DK0597960T3 - Behandling af cellepopulationer - Google Patents

Behandling af cellepopulationer

Info

Publication number
DK0597960T3
DK0597960T3 DK92916742T DK92916742T DK0597960T3 DK 0597960 T3 DK0597960 T3 DK 0597960T3 DK 92916742 T DK92916742 T DK 92916742T DK 92916742 T DK92916742 T DK 92916742T DK 0597960 T3 DK0597960 T3 DK 0597960T3
Authority
DK
Denmark
Prior art keywords
pct
copies
sec
treatment
cells
Prior art date
Application number
DK92916742T
Other languages
Danish (da)
English (en)
Inventor
Michael Jim Embleton
Gregory Paul Winter
Guy Gorochov
Peter Thomas Jones
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919117352A external-priority patent/GB9117352D0/en
Priority claimed from GB929212419A external-priority patent/GB9212419D0/en
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of DK0597960T3 publication Critical patent/DK0597960T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK92916742T 1991-08-10 1992-08-10 Behandling af cellepopulationer DK0597960T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919117352A GB9117352D0 (en) 1991-08-10 1991-08-10 Recombinant dna method
GB929212419A GB9212419D0 (en) 1992-06-11 1992-06-11 Recombinant dna method
PCT/GB1992/001483 WO1993003151A1 (en) 1991-08-10 1992-08-10 Treatment of cell populations

Publications (1)

Publication Number Publication Date
DK0597960T3 true DK0597960T3 (da) 1999-09-13

Family

ID=26299394

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92916742T DK0597960T3 (da) 1991-08-10 1992-08-10 Behandling af cellepopulationer

Country Status (11)

Country Link
US (1) US5830663A (de)
EP (1) EP0597960B1 (de)
JP (1) JPH06509473A (de)
AT (1) ATE175997T1 (de)
AU (1) AU665365B2 (de)
CA (1) CA2114950A1 (de)
DE (1) DE69228247T2 (de)
DK (1) DK0597960T3 (de)
ES (1) ES2130177T3 (de)
GR (1) GR3029913T3 (de)
WO (1) WO1993003151A1 (de)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830713A (en) * 1986-11-04 1998-11-03 Protein Polymer Technologies, Inc. Methods for preparing synthetic repetitive DNA
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
GB9216983D0 (en) * 1992-08-11 1992-09-23 Unilever Plc Polypeptide production
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
DE69534347T2 (de) * 1994-01-31 2006-05-24 Trustees Of Boston University, Boston Bibliotheken aus Polyklonalen Antikörpern
GB9401815D0 (en) * 1994-01-31 1994-03-23 Ray Ronnie A A new method for combined intracellular reverse transciption and amplification
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
JP2002503954A (ja) * 1997-04-01 2002-02-05 グラクソ、グループ、リミテッド 核酸増幅法
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
ES2230701T3 (es) 1997-07-07 2005-05-01 Medical Research Council Procedimiento de seleccion in vitro.
PT1095143E (pt) * 1998-05-08 2008-11-28 Sanquin Bloedvoorziening Inibidor para o diagnóstico e tratamento de doentes com hemofilia a
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
EP1961813B1 (de) 1998-12-16 2011-08-10 Novartis Vaccines and Diagnostics, Inc. Menschliche Cyclin-abhängige Kinase (hPNQALRE)
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6280977B1 (en) * 1999-03-24 2001-08-28 Gene Therapy Systems Method for generating transcriptionally active DNA fragments
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1259601A2 (de) * 2000-02-22 2002-11-27 Ahuva Nissim Chimäre und tcr phagen-display-bibliotheken, chimäre und tcr reagentien und anwendungsmethoden
US6211164B1 (en) * 2000-03-10 2001-04-03 Abbott Laboratories Antisense oligonucleotides of the human chk1 gene and uses thereof
CA2798625C (en) * 2000-04-17 2017-01-24 Dyax Corp. Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
GB0022458D0 (en) * 2000-09-13 2000-11-01 Medical Res Council Directed evolution method
WO2002023163A1 (en) * 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
US20050196755A1 (en) * 2000-11-17 2005-09-08 Maurice Zauderer In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
AU2001297872B2 (en) * 2000-11-17 2006-11-09 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
WO2002061071A2 (en) * 2000-12-18 2002-08-08 Dyax Corp. Focused libraries of genetic packages
US20030104402A1 (en) * 2001-01-23 2003-06-05 University Of Rochester Methods of producing or identifying intrabodies in eukaryotic cells
WO2002070678A2 (en) 2001-02-05 2002-09-12 Bayer Aktiengesellschaft Regulation of human serine/threonine protein kinase
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
EP1365034A3 (de) 2002-05-21 2004-02-18 Bayer HealthCare AG Verfahren und Zusammensetzungen zur Vorhersage, Diagnose, Prognose, Prävention und Behandlung von malignen Tumoren
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
JP4395133B2 (ja) * 2002-12-20 2010-01-06 カリパー・ライフ・サイエンシズ・インク． Ｄｎａの単一分子増幅および検出
CA2513899C (en) 2003-01-29 2013-03-26 454 Corporation Methods of amplifying and sequencing nucleic acids
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
PL1644493T3 (pl) 2003-06-27 2010-11-30 Axikin Pharmaceuticals Inc Regulacja kinazy regulowanej w COPD (kinaza RC)
US8048627B2 (en) 2003-07-05 2011-11-01 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
AU2004286201B2 (en) * 2003-09-10 2010-09-09 Altheadx, Inc. Expression profiling using microarrays
HRP20080197T8 (hr) * 2003-09-18 2008-07-31 Symphogen A/S Postupak za povezivanje sekvenci od interesa
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
EP1522594A3 (de) 2003-10-06 2005-06-22 Bayer HealthCare AG Verfahren und kit zur untersuchung von krebs
EP1691792A4 (de) * 2003-11-24 2008-05-28 Yeda Res & Dev Zusammensetzungen und verfahren für die sortierung in vitro von molekül- und zell-bibliotheken
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
EP1745292A2 (de) 2004-04-28 2007-01-24 Bayer HealthCare AG Diagnositka und therapeutika für mit dipeptidyl-peptidase 1 (dpp1) assoziierten krankheiten
GB0418651D0 (en) * 2004-08-20 2004-09-22 Medical Res Council Method
US7968287B2 (en) * 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP2230316A1 (de) 2005-02-01 2010-09-22 AB Advanced Genetic Analysis Corporation Nukleinsäuresequenzierung durch schrittweise Duplexverlängerung
EP2241637A1 (de) 2005-02-01 2010-10-20 AB Advanced Genetic Analysis Corporation Nukleinsäuresequenzierung durch schrittweise Duplexverlängerung
AU2006243757B2 (en) * 2005-05-03 2012-02-09 Altheadx, Inc. Compositions and methods for the analysis of degraded nucleic acids
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
US20080287857A1 (en) * 2006-02-11 2008-11-20 Rune Kjeken Device and method for single-needle in vivo electroporation
JP5059786B2 (ja) 2006-02-11 2012-10-31 ジェネトロニクス，インコーポレイティド 単針生体内エレクトロポレーションのための装置および方法
WO2007111937A1 (en) 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
WO2007115059A2 (en) 2006-03-29 2007-10-11 Merial Limited Vaccine against streptococci
CN101495654A (zh) * 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
EP2530167A1 (de) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
CA2653321A1 (en) * 2006-05-26 2007-12-06 Althea Technologies, Inc. Biochemical analysis of partitioned cells
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
DK2121920T3 (da) 2007-03-01 2011-11-21 Symphogen As Fremgangsmåde til kloning af sammenhørende antistoffer
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US7883265B2 (en) * 2007-06-01 2011-02-08 Applied Biosystems, Llc Devices, systems, and methods for preparing emulsions
CA2694990A1 (en) * 2007-07-31 2009-02-05 Merck Sharp & Dohme Corp. Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
KR101621837B1 (ko) 2007-09-12 2016-05-17 노파르티스 아게 Ｇａｓ57 돌연변이 항원 및 ｇａｓ57 항체
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP3124497B1 (de) 2007-09-14 2020-04-15 Adimab, LLC Synthetische antikörperbibliotheken mit rationalem design und verwendungen davon
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
JP2010539982A (ja) * 2007-10-01 2010-12-24 アプライド バイオシステムズ， エルエルシー チェイスライゲーション配列決定法
EP2537857B1 (de) 2007-12-21 2017-01-18 GlaxoSmithKline Biologicals SA Mutante Formen von Streptolysin O
US8211673B2 (en) 2008-02-04 2012-07-03 Life Technologies Corporation Composition and method for sequencing nucleic acid
EP2100970B1 (de) * 2008-03-13 2017-05-10 National Institute of Immunology IG-genspezifische Oligonukleotide und Verwendungen dafür
WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
JP5780951B2 (ja) 2008-04-24 2015-09-16 ダイアックス コーポレーション 新規のｈｃｃｄｒ１、ｃｄｒ２、およびｃｄｒ３設計、ならびに新規のｌｃｃｄｒ１、ｃｄｒ２、およびｃｄｒ３設計を含む、遺伝子パッケージのライブラリ
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010038042A1 (en) 2008-10-02 2010-04-08 Illumina Cambridge Ltd. Nucleic acid sample enrichment for sequencing applications
CA2743904A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
CN102459591B (zh) * 2009-05-20 2015-05-13 诺维莫尼公司 合成性的多肽文库以及用于建立具有天然多样性的多肽变体的方法
CA2758356C (en) 2009-05-29 2016-07-26 Morphosys Ag A collection of vh and vl pairs having favourable biophysical properties and methods for its use
CA2765511C (en) 2009-06-16 2015-05-12 The Regents Of The University Of Michigan Nanoemulsion vaccines
AU2010291902A1 (en) * 2009-09-14 2012-04-05 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
US8182994B2 (en) * 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
EP4484577A3 (de) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digitale analytanalyse
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
RS57937B1 (sr) 2010-05-14 2019-01-31 Alltech Inc Komponente ćelijskog zida kvasca i njihova detekcija
KR102318383B1 (ko) 2010-07-16 2021-10-27 아디맵 엘엘씨 항체 라이브러리
US8465707B2 (en) 2010-07-22 2013-06-18 Gencell Biosystems Ltd. Composite liquid cells
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
US20120135414A1 (en) 2010-10-28 2012-05-31 Life Technologies Corporation Chemically-enhanced primer compositions, methods and kits
US8367586B2 (en) 2010-11-19 2013-02-05 Morphosys Ag Collection and methods for its use
WO2012083225A2 (en) 2010-12-16 2012-06-21 Gigagen, Inc. System and methods for massively parallel analysis of nycleic acids in single cells
EP3604339B1 (de) 2011-01-14 2021-03-10 The Regents Of The University Of California Therapeutische antikörper gegen das ror-1-protein und verfahren zur verwendung davon
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP2684055A1 (de) 2011-03-09 2014-01-15 Bayer Intellectual Property GmbH Slc22a7-modulatoren
CN103732738A (zh) 2011-04-28 2014-04-16 小利兰斯坦福大学托管委员会 与样品相关的多核苷酸的鉴定
CN103797029B (zh) 2011-05-17 2016-08-17 洛克菲勒大学 人类免疫缺陷病毒中和抗体及其使用方法
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3216872B1 (de) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzymquantifizierung
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
KR102276528B1 (ko) 2011-09-30 2021-07-12 추가이 세이야쿠 가부시키가이샤 이온 농도 의존성 결합 분자 라이브러리
EP2612916A1 (de) 2012-01-09 2013-07-10 Universität Zürich Zellverkapselung mit hohem Durchsatz für Screening oder Auswahl
EP2807255B1 (de) 2012-01-25 2017-08-02 Gencell Biosystems Limited Biomolekülisolierung
EP2626433B1 (de) 2012-02-09 2017-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zum Koppeln von Nukleinsäuren in einem Mikrosom aus den endoplasmatischen Retikuli.
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
CA2888042A1 (en) 2012-11-27 2014-06-05 Gencell Biosystems Ltd. Handling liquid samples
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR20200140929A (ko) 2013-02-08 2020-12-16 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
US10384187B2 (en) 2014-02-10 2019-08-20 Gencell Biosystems Ltd Composite liquid cell (CLC) mediated nucleic acid library preparation device, and methods for using the same
BR112016023625A2 (pt) 2014-04-10 2018-06-26 10X Genomics, Inc. dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos
CN105085673B (zh) * 2014-05-19 2018-09-11 厦门大学 用于检测柯萨奇病毒a16型病毒实心颗粒的单克隆抗体及其用途
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
CA2953469A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
US20170247756A1 (en) 2014-10-03 2017-08-31 Life Technologies Corporation Genetic sequence verification compositions, methods and kits
JP6574257B2 (ja) 2014-10-07 2019-09-11 アン アンド ロバート エイチ． ルーリー チルドレンズ ホスピタル オブ シカゴ 新規の抗Ｎｏｄａｌ抗体及びその使用方法
JP6769969B2 (ja) 2015-01-12 2020-10-14 １０エックス ジェノミクス， インコーポレイテッド 核酸配列決定ライブラリーを作製するためのプロセス及びシステム、並びにこれらを使用して作製したライブラリー
EP3262407B1 (de) 2015-02-24 2023-08-30 10X Genomics, Inc. Partitionsverarbeitungsverfahren und -systeme
US9422547B1 (en) 2015-06-09 2016-08-23 Gigagen, Inc. Recombinant fusion proteins and libraries from immune cell repertoires
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
JP7132233B2 (ja) 2016-11-11 2022-09-06 アセンダント ディーエックス， エルエルシー 全身型若年性特発性関節炎および川崎病を診断および識別するための組成物および方法
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4029939B1 (de) 2017-01-30 2023-06-28 10X Genomics, Inc. Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis
EP3445876B1 (de) 2017-05-26 2023-07-05 10X Genomics, Inc. Einzelzellenanalyse von transposasezugänglichem chromatin
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019143961A2 (en) * 2018-01-19 2019-07-25 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting gamma delta t cells with chimeric antigen receptors
CN112262218B (zh) 2018-04-06 2024-11-08 10X基因组学有限公司 用于单细胞处理中的质量控制的系统和方法
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11929171B2 (en) 2018-10-18 2024-03-12 The Board Of Trustees Of The Leland Stanford Junior University Methods for evaluation and treatment of glycemic dysregulation and atherosclerotic cardiovascular disease and applications thereof
WO2020191365A1 (en) 2019-03-21 2020-09-24 Gigamune, Inc. Engineered cells expressing anti-viral t cell receptors and methods of use thereof
CN114107449B (zh) * 2020-08-31 2024-04-09 中山大学孙逸仙纪念医院 一种单细胞内原位qPCR方法
US12426782B2 (en) 2020-11-06 2025-09-30 The Board Of Trustees Of The Leland Stanford Junior University Systems and temporal alignment methods for evaluation of gestational age and time to delivery
WO2024050450A1 (en) 2022-08-31 2024-03-07 Gigamune, Inc. Engineered enveloped vectors and methods of use thereof
CN116590283B (zh) * 2023-07-17 2023-11-07 北京微岩医疗器械有限公司 一种细胞结合增强剂和去除人源游离核酸的方法

Also Published As

Publication number Publication date
EP0597960B1 (de) 1999-01-20
AU665365B2 (en) 1996-01-04
ATE175997T1 (de) 1999-02-15
AU2400192A (en) 1993-03-02
ES2130177T3 (es) 1999-07-01
CA2114950A1 (en) 1993-02-11
JPH06509473A (ja) 1994-10-27
GR3029913T3 (en) 1999-07-30
DE69228247T2 (de) 1999-07-08
DE69228247D1 (de) 1999-03-04
WO1993003151A1 (en) 1993-02-18
US5830663A (en) 1998-11-03
EP0597960A1 (de) 1994-05-25

Similar Documents

Publication Publication Date Title
DK0597960T3 (da) Behandling af cellepopulationer
DE69834267D1 (de) Gentherapeutische verfahren zur bereitstellung von apolipoprotein a-i agonisten sowie deren verwendung zur behandlung dyslipidämischer erkrankungen
ATE335086T1 (de) Künstliche chromosomen, die die genetische information für die bildung von rekombinantem virus enthalten
DK0544713T3 (da) Oligonukleutider til modulering af virkningerne af cytomegalovirusinfektioner
ATE466948T1 (de) Dns-basiertes transposon-system für die einführung von nucleinsäure in die dns einer zelle
ATE266723T1 (de) Lösung die chaotropische mittel enthält und verwendung dieser lösung in verfahren zur isolierung von dna, rna und proteinen
ATE239090T1 (de) Methode zum generieren von einzelsträngigen dna molekülen
ES2180641T3 (es) Inhibicion citoplasmica de la expresion genetica.
DE69333747D1 (de) Rekombinante zelle, dna-konstruktionen, vektoren und methoden zur expression von phytatabbauenden enzymen in gewünschten verhältnissen
DE69636895D1 (de) Die Verwendung der 3'-wesentlichen Bearbeitungswirksamkeit von DNS-Polymerase
DE59309183D1 (de) Simultane sequenzierung von nukleinsäuren
DE69831500T2 (de) Humane checkpointkinase, hcds1, zusammensetzungen und verfahren
ATE264913T1 (de) Protease-resistente analoge des thrombomodulin
BR9811592A (pt) Oxidase de citocinina
ATE360688T1 (de) Dna-fragment, dieses enthaltender rekombinanter vektor und verfahren zur expression von fremdgenen unter dessen verwendung
ATE338814T1 (de) Verfahren zur kultivierung von zellen und zur vermehrung von viren
DE69433243D1 (de) Verwendunf von ApoE zum Binden von TAU und MAP2c Proteinen und zur Behandlung von Alzheimer's Krankheit
ATE296886T1 (de) Männliche fertilität vermittelnde nukleotidsequenzen und verfahren zu ihrer verwendung
DE59712554D1 (de) Rekombinante expression von s-layer-proteinen
DE69613685D1 (de) D-aminosäure-oxidase kodierendes dns-fragment
Sarich A macromolecular perspective on the material basis of evolution
KR910004802A (ko) 긴팔원숭이 백혈병 비루스 리셉터 단백질, 이를 암호화하는 단리된 정제 dna 서열 및 이들을 동정하는 방법
ATE281523T1 (de) Acarbose-biosynthesegene aus actinoplanes sp., verfahren zu ihrer isolierung sowie ihrer verwendung
ATE301189T1 (de) Neues verfahren zum nachweis von cryptosporidium
ATE329041T1 (de) Nukleinsäurefragmente, rekombinante vektoren, welche diese enthalten und verfahren zum unterstützen der expression von strukturellen genen durch anwendung derselben