NO313083B1 - Anvendelse av forbindelser for fremstilling av preparat for å inhibere LDL-oksydasjon og arteriosclerosis - Google Patents

Anvendelse av forbindelser for fremstilling av preparat for å inhibere LDL-oksydasjon og arteriosclerosis Download PDF

Info

Publication number: NO313083B1
Authority: NO; Norway
Prior art keywords: compound; arteriosclerosis; compounds; preparation; ldl
Prior art date: 1993-12-21

Application number

NO19944913A

Other languages

English (en)

Norwegian (no)

Other versions

NO944913D0 (no

NO944913L (no

Inventor

Steven Harold Zuckerman

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-21

Filing date

1994-12-19

Publication date

2002-08-12

1994-12-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-12-19 Publication of NO944913D0 publication Critical patent/NO944913D0/no

1995-06-22 Publication of NO944913L publication Critical patent/NO944913L/no

2002-08-12 Publication of NO313083B1 publication Critical patent/NO313083B1/no

Links

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TVZISJTYELEYPI-UHFFFAOYSA-N hypodiphosphoric acid Chemical compound OP(O)(=O)P(O)(O)=O TVZISJTYELEYPI-UHFFFAOYSA-N 0.000 description 1
238000011534 incubation Methods 0.000 description 1
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SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
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VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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IWYDHOAUDWTVEP-UHFFFAOYSA-M mandelate Chemical compound [O-]C(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-M 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
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238000002156 mixing Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
KVNYFPKFSJIPBJ-UHFFFAOYSA-N ortho-diethylbenzene Natural products CCC1=CC=CC=C1CC KVNYFPKFSJIPBJ-UHFFFAOYSA-N 0.000 description 1
108010071584 oxidized low density lipoprotein Proteins 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
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239000000825 pharmaceutical preparation Substances 0.000 description 1
DYUMLJSJISTVPV-UHFFFAOYSA-N phenyl propanoate Chemical compound CCC(=O)OC1=CC=CC=C1 DYUMLJSJISTVPV-UHFFFAOYSA-N 0.000 description 1
229940049953 phenylacetate Drugs 0.000 description 1
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
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NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
230000007505 plaque formation Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
229960003912 probucol Drugs 0.000 description 1
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239000001294 propane Substances 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
UORVCLMRJXCDCP-UHFFFAOYSA-M propynoate Chemical compound [O-]C(=O)C#C UORVCLMRJXCDCP-UHFFFAOYSA-M 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
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229960001860 salicylate Drugs 0.000 description 1
230000002000 scavenging effect Effects 0.000 description 1
229940116351 sebacate Drugs 0.000 description 1
CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000010703 silicon Substances 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
210000000329 smooth muscle myocyte Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000007787 solid Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000007858 starting material Substances 0.000 description 1
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238000007920 subcutaneous administration Methods 0.000 description 1
TYFQFVWCELRYAO-UHFFFAOYSA-L suberate(2-) Chemical compound [O-]C(=O)CCCCCCC([O-])=O TYFQFVWCELRYAO-UHFFFAOYSA-L 0.000 description 1
239000000126 substance Substances 0.000 description 1
229940086735 succinate Drugs 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
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KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
238000012546 transfer Methods 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229940071104 xylenesulfonate Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Semiconductor Lasers (AREA)
Liquid Crystal Substances (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Finger-Pressure Massage (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO19944913A 1993-12-21 1994-12-19 Anvendelse av forbindelser for fremstilling av preparat for å inhibere LDL-oksydasjon og arteriosclerosis NO313083B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17060693A	1993-12-21	1993-12-21

Publications (3)

Publication Number	Publication Date
NO944913D0 NO944913D0 (no)	1994-12-19
NO944913L NO944913L (no)	1995-06-22
NO313083B1 true NO313083B1 (no)	2002-08-12

Family

ID=22620568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19944913A NO313083B1 (no)	1993-12-21	1994-12-19	Anvendelse av forbindelser for fremstilling av preparat for å inhibere LDL-oksydasjon og arteriosclerosis

Country Status (20)

Country	Link
EP (3)	EP1095654B1 (da)
JP (1)	JPH07196498A (da)
KR (1)	KR950016722A (da)
CN (1)	CN1095663C (da)
AT (3)	ATE207749T1 (da)
AU (1)	AU698389B2 (da)
CA (1)	CA2138508A1 (da)
CZ (1)	CZ286365B6 (da)
DE (3)	DE69433578T2 (da)
DK (2)	DK1095654T3 (da)
ES (3)	ES2163425T3 (da)
HU (1)	HUT71476A (da)
IL (1)	IL112034A (da)
NO (1)	NO313083B1 (da)
NZ (1)	NZ270162A (da)
PT (3)	PT1095654E (da)
RU (1)	RU2127592C1 (da)
TW (1)	TW427902B (da)
UA (1)	UA39941C2 (da)
ZA (1)	ZA9410091B (da)

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US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
WO1996040098A2 (en)	1995-06-07	1996-12-19	Neorx Corporation	Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5622975A (en) *	1995-06-01	1997-04-22	Eli Lilly And Company	Methods for inhibiting vascular smooth muscle cell migration
US6545027B1 (en) *	1995-06-07	2003-04-08	Eli Lilly And Company	Methods of modulating NF-kB transcription factor
EP0747051B1 (en) *	1995-06-07	2002-07-24	Eli Lilly And Company	Treatment of diseases by inducing BEF-1 transcription factor
US5731328A (en) *	1995-10-10	1998-03-24	Eli Lilly And Company	Methods of inhibiting plasminogen activator inhibitor 1
TW442286B (en) *	1996-02-28	2001-06-23	Pfizer	New therapeutic uses of estrogen agonists
IL120266A (en)	1996-02-28	2005-05-17	Pfizer	Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
EP0801066A1 (en) *	1996-03-12	1997-10-15	Eli Lilly And Company	Heterocyclic substituted benzothiophenes and pharmaceutical compositions
US5811437A (en) *	1996-05-21	1998-09-22	Eli Lilly And Company	Methods of increasing nitric oxide synthesis
US5747509A (en) *	1996-06-03	1998-05-05	Schering Aktiengesellschaft	Method for lowering plasma levels of lipoprotein(a)
US5980938A (en) *	1996-07-15	1999-11-09	Eli Lilly And Company	Effect of compounds that suppress induction of plasminogen activator inhibitor 1 (PAI-1)
US6069175A (en) *	1996-11-15	2000-05-30	Pfizer Inc.	Estrogen agonist/antagonists treatment of atherosclerosis
US6353003B1 (en) *	1998-06-17	2002-03-05	Eli Lilly And Company	Method for reducing levels of homocysteine and C-reactive protein
CA2339879C (en)	1998-08-24	2011-11-15	Toshio Miyata	Carbonyl-stress improving agent and peritoneal dialysate
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
RU2464794C1 (ru) *	2011-10-25	2012-10-27	Канапья Табылдыевич Шагиев	Состав для производства кисломолочного продукта "курт"
CN103768601A (zh) *	2012-10-22	2014-05-07	中国科学院上海生命科学研究院	抑制micro-RNA155用于预防和治疗动脉粥样硬化的方法

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US3983245A (en) *	1975-02-06	1976-09-28	Smithkline Corporation	Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
TW383306B (en) *	1992-12-22	2000-03-01	Lilly Co Eli	New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol

1994
- 1994-12-19 RU RU94045270A patent/RU2127592C1/ru not_active IP Right Cessation
- 1994-12-19 NZ NZ270162A patent/NZ270162A/en unknown
- 1994-12-19 EP EP01200197A patent/EP1095654B1/en not_active Expired - Lifetime
- 1994-12-19 UA UA94129199A patent/UA39941C2/uk unknown
- 1994-12-19 ES ES94309461T patent/ES2163425T3/es not_active Expired - Lifetime
- 1994-12-19 EP EP98201404A patent/EP0963756B1/en not_active Expired - Lifetime
- 1994-12-19 DE DE69433578T patent/DE69433578T2/de not_active Expired - Fee Related
- 1994-12-19 TW TW083111830A patent/TW427902B/zh not_active IP Right Cessation
- 1994-12-19 CZ CZ19943204A patent/CZ286365B6/cs not_active IP Right Cessation
- 1994-12-19 ZA ZA9410091A patent/ZA9410091B/xx unknown
- 1994-12-19 ES ES01200197T patent/ES2210089T3/es not_active Expired - Lifetime
- 1994-12-19 AT AT94309461T patent/ATE207749T1/de not_active IP Right Cessation
- 1994-12-19 DE DE69428882T patent/DE69428882T2/de not_active Expired - Fee Related
- 1994-12-19 NO NO19944913A patent/NO313083B1/no not_active IP Right Cessation
- 1994-12-19 HU HU9403660A patent/HUT71476A/hu unknown
- 1994-12-19 KR KR1019940034913A patent/KR950016722A/ko not_active Ceased
- 1994-12-19 CA CA002138508A patent/CA2138508A1/en not_active Abandoned
- 1994-12-19 ES ES98201404T patent/ES2215270T3/es not_active Expired - Lifetime
- 1994-12-19 AT AT98201404T patent/ATE260104T1/de not_active IP Right Cessation
- 1994-12-19 DK DK01200197T patent/DK1095654T3/da active
- 1994-12-19 AU AU81563/94A patent/AU698389B2/en not_active Ceased
- 1994-12-19 PT PT01200197T patent/PT1095654E/pt unknown
- 1994-12-19 JP JP6314536A patent/JPH07196498A/ja active Pending
- 1994-12-19 EP EP94309461A patent/EP0664121B1/en not_active Expired - Lifetime
- 1994-12-19 IL IL11203494A patent/IL112034A/he not_active IP Right Cessation
- 1994-12-19 DK DK94309461T patent/DK0664121T3/da active
- 1994-12-19 DE DE69433348T patent/DE69433348T2/de not_active Expired - Fee Related
- 1994-12-19 CN CN94119272A patent/CN1095663C/zh not_active Expired - Fee Related
- 1994-12-19 AT AT01200197T patent/ATE254459T1/de not_active IP Right Cessation
- 1994-12-19 PT PT94309461T patent/PT664121E/pt unknown
- 1994-12-19 PT PT98201404T patent/PT963756E/pt unknown

Also Published As

Publication number	Publication date
ATE260104T1 (de)	2004-03-15
DE69433578D1 (de)	2004-04-01
DE69433348D1 (de)	2003-12-24
RU2127592C1 (ru)	1999-03-20
ATE207749T1 (de)	2001-11-15
HU9403660D0 (en)	1995-02-28
NO944913D0 (no)	1994-12-19
EP0963756A2 (en)	1999-12-15
ES2163425T3 (es)	2002-02-01
CA2138508A1 (en)	1995-06-22
EP1095654A2 (en)	2001-05-02
EP0664121B1 (en)	2001-10-31
NZ270162A (en)	1997-06-24
AU698389B2 (en)	1998-10-29
DE69428882D1 (de)	2001-12-06
EP0963756B1 (en)	2004-02-25
EP0664121A1 (en)	1995-07-26
HUT71476A (en)	1995-11-28
ES2215270T3 (es)	2004-10-01
TW427902B (en)	2001-04-01
EP0963756A3 (en)	1999-12-22
DE69433348T2 (de)	2004-08-26
CZ286365B6 (cs)	2000-03-15
DE69433578T2 (de)	2004-12-16
JPH07196498A (ja)	1995-08-01
KR950016722A (ko)	1995-07-20
CN1108090A (zh)	1995-09-13
PT963756E (pt)	2004-06-30
PT1095654E (pt)	2004-04-30
ATE254459T1 (de)	2003-12-15
PT664121E (pt)	2002-03-28
CN1095663C (zh)	2002-12-11
DK0664121T3 (da)	2001-12-03
NO944913L (no)	1995-06-22
EP1095654A3 (en)	2001-06-13
ZA9410091B (en)	1996-06-19
AU8156394A (en)	1995-06-29
IL112034A (en)	1999-03-12
CZ320494A3 (en)	1995-09-13
EP1095654B1 (en)	2003-11-19
DE69428882T2 (de)	2002-04-25
IL112034A0 (en)	1995-03-15
ES2210089T3 (es)	2004-07-01
DK1095654T3 (da)	2004-03-15
RU94045270A (ru)	1996-10-20
UA39941C2 (uk)	2001-07-16

Legal Events

Date	Code	Title	Description
2005-09-12	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP0664121B1 (en)	2001-10-31	Use of raloxifene and its analogs for the manufacture of a medicament for the treatment of atherosclerose and ischaemic heart disease
AU688815B2 (en)	1998-03-19	Methods of increasing TGF-13 in the brain, inhibiting Alzeheimers disease and inhibiting B-amyloid peptide mediated neurotoxicity.
US6017964A (en)	2000-01-25	Method of increasing testosterone
EP0771200B1 (en)	2000-02-09	Use of raloxifene and its analogs for the manufacture of a medicament for the treatment of viral diseases
AU707756B2 (en)	1999-07-22	Methods for inhibiting vascular smooth muscle cell migration
US5610166A (en)	1997-03-11	Methods for inhibiting angiogenesis
KR19980702079A (ko)	1998-07-15	세포-세포 접착의 억제 방법
CA2138496A1 (en)	1995-06-22	Methods of inhibiting pulmonary hypertensive diseases
EP0659413B1 (en)	2001-10-17	Inhibition of CNS problems in post-menopausal women
AU701701B2 (en)	1999-02-04	Methods of inhibiting breast disorders
HUT71477A (en)	1995-11-28	Pharmaceutical compositions for increasing libido in post-menopausal women containing 2-phenyl-3-aroil-benzothiophene derivatives and process for their preparation
US6489355B2 (en)	2002-12-03	Methods of inhibiting the effects of amyloidogenic proteins
CA2234404A1 (en)	1997-04-17	Methods of inhibiting plasminogen activator inhibitor 1
US5502074A (en)	1996-03-26	Benzothiophenes for bone healing and fracture repair