DK0637299T3 - 20-methylsubstituerede vitamin D-derivater - Google Patents

20-methylsubstituerede vitamin D-derivater

Info

Publication number: DK0637299T3
Authority: DK; Denmark
Prior art keywords: group; derivatives; methyl; carbon atoms; production
Prior art date: 1991-12-13

Application number

DK92924724.5T

Other languages

English (en)

Inventor

Martin Haberey

Guenter Neef

Andreas Steinmeyer

Gerald Kirsch

Katica Schwarz

Ruth Thieroff-Ekerdt

Herbert Wiesinger

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-13

Filing date

1992-12-14

Publication date

1996-09-30

1992-12-14 Application filed by Schering Ag filed Critical Schering Ag

1996-09-30 Application granted granted Critical

1996-09-30 Publication of DK0637299T3 publication Critical patent/DK0637299T3/da

Links

150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 3
239000004215 Carbon black (E152) Substances 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
229960005084 calcitriol Drugs 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000006698 induction Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Nutrition Science (AREA)
Oncology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK92924724.5T 1991-12-13 1992-12-14 20-methylsubstituerede vitamin D-derivater DK0637299T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4141746A DE4141746A1 (de)	1991-12-13	1991-12-13	20-methyl-substituierte vitamin d-derivate

Publications (1)

Publication Number	Publication Date
DK0637299T3 true DK0637299T3 (da)	1996-09-30

Family

ID=6447341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92924724.5T DK0637299T3 (da)	1991-12-13	1992-12-14	20-methylsubstituerede vitamin D-derivater

Country Status (24)

Country	Link
US (1)	US5446035A (da)
EP (1)	EP0637299B1 (da)
JP (1)	JP3280975B2 (da)
KR (1)	KR100271462B1 (da)
CN (1)	CN1035177C (da)
AT (1)	ATE138366T1 (da)
AU (1)	AU670585B2 (da)
CA (1)	CA2125476C (da)
CZ (1)	CZ286579B6 (da)
DE (2)	DE4141746A1 (da)
DK (1)	DK0637299T3 (da)
ES (1)	ES2089585T3 (da)
FI (1)	FI108226B (da)
GR (1)	GR3020097T3 (da)
HU (1)	HUT68263A (da)
IL (1)	IL104074A (da)
MX (1)	MX9207101A (da)
NO (1)	NO305949B1 (da)
NZ (1)	NZ246052A (da)
PL (1)	PL171403B1 (da)
SK (1)	SK280450B6 (da)
TW (1)	TW275060B (da)
WO (1)	WO1993012081A1 (da)
ZA (1)	ZA929650B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
GB9220272D0 (en) *	1992-09-25	1992-11-11	Leo Pharm Prod Ltd	Chemical compounds
IL107185A (en) *	1992-10-06	1998-02-22	Schering Ag	Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US6407082B1 (en) *	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US20040167106A1 (en) *	1993-06-04	2004-08-26	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of a Vitamin D compound
GB9315253D0 (en) *	1993-07-23	1993-09-08	Res Inst Medicine Chem	Chemical compounds
US5428029A (en) *	1993-11-24	1995-06-27	Hoffmann-La Roche Inc.	Vitamin D3 fluorinated analogs
US5981597A (en) *	1995-02-13	1999-11-09	Trustees Of The University Of Pennsylvania	Differentiating agents for the treatment of inflammatory intestinal diseases
EP1640003A2 (en) *	1996-02-13	2006-03-29	G.D. SEARLE & CO.	Compositions comprising a Cyclooxygenase-2 Inhibitor and a Leukotriene B4 receptor antagonist
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
SG70010A1 (en) *	1996-05-23	2000-01-25	Hoffmann La Roche	Fluorinated vitamin d3 analogs
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en) *	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
WO1999012894A1 (en) *	1997-09-08	1999-03-18	F. Hoffmann-La Roche Ag	1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
WO1999049870A1 (en)	1998-03-27	1999-10-07	Oregon Health Sciences University	Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
US6443856B1 (en)	1999-11-01	2002-09-03	Callaway Golf Company	Contoured scorelines for the face of a golf club
US20030188756A1 (en) *	2002-08-19	2003-10-09	Cantorna Margherita T	Treatment of inflammatory bowel disease with vitamin d compounds
US6989377B2 (en)	1999-12-21	2006-01-24	Wisconsin Alumni Research Foundation	Treating vitamin D responsive diseases
US6358939B1 (en)	1999-12-21	2002-03-19	Northern Lights Pharmaceuticals, Llc	Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
AU2001278744A1 (en) *	2000-08-17	2002-02-25	Chugai Seiyaku Kabushiki Kaisha	Remedial agent for osteoporosis
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
CN102358738A (zh)	2003-07-30	2012-02-22	里格尔药品股份有限公司	2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途
CA2608021A1 (en) *	2005-05-10	2006-11-16	Dermipsor Ltd.	Compositions and methods for skin care
AU2006245283B2 (en)	2005-05-10	2012-11-01	Dermipsor Ltd.	Compositions and methods for treating hyperproliferative epidermal diseases
CA2607901C (en)	2005-06-13	2016-08-16	Rigel Pharmaceuticals, Inc.	Methods and compositions for treating degenerative bone disorders using a syk inhibitory 2,4-pyrimidinediamine
DE602005000514T2 (de) *	2005-06-17	2007-10-25	Magneti Marelli Powertrain S.P.A.	Brennstoffeinspritzventil
NZ570816A (en) *	2006-04-10	2011-07-29	Wisconsin Alumni Res Found	1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain
US20080051375A1 (en) *	2006-08-25	2008-02-28	Auerbach Alan H	Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
WO2008024485A2 (en)	2006-08-25	2008-02-28	Cougar Biotechnology, Inc.	Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent
US20080051380A1 (en) *	2006-08-25	2008-02-28	Auerbach Alan H	Methods and compositions for treating cancer
US20090124587A1 (en) *	2007-07-12	2009-05-14	Auerbach Alan H	METHODS FOR TREATING CANCER USING 17alpha-HYDROXYLASE/C17,20-LYASE INHIBITORS
AU2010208323B2 (en)	2009-01-27	2016-03-10	Berg Llc	Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en)	2009-08-14	2019-05-22	Berg LLC	Vitamin d3 and analogs thereof for treating alopecia
US20190183908A1 (en)	2016-05-13	2019-06-20	Case Western Reserve University	Autophagy activators for treating or preventing skin injury
CN119606965A (zh)	2016-07-29	2025-03-14	詹森药业有限公司	治疗前列腺癌的方法
US10548908B2 (en) *	2016-09-15	2020-02-04	Nostopharma, LLC	Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
US11903952B2 (en)	2020-05-27	2024-02-20	Northwestern University	Vitamin D as an immune modulator to prevent immune-related complication from COVID-19 infection

1991
- 1991-12-13 DE DE4141746A patent/DE4141746A1/de not_active Withdrawn
1992
- 1992-12-08 MX MX9207101A patent/MX9207101A/es not_active IP Right Cessation
- 1992-12-11 ZA ZA929650A patent/ZA929650B/xx unknown
- 1992-12-12 CN CN92114249A patent/CN1035177C/zh not_active Expired - Fee Related
- 1992-12-13 IL IL104074A patent/IL104074A/en not_active IP Right Cessation
- 1992-12-14 AU AU40356/93A patent/AU670585B2/en not_active Ceased
- 1992-12-14 WO PCT/EP1992/002887 patent/WO1993012081A1/de not_active Ceased
- 1992-12-14 EP EP92924724A patent/EP0637299B1/de not_active Expired - Lifetime
- 1992-12-14 JP JP51062193A patent/JP3280975B2/ja not_active Expired - Fee Related
- 1992-12-14 DE DE59206393T patent/DE59206393D1/de not_active Expired - Lifetime
- 1992-12-14 DK DK92924724.5T patent/DK0637299T3/da active
- 1992-12-14 KR KR1019940702001A patent/KR100271462B1/ko not_active Expired - Fee Related
- 1992-12-14 NZ NZ246052A patent/NZ246052A/xx unknown
- 1992-12-14 CA CA002125476A patent/CA2125476C/en not_active Expired - Fee Related
- 1992-12-14 AT AT92924724T patent/ATE138366T1/de not_active IP Right Cessation
- 1992-12-14 HU HU9401456A patent/HUT68263A/hu unknown
- 1992-12-14 PL PL92304142A patent/PL171403B1/pl not_active IP Right Cessation
- 1992-12-14 CZ CZ19941416A patent/CZ286579B6/cs not_active IP Right Cessation
- 1992-12-14 ES ES92924724T patent/ES2089585T3/es not_active Expired - Lifetime
- 1992-12-14 SK SK661-94A patent/SK280450B6/sk unknown
1993
- 1993-01-13 TW TW082100181A patent/TW275060B/zh active
1994
- 1994-06-10 FI FI942766A patent/FI108226B/fi not_active IP Right Cessation
- 1994-06-10 NO NO942178A patent/NO305949B1/no unknown
- 1994-09-16 US US08/307,081 patent/US5446035A/en not_active Expired - Fee Related
1996
- 1996-05-30 GR GR960401459T patent/GR3020097T3/el unknown

Also Published As

Publication number	Publication date
FI108226B (fi)	2001-12-14
IL104074A0 (en)	1993-05-13
JPH07505132A (ja)	1995-06-08
GR3020097T3 (en)	1996-08-31
EP0637299A1 (de)	1995-02-08
NO942178D0 (no)	1994-06-10
NO305949B1 (no)	1999-08-23
AU670585B2 (en)	1996-07-25
MX9207101A (es)	1993-08-01
US5446035A (en)	1995-08-29
DE4141746A1 (de)	1993-06-17
FI942766A0 (fi)	1994-06-10
SK66194A3 (en)	1995-02-08
CN1073677A (zh)	1993-06-30
SK280450B6 (sk)	2000-02-14
IL104074A (en)	1998-01-04
NO942178L (da)	1994-06-10
CA2125476A1 (en)	1993-06-24
EP0637299B1 (de)	1996-05-22
KR100271462B1 (ko)	2000-11-15
CZ141694A3 (en)	1995-01-18
ES2089585T3 (es)	1996-10-01
ZA929650B (en)	1993-06-09
KR940703806A (ko)	1994-12-12
CA2125476C (en)	2003-02-11
CZ286579B6 (cs)	2000-05-17
WO1993012081A1 (de)	1993-06-24
HUT68263A (en)	1995-06-28
CN1035177C (zh)	1997-06-18
NZ246052A (en)	1995-07-26
HU9401456D0 (en)	1994-08-29
DE59206393D1 (de)	1996-06-27
TW275060B (da)	1996-05-01
PL171403B1 (pl)	1997-04-30
AU4035693A (en)	1993-07-19
ATE138366T1 (de)	1996-06-15
JP3280975B2 (ja)	2002-05-13
FI942766A7 (fi)	1994-06-10

Publication	Publication Date	Title
ATE138366T1 (de)	1996-06-15	20-methyl-substituierte vitamin d-derivate
ES2000823A6 (es)	1988-03-16	Metodo para la produccion de compuestos analogos a la vitamina d
ES8802017A1 (es)	1988-03-16	Un procedimiento para preparar derivados de diamidas sustituidas con 7-oxabicicloheptano y sus analogos de prostaglandina
NO951813D0 (no)	1995-05-09	Bicyklisk heterocyklisk sulfonamid og sulfonester-derivater
EP0648207A1 (en)	1995-04-19	VITAMIN D DERIVATE.
ES2117281T3 (es)	1998-08-01	Nuevos analogos de la vitamina d.
ES458264A1 (es)	1978-07-16	Procedimiento para la preparacion de nuevos compuestos ana- logos a prostaglandinas.
ES459050A1 (es)	1978-11-01	Un procedimiento para la preparacion de nuevos derivados de acido prostanoico.
MX9204858A (es)	1993-05-01	Mejoras en derivados de 2-(piperazinoalquil)indol condensados en posiciones 1,7, asi como un procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos.
DE3575715D1 (de)	1990-03-08	Adamantanamin-derivate, verfahren zur herstellung und diese enthaltende heilmittel.
ES449963A2 (es)	1977-10-01	Procedimiento de preparacion de derivados piridinicos.
ES473441A1 (es)	1979-05-01	Procedimiento para la preparacion de nuevos derivados de 5,-11-dihidro-6h-pirido (2,3-b)(1,4-benzodiazepin-6-ona).
ES2098403T3 (es)	1997-05-01	Derivados de la imidazoindolizina y procedimiento para su preparacion.
ES2072765T3 (es)	1995-07-16	Procedimiento para la obtencion de 5,6-dihidroxi-indolinas.
ATE175418T1 (de)	1999-01-15	15,15-dialkylsubstituierte östradiolderivate
AU563426B2 (en)	1987-07-09	3-alkoxy-2(n-pyrrolidino)-n-pyridyl-n-furyl (or thienyl) methyl propylamines
ES462887A1 (es)	1978-12-16	Procedimiento para la preparacion de nuevos derivados de la 9-cloroprednisolana.
ES8608492A1 (es)	1986-06-16	Procedimiento para la obtencion de derivados de 3-(ureidociclohexilamino) propan-1, 2-diol
TW252976B (da)	1995-08-01
HUT35658A (en)	1985-07-29	Process for producing 7-oxo-prostacycline derivatives of selective biological activity
ES444879A1 (es)	1977-08-16	Procedimiento para la preparacion de derivados de acido di- carboxilico de mono (amidas de aminoacido) de acido triyodo-isoftalico.
DK0746556T3 (da)	2002-12-16	Tricycliske forbindelser med affinitet for 5-HT1A-receptoren
ES2059702T3 (es)	1994-11-16	Politioureas, procedimiento para su fabricacion y empleo de estas politioureas para evitar o reducir la formacion de costras en reactores.
ES2085544T3 (es)	1996-06-01	Procedimiento para la fabricacion de 8-n,n-dialquilaminotriciclo-(5.2.1.02,6)decano.
JPS5229251A (en)	1977-03-04	Support e1uipment for measurement instrument