CU22713A3 - Procedimiento de obtencion del compuesto 4-(2-cloro-3-ciano-fenil)-1,4-dihidro-2,6-dimetilpiridin-3,5-dicarboxilato de isopropilo y 2-metoxietilo - Google Patents

Procedimiento de obtencion del compuesto 4-(2-cloro-3-ciano-fenil)-1,4-dihidro-2,6-dimetilpiridin-3,5-dicarboxilato de isopropilo y 2-metoxietilo

Info

Publication number
CU22713A3
CU22713A3 CU13794A CU1994137A CU22713A3 CU 22713 A3 CU22713 A3 CU 22713A3 CU 13794 A CU13794 A CU 13794A CU 1994137 A CU1994137 A CU 1994137A CU 22713 A3 CU22713 A3 CU 22713A3
Authority
CU
Cuba
Prior art keywords
chloro
metoxietilo
isopropilo
dimetilpiridin
dicarboxilato
Prior art date
Application number
CU13794A
Other languages
English (en)
Inventor
Gao Zhan
Wolfgang Harwig
Heinrich Meier
Teunis Nis Schuurman
Jonge Maarten De De
Rudolf Op Schohe-Loop
Bodo Junge
Bernard Schmidt
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4342194A external-priority patent/DE4342194A1/de
Priority claimed from DE19944424677 external-priority patent/DE4424677A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CU22713A3 publication Critical patent/CU22713A3/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

La presente invención se refiere el nuevo compuesto rac-4-(2-cloro-3-ciano-fenil)-1,4-dihidro-2,6-dimetil-piridin-3,5-dicarboxilato de isopropilo y 2-metoxietilo y sus enantiómeros puros, procedimiento para su fabricación y su uso como medicamento, especialmente para el tratamiento de enfermedades cerebrales y neuronales, así como a un nuevo producto intermedio para su fabricación.
CU13794A 1993-12-10 1994-12-02 Procedimiento de obtencion del compuesto 4-(2-cloro-3-ciano-fenil)-1,4-dihidro-2,6-dimetilpiridin-3,5-dicarboxilato de isopropilo y 2-metoxietilo CU22713A3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4342194A DE4342194A1 (de) 1993-12-10 1993-12-10 Halogen-phenyl-substituierte 1,4-Dihydropyridine
DE19944424677 DE4424677A1 (de) 1994-07-13 1994-07-13 Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat

Publications (1)

Publication Number Publication Date
CU22713A3 true CU22713A3 (es) 1996-07-05

Family

ID=25931956

Family Applications (1)

Application Number Title Priority Date Filing Date
CU13794A CU22713A3 (es) 1993-12-10 1994-12-02 Procedimiento de obtencion del compuesto 4-(2-cloro-3-ciano-fenil)-1,4-dihidro-2,6-dimetilpiridin-3,5-dicarboxilato de isopropilo y 2-metoxietilo

Country Status (35)

Country Link
US (1) US5665740A (es)
EP (1) EP0657430B1 (es)
JP (1) JP3751041B2 (es)
KR (1) KR100332325B1 (es)
CN (2) CN1056606C (es)
AT (1) ATE180774T1 (es)
AU (1) AU686976B2 (es)
BG (1) BG62487B1 (es)
CA (1) CA2137525C (es)
CO (1) CO4290426A1 (es)
CU (1) CU22713A3 (es)
CZ (1) CZ286065B6 (es)
DE (1) DE59408350D1 (es)
DK (1) DK0657430T3 (es)
DZ (1) DZ1831A1 (es)
EE (1) EE03192B1 (es)
ES (1) ES2132308T3 (es)
FI (1) FI105681B (es)
GR (1) GR3030436T3 (es)
HR (1) HRP940967B1 (es)
HU (1) HU215593B (es)
IL (1) IL111922A (es)
LV (1) LV11321B (es)
MA (1) MA23392A1 (es)
MY (1) MY111976A (es)
NO (1) NO302362B1 (es)
NZ (1) NZ270087A (es)
PL (1) PL179973B1 (es)
RO (1) RO115800B1 (es)
SA (1) SA95160078B1 (es)
SK (1) SK282399B6 (es)
SV (1) SV1994000072A (es)
TN (1) TNSN94127A1 (es)
TW (1) TW412529B (es)
YU (1) YU48920B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2546395A1 (en) * 2003-11-21 2005-06-09 Memory Pharmaceutical Corporation Compositions and methods of treatment using l-type calcium channel blockers and cholinesterase inhibitors
WO2008058234A2 (en) * 2006-11-08 2008-05-15 Memory Pharmaceuticals Corporation Pharmaceutical formulations for 1,4-dihyrdropyridine compounds having improved solubility
US11512052B2 (en) 2017-11-21 2022-11-29 Icahn School Of Medicine At Mount Sinai Dihydropyridines for the treatment of cognitive impairment or traumatic brain injury

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3239273A1 (de) * 1982-10-23 1984-04-26 Bayer Ag, 5090 Leverkusen Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
DE3718398A1 (de) * 1987-06-02 1988-12-22 Troponwerke Gmbh & Co Kg Neue kombinationspraeparate mit antidepressiver wirkung
US5114946A (en) * 1987-06-12 1992-05-19 American Cyanamid Company Transdermal delivery of pharmaceuticals
DE3806277A1 (de) * 1988-02-27 1989-09-07 Troponwerke Gmbh & Co Kg Verwendung von 1,4-dihydropyridin-derivaten
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
FR2671349B1 (fr) * 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester

Also Published As

Publication number Publication date
SV1994000072A (es) 1995-08-09
HRP940967A2 (en) 1997-08-31
AU8030694A (en) 1995-06-15
SK151694A3 (en) 1995-07-11
EP0657430A1 (de) 1995-06-14
CZ286065B6 (cs) 2000-01-12
YU71794A (sh) 1996-10-18
SA95160078B1 (ar) 2006-09-25
LV11321A (lv) 1996-06-20
NO302362B1 (no) 1998-02-23
DE59408350D1 (de) 1999-07-08
EP0657430B1 (de) 1999-06-02
NO944787D0 (no) 1994-12-09
HUT70937A (en) 1995-11-28
CO4290426A1 (es) 1996-04-17
KR950017958A (ko) 1995-07-22
DK0657430T3 (da) 1999-11-15
CN1109874A (zh) 1995-10-11
PL306157A1 (en) 1995-06-12
MA23392A1 (fr) 1995-07-01
CN1124258C (zh) 2003-10-15
PL179973B1 (pl) 2000-11-30
CA2137525C (en) 2005-07-12
IL111922A (en) 1999-05-09
IL111922A0 (en) 1995-03-15
MY111976A (en) 2001-03-31
NZ270087A (en) 1996-08-27
TW412529B (en) 2000-11-21
BG99249A (en) 1995-09-29
EE03192B1 (et) 1999-06-15
FI105681B (fi) 2000-09-29
FI945777A7 (fi) 1995-06-11
HRP940967B1 (en) 1999-12-31
FI945777A0 (fi) 1994-12-08
KR100332325B1 (ko) 2002-09-04
AU686976B2 (en) 1998-02-12
RO115800B1 (ro) 2000-06-30
LV11321B (en) 1996-12-20
NO944787L (no) 1995-06-12
JPH07242632A (ja) 1995-09-19
SK282399B6 (sk) 2002-01-07
CZ309394A3 (en) 1995-11-15
TNSN94127A1 (en) 1995-09-21
CA2137525A1 (en) 1995-06-11
BG62487B1 (bg) 1999-12-30
CN1056606C (zh) 2000-09-20
ES2132308T3 (es) 1999-08-16
GR3030436T3 (en) 1999-09-30
HU9403551D0 (en) 1995-02-28
US5665740A (en) 1997-09-09
ATE180774T1 (de) 1999-06-15
DZ1831A1 (fr) 2002-02-17
CN1244525A (zh) 2000-02-16
HU215593B (hu) 1999-01-28
JP3751041B2 (ja) 2006-03-01
YU48920B (sh) 2002-11-15

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