-amino-1,2-hidro- carbilpirazolidinas