DK0675878T3 - Nye D-vitaminanaloger - Google Patents

Nye D-vitaminanaloger

Info

Publication number: DK0675878T3
Authority: DK; Denmark
Prior art keywords: pct; compounds; thiol; sec; date
Prior art date: 1992-12-23

Application number

DK94903741.0T

Other languages

Danish (da)

English (en)

Inventor

Gunnar Grue-Soerensen

Erik Rytter Ottosen

Original Assignee

Leo Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-23

Filing date

1993-12-17

Publication date

1997-04-28

1993-12-17 Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd

1997-04-28 Application granted granted Critical

1997-04-28 Publication of DK0675878T3 publication Critical patent/DK0675878T3/da

Links

229930003316 Vitamin D Natural products 0.000 title 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
235000019166 vitamin D Nutrition 0.000 title 1
239000011710 vitamin D Substances 0.000 title 1
150000003710 vitamin D derivatives Chemical class 0.000 title 1
229940046008 vitamin d Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000006324 decarbonylation Effects 0.000 abstract 1
238000006606 decarbonylation reaction Methods 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000006552 photochemical reaction Methods 0.000 abstract 1
JCBJVAJGLKENNC-UHFFFAOYSA-M potassium ethyl xanthate Chemical compound [K+].CCOC([S-])=S JCBJVAJGLKENNC-UHFFFAOYSA-M 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Nutrition Science (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK94903741.0T 1992-12-23 1993-12-17 Nye D-vitaminanaloger DK0675878T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929226877A GB9226877D0 (en)	1992-12-23	1992-12-23	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK0675878T3 true DK0675878T3 (da)	1997-04-28

Family

ID=10727157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94903741.0T DK0675878T3 (da)	1992-12-23	1993-12-17	Nye D-vitaminanaloger

Country Status (15)

Country	Link
US (1)	US5554599A (de)
EP (1)	EP0675878B1 (de)
KR (1)	KR100295977B1 (de)
AT (1)	ATE148454T1 (de)
AU (1)	AU668638B2 (de)
CA (1)	CA2146775C (de)
DE (1)	DE69307929T2 (de)
DK (1)	DK0675878T3 (de)
ES (1)	ES2098123T3 (de)
FI (1)	FI108225B (de)
GB (1)	GB9226877D0 (de)
GR (1)	GR3022774T3 (de)
NZ (1)	NZ259317A (de)
RU (1)	RU2136660C1 (de)
WO (1)	WO1994014766A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5830885A (en) *	1992-03-12	1998-11-03	The Johns Hopkins University	Antiproliferative vitamin D3 hybrids
US6407082B1 (en) *	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US20040167106A1 (en) *	1993-06-04	2004-08-26	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of a Vitamin D compound
GB9314400D0 (en) *	1993-07-12	1993-08-25	Leo Pharm Prod Ltd	Produktionsaktieselskab) chemical compounds
WO1995027697A1 (en) *	1994-04-11	1995-10-19	Chugai Seiyaku Kabushiki Kaisha	22-thiavitamin d3 derivative
ATE290869T1 (de)	1995-12-28	2005-04-15	Chugai Pharmaceutical Co Ltd	Verwendung von vitamin d derivaten zur herstellung eines medikaments zur behandlung von bösartigen tumormetastase
US6869940B2 (en)	1995-12-28	2005-03-22	Chugai Seiyaku Kabushiki Kaisha	Malignant tumor metastasis inhibitors
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6184398B1 (en)	1996-12-20	2001-02-06	Chugai Seiyaku Kabushiki Kaisha	16-ene-vitamin D derivatives
CA2275382A1 (en) *	1996-12-20	1998-07-02	Chugai Seiyaku Kabushiki Kaisha	16-ene-vitamin d derivatives
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
ES2274785T3 (es)	1999-04-01	2007-06-01	Johns Hopkins University	Analogos de 1-alfa,25-dihidroxi vitamina d3 no calcemicos, antiproliferativos, transcripcionalmente activos que contienen azufre.
DK1220676T3 (da)	1999-09-29	2005-09-05	Colotech As	Forebyggelse af colorektal cancer
US6703380B2 (en)	1999-09-29	2004-03-09	Colotech A/S	Prevention of cancer
WO2001030751A2 (en) *	1999-10-25	2001-05-03	Strakan Limited	USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
JP4803939B2 (ja)	2000-04-19	2011-10-26	中外製薬株式会社	ビタミンｄ誘導体
CN100469764C (zh) *	2000-06-15	2009-03-18	中外制药株式会社	维生素d衍生物
ATE428692T1 (de) *	2001-08-22	2009-05-15	Univ Johns Hopkins	24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen
HRP20070058B1 (hr)	2001-10-19	2014-05-23	Isotechnika Inc.	Sinteza ciklosporinskih analoga
US7101865B2 (en)	2002-06-13	2006-09-05	Cytochroma Inc.	24-sulfoximine vitamin D3 compounds
CA2510228C (en)	2002-12-18	2012-10-30	Johns Hopkins University	25-so2-substituted analogs of 1.alpha.,25-dihydroxyvitamin d3
SG173119A1 (en)	2009-01-27	2011-08-29	Berg Biosystems Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es)	2009-08-14	2019-06-27	Berg Llc	Vitamina d3 y analogos de la misma para tratar alopecia.
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4749710A (en) *	1985-05-01	1988-06-07	Hoffmann-La Roche Inc.	Immunosuppressive agents
SU1445729A1 (ru) *	1986-04-08	1988-12-23	Харьковский научно-исследовательский институт дерматологии и венерологии	Способ лечени псориаза
FR2631025B1 (fr) *	1988-05-04	1991-04-12	Ire Medgenix Sa	Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3
GB8904153D0 (en) *	1989-02-23	1989-04-05	Leo Pharm Prod Ltd	Chemical compounds
WO1995027697A1 (en) *	1994-04-11	1995-10-19	Chugai Seiyaku Kabushiki Kaisha	22-thiavitamin d3 derivative

1992
- 1992-12-23 GB GB929226877A patent/GB9226877D0/en active Pending
1993
- 1993-12-17 AU AU58087/94A patent/AU668638B2/en not_active Ceased
- 1993-12-17 RU RU95113480A patent/RU2136660C1/ru not_active IP Right Cessation
- 1993-12-17 NZ NZ259317A patent/NZ259317A/en unknown
- 1993-12-17 EP EP94903741A patent/EP0675878B1/de not_active Expired - Lifetime
- 1993-12-17 DK DK94903741.0T patent/DK0675878T3/da active
- 1993-12-17 CA CA002146775A patent/CA2146775C/en not_active Expired - Fee Related
- 1993-12-17 DE DE69307929T patent/DE69307929T2/de not_active Expired - Fee Related
- 1993-12-17 ES ES94903741T patent/ES2098123T3/es not_active Expired - Lifetime
- 1993-12-17 AT AT94903741T patent/ATE148454T1/de not_active IP Right Cessation
- 1993-12-17 WO PCT/DK1993/000425 patent/WO1994014766A1/en not_active Ceased
- 1993-12-17 KR KR1019950701331A patent/KR100295977B1/ko not_active Expired - Fee Related
- 1993-12-17 US US08/411,634 patent/US5554599A/en not_active Expired - Fee Related
1995
- 1995-06-16 FI FI952972A patent/FI108225B/fi active
1997
- 1997-03-07 GR GR970400458T patent/GR3022774T3/el unknown

Also Published As

Publication number	Publication date
DE69307929D1 (de)	1997-03-13
RU2136660C1 (ru)	1999-09-10
ES2098123T3 (es)	1997-04-16
CA2146775C (en)	2005-06-28
KR950703501A (ko)	1995-09-20
AU5808794A (en)	1994-07-19
EP0675878A1 (de)	1995-10-11
RU95113480A (ru)	1997-03-20
GR3022774T3 (en)	1997-06-30
KR100295977B1 (ko)	2001-11-14
CA2146775A1 (en)	1994-07-07
DE69307929T2 (de)	1997-09-04
AU668638B2 (en)	1996-05-09
ATE148454T1 (de)	1997-02-15
FI952972A0 (fi)	1995-06-16
WO1994014766A1 (en)	1994-07-07
FI108225B (fi)	2001-12-14
EP0675878B1 (de)	1997-01-29
NZ259317A (en)	1997-05-26
US5554599A (en)	1996-09-10
GB9226877D0 (en)	1993-02-17
FI952972L (fi)	1995-06-16

Publication	Publication Date	Title
FI952972A0 (fi)	1995-06-16	Uudet D-vitamiinianalogit
Bahrami et al.	2010	Direct conversion of thiols and disulfides into sulfonamides
LV10456A (lv)	1995-02-20	Triazolpiridazina atvasinajumi to iegusanas panemiens un pielietojums
ES2032749T3 (es)	1993-03-01	Acidos oxoftalazinil-aceticos heterociclicos.
ES8506566A1 (es)	1985-08-01	Procedimiento para la produccion de derivados de 1-carbonil-1-fenil-2-azolil-etanol
SU633479A3 (ru)	1978-11-15	Способ получени стильбеновых соединений
IE58065B1 (en)	1993-06-30	1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions
US4018830A (en)	1977-04-19	Phenylthioaralkylamines
US2835704A (en)	1958-05-20	Pantetheine intermediates
UA75598C2 (uk)	2006-05-15	Спосіб одержання анілінових сполук, проміжна сполука та її застосування
GB1077076A (en)	1967-07-26	Novel imidazole derivatives and a process for the manufacture thereof
EP0030140A2 (de)	1981-06-10	Verfahren zur Herstellung aromatischer Sulfonamide N-(substituiert durch heterocyclische-aminocarbonyl) mit herbizider Wirkung
FI86057C (fi)	1992-07-10	2-bensyltio- eller 2-bensylsulfoxid-1- cyklopenten-1-karboxamider, foerfaranden foer deras framstaellning och deras anvaendning vid syntes av 4,5-trimetylen-4-isotiazolin-3-oner.
EP0424194A2 (de)	1991-04-24	Benzanilidederivate und Ihre Verwendung als anti-atherosclerosis Wirkstoffe
US2467895A (en)	1949-04-19	Piperazine derivatives and method of preparing the same
DK0612310T3 (da)	1997-03-24	Fremgangsmåde til fremstilling af kanelsyrederivater
HU199113B (en)	1990-01-29	Process for production of new derivatives of 2,3-diamin-acryl-acid-nitril
ES8703825A1 (es)	1987-03-01	Un procedimiento para la preparacion de derivados del acido fenil nonatetraenoico
US3856825A (en)	1974-12-24	3-diethylamino-2,2-dimethylpropyl 5-(substituted phenyl)-2-furoates
KR850001173A (ko)	1985-03-16	2-치환된 4-페닐이미다졸 아미딘 유도체의 제조방법
AU6520698A (en)	1998-11-11	Process for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof
US7033564B2 (en)	2006-04-25	Lithium aluminum hydride-based selenating reagent and preparation methods using same
US3308132A (en)	1967-03-07	6, 8-dithiooctanoyl amides and intermediates
US3631071A (en)	1971-12-28	S-aroyl- s-thioaroyl- and s-((n-aryl) hydrocarbylimidoyl)hydrosulfamines
CN110437114A (zh)	2019-11-12	一种合成不对称氰基烷基二硫醚的方法