DK0657430T3 - Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat - Google Patents

Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat

Info

Publication number: DK0657430T3
Authority: DK; Denmark
Prior art keywords: methoxyethyl; dihydro; chloro; isopropyl; dicarboxylate
Prior art date: 1993-12-10

Application number

DK94118671T

Other languages

English (en)

Inventor

Heinrich Dr Meier

Wolfgang Dr Hartwig

Bodo Dr Junge

Rudolf Dr Schohe-Loop

Zhan Dr Gao

Bernard Dr Schmidt

Jong Maarten Dr De

Teunis Dr Schuurman

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-10

Filing date

1994-11-28

Publication date

1999-11-15

1993-12-10 Priority claimed from DE4342194A external-priority patent/DE4342194A1/de

1994-07-13 Priority claimed from DE19944424677 external-priority patent/DE4424677A1/de

1994-11-28 Application filed by Bayer Ag filed Critical Bayer Ag

1999-11-15 Application granted granted Critical

1999-11-15 Publication of DK0657430T3 publication Critical patent/DK0657430T3/da

Links

KJLJYTLPUUKRCU-UHFFFAOYSA-N CC(C)OC(=O)C1=C(C)N(CCOC)C(C)=C(C(O)=O)C1C1=CC=CC(C#N)=C1Cl Chemical compound CC(C)OC(=O)C1=C(C)N(CCOC)C(C)=C(C(O)=O)C1C1=CC=CC(C#N)=C1Cl KJLJYTLPUUKRCU-UHFFFAOYSA-N 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
-1 compound rac-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyanophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarb oxylate Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001537 neural effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Liquid Crystal Substances (AREA)

DK94118671T 1993-12-10 1994-11-28 Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat DK0657430T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4342194A DE4342194A1 (de)	1993-12-10	1993-12-10	Halogen-phenyl-substituierte 1,4-Dihydropyridine
DE19944424677 DE4424677A1 (de)	1994-07-13	1994-07-13	Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat

Publications (1)

Publication Number	Publication Date
DK0657430T3 true DK0657430T3 (da)	1999-11-15

Family

ID=25931956

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94118671T DK0657430T3 (da)	1993-12-10	1994-11-28	Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat

Country Status (35)

Country	Link
US (1)	US5665740A (da)
EP (1)	EP0657430B1 (da)
JP (1)	JP3751041B2 (da)
KR (1)	KR100332325B1 (da)
CN (2)	CN1056606C (da)
AT (1)	ATE180774T1 (da)
AU (1)	AU686976B2 (da)
BG (1)	BG62487B1 (da)
CA (1)	CA2137525C (da)
CO (1)	CO4290426A1 (da)
CU (1)	CU22713A3 (da)
CZ (1)	CZ286065B6 (da)
DE (1)	DE59408350D1 (da)
DK (1)	DK0657430T3 (da)
DZ (1)	DZ1831A1 (da)
EE (1)	EE03192B1 (da)
ES (1)	ES2132308T3 (da)
FI (1)	FI105681B (da)
GR (1)	GR3030436T3 (da)
HR (1)	HRP940967B1 (da)
HU (1)	HU215593B (da)
IL (1)	IL111922A (da)
LV (1)	LV11321B (da)
MA (1)	MA23392A1 (da)
MY (1)	MY111976A (da)
NO (1)	NO302362B1 (da)
NZ (1)	NZ270087A (da)
PL (1)	PL179973B1 (da)
RO (1)	RO115800B1 (da)
SA (1)	SA95160078B1 (da)
SK (1)	SK282399B6 (da)
SV (1)	SV1994000072A (da)
TN (1)	TNSN94127A1 (da)
TW (1)	TW412529B (da)
YU (1)	YU48920B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004292966A1 (en) *	2003-11-21	2005-06-09	Memory Pharmaceutical Corporation	Compositions and methods of treatment using L-type calcium channel blockers and cholinesterase inhibitors
WO2008058234A2 (en) *	2006-11-08	2008-05-15	Memory Pharmaceuticals Corporation	Pharmaceutical formulations for 1,4-dihyrdropyridine compounds having improved solubility
US11512052B2 (en) *	2017-11-21	2022-11-29	Icahn School Of Medicine At Mount Sinai	Dihydropyridines for the treatment of cognitive impairment or traumatic brain injury

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963188A1 (de) *	1969-12-17	1971-06-24	Bayer Ag	Neue Cyanphenyl-1,4-dihydropyridinderivate
DE2117572C3 (de) *	1971-04-10	1980-03-20	Bayer Ag, 5090 Leverkusen	Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3932646A (en) *	1971-04-10	1976-01-13	Farbenfabriken Bayer Ag	Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
DE2508181A1 (de) *	1975-02-26	1976-09-09	Bayer Ag	1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2815578C2 (de) *	1978-04-11	1986-01-16	Bayer Ag, 5090 Leverkusen	Neue pharmazeutische Verwendung von Nimodipin
DE2935451A1 (de) *	1979-09-01	1981-03-19	Bayer Ag, 5090 Leverkusen	Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3208628A1 (de) *	1982-03-10	1983-09-22	Bayer Ag, 5090 Leverkusen	Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3239273A1 (de) *	1982-10-23	1984-04-26	Bayer Ag, 5090 Leverkusen	Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5137889A (en) *	1983-12-02	1992-08-11	Otsuka Pharmaceutical Co., Ltd.	Dihydropyridine derivatives and process for preparing the same
DE3718398A1 (de) *	1987-06-02	1988-12-22	Troponwerke Gmbh & Co Kg	Neue kombinationspraeparate mit antidepressiver wirkung
US5114946A (en) *	1987-06-12	1992-05-19	American Cyanamid Company	Transdermal delivery of pharmaceuticals
DE3806277A1 (de) *	1988-02-27	1989-09-07	Troponwerke Gmbh & Co Kg	Verwendung von 1,4-dihydropyridin-derivaten
DE4011695A1 (de) *	1990-04-11	1991-10-17	Bayer Ag	Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
FR2671349B1 (fr) *	1991-01-09	1993-04-23	Lafon Labor	Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
DE4125271A1 (de) *	1991-07-31	1993-02-11	Bayer Ag	Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester

1994
- 1994-11-22 EE EE9400393A patent/EE03192B1/xx not_active IP Right Cessation
- 1994-11-28 DK DK94118671T patent/DK0657430T3/da active
- 1994-11-28 ES ES94118671T patent/ES2132308T3/es not_active Expired - Lifetime
- 1994-11-28 EP EP94118671A patent/EP0657430B1/de not_active Expired - Lifetime
- 1994-11-28 AT AT94118671T patent/ATE180774T1/de active
- 1994-11-28 DE DE59408350T patent/DE59408350D1/de not_active Expired - Lifetime
- 1994-12-01 HR HRP4424677.3A patent/HRP940967B1/xx not_active IP Right Cessation
- 1994-12-02 CU CU13794A patent/CU22713A3/es unknown
- 1994-12-02 CO CO94055078A patent/CO4290426A1/es unknown
- 1994-12-02 US US08/348,436 patent/US5665740A/en not_active Expired - Lifetime
- 1994-12-06 RO RO94-01950A patent/RO115800B1/ro unknown
- 1994-12-06 JP JP32981994A patent/JP3751041B2/ja not_active Expired - Fee Related
- 1994-12-07 DZ DZ940128A patent/DZ1831A1/fr active
- 1994-12-07 PL PL94306157A patent/PL179973B1/pl not_active IP Right Cessation
- 1994-12-07 IL IL11192294A patent/IL111922A/xx not_active IP Right Cessation
- 1994-12-07 TN TNTNSN94127A patent/TNSN94127A1/fr unknown
- 1994-12-07 SK SK1516-94A patent/SK282399B6/sk not_active IP Right Cessation
- 1994-12-07 CA CA002137525A patent/CA2137525C/en not_active Expired - Fee Related
- 1994-12-07 NZ NZ270087A patent/NZ270087A/en not_active IP Right Cessation
- 1994-12-08 YU YU71794A patent/YU48920B/sh unknown
- 1994-12-08 SV SV1994000072A patent/SV1994000072A/es not_active Application Discontinuation
- 1994-12-08 FI FI945777A patent/FI105681B/fi not_active IP Right Cessation
- 1994-12-08 CZ CZ19943093A patent/CZ286065B6/cs not_active IP Right Cessation
- 1994-12-08 AU AU80306/94A patent/AU686976B2/en not_active Ceased
- 1994-12-08 BG BG99249A patent/BG62487B1/bg unknown
- 1994-12-09 MY MYPI94003289A patent/MY111976A/en unknown
- 1994-12-09 CN CN94112892A patent/CN1056606C/zh not_active Expired - Fee Related
- 1994-12-09 LV LVP-94-242A patent/LV11321B/lv unknown
- 1994-12-09 KR KR1019940033434A patent/KR100332325B1/ko not_active Expired - Fee Related
- 1994-12-09 NO NO944787A patent/NO302362B1/no not_active IP Right Cessation
- 1994-12-09 HU HU9403551A patent/HU215593B/hu not_active IP Right Cessation
- 1994-12-09 MA MA23720A patent/MA23392A1/fr unknown
1995
- 1995-02-14 TW TW084101294A patent/TW412529B/zh not_active IP Right Cessation
- 1995-06-28 SA SA95160078A patent/SA95160078B1/ar unknown
1999
- 1999-06-09 GR GR990401523T patent/GR3030436T3/el unknown
- 1999-06-30 CN CN99108967A patent/CN1124258C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL179973B1 (pl)	2000-11-30
NZ270087A (en)	1996-08-27
CZ286065B6 (cs)	2000-01-12
SK282399B6 (sk)	2002-01-07
CZ309394A3 (en)	1995-11-15
EP0657430A1 (de)	1995-06-14
US5665740A (en)	1997-09-09
SK151694A3 (en)	1995-07-11
JP3751041B2 (ja)	2006-03-01
SA95160078B1 (ar)	2006-09-25
YU48920B (sh)	2002-11-15
IL111922A (en)	1999-05-09
PL306157A1 (en)	1995-06-12
RO115800B1 (ro)	2000-06-30
TNSN94127A1 (en)	1995-09-21
CN1056606C (zh)	2000-09-20
ATE180774T1 (de)	1999-06-15
KR100332325B1 (ko)	2002-09-04
CA2137525A1 (en)	1995-06-11
EE03192B1 (et)	1999-06-15
CO4290426A1 (es)	1996-04-17
CN1244525A (zh)	2000-02-16
NO944787D0 (no)	1994-12-09
EP0657430B1 (de)	1999-06-02
FI945777A7 (fi)	1995-06-11
HU215593B (hu)	1999-01-28
AU8030694A (en)	1995-06-15
IL111922A0 (en)	1995-03-15
NO944787L (no)	1995-06-12
MY111976A (en)	2001-03-31
TW412529B (en)	2000-11-21
CA2137525C (en)	2005-07-12
FI105681B (fi)	2000-09-29
BG99249A (en)	1995-09-29
CN1109874A (zh)	1995-10-11
MA23392A1 (fr)	1995-07-01
CN1124258C (zh)	2003-10-15
HUT70937A (en)	1995-11-28
GR3030436T3 (en)	1999-09-30
FI945777A0 (fi)	1994-12-08
BG62487B1 (bg)	1999-12-30
DZ1831A1 (fr)	2002-02-17
HRP940967B1 (en)	1999-12-31
JPH07242632A (ja)	1995-09-19
CU22713A3 (es)	1996-07-05
KR950017958A (ko)	1995-07-22
YU71794A (sh)	1996-10-18
LV11321B (en)	1996-12-20
LV11321A (lv)	1996-06-20
NO302362B1 (no)	1998-02-23
HRP940967A2 (en)	1997-08-31
ES2132308T3 (es)	1999-08-16
SV1994000072A (es)	1995-08-09
AU686976B2 (en)	1998-02-12
DE59408350D1 (de)	1999-07-08
HU9403551D0 (en)	1995-02-28

Publication	Publication Date	Title
DE69109021D1 (de)	1995-05-24	Augentropfenarzneimittel.
NO941884L (no)	1994-05-19	1,3-substituerte cykloalkener og cykloalkaner som sentralnervesystem-midler
CA2094702A1 (en)	1992-05-06	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
FR2691065B1 (fr)	1994-07-29	Nouvelles compositions oculaires destinees a la prevention et au traitement de certains troubles de la vision.
HUP9900927A3 (en)	2002-02-28	Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
NO944787D0 (no)	1994-12-09	Isopropyl-(2-metoksyetyl)-4-(2-klor-3-cyanofenyl)-1,4-dihydro-2,6-dimetylpyridin-3,5-dikarboksylat
EE04551B1 (et)	2005-10-17	Optiliselt aktiivne pridl-4H-1,2,4-oksadiasiini derivaat ja selle kasutamine vaskulaarsete haiguste ravis
NO970573D0 (no)	1997-02-07	Ylidenforbindelser og deres fremstilling
ATE116851T1 (de)	1995-01-15	5-aryl-3h-1,2,4-triazol-3-one und ihre verwendung in der behandlung neurodegenerativer beschwerden.
NO932874L (no)	1993-08-12	Anvendelse av lacidipin for behandling av arteriosklerose
DE69827706D1 (de)	2004-12-30	5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems
BR9714184A (pt)	2000-02-29	Utilização de bonzoillquil-1,2,3,6-tetraidropiridinas
EP0311053A3 (en)	1991-05-08	Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use
DK0525537T3 (da)	1995-02-20	Anvendelse af 1,4 dihydropyridiner til fremstilling af lægemiddel til behandling af neuropatier fremkaldt af diabetes mellitus
PT80521A (en)	1985-06-01	Process for the preparation of esters of the 1,4-dihydro-2,6-dimethyl-3-(alcoxicarbonyl or alcoxialcoxicarbonyl)-4-(substituted phenyl) pyridin-5-carboxylic acid of stereochemical isomers and pharmaceutically acceptable salts thereof