EE03071B1 - Karbasolooni derivaadid ja nende saamise protsess - Google Patents

Karbasolooni derivaadid ja nende saamise protsess

Info

Publication number: EE03071B1
Authority: EE; Estonia
Prior art keywords: formula; methyl; group; chem; production process
Prior art date: 1992-10-14

Application number

EE9400092A

Other languages

English (en)

Estonian (et)

Inventor

Bod P�ter

Hars�nyi K�lm�n

Trischler Ferenc

Fekecs Va

Csehi Attila

Heged�s B�la

Mersich n�e Don�t �va

Szab� n�e Koml�si Gy�rgyi

Horv�th n�e Sziki Erika

Original Assignee

Richter Gedeon Vegy�Szeti Gy�R Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-14

Filing date

1994-07-19

Publication date

1998-02-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26318102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03071(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-10-14 Priority claimed from HU9203222A external-priority patent/HU212934B/hu

1992-10-14 Priority claimed from HU9203223A external-priority patent/HU212785B/hu

1994-07-19 Application filed by Richter Gedeon Vegy�Szeti Gy�R Rt. filed Critical Richter Gedeon Vegy�Szeti Gy�R Rt.

1998-02-16 Publication of EE03071B1 publication Critical patent/EE03071B1/xx

Links

AMLYRCOEFHJSFS-UHFFFAOYSA-N carbazol-1-one Chemical class C1=CC=C2C3=CC=CC(=O)C3=NC2=C1 AMLYRCOEFHJSFS-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
-1 2-methyl-1H-imidazol-1-yl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229960005343 ondansetron Drugs 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Photoreceptors In Electrophotography (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

EE9400092A 1992-10-14 1994-07-19 Karbasolooni derivaadid ja nende saamise protsess EE03071B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9203222A HU212934B (en)	1992-10-14	1992-10-14	Process for producing novel alkoxalylated carbazolone derivatives
HU9203223A HU212785B (en)	1992-10-14	1992-10-14	Process for producing of a carbazolone derivative

Publications (1)

Publication Number	Publication Date
EE03071B1 true EE03071B1 (et)	1998-02-16

Family

ID=26318102

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9400092A EE03071B1 (et)	1992-10-14	1994-07-19	Karbasolooni derivaadid ja nende saamise protsess

Country Status (20)

Country	Link
US (2)	US5416221A (fr)
EP (1)	EP0595111B2 (fr)
JP (1)	JP3378315B2 (fr)
KR (1)	KR100289912B1 (fr)
CN (2)	CN1052979C (fr)
AT (1)	ATE157973T1 (fr)
CA (1)	CA2106642C (fr)
CZ (1)	CZ284223B6 (fr)
DE (1)	DE69313771T3 (fr)
DK (1)	DK0595111T4 (fr)
EE (1)	EE03071B1 (fr)
ES (1)	ES2106936T5 (fr)
GR (1)	GR3025599T3 (fr)
HR (1)	HRP931292B1 (fr)
PL (2)	PL174173B1 (fr)
RO (1)	RO115799B1 (fr)
RU (1)	RU2119914C1 (fr)
SI (1)	SI9300537B (fr)
SK (1)	SK281243B6 (fr)
UA (2)	UA26893C2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU226135B1 (en) *	2000-03-28	2008-05-28	Richter Gedeon Nyrt	Intermediate of ondansetron and process for its production
KR100368895B1 (ko) *	2000-03-30	2003-01-24	하나제약 주식회사	1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법
SK6182003A3 (en) *	2000-10-30	2004-03-02	Teva Pharma	Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
EP1207160A1 (fr) *	2000-11-20	2002-05-22	Hanmi Pharm. Co., Ltd.	Procédé de préparation de la 1,2,3,9-tétrahydro-9-méthyl-3-((2-méthyl-1H-imidazol-1-yl)-méthyl)-4H-carbazol-4-one
RU2207340C2 (ru) *	2001-08-10	2003-06-27	Ципла Лтд.	Способ получения 1,2,3,9-тетрагидро-9-метил-3-[(2-метил-1н-имидазол-1-ил)метил]-4н-карбазол -4-она или его фармацевтически приемлемых солей
ATE364611T1 (de) *	2002-04-29	2007-07-15	Teva Gyogyszergyar Zartkoeruee	Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on
US20050131045A1 (en) *	2002-04-30	2005-06-16	Judith Aronhime	Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
HRP20041136A2 (en) *	2002-04-30	2005-04-30	Teva Gy�gyszergy�r R�szv�nyt�rsas�g	Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them
FI6164U1 (fi) *	2003-01-09	2004-03-15	Synthon Bv	Ondansetronmuotoja
EP1654228B1 (fr) *	2003-06-10	2008-10-22	Smithkline Beecham Corporation	Derives de tetrahydrocarbazole et leur utilisation pharmaceutique
US7390503B1 (en)	2003-08-22	2008-06-24	Barr Laboratories, Inc.	Ondansetron orally disintegrating tablets
CA2586011C (fr) *	2004-07-12	2011-07-19	Cadila Healthcare Limited	Derives tricycliques de la pyrazole en tant que modulateurs de recepteurs cannabinoides
US7696356B2 (en) *	2004-08-17	2010-04-13	Taro Pharmaceutical Industries Limited	Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (fr) *	2004-10-26	2006-05-04	Ipca Laboratories Limited	Procede monotope de preparation de l'agent antiemetique 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl-1h-imidazole-1-yl)methyl]-4h-carbazol-4-one
KR101329903B1 (ko) *	2004-12-27	2013-11-14	액테리온 파마슈티칼 리미티드	Ｃｒｔｈ2 수용체 길항제로서의2,3,4,9-테트라하이드로-1ｈ-카르바졸유도체
CN115677561B (zh) *	2022-11-01	2024-04-05	常州兰陵制药有限公司	一种1,2,3,4-四氢-9-甲基-4h-咔唑酮及其合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3579534A (en) *	1969-05-09	1971-05-18	American Cyanamid Co	Tetrahydrocarbazolecarboxylates
PH22672A (en) *	1984-01-25	1988-11-14	Glaxo Group Ltd	Imidazolylmethyltetrahydrocarbazolone derivatives, composition and method of use thereof
CN1011237B (zh) *	1984-01-25	1991-01-16	格拉克索公司	1，2，3，9-四氢-3-[(2-甲基-1h-咪唑-1-基)甲基]-4h-咔唑-4-酮类和其盐以及溶剂化物的制备
GB8518742D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8518743D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8617994D0 (en) *	1986-07-23	1986-08-28	Glaxo Group Ltd	Heterocyclic compounds
GB8628473D0 (en) *	1986-11-28	1987-01-07	Glaxo Group Ltd	Chemical compounds
EP0317088A1 (fr) *	1987-10-22	1989-05-24	Glaxo Group Limited	Dérivés cétoniques

1993
- 1993-09-21 CA CA002106642A patent/CA2106642C/fr not_active Expired - Fee Related
- 1993-10-08 HR HR3223/92A patent/HRP931292B1/xx not_active IP Right Cessation
- 1993-10-11 UA UA93002172A patent/UA26893C2/uk unknown
- 1993-10-13 PL PL93300685A patent/PL174173B1/pl not_active IP Right Cessation
- 1993-10-13 ES ES93116542T patent/ES2106936T5/es not_active Expired - Lifetime
- 1993-10-13 EP EP93116542A patent/EP0595111B2/fr not_active Expired - Lifetime
- 1993-10-13 DK DK93116542T patent/DK0595111T4/da active
- 1993-10-13 US US08/135,407 patent/US5416221A/en not_active Expired - Lifetime
- 1993-10-13 RU RU93049416A patent/RU2119914C1/ru not_active IP Right Cessation
- 1993-10-13 SK SK1110-93A patent/SK281243B6/sk unknown
- 1993-10-13 CZ CZ932156A patent/CZ284223B6/cs not_active IP Right Cessation
- 1993-10-13 RO RO93-01370A patent/RO115799B1/ro unknown
- 1993-10-13 AT AT93116542T patent/ATE157973T1/de not_active IP Right Cessation
- 1993-10-13 PL PL93324329A patent/PL174526B1/pl not_active IP Right Cessation
- 1993-10-13 JP JP25588093A patent/JP3378315B2/ja not_active Expired - Fee Related
- 1993-10-13 KR KR1019930021223A patent/KR100289912B1/ko not_active Expired - Fee Related
- 1993-10-13 DE DE69313771T patent/DE69313771T3/de not_active Expired - Fee Related
- 1993-10-13 CN CN93119192A patent/CN1052979C/zh not_active Expired - Fee Related
- 1993-10-13 SI SI9300537A patent/SI9300537B/sl not_active IP Right Cessation
1994
- 1994-07-19 EE EE9400092A patent/EE03071B1/xx not_active IP Right Cessation
- 1994-11-25 US US08/344,871 patent/US5478949A/en not_active Expired - Lifetime
1997
- 1997-12-04 GR GR970403244T patent/GR3025599T3/el unknown
1999
- 1999-05-11 CN CN99106445A patent/CN1083430C/zh not_active Expired - Fee Related
- 1999-05-24 UA UA99052847A patent/UA27022C2/uk unknown

Also Published As

Publication number	Publication date
JP3378315B2 (ja)	2003-02-17
UA27022C2 (uk)	2000-02-28
US5478949A (en)	1995-12-26
KR940009152A (ko)	1994-05-20
CN1052979C (zh)	2000-05-31
HRP931292B1 (en)	1999-08-31
ES2106936T3 (es)	1997-11-16
CZ215693A3 (en)	1994-05-18
CA2106642A1 (fr)	1994-04-15
EP0595111A1 (fr)	1994-05-04
PL300685A1 (en)	1994-04-18
CA2106642C (fr)	2005-08-16
RO115799B1 (ro)	2000-06-30
PL174173B1 (pl)	1998-06-30
DE69313771T2 (de)	1998-02-12
DE69313771D1 (de)	1997-10-16
DK0595111T4 (da)	2001-10-22
GR3025599T3 (en)	1998-03-31
DE69313771T3 (de)	2002-04-18
SK281243B6 (sk)	2001-01-18
SK111093A3 (en)	1994-11-09
JPH06293734A (ja)	1994-10-21
KR100289912B1 (ko)	2001-09-17
PL174526B1 (pl)	1998-08-31
US5416221A (en)	1995-05-16
DK0595111T3 (da)	1998-04-14
CZ284223B6 (cs)	1998-09-16
RU2119914C1 (ru)	1998-10-10
CN1235967A (zh)	1999-11-24
SI9300537A (en)	1994-06-30
EP0595111B2 (fr)	2001-08-16
EP0595111B1 (fr)	1997-09-10
UA26893C2 (uk)	1999-12-29
SI9300537B (sl)	2003-02-28
CN1083430C (zh)	2002-04-24
HRP931292A2 (en)	1994-12-31
ES2106936T5 (es)	2001-12-16
CN1089941A (zh)	1994-07-27
ATE157973T1 (de)	1997-09-15

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2010-04-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20090719

Publication	Publication Date	Title
ATE157973T1 (de)	1997-09-15	Carbazolon - derivate und verfahren zu ihrer herstellung
HUT57722A (en)	1991-12-30	Process for producing azaspiran derivatives and pharmaceutical compositions comprising such compounds
HUT47550A (en)	1989-03-28	Process for producing tetrazole derivatives
HUT68057A (en)	1995-05-29	2-[1-(1,3-thiazolin-2-yl)-azetidin-3-yl]-thio-carbapeneme derivatives, pharmaceutical compositions containing them and process for their production
DK0625147T3 (da)	1996-11-11	Fremgangsmåde til fremstilling af taxanderivater
AU1120095A (en)	1995-06-27	Novel imidazole derivative and process for producing the same
DE69226815D1 (de)	1998-10-08	1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika
PL309874A1 (en)	1996-02-05	Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
HUT59378A (en)	1992-05-28	Process for producing urea derivatives and pharmaceutical compositions comprising such compounds
DK0597423T3 (da)	2002-05-21	Azetidinonforbindelse og fremgangsmåde til fremstilling deraf
HU9200172D0 (en)	1992-04-28	Substituted 1,2,3,4-tetrahydro-cyclopenta/b/indole-and 1,2,3,3a,4,8a-hexahydro-cyclopenta/b/indole derivatives, their intermediate products, process for their production and medical preparations containing them
MY105538A (en)	1994-10-31	Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
DE3781879D1 (de)	1992-10-29	Anthracyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE171942T1 (de)	1998-10-15	1-piperazinyl-2-butene und 2-butyne, zwischenverbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE168371T1 (de)	1998-08-15	5-amino-5,6,7,8-tetrahydrochinoline und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE247641T1 (de)	2003-09-15	Pyridin-zwischenprodukte, verwendbar zur herstellung von beta-adrenergischen rezeptor- agonisten
DE69204480D1 (de)	1995-10-12	Anilinderivate und Verfahren zu ihrer Herstellung.
ATE151422T1 (de)	1997-04-15	8-azabicyclo(3.2.1>octylalkylthiazolidinone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3777464D1 (de)	1992-04-23	Fluorine enthaltende vitamin-d3-derivate und verfahren zu ihrer herstellung.
NZ332245A (en)	2000-03-27	Substituted benzo-oxazolol carboxylic acid derivatives, process for their production and medicaments containing them
ATE52510T1 (de)	1990-05-15	Benzo(c>-1,5-naphthyridine, ein verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
ES2074770T3 (es)	1995-09-16	Procedimiento de preparacion de derivados de 1,3-dioxano-4,6-diona.
DE68909143D1 (de)	1993-10-21	Prostaglandin-Vorläufer und ihre Herstellung.
ZA924888B (en)	1993-04-28	Process for the synthesis of enantiomers of 3-aminochroman compounds
AU2639999A (en)	1999-09-15	Intermediate compounds in the synthesis of the a ring moiety of 2-substituted vitamin d derivatives