DK0608313T3 - Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner - Google Patents

Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner

Info

Publication number
DK0608313T3
DK0608313T3 DK92921634T DK92921634T DK0608313T3 DK 0608313 T3 DK0608313 T3 DK 0608313T3 DK 92921634 T DK92921634 T DK 92921634T DK 92921634 T DK92921634 T DK 92921634T DK 0608313 T3 DK0608313 T3 DK 0608313T3
Authority
DK
Denmark
Prior art keywords
polymer matrix
blood clot
delivery
matrix formulations
osteogenic proteins
Prior art date
Application number
DK92921634T
Other languages
Danish (da)
English (en)
Inventor
Eyal Ron
George Schaub Robert
Joseph Turek Thomas
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Application granted granted Critical
Publication of DK0608313T3 publication Critical patent/DK0608313T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK92921634T 1991-10-11 1992-10-09 Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner DK0608313T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/776,514 US5171579A (en) 1991-10-11 1991-10-11 Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
PCT/US1992/008628 WO1993006872A1 (fr) 1991-10-11 1992-10-09 Formulations de caillot de sang-matrice polymere d'apport de proteines osteogenes

Publications (1)

Publication Number Publication Date
DK0608313T3 true DK0608313T3 (da) 2000-05-15

Family

ID=25107596

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92921634T DK0608313T3 (da) 1991-10-11 1992-10-09 Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner

Country Status (11)

Country Link
US (1) US5171579A (fr)
EP (1) EP0608313B1 (fr)
JP (1) JP3336010B2 (fr)
KR (1) KR0181984B1 (fr)
AT (1) ATE189611T1 (fr)
AU (1) AU669133B2 (fr)
DE (1) DE69230670T2 (fr)
DK (1) DK0608313T3 (fr)
ES (1) ES2145013T3 (fr)
GR (1) GR3033204T3 (fr)
WO (1) WO1993006872A1 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6399569B1 (en) * 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
WO1993009229A1 (fr) 1991-11-04 1993-05-13 Genetics Institute, Inc. Proteines heterodimeres morphogenetiques d'os de recombinaison, compositions et procedes d'utilisation
WO1994026892A1 (fr) * 1993-05-12 1994-11-24 Genetics Institute, Inc. Compositions de bmp-11
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US6074840A (en) 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6620406B1 (en) 1994-03-08 2003-09-16 Genetics Institute, Llc. Methods for treatment of periodontal diseases and lesions using bone morphogenetic proteins
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
CA2151547C (fr) 1994-06-10 2010-10-12 Elliott A. Gruskin Proteines chimeriques recombinantes et modes d'utilisation de ces proteines
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
WO1996033215A1 (fr) * 1995-04-19 1996-10-24 Hoechst Pharmaceuticals & Chemicals K.K. Proteine nouvelle et son procede de fabrication
EP1364656B1 (fr) 1995-06-05 2013-11-20 Genetics Institute, LLC Utilisation de protéines morphogéniques osseuses pour soigner et réparer les insertions du tissu conjonctif
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
DE19548476A1 (de) * 1995-12-22 1997-06-26 Bioph Biotech Entw Pharm Gmbh Zielgerichtete Verbindungen mit knorpel- und/oder knocheninduzierender Aktivität
US5756652A (en) * 1996-02-29 1998-05-26 Depuy Orthopaedics, Inc. Poly (ester-anhydrides) and intermediates therefor
US5668288A (en) * 1996-04-16 1997-09-16 Depuy Orthopaedics, Inc. Polyester ionomers for implant fabrication
US5733868A (en) * 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
US6299905B1 (en) 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
WO1998000161A1 (fr) * 1996-05-24 1998-01-08 Buford Biomedical, Inc. Systemes a base de fibrine permettant d'effectuer l'administration regulee de produits medicinaux
US6927287B1 (en) * 1996-06-03 2005-08-09 United States Surgical Corporation Nucleic acid encoding extracellular matrix protein or fragment thereof
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US20040132653A1 (en) * 1997-01-30 2004-07-08 Biopharm Gmbh Lyophilized composition of bone morphogenetic factor human MP52
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
ES2320603T3 (es) 1997-07-30 2009-05-25 Emory University Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos.
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
AU6617300A (en) * 1999-08-31 2001-03-26 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
DK1223990T3 (da) 1999-10-15 2004-11-29 Inst Genetics Llc Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
DE10043151A1 (de) * 2000-08-31 2002-03-28 Peter Steinruecke Knochenzement mit antimikrobieller Wirksamkeit
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
TW200526779A (en) * 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
US7226587B2 (en) 2001-06-01 2007-06-05 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
EP1578348A4 (fr) * 2002-02-08 2011-03-16 Wyeth Llc Preparation contenant des agents bioactifs et son procede d'utilisation
US20040037819A1 (en) * 2002-06-06 2004-02-26 The Brigham And Women's Hospital, Inc. Non-polymeric hematopoeitic cell clots for delivery of active agents
US20060155234A1 (en) * 2002-09-10 2006-07-13 American National Red Cross Hemostatic dressing
DE10340277B4 (de) * 2003-08-29 2006-11-23 Bio-Gate Bioinnovative Materials Gmbh Körperpflegemittel mit Silber-Agglomeraten
JP5392981B2 (ja) 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
EP1684624A2 (fr) * 2003-10-02 2006-08-02 The Regents Of The University Of Michigan Facteurs(s) de cellules du cancer de la prostate chez l'homme qui induisent une activite des cellules souches et l'osteogenese
JP4694163B2 (ja) * 2004-07-26 2011-06-08 株式会社ジーシー 生体吸収性顆粒状多孔質骨補填材の製造方法
EP1838335A1 (fr) * 2005-01-19 2007-10-03 Bonoss Medical AB Composition de facteur de croissance
US7754689B2 (en) 2006-06-02 2010-07-13 Wyeth Llc Finger-1 peptide analogs of the TGF-β superfamily
EP2024386A2 (fr) 2006-06-02 2009-02-18 Wyeth Utilisation de protéines et de peptides de la superfamille tgf-bêta pour des procédés de purification et de thérapie
US8197840B2 (en) * 2006-07-21 2012-06-12 Genera Istrazivanja D.O.O. Whole blood-derived coagulum device for treating bone defects
NZ574653A (en) * 2006-08-04 2012-11-30 Stb Lifesaving Technologies Inc Solid dressing for treating wounded tissue
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
WO2009020612A1 (fr) * 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Procédés et pansement pour refermer des plaies internes
US8613938B2 (en) 2010-11-15 2013-12-24 Zimmer Orthobiologics, Inc. Bone void fillers
US8455436B2 (en) * 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
CN107753138A (zh) * 2017-11-09 2018-03-06 中山大学附属口腔医院 一种评估微量元素成骨作用的方法及其动物模型的构建方法
WO2025168104A1 (fr) * 2024-02-08 2025-08-14 Angitia Biomedicines Limited Composition pharmaceutique pour induire une nouvelle formation osseuse et procédé pour améliorer la fusion vertébrale et traiter des défauts osseux

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
US4526909A (en) * 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4639366A (en) * 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4620327A (en) * 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
EP0383363A3 (fr) * 1984-11-29 1990-10-03 Regents Of The University Of Minnesota Application d'agents pour la guérison de blessures
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US4743259A (en) * 1986-10-29 1988-05-10 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
US4902296A (en) * 1986-10-29 1990-02-20 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
WO1989004646A1 (fr) * 1987-11-13 1989-06-01 Jefferies Steven R Materiaux de reparation des os et administration de medicaments retardee
GB2215209B (en) * 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
ES2064439T3 (es) * 1988-05-02 1995-02-01 Project Hear Material adhesivo quirurgico.
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
ES2093647T3 (es) * 1989-06-05 1997-01-01 Massachusetts Inst Technology Polimeros bioerosionables para la liberacion de farmacos en los huesos.
WO1991005802A1 (fr) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Dispositifs osteogenes
WO1991018098A1 (fr) 1990-05-16 1991-11-28 Genetics Institute, Inc. Proteines d'induction osseuse et cartilagineuse
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
DE69213739T2 (de) * 1991-06-21 1997-02-20 Genetics Institute, Inc., Cambridge, Mass. Osteogene proteine enthaltende arzneimittel

Also Published As

Publication number Publication date
WO1993006872A1 (fr) 1993-04-15
AU2788592A (en) 1993-05-03
KR0181984B1 (ko) 1999-04-01
ATE189611T1 (de) 2000-02-15
JPH07500038A (ja) 1995-01-05
JP3336010B2 (ja) 2002-10-21
ES2145013T3 (es) 2000-07-01
DE69230670T2 (de) 2000-09-21
DE69230670D1 (de) 2000-03-16
AU669133B2 (en) 1996-05-30
US5171579A (en) 1992-12-15
EP0608313A1 (fr) 1994-08-03
GR3033204T3 (en) 2000-08-31
EP0608313B1 (fr) 2000-02-09

Similar Documents

Publication Publication Date Title
DK0608313T3 (da) Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner
KR960704587A (ko) 골형성 단백질 전달용 제제(formulations for delivery of osteogenic proteins)
ES2094359T3 (es) Formulaciones farmaceuticas de proteinas osteogenicas.
DE59711959D1 (de) Stabile lyophilisierte pharmazeutische zubereitungen von mono- oder polykonalen antikörpern
FI920764A0 (fi) Fusionsproteiner omfattande gm-csf och il-3.
HUT72325A (en) Stabile, liophylised composition containing proteins and kit applicabe for dosing
DE69128968D1 (de) Biologisch aktive bakterizide/permeabilitätserhöhende proteinbruchstücke
ATE136221T1 (de) Osteo-induktive pharmazeutische formulierungen
ATE380202T1 (de) Interaktionssystem zur präsentation und entfernung von substanzen
MX9302927A (es) Nuevos peptidos, la preparacion y utilizacion de los mimos.
DE69520475D1 (de) Pharmaceutische Zusammensetzung von biologisch aktiven Peptiden oder Proteinen
KR960702754A (ko) 생리적으로 활성인 펩티드를 함유하는 질내 투여 제제(vaginal preparation containing physiologically active peptide)
DE69012031D1 (de) Optisch aktive Benzylalkoholverbindung und pharmazeutische Zusammensetzung.
DK341489A (da) Fremgangsmaade til fremstilling af praeparater til anvendelse af biologiske aktive peptider til rektale og vaginale formaal
ATE189262T1 (de) Interferon-alpha/beta bindendes protein, seine herstellung und seine enthaltende pharmazeutische zusammensetzungen
NO891926D0 (no) Fremgangsmaate for fremstilling av stabile protein- eller peptidpreparater.
FI896042A0 (fi) Polymerkompositioner och foerfarande foer deras framstaellning.
FR2693199B1 (fr) Nouveaux polypeptides biologiquement actifs, préparation et utilisation.
NL1000332C1 (nl) Graduele chemische modificatie van biologisch actieve peptiden en eiwitten.
ATE119940T1 (de) Gewebs-plasminogen-aktivator-derivat.
FI906112A7 (fi) Menetelmiä ja koostumuksia nisäkkäiden infektioiden käsittelemiseksi k äyttämällä lääkkeitä, jotka käsittävät pistiäisten myrkkyä, sen protei ini- tai polypeptidiainesosia tai näiden porteiini- tai polypeptidiain eosien analogeja
IT1216535B (it) O_(1,2_di_0_acetilglicero_3_fosforil)etanolamina, procedimento per la sua preparazione e suo uso terapeutico.