DK0695293T3 - 10,11-methanodibenzosuberanderivater anvendt som kemosensibiliserende midler - Google Patents

10,11-methanodibenzosuberanderivater anvendt som kemosensibiliserende midler

Info

Publication number
DK0695293T3
DK0695293T3 DK94914200T DK94914200T DK0695293T3 DK 0695293 T3 DK0695293 T3 DK 0695293T3 DK 94914200 T DK94914200 T DK 94914200T DK 94914200 T DK94914200 T DK 94914200T DK 0695293 T3 DK0695293 T3 DK 0695293T3
Authority
DK
Denmark
Prior art keywords
chr
formula
cyclic
branched
carbon atoms
Prior art date
Application number
DK94914200T
Other languages
Danish (da)
English (en)
Inventor
Jurg Roland Pfister
Doris Lynne Slate
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of DK0695293T3 publication Critical patent/DK0695293T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Addiction (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
DK94914200T 1993-04-19 1994-04-13 10,11-methanodibenzosuberanderivater anvendt som kemosensibiliserende midler DK0695293T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/049,065 US5643909A (en) 1993-04-19 1993-04-19 10,11-Methanodibenzosuberane derivatives
PCT/US1994/004215 WO1994024107A1 (fr) 1993-04-19 1994-04-13 Derives de 10,11-methanodibenzosuberane utilises comme agents de chimiosensibilisation

Publications (1)

Publication Number Publication Date
DK0695293T3 true DK0695293T3 (da) 1999-06-23

Family

ID=21957890

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94914200T DK0695293T3 (da) 1993-04-19 1994-04-13 10,11-methanodibenzosuberanderivater anvendt som kemosensibiliserende midler

Country Status (21)

Country Link
US (5) US5643909A (fr)
EP (2) EP0695293B1 (fr)
JP (1) JP3020607B2 (fr)
KR (1) KR100248591B1 (fr)
CN (2) CN1045204C (fr)
AT (1) ATE172194T1 (fr)
AU (1) AU678470B2 (fr)
BR (1) BR9405965A (fr)
CA (1) CA2160881C (fr)
CZ (1) CZ287273B6 (fr)
DE (1) DE69413958T2 (fr)
DK (1) DK0695293T3 (fr)
ES (1) ES2121603T3 (fr)
FI (1) FI111161B (fr)
HU (2) HU227824B1 (fr)
NO (1) NO313284B1 (fr)
NZ (1) NZ265547A (fr)
PL (1) PL183375B1 (fr)
RU (1) RU2167154C2 (fr)
UA (1) UA42720C2 (fr)
WO (1) WO1994024107A1 (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643909A (en) * 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6075025A (en) 1993-10-15 2000-06-13 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5567592A (en) * 1994-02-02 1996-10-22 Regents Of The University Of California Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
EP0777472A2 (fr) 1994-08-31 1997-06-11 Eli Lilly And Company Procedes d'identification et de traitement de tumeurs resistantes
US5684013A (en) * 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5891872A (en) * 1995-04-07 1999-04-06 Schering Corporation Tricyclic compounds
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5874442A (en) * 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
ES2151277T3 (es) * 1996-05-22 2000-12-16 Protarga Inc Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
AU3486297A (en) * 1996-06-17 1998-01-07 Eli Lilly And Company Drug resistance and multidrug resistance modulators
IL130055A0 (en) * 1996-11-22 2000-02-29 Lilly Co Eli Drug resistance and multidrug resistance modulators
US6268500B1 (en) 1997-01-31 2001-07-31 Eli Lilly And Company Separation of 5-nitroquinoline and 8-nitroquinoline
US5776939A (en) * 1997-06-12 1998-07-07 Eli Lilly And Company Drug resistance and multidrug resistance modulators
US6635281B2 (en) 1998-12-23 2003-10-21 Alza Corporation Gastric retaining oral liquid dosage form
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
CA2373484C (fr) 1999-05-19 2009-01-20 Noboru Kaneko Utilisation de derives 1,4-benzothiazepine en tant que medicaments contre la tolerance cancerostatique
TWI267511B (en) 1999-06-03 2006-12-01 Lilly Co Eli Process for preparing 10,11-methanobenzosuberane derivatives
DE60014386T2 (de) 1999-06-03 2005-10-13 Eli Lilly And Co., Indianapolis Verfahren zur herstellung von 10,11methanodibenzosuberanderivaten
WO2001010387A2 (fr) * 1999-08-09 2001-02-15 Vanderbilt University Utilisation de modulateurs de p-glycoproteine dans un traitement antiviral
US6426342B2 (en) * 1999-08-16 2002-07-30 Revaax Pharmaceuticals, Llc Use of β-lactamase inhibitors as neuroprotectants
ATE518540T1 (de) * 1999-08-16 2011-08-15 Revaax Pharmaceuticals Llc Beta-lactam verbindung enthaltende neurotherapeutische zusammensetzung
WO2002005818A2 (fr) * 2000-07-18 2002-01-24 Eli Lilly And Company Methode d'utilisation de modulateurs de la resistance multiple aux medicaments
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
DE60202944T2 (de) * 2001-04-25 2006-03-23 Eli Lilly And Co., Indianapolis Neue salze und kristalline formen von (2r)-anti-5-3-(4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl)-2-hydroxypropoxy quinolin
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20050208132A1 (en) * 2002-07-29 2005-09-22 Gayatri Sathyan Methods and dosage forms for reducing side effects of benzisozazole derivatives
US20050152967A1 (en) * 2003-03-28 2005-07-14 Pfab, Lp Dynamic variable release
AU2004291081A1 (en) * 2003-11-14 2005-06-02 Alza Corporation Controlled release of topirimate in liquid dosage forms
WO2006023286A2 (fr) * 2004-08-19 2006-03-02 Alza Corporation Formes posologiques renfermant une formulation d'agent actif nanoparticulaire a liberation retardee et procedes
KR20080005429A (ko) * 2005-04-19 2008-01-11 알자 코포레이션 트라마돌 및 가바펜틴을 포함하는 물질의 배합물
US20070010486A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
US20070009531A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Treatment of patients with cancer using a calicheamicin-antibody conjugate in combination with zosuquidar
US20070009535A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Treatment of cancer patients exhibiting activation of the P-glycoprotein efflux pump mechanism
US20070010478A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer
US20070009534A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Treatment of cancer patients exhibiting activation of the P-glycoprotein efflux pump mechanism
AU2006269498A1 (en) * 2005-07-06 2007-01-18 Edgar, Mark Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
US20070009533A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Treatment of cancer patients exhibiting activation of the P-glycoprotein efflux pump mechanism
US20070010487A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
US20070010485A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
AR055099A1 (es) * 2005-07-28 2007-08-08 Alza Corp Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol
EP1933811A2 (fr) * 2005-09-30 2008-06-25 Alza Corporation Formes posologiques a liberation regulee a bandelettes renfermant des preparations d'agents actifs nanoparticulaires
PL116330U1 (en) * 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
TW200908957A (en) * 2007-06-15 2009-03-01 Xenoport Inc Use of prodrugs of GABA analogs, antispasticity agents, and prodrugs of GABAB receptor agonists for treating spasticity
CN102413814A (zh) * 2009-04-29 2012-04-11 瑞恩药品公司 用于神经保护和治疗神经变性病症的克拉维酸类物质制剂
US9617230B2 (en) 2014-12-22 2017-04-11 Farmington Pharma Development Creatine prodrugs, compositions and methods of use thereof
US11240349B2 (en) 2014-12-31 2022-02-01 Ebay Inc. Multimodal content recognition and contextual advertising and content delivery
US11332438B2 (en) 2017-12-01 2022-05-17 Ultragenyx Pharmaceutical Inc. Creatine prodrugs, compositions and methods of use thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133925A (en) * 1960-12-22 1964-05-19 Searle & Co Ether derivatives of n-benzhydryl-n'-dihydroxypropylpiperazines and homopiperazines
GB1317034A (en) * 1970-11-06 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy- or -phenylthiopropyl-piperazine derivatives
IT1037099B (it) * 1975-01-24 1979-11-10 Erba Carlo Spa N derivati tricilici dell azetidina
US4015003A (en) * 1975-09-26 1977-03-29 E. I. Du Pont De Nemours And Company Antidepressant 1,1a,6,10b-tetrahydrodibenzo[a,e]-cyclopropa-[c]-cyclohepten-6-substituted oximes
JPS5278882A (en) * 1975-12-24 1977-07-02 Sumitomo Chem Co Ltd Synthesis of novel morpholine derivatives
JPS5278881A (en) * 1975-12-24 1977-07-02 Sumitomo Chem Co Ltd Synthesis of novel morpholine derivativs
JPS5278884A (en) * 1975-12-25 1977-07-02 Sumitomo Chem Co Ltd Synthesis of novel morpholine derivatives
JPS52105184A (en) * 1976-02-26 1977-09-03 Sumitomo Chem Co Ltd Novel morpholine derivatives
GB2163150B (en) * 1984-07-19 1988-05-25 Sandoz Ltd 3-aminopropoxyaryl derivatives
JPS6147466A (ja) * 1984-08-10 1986-03-07 Dainippon Pharmaceut Co Ltd アミン誘導体
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
JPH0278884A (ja) * 1987-11-06 1990-03-19 Sanyo Electric Co Ltd 断熱箱体の内箱
JPH0278881A (ja) * 1988-09-13 1990-03-19 Waaku:Kk 真空冷却装置
JPH0278882A (ja) * 1988-09-14 1990-03-19 Toshiba Corp 冷蔵庫
CA1340821C (fr) * 1988-10-06 1999-11-16 Nobuyuki Fukazawa Composes heterocycliques, ainsi que des adjuvants de produits anti-cancereux les comprenant
JPH02105184A (ja) * 1988-10-14 1990-04-17 Canon Inc 現像装置
JP2781073B2 (ja) * 1991-02-16 1998-07-30 三井化学株式会社 新規キノリン誘導体及びそれを有効成分として含有する制癌剤効果増強剤
JPH0525168A (ja) * 1991-07-15 1993-02-02 Kyorin Pharmaceut Co Ltd 癌細胞に対する感受性増強剤及びその製造方法
CA2074061A1 (fr) * 1991-08-26 1993-02-27 Ivo Monkovic Benzamides, agents d'inversion de la resistance multiple aux anti-cancereux
JP3076672B2 (ja) * 1992-06-18 2000-08-14 三井化学株式会社 キノリン誘導体のフマル酸塩
US5643909A (en) * 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives

Also Published As

Publication number Publication date
JPH08509223A (ja) 1996-10-01
FI954979A7 (fi) 1995-10-18
HU211682A9 (en) 1995-12-28
NZ265547A (en) 1997-03-24
EP0695293B1 (fr) 1998-10-14
RU2167154C2 (ru) 2001-05-20
AU6636294A (en) 1994-11-08
CZ272495A3 (en) 1996-04-17
CN1235826A (zh) 1999-11-24
NO954161L (no) 1995-12-05
FI111161B (fi) 2003-06-13
US5654304A (en) 1997-08-05
NO954161D0 (no) 1995-10-18
PL311164A1 (en) 1996-02-05
CN1045204C (zh) 1999-09-22
PL183375B1 (pl) 2002-06-28
CN1119149C (zh) 2003-08-27
HK1011981A1 (en) 1999-07-23
US5889007A (en) 1999-03-30
DE69413958D1 (de) 1998-11-19
NO313284B1 (no) 2002-09-09
AU678470B2 (en) 1997-05-29
CZ287273B6 (en) 2000-10-11
DE69413958T2 (de) 1999-03-11
FI954979A0 (fi) 1995-10-18
HU227824B1 (en) 2012-03-28
EP0695293A1 (fr) 1996-02-07
UA42720C2 (uk) 2001-11-15
HUT73180A (en) 1996-06-28
EP0866063A1 (fr) 1998-09-23
US6087365A (en) 2000-07-11
CA2160881A1 (fr) 1994-10-27
US5643909A (en) 1997-07-01
BR9405965A (pt) 1996-01-30
KR100248591B1 (ko) 2000-04-01
ES2121603T3 (es) 1998-12-01
JP3020607B2 (ja) 2000-03-15
WO1994024107A1 (fr) 1994-10-27
US5874434A (en) 1999-02-23
CN1121346A (zh) 1996-04-24
CA2160881C (fr) 2000-12-12
ATE172194T1 (de) 1998-10-15
HU9503004D0 (en) 1995-12-28

Similar Documents

Publication Publication Date Title
DK0695293T3 (da) 10,11-methanodibenzosuberanderivater anvendt som kemosensibiliserende midler
EA200100755A1 (ru) 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
DE60220188D1 (de) Hemmer des phosphattransports
PT870768E (pt) Derivados azaindole-etilamina como agentes de ligacao nicotinicos aos receptores de acetilcolina
ATE190057T1 (de) Amid-derivate mit anti-hypercholesterolemischer wirkung, deren herstellung und deren verwendungen als heilmittel
PT99134A (pt) Processo para a preparacao de derivados da piperazina
FI953710A0 (fi) Uusia pyrrolokarbatsoleja
ATE143014T1 (de) Benzimidazol-derivate und therapeutische, diese enthaltende mittel gegen ulcer
FI925501A0 (fi) Imidazolfoereningar, deras framstaellning och anvaendning
DK0806413T3 (da) 2-substituerede viatmin D3-derivater
DE69120603D1 (de) Isochromanderivate
KR900016178A (ko) 2-치환 n,n'-디트리메톡시벤조일 피페라진, 그의 제조 방법 및 그를 함유하는 치료 조성물
DE69302087D1 (de) Trazodone alkyl derivate mit zns wirkung
DK0594329T3 (da) Antimikrobielle midler, der omfatter polykvaternære ammoniumforbindelser
KR920012100A (ko) 비스포스폰산 유도체, 이의 제조 및 용도
NO20004477D0 (no) Anvendelse av organiske karbonater som løsningsmidler for vasking av metalloverflater
ID26809A (id) Senyawa-senyawa turunan sianoiminokuinoksalin
ATE208761T1 (de) Quinolin-derivate und diese enthaltende pharmazeutische zusammensetzungen
ECSP992845A (es) Compuestos quimicos
TW288015B (en) New chromene derivatives