DK0664121T3 - Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af aterosclerose og iskæmisk hjertesygdom - Google Patents

Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af aterosclerose og iskæmisk hjertesygdom

Info

Publication number: DK0664121T3
Authority: DK; Denmark
Prior art keywords: medicament; raloxifene; atherosclerosis; analogues; manufacture
Prior art date: 1993-12-21

Application number

DK94309461T

Other languages

English (en)

Inventor

Steven Harold Zuckerman

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-21

Filing date

1994-12-19

Publication date

2001-12-03

1994-12-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-12-03 Application granted granted Critical

2001-12-03 Publication of DK0664121T3 publication Critical patent/DK0664121T3/da

Links

239000003814 drug Substances 0.000 title abstract 2
201000001320 Atherosclerosis Diseases 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
208000031225 myocardial ischemia Diseases 0.000 title 1
GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 title 1
229960004622 raloxifene Drugs 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Semiconductor Lasers (AREA)
Liquid Crystal Substances (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Finger-Pressure Massage (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK94309461T 1993-12-21 1994-12-19 Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af aterosclerose og iskæmisk hjertesygdom DK0664121T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17060693A	1993-12-21	1993-12-21

Publications (1)

Publication Number	Publication Date
DK0664121T3 true DK0664121T3 (da)	2001-12-03

Family

ID=22620568

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK01200197T DK1095654T3 (da)	1993-12-21	1994-12-19	Anvendelse af raloxifen og dens analoger til fremstilling af et medikament til inhibering af LDL-oxidation og aterosklerose
DK94309461T DK0664121T3 (da)	1993-12-21	1994-12-19	Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af aterosclerose og iskæmisk hjertesygdom

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK01200197T DK1095654T3 (da)	1993-12-21	1994-12-19	Anvendelse af raloxifen og dens analoger til fremstilling af et medikament til inhibering af LDL-oxidation og aterosklerose

Country Status (20)

Country	Link
EP (3)	EP1095654B1 (da)
JP (1)	JPH07196498A (da)
KR (1)	KR950016722A (da)
CN (1)	CN1095663C (da)
AT (3)	ATE207749T1 (da)
AU (1)	AU698389B2 (da)
CA (1)	CA2138508A1 (da)
CZ (1)	CZ286365B6 (da)
DE (3)	DE69433578T2 (da)
DK (2)	DK1095654T3 (da)
ES (3)	ES2163425T3 (da)
HU (1)	HUT71476A (da)
IL (1)	IL112034A (da)
NO (1)	NO313083B1 (da)
NZ (1)	NZ270162A (da)
PT (3)	PT1095654E (da)
RU (1)	RU2127592C1 (da)
TW (1)	TW427902B (da)
UA (1)	UA39941C2 (da)
ZA (1)	ZA9410091B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
WO1996040098A2 (en)	1995-06-07	1996-12-19	Neorx Corporation	Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5622975A (en) *	1995-06-01	1997-04-22	Eli Lilly And Company	Methods for inhibiting vascular smooth muscle cell migration
US6545027B1 (en) *	1995-06-07	2003-04-08	Eli Lilly And Company	Methods of modulating NF-kB transcription factor
EP0747051B1 (en) *	1995-06-07	2002-07-24	Eli Lilly And Company	Treatment of diseases by inducing BEF-1 transcription factor
US5731328A (en) *	1995-10-10	1998-03-24	Eli Lilly And Company	Methods of inhibiting plasminogen activator inhibitor 1
TW442286B (en) *	1996-02-28	2001-06-23	Pfizer	New therapeutic uses of estrogen agonists
IL120266A (en)	1996-02-28	2005-05-17	Pfizer	Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
EP0801066A1 (en) *	1996-03-12	1997-10-15	Eli Lilly And Company	Heterocyclic substituted benzothiophenes and pharmaceutical compositions
US5811437A (en) *	1996-05-21	1998-09-22	Eli Lilly And Company	Methods of increasing nitric oxide synthesis
US5747509A (en) *	1996-06-03	1998-05-05	Schering Aktiengesellschaft	Method for lowering plasma levels of lipoprotein(a)
US5980938A (en) *	1996-07-15	1999-11-09	Eli Lilly And Company	Effect of compounds that suppress induction of plasminogen activator inhibitor 1 (PAI-1)
US6069175A (en) *	1996-11-15	2000-05-30	Pfizer Inc.	Estrogen agonist/antagonists treatment of atherosclerosis
US6353003B1 (en) *	1998-06-17	2002-03-05	Eli Lilly And Company	Method for reducing levels of homocysteine and C-reactive protein
CA2339879C (en)	1998-08-24	2011-11-15	Toshio Miyata	Carbonyl-stress improving agent and peritoneal dialysate
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
RU2464794C1 (ru) *	2011-10-25	2012-10-27	Канапья Табылдыевич Шагиев	Состав для производства кисломолочного продукта "курт"
CN103768601A (zh) *	2012-10-22	2014-05-07	中国科学院上海生命科学研究院	抑制micro-RNA155用于预防和治疗动脉粥样硬化的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3983245A (en) *	1975-02-06	1976-09-28	Smithkline Corporation	Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
TW383306B (en) *	1992-12-22	2000-03-01	Lilly Co Eli	New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol

1994
- 1994-12-19 RU RU94045270A patent/RU2127592C1/ru not_active IP Right Cessation
- 1994-12-19 NZ NZ270162A patent/NZ270162A/en unknown
- 1994-12-19 EP EP01200197A patent/EP1095654B1/en not_active Expired - Lifetime
- 1994-12-19 UA UA94129199A patent/UA39941C2/uk unknown
- 1994-12-19 ES ES94309461T patent/ES2163425T3/es not_active Expired - Lifetime
- 1994-12-19 EP EP98201404A patent/EP0963756B1/en not_active Expired - Lifetime
- 1994-12-19 DE DE69433578T patent/DE69433578T2/de not_active Expired - Fee Related
- 1994-12-19 TW TW083111830A patent/TW427902B/zh not_active IP Right Cessation
- 1994-12-19 CZ CZ19943204A patent/CZ286365B6/cs not_active IP Right Cessation
- 1994-12-19 ZA ZA9410091A patent/ZA9410091B/xx unknown
- 1994-12-19 ES ES01200197T patent/ES2210089T3/es not_active Expired - Lifetime
- 1994-12-19 AT AT94309461T patent/ATE207749T1/de not_active IP Right Cessation
- 1994-12-19 DE DE69428882T patent/DE69428882T2/de not_active Expired - Fee Related
- 1994-12-19 NO NO19944913A patent/NO313083B1/no not_active IP Right Cessation
- 1994-12-19 HU HU9403660A patent/HUT71476A/hu unknown
- 1994-12-19 KR KR1019940034913A patent/KR950016722A/ko not_active Ceased
- 1994-12-19 CA CA002138508A patent/CA2138508A1/en not_active Abandoned
- 1994-12-19 ES ES98201404T patent/ES2215270T3/es not_active Expired - Lifetime
- 1994-12-19 AT AT98201404T patent/ATE260104T1/de not_active IP Right Cessation
- 1994-12-19 DK DK01200197T patent/DK1095654T3/da active
- 1994-12-19 AU AU81563/94A patent/AU698389B2/en not_active Ceased
- 1994-12-19 PT PT01200197T patent/PT1095654E/pt unknown
- 1994-12-19 JP JP6314536A patent/JPH07196498A/ja active Pending
- 1994-12-19 EP EP94309461A patent/EP0664121B1/en not_active Expired - Lifetime
- 1994-12-19 IL IL11203494A patent/IL112034A/he not_active IP Right Cessation
- 1994-12-19 DK DK94309461T patent/DK0664121T3/da active
- 1994-12-19 DE DE69433348T patent/DE69433348T2/de not_active Expired - Fee Related
- 1994-12-19 CN CN94119272A patent/CN1095663C/zh not_active Expired - Fee Related
- 1994-12-19 AT AT01200197T patent/ATE254459T1/de not_active IP Right Cessation
- 1994-12-19 PT PT94309461T patent/PT664121E/pt unknown
- 1994-12-19 PT PT98201404T patent/PT963756E/pt unknown

Also Published As

Publication number	Publication date
ATE260104T1 (de)	2004-03-15
DE69433578D1 (de)	2004-04-01
DE69433348D1 (de)	2003-12-24
RU2127592C1 (ru)	1999-03-20
ATE207749T1 (de)	2001-11-15
HU9403660D0 (en)	1995-02-28
NO313083B1 (no)	2002-08-12
NO944913D0 (no)	1994-12-19
EP0963756A2 (en)	1999-12-15
ES2163425T3 (es)	2002-02-01
CA2138508A1 (en)	1995-06-22
EP1095654A2 (en)	2001-05-02
EP0664121B1 (en)	2001-10-31
NZ270162A (en)	1997-06-24
AU698389B2 (en)	1998-10-29
DE69428882D1 (de)	2001-12-06
EP0963756B1 (en)	2004-02-25
EP0664121A1 (en)	1995-07-26
HUT71476A (en)	1995-11-28
ES2215270T3 (es)	2004-10-01
TW427902B (en)	2001-04-01
EP0963756A3 (en)	1999-12-22
DE69433348T2 (de)	2004-08-26
CZ286365B6 (cs)	2000-03-15
DE69433578T2 (de)	2004-12-16
JPH07196498A (ja)	1995-08-01
KR950016722A (ko)	1995-07-20
CN1108090A (zh)	1995-09-13
PT963756E (pt)	2004-06-30
PT1095654E (pt)	2004-04-30
ATE254459T1 (de)	2003-12-15
PT664121E (pt)	2002-03-28
CN1095663C (zh)	2002-12-11
NO944913L (no)	1995-06-22
EP1095654A3 (en)	2001-06-13
ZA9410091B (en)	1996-06-19
AU8156394A (en)	1995-06-29
IL112034A (en)	1999-03-12
CZ320494A3 (en)	1995-09-13
EP1095654B1 (en)	2003-11-19
DE69428882T2 (de)	2002-04-25
IL112034A0 (en)	1995-03-15
ES2210089T3 (es)	2004-07-01
DK1095654T3 (da)	2004-03-15
RU94045270A (ru)	1996-10-20
UA39941C2 (uk)	2001-07-16

Publication	Publication Date	Title
DK1095654T3 (da)	2004-03-15	Anvendelse af raloxifen og dens analoger til fremstilling af et medikament til inhibering af LDL-oxidation og aterosklerose
DK0664126T3 (da)	1997-09-01	Hæmning af trombin
NO944911L (no)	1995-06-22	Ikke-peptid-takykininreseptorantagonister
ES2157957T3 (es)	2001-09-01	Procedimientos para inhibir la endometriosis.
DK0651999T3 (da)	2002-06-17	Fremgangsmåder til inhibering af livmoderfibrose
ATE150307T1 (de)	1997-04-15	Hemmung von seborrhoe und akne
DK0652000T3 (da)	2001-11-12	Anvendelse af 2-phenyl-3-aroylbenzothiophener til fremstilling af et lægemiddel til inhibering af angiogenese og angiogene sygdomme
DK0652002T3 (da)	2001-04-17	Anvendelse af 2-phenyl-3-aroylebenzothiophener til fremstilling af et medikament til hæmning af brusknedbrydning
DK0652004T3 (da)	2002-09-02	Fremgangsmåder til behandling af resistente neoplasmer
NO20000750D0 (no)	2000-02-15	Fremgangsmåte for å redusere blodplatetall