DK0789701T3 - Substituerede tetracykliske azepinderivater med 5-HT2-receptoraffinitet - Google Patents

Substituerede tetracykliske azepinderivater med 5-HT2-receptoraffinitet

Info

Publication number: DK0789701T3
Authority: DK; Denmark
Prior art keywords: receptor affinity; substituted tetracyclic; azepine derivatives; tetracyclic azepine; derivatives
Prior art date: 1994-11-02

Application number

DK95937006T

Other languages

English (en)

Inventor

Victor Karel Sipido

Francisco Javi Fernandez-Gadea

Theo Frans Meert

Pilar Gil-Lopetegui

Jose Ignacio Andres-Gil

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-02

Filing date

1995-10-25

Publication date

2001-06-18

1995-10-25 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-06-18 Application granted granted Critical

2001-06-18 Publication of DK0789701T3 publication Critical patent/DK0789701T3/da

Links

102000056834 5-HT2 Serotonin Receptors Human genes 0.000 title 1
108091005479 5-HT2 receptors Proteins 0.000 title 1
150000001538 azepines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK95937006T 1994-11-02 1995-10-25 Substituerede tetracykliske azepinderivater med 5-HT2-receptoraffinitet DK0789701T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94203178		1994-11-02
US08/457,968 US5552399A (en)	1994-11-02	1995-05-31	Substituted tetracyclic azepine derivatives
PCT/EP1995/004196 WO1996014320A1 (en)	1994-11-02	1995-10-25	Substituted tetracyclic azepine derivatives which have affinity for 5-ht2 receptors

Publications (1)

Publication Number	Publication Date
DK0789701T3 true DK0789701T3 (da)	2001-06-18

Family

ID=8217337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95937006T DK0789701T3 (da)	1994-11-02	1995-10-25	Substituerede tetracykliske azepinderivater med 5-HT2-receptoraffinitet

Country Status (30)

Country	Link
US (1)	US5552399A (da)
EP (1)	EP0789701B1 (da)
JP (1)	JP3818541B2 (da)
KR (1)	KR100392060B1 (da)
CN (1)	CN1085667C (da)
AR (1)	AR002238A1 (da)
AT (1)	ATE199087T1 (da)
AU (1)	AU704285B2 (da)
BR (1)	BR9509552A (da)
CA (1)	CA2203661A1 (da)
CZ (1)	CZ286945B6 (da)
DE (1)	DE69520070T2 (da)
DK (1)	DK0789701T3 (da)
ES (1)	ES2155898T3 (da)
FI (1)	FI113050B (da)
GR (1)	GR3035680T3 (da)
HR (1)	HRP950537A2 (da)
HU (1)	HUT77408A (da)
IL (1)	IL115819A (da)
MY (1)	MY113325A (da)
NO (1)	NO308035B1 (da)
NZ (1)	NZ295656A (da)
PL (1)	PL183686B1 (da)
PT (1)	PT789701E (da)
RU (1)	RU2163240C2 (da)
SI (1)	SI0789701T1 (da)
TR (1)	TR199501356A2 (da)
TW (1)	TW349950B (da)
WO (1)	WO1996014320A1 (da)
ZA (1)	ZA959215B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL186541B1 (pl) *	1996-04-12	2004-01-30	Janssen Pharmaceutica Nv	Nowy związek, pochodna izoksazolidyny, kompozycjafarmaceutyczna, zastosowanie pochodnej izoksazolidyny i sposób wytwarzania pochodnej izoksazolidyny
UA52778C2 (uk) *	1997-10-10	2003-01-15	Янссен Фармацевтика Н.В.	Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) *	2003-11-03	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) *	2003-11-21	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
US20110086086A1 (en) *	2005-07-26	2011-04-14	Pfizer Inc	Transdermal system for varenicline
CA3069699A1 (en) *	2017-07-13	2019-01-17	Tonix Pharmaceuticals Holding Corp.	Analogs of cyclobenzaprine and amitryptilene

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT338799B (de) *	1974-03-02	1977-09-12	Boehringer Sohn Ingelheim	Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
NL7414038A (nl) *	1974-10-28	1976-05-03	Akzo Nv	Nieuwe tetracyclische pyrrolidino derivaten.
DE2647114A1 (de) *	1975-10-21	1977-05-05	Hans Fickler	Vorrichtung zur erzeugung einer laengsbewegung
JPS5572177A (en) *	1978-11-27	1980-05-30	Shionogi & Co Ltd	4,1-benzoxazepine or 4,1-benzothiazepine
PT95522B (pt) *	1989-10-05	1997-08-29	Sankyo Co	Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists

1995
- 1995-05-31 US US08/457,968 patent/US5552399A/en not_active Expired - Fee Related
- 1995-10-20 TW TW084111063A patent/TW349950B/zh active
- 1995-10-25 PL PL95319939A patent/PL183686B1/pl not_active IP Right Cessation
- 1995-10-25 CA CA002203661A patent/CA2203661A1/en not_active Abandoned
- 1995-10-25 DK DK95937006T patent/DK0789701T3/da active
- 1995-10-25 CN CN95195969A patent/CN1085667C/zh not_active Expired - Fee Related
- 1995-10-25 AU AU39249/95A patent/AU704285B2/en not_active Ceased
- 1995-10-25 RU RU97108691/04A patent/RU2163240C2/ru not_active IP Right Cessation
- 1995-10-25 HU HU9702298A patent/HUT77408A/hu unknown
- 1995-10-25 ES ES95937006T patent/ES2155898T3/es not_active Expired - Lifetime
- 1995-10-25 EP EP95937006A patent/EP0789701B1/en not_active Expired - Lifetime
- 1995-10-25 BR BR9509552A patent/BR9509552A/pt not_active IP Right Cessation
- 1995-10-25 CZ CZ19971323A patent/CZ286945B6/cs not_active IP Right Cessation
- 1995-10-25 NZ NZ295656A patent/NZ295656A/xx unknown
- 1995-10-25 JP JP51500996A patent/JP3818541B2/ja not_active Expired - Fee Related
- 1995-10-25 DE DE69520070T patent/DE69520070T2/de not_active Expired - Fee Related
- 1995-10-25 SI SI9530482T patent/SI0789701T1/xx unknown
- 1995-10-25 WO PCT/EP1995/004196 patent/WO1996014320A1/en not_active Ceased
- 1995-10-25 PT PT95937006T patent/PT789701E/pt unknown
- 1995-10-25 AT AT95937006T patent/ATE199087T1/de not_active IP Right Cessation
- 1995-10-25 KR KR1019970702800A patent/KR100392060B1/ko not_active Expired - Fee Related
- 1995-10-31 HR HR08/457,968A patent/HRP950537A2/hr not_active Application Discontinuation
- 1995-10-31 ZA ZA959215A patent/ZA959215B/xx unknown
- 1995-10-31 IL IL11581995A patent/IL115819A/en not_active IP Right Cessation
- 1995-11-01 AR ARP950100010A patent/AR002238A1/es unknown
- 1995-11-02 MY MYPI95003312A patent/MY113325A/en unknown
- 1995-11-02 TR TR95/01356A patent/TR199501356A2/xx unknown
1997
- 1997-04-30 NO NO972017A patent/NO308035B1/no unknown
- 1997-04-30 FI FI971854A patent/FI113050B/fi not_active IP Right Cessation
2001
- 2001-03-30 GR GR20010400530T patent/GR3035680T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3818541B2 (ja)	2006-09-06
FI971854A0 (fi)	1997-04-30
BR9509552A (pt)	1997-09-16
FI113050B (fi)	2004-02-27
US5552399A (en)	1996-09-03
MX9703255A (es)	1997-07-31
GR3035680T3 (en)	2001-06-29
CZ132397A3 (cs)	1998-01-14
CN1085667C (zh)	2002-05-29
DE69520070D1 (de)	2001-03-15
ZA959215B (en)	1997-04-30
ATE199087T1 (de)	2001-02-15
EP0789701A1 (en)	1997-08-20
IL115819A0 (en)	1996-01-19
WO1996014320A1 (en)	1996-05-17
CZ286945B6 (en)	2000-08-16
PL319939A1 (en)	1997-09-01
AU704285B2 (en)	1999-04-15
NZ295656A (en)	1998-10-28
CA2203661A1 (en)	1996-05-17
AU3924995A (en)	1996-05-31
NO308035B1 (no)	2000-07-10
EP0789701B1 (en)	2001-02-07
NO972017L (no)	1997-04-30
ES2155898T3 (es)	2001-06-01
FI971854A7 (fi)	1997-04-30
TW349950B (en)	1999-01-11
NO972017D0 (no)	1997-04-30
AR002238A1 (es)	1998-03-11
CN1162313A (zh)	1997-10-15
KR100392060B1 (ko)	2003-11-28
PT789701E (pt)	2001-07-31
JPH10508308A (ja)	1998-08-18
TR199501356A2 (tr)	1996-06-21
SI0789701T1 (en)	2001-08-31
PL183686B1 (pl)	2002-06-28
MY113325A (en)	2002-01-31
DE69520070T2 (de)	2001-09-13
HRP950537A2 (en)	1997-08-31
HUT77408A (hu)	1998-04-28
IL115819A (en)	1998-10-30
RU2163240C2 (ru)	2001-02-20

Publication	Publication Date	Title
NO982589L (no)	1998-08-03	3-pyrazol-karboksamid-derivater med cannabinoid reseptor-affinitet
FI973205A0 (fi)	1997-08-01	Indolijohdannaisia 5-HT-reseptoriantagonisteina
FI951249A7 (fi)	1995-03-16	Serotiinireseptoriaineita
NO304693B1 (no)	1999-02-01	Kinoksalinderivater med affinitet for quisqualatreseptorer
FI943941L (fi)	1994-10-26	CCK-reseptoriantagonisteina käyttökelpoiset bentsodiatsepiinijohdannaiset
DK0708105T3 (da)	1999-08-23	5-HT4-receptoragonister
PL330708A1 (en)	1999-05-24	Derivatives of indolydine useful as antagonists of 5-ht-2c receptor
HU9501073D0 (en)	1995-06-28	Benzofuran derivatives as 5-hti-like receptor antagonists
NO976157L (no)	1997-12-30	Kondenserte tiazolderivater med 5-HT-reseptor-affinitet
ATE199087T1 (de)	2001-02-15	Substituierte tetracyclische azepinederivate mit 5-ht2 rezeptoraffinität
IL127417A0 (en)	1999-10-28	Indoline derivatives useful as 5-HT-2C receptor antagonists
NO20006041D0 (no)	2000-11-29	N-Benzodioksanylmetyl-1-piperidyl-metylamin-forbindelser med affinitet for 5-HT-reseptorer
NO972018D0 (no)	1997-04-30	Substituerte tetracykliske oksazepin- og tiazepinderivater med 5-HT2 -reseptoraffinitet
FI963463L (fi)	1996-09-04	Indolijohdannaiset CCK-reseptoriantagonisteina
SI0912556T1 (en)	2001-02-28	Indoline derivatives useful as 5-ht-2c receptor antagonists
BR7600306U (pt)	1998-06-09	Pista tubular com looping vertical
DK0660832T3 (da)	1998-09-14	Serotoninreceptor-midler