GR3033204T3 - Formulations of blood clot-polymer matrix for delivery of osteogenic proteins. - Google Patents

Formulations of blood clot-polymer matrix for delivery of osteogenic proteins.

Info

Publication number
GR3033204T3
GR3033204T3 GR20000400898T GR20000400898T GR3033204T3 GR 3033204 T3 GR3033204 T3 GR 3033204T3 GR 20000400898 T GR20000400898 T GR 20000400898T GR 20000400898 T GR20000400898 T GR 20000400898T GR 3033204 T3 GR3033204 T3 GR 3033204T3
Authority
GR
Greece
Prior art keywords
polymer matrix
blood clot
formulations
delivery
osteogenic proteins
Prior art date
Application number
GR20000400898T
Other languages
English (en)
Inventor
Eyal Ron
Robert George Schaub
Thomas Joseph Turek
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of GR3033204T3 publication Critical patent/GR3033204T3/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GR20000400898T 1991-10-11 2000-04-12 Formulations of blood clot-polymer matrix for delivery of osteogenic proteins. GR3033204T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/776,514 US5171579A (en) 1991-10-11 1991-10-11 Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
PCT/US1992/008628 WO1993006872A1 (en) 1991-10-11 1992-10-09 Formulations of blood clot-polymer matrix for delivery of osteogenic proteins

Publications (1)

Publication Number Publication Date
GR3033204T3 true GR3033204T3 (en) 2000-08-31

Family

ID=25107596

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000400898T GR3033204T3 (en) 1991-10-11 2000-04-12 Formulations of blood clot-polymer matrix for delivery of osteogenic proteins.

Country Status (11)

Country Link
US (1) US5171579A (el)
EP (1) EP0608313B1 (el)
JP (1) JP3336010B2 (el)
KR (1) KR0181984B1 (el)
AT (1) ATE189611T1 (el)
AU (1) AU669133B2 (el)
DE (1) DE69230670T2 (el)
DK (1) DK0608313T3 (el)
ES (1) ES2145013T3 (el)
GR (1) GR3033204T3 (el)
WO (1) WO1993006872A1 (el)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US5739107A (en) * 1991-03-11 1998-04-14 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
DE69233022T2 (de) 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
DK0698094T3 (da) * 1993-05-12 2004-05-03 Inst Genetics Llc BMP-11-sammensætninger
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
DE69434651T2 (de) 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6074840A (en) * 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US6620406B1 (en) 1994-03-08 2003-09-16 Genetics Institute, Llc. Methods for treatment of periodontal diseases and lesions using bone morphogenetic proteins
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
CA2151547C (en) 1994-06-10 2010-10-12 Elliott A. Gruskin Recombinant chimeric proteins and methods of use thereof
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US7235527B2 (en) * 1995-04-19 2007-06-26 Biopharm Gesellschaft Zur Biotechnologieschen Entwicklung Von Pharmaka Mbh Protein and process for producing the same
DE69629294T2 (de) 1995-06-05 2004-04-29 Genetics Institute, LLC, Cambridge Verwendung von knochenmorphogeneseproteinen zur heilung und reparatur von bindegewebebefestigung
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
DE19548476A1 (de) * 1995-12-22 1997-06-26 Bioph Biotech Entw Pharm Gmbh Zielgerichtete Verbindungen mit knorpel- und/oder knocheninduzierender Aktivität
US5756652A (en) * 1996-02-29 1998-05-26 Depuy Orthopaedics, Inc. Poly (ester-anhydrides) and intermediates therefor
US6299905B1 (en) 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
US5733868A (en) * 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
US5668288A (en) * 1996-04-16 1997-09-16 Depuy Orthopaedics, Inc. Polyester ionomers for implant fabrication
AU3143197A (en) * 1996-05-24 1998-01-21 Buford Biomedical, Inc. Fibrin-based systems for the controlled release of medicinals
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US6927287B1 (en) * 1996-06-03 2005-08-09 United States Surgical Corporation Nucleic acid encoding extracellular matrix protein or fragment thereof
US20040132653A1 (en) * 1997-01-30 2004-07-08 Biopharm Gmbh Lyophilized composition of bone morphogenetic factor human MP52
ES2320603T3 (es) 1997-07-30 2009-05-25 Emory University Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos.
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
EP1212107B1 (en) * 1999-08-31 2005-06-08 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
ATE271886T1 (de) 1999-10-15 2004-08-15 Inst Genetics Llc Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
DE10043151A1 (de) * 2000-08-31 2002-03-28 Peter Steinruecke Knochenzement mit antimikrobieller Wirksamkeit
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
WO2002099037A2 (en) 2001-06-01 2002-12-12 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
CA2474919A1 (en) * 2002-02-08 2003-08-14 Wyeth Formulation comprising bioactive agents and method of using same
AU2003247492B2 (en) * 2002-06-06 2009-05-14 The Brigham And Women's Hospital, Inc. Non-polymeric hematopoietic cell clots for delivery of active agents
AU2003270401B2 (en) * 2002-09-10 2008-03-13 American National Red Cross Hemostatic dressing
DE10340277B4 (de) * 2003-08-29 2006-11-23 Bio-Gate Bioinnovative Materials Gmbh Körperpflegemittel mit Silber-Agglomeraten
DE602004005477T2 (de) 2003-09-12 2007-12-13 Wyeth Injizierbare feste Calciumphosphat-Stäbe zur Abgabe von osteogenen Proteinen
EP1684624A2 (en) * 2003-10-02 2006-08-02 The Regents Of The University Of Michigan Human prostate cancer cell factor(s) that induce stem cell commitment and osteogenesis
JP4694163B2 (ja) * 2004-07-26 2011-06-08 株式会社ジーシー 生体吸収性顆粒状多孔質骨補填材の製造方法
JP2008527033A (ja) * 2005-01-19 2008-07-24 ボンオス・メディカル・アー・ベー 増殖因子組成物
MX2008015263A (es) 2006-06-02 2008-12-17 Wyeth Corp Uso de proteinas y pepetidos de la superfamilia del factor beta transformador de crecimiento para purificacion y metodos terapeuticos.
US7754689B2 (en) 2006-06-02 2010-07-13 Wyeth Llc Finger-1 peptide analogs of the TGF-β superfamily
DK2049040T3 (en) * 2006-07-21 2015-06-29 Genera Istrazivanja D O O Whole blood derived coagulum device for the treatment of bone defects
EP2063831A4 (en) * 2006-08-04 2010-10-06 Stb Lifesaving Technologies In SOLID FIRM FOR THE TREATMENT OF WOUND FABRICS
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
WO2009020612A1 (en) * 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8455436B2 (en) * 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
CN107753138A (zh) * 2017-11-09 2018-03-06 中山大学附属口腔医院 一种评估微量元素成骨作用的方法及其动物模型的构建方法
WO2025168104A1 (en) * 2024-02-08 2025-08-14 Angitia Biomedicines Limited Pharmaceutical composition for inducing new bone formation and method for enhancing spinal fusion and treating bone defects

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
US4526909A (en) * 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4639366A (en) * 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4620327A (en) * 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
EP0383363A3 (en) * 1984-11-29 1990-10-03 Regents Of The University Of Minnesota Use of wound healing agents
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US4902296A (en) * 1986-10-29 1990-02-20 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
US4743259A (en) * 1986-10-29 1988-05-10 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
WO1989004646A1 (en) * 1987-11-13 1989-06-01 Jefferies Steven R Bone repair material and delayed drug delivery
GB2215209B (en) * 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
ATE111360T1 (de) * 1988-05-02 1994-09-15 Project Hear Chirurgisches klebstoffmaterial.
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
DK0476045T3 (da) * 1989-06-05 1996-09-16 Massachusetts Inst Technology Bionedbrydelige polymerer til lægemiddel-afgivelse i knogler
ES2118723T3 (es) * 1989-10-17 1998-10-01 Stryker Corp Dispositivos osteogenicos.
DE69132823T2 (de) 1990-05-16 2002-07-18 Genetics Institute, Inc. Knochen- und knorpel-bildung hervorrufende proteine
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
JP3351525B2 (ja) * 1991-06-21 2002-11-25 ジェネティックス・インスティテュート・インコーポレイテッド 骨形成性蛋白医薬処方物

Also Published As

Publication number Publication date
JPH07500038A (ja) 1995-01-05
US5171579A (en) 1992-12-15
DE69230670T2 (de) 2000-09-21
DK0608313T3 (da) 2000-05-15
AU2788592A (en) 1993-05-03
EP0608313A1 (en) 1994-08-03
WO1993006872A1 (en) 1993-04-15
ATE189611T1 (de) 2000-02-15
ES2145013T3 (es) 2000-07-01
JP3336010B2 (ja) 2002-10-21
EP0608313B1 (en) 2000-02-09
KR0181984B1 (ko) 1999-04-01
AU669133B2 (en) 1996-05-30
DE69230670D1 (de) 2000-03-16

Similar Documents

Publication Publication Date Title
DK0608313T3 (da) Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner
KR960704587A (ko) 골형성 단백질 전달용 제제(formulations for delivery of osteogenic proteins)
HUT72325A (en) Stabile, liophylised composition containing proteins and kit applicabe for dosing
EP0950665A4 (en) PHYSIOLOGICALLY ACTIVE MODIFIED PROTEINS AND DRUG COMPOSITIONS CONTAINING THEM
ES2094359T3 (es) Formulaciones farmaceuticas de proteinas osteogenicas.
AU3228789A (en) Biologically active proteins
CA2085750A1 (en) Osteoinductive pharmaceutical formulations
EP0129582A4 (en) BIOLOGICALLY ACTIVE PEPTIDES AND PROTEINS FOR ORAL ADMINISTRATION.
BR9507452A (pt) Composição farmacêutica uso de um polipeptídeo não-interferon uso de uma quantidade de um antígeno padronizado e uma quantidade de um polipeptídeo não-interferon e produto contendo (1) uma quantidade de um antígeno padronizado e (11) uma quantidade de um polipeptídeo não-interferon
BR9507451A (pt) Composição farmacêutica uso de uma quantidade de (i) um antígeno padronizado em conjunto com uma quantidade de (ii) um polipeptídeo e produto contendo uma quantidade de (i) um antígeno padronizado em conjunto com uma quantidade de (ii) um polipeptídeo
AU8769791A (en) Pharmaceutically active proteins comprising an active protein and an integrinaffinity sequence
ATE189262T1 (de) Interferon-alpha/beta bindendes protein, seine herstellung und seine enthaltende pharmazeutische zusammensetzungen
AU1996388A (en) Proteins and protein compositions and their use
NL1000332C1 (nl) Graduele chemische modificatie van biologisch actieve peptiden en eiwitten.
DE58902178D1 (en) Isomere formyl-trimethylbicyclo(2,2,2)oct-7-ene.
DE59008693D1 (de) Gewebs-Plasminogen-Aktivator-Derivat.
AU2328788A (en) Preparation containing high molecular staphylococcal protein; antibody preparation directed against the protein; and the use of the preparations
AU609337B2 (en) Tissue plasminogen activator (t-pa) muteins and processes for the preparation thereof
IE891007L (en) Biologically active proteins
ZA902525B (en) Composition and treatment with biologically active peptides and antibiotic
AU3975693A (en) Recombinant active forms of ECEF, proteins that associate therewith, and uses thereof

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees