ATE199087T1 - Substituierte tetracyclische azepinederivate mit 5-ht2 rezeptoraffinität - Google Patents

Substituierte tetracyclische azepinederivate mit 5-ht2 rezeptoraffinität

Info

Publication number: ATE199087T1
Authority: AT; Austria
Prior art keywords: receptor affinity; substituted tetracyclic; azepine derivatives; tetracyclic azepine; derivatives
Prior art date: 1994-11-02

Application number

AT95937006T

Other languages

English (en)

Inventor

Victor Karel Sipido

Francisco Javi Fernandez-Gadea

Jose Ignacio Andres-Gil

Theo Frans Meert

Pilar Gil-Lopetegui

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-02

Filing date

1995-10-25

Publication date

2001-02-15

1995-10-25 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE199087T1 publication Critical patent/ATE199087T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT95937006T 1994-11-02 1995-10-25 Substituierte tetracyclische azepinederivate mit 5-ht2 rezeptoraffinität ATE199087T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94203178		1994-11-02
US08/457,968 US5552399A (en)	1994-11-02	1995-05-31	Substituted tetracyclic azepine derivatives
PCT/EP1995/004196 WO1996014320A1 (en)	1994-11-02	1995-10-25	Substituted tetracyclic azepine derivatives which have affinity for 5-ht2 receptors

Publications (1)

Publication Number	Publication Date
ATE199087T1 true ATE199087T1 (de)	2001-02-15

Family

ID=8217337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937006T ATE199087T1 (de)	1994-11-02	1995-10-25	Substituierte tetracyclische azepinederivate mit 5-ht2 rezeptoraffinität

Country Status (30)

Country	Link
US (1)	US5552399A (de)
EP (1)	EP0789701B1 (de)
JP (1)	JP3818541B2 (de)
KR (1)	KR100392060B1 (de)
CN (1)	CN1085667C (de)
AR (1)	AR002238A1 (de)
AT (1)	ATE199087T1 (de)
AU (1)	AU704285B2 (de)
BR (1)	BR9509552A (de)
CA (1)	CA2203661A1 (de)
CZ (1)	CZ286945B6 (de)
DE (1)	DE69520070T2 (de)
DK (1)	DK0789701T3 (de)
ES (1)	ES2155898T3 (de)
FI (1)	FI113050B (de)
GR (1)	GR3035680T3 (de)
HR (1)	HRP950537A2 (de)
HU (1)	HUT77408A (de)
IL (1)	IL115819A (de)
MY (1)	MY113325A (de)
NO (1)	NO308035B1 (de)
NZ (1)	NZ295656A (de)
PL (1)	PL183686B1 (de)
PT (1)	PT789701E (de)
RU (1)	RU2163240C2 (de)
SI (1)	SI0789701T1 (de)
TR (1)	TR199501356A2 (de)
TW (1)	TW349950B (de)
WO (1)	WO1996014320A1 (de)
ZA (1)	ZA959215B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0892804T3 (da) *	1996-04-12	2002-12-02	Janssen Pharmaceutica Nv	Isoxazolidin derivater
UA52778C2 (uk)	1997-10-10	2003-01-15	Янссен Фармацевтика Н.В.	Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) *	2003-11-03	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) *	2003-11-21	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
US20110086086A1 (en) *	2005-07-26	2011-04-14	Pfizer Inc	Transdermal system for varenicline
US11517557B2 (en) *	2017-07-13	2022-12-06	Tonix Pharmaceuticals Holding Corp.	Analogs of cyclobenzaprine and amitriptyline

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT338799B (de) *	1974-03-02	1977-09-12	Boehringer Sohn Ingelheim	Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
NL7414038A (nl) *	1974-10-28	1976-05-03	Akzo Nv	Nieuwe tetracyclische pyrrolidino derivaten.
DE2647114A1 (de) *	1975-10-21	1977-05-05	Hans Fickler	Vorrichtung zur erzeugung einer laengsbewegung
JPS5572177A (en) *	1978-11-27	1980-05-30	Shionogi & Co Ltd	4,1-benzoxazepine or 4,1-benzothiazepine
TW206227B (de) *	1989-10-05	1993-05-21	Sankyo Co
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists

1995
- 1995-05-31 US US08/457,968 patent/US5552399A/en not_active Expired - Fee Related
- 1995-10-20 TW TW084111063A patent/TW349950B/zh active
- 1995-10-25 PT PT95937006T patent/PT789701E/pt unknown
- 1995-10-25 EP EP95937006A patent/EP0789701B1/de not_active Expired - Lifetime
- 1995-10-25 JP JP51500996A patent/JP3818541B2/ja not_active Expired - Fee Related
- 1995-10-25 KR KR1019970702800A patent/KR100392060B1/ko not_active Expired - Fee Related
- 1995-10-25 BR BR9509552A patent/BR9509552A/pt not_active IP Right Cessation
- 1995-10-25 SI SI9530482T patent/SI0789701T1/xx unknown
- 1995-10-25 CZ CZ19971323A patent/CZ286945B6/cs not_active IP Right Cessation
- 1995-10-25 PL PL95319939A patent/PL183686B1/pl not_active IP Right Cessation
- 1995-10-25 DK DK95937006T patent/DK0789701T3/da active
- 1995-10-25 ES ES95937006T patent/ES2155898T3/es not_active Expired - Lifetime
- 1995-10-25 RU RU97108691/04A patent/RU2163240C2/ru not_active IP Right Cessation
- 1995-10-25 WO PCT/EP1995/004196 patent/WO1996014320A1/en not_active Ceased
- 1995-10-25 AT AT95937006T patent/ATE199087T1/de not_active IP Right Cessation
- 1995-10-25 AU AU39249/95A patent/AU704285B2/en not_active Ceased
- 1995-10-25 CA CA002203661A patent/CA2203661A1/en not_active Abandoned
- 1995-10-25 DE DE69520070T patent/DE69520070T2/de not_active Expired - Fee Related
- 1995-10-25 NZ NZ295656A patent/NZ295656A/xx unknown
- 1995-10-25 HU HU9702298A patent/HUT77408A/hu unknown
- 1995-10-25 CN CN95195969A patent/CN1085667C/zh not_active Expired - Fee Related
- 1995-10-31 IL IL11581995A patent/IL115819A/en not_active IP Right Cessation
- 1995-10-31 ZA ZA959215A patent/ZA959215B/xx unknown
- 1995-10-31 HR HR08/457,968A patent/HRP950537A2/hr not_active Application Discontinuation
- 1995-11-01 AR ARP950100010A patent/AR002238A1/es unknown
- 1995-11-02 MY MYPI95003312A patent/MY113325A/en unknown
- 1995-11-02 TR TR95/01356A patent/TR199501356A2/xx unknown
1997
- 1997-04-30 FI FI971854A patent/FI113050B/fi not_active IP Right Cessation
- 1997-04-30 NO NO972017A patent/NO308035B1/no unknown
2001
- 2001-03-30 GR GR20010400530T patent/GR3035680T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
MY113325A (en)	2002-01-31
EP0789701A1 (de)	1997-08-20
ZA959215B (en)	1997-04-30
CN1162313A (zh)	1997-10-15
AR002238A1 (es)	1998-03-11
FI113050B (fi)	2004-02-27
PL183686B1 (pl)	2002-06-28
CZ132397A3 (cs)	1998-01-14
DE69520070D1 (de)	2001-03-15
WO1996014320A1 (en)	1996-05-17
IL115819A0 (en)	1996-01-19
FI971854A7 (fi)	1997-04-30
EP0789701B1 (de)	2001-02-07
MX9703255A (es)	1997-07-31
RU2163240C2 (ru)	2001-02-20
PT789701E (pt)	2001-07-31
CN1085667C (zh)	2002-05-29
CZ286945B6 (en)	2000-08-16
JP3818541B2 (ja)	2006-09-06
HRP950537A2 (en)	1997-08-31
NO972017L (no)	1997-04-30
NO308035B1 (no)	2000-07-10
US5552399A (en)	1996-09-03
JPH10508308A (ja)	1998-08-18
BR9509552A (pt)	1997-09-16
ES2155898T3 (es)	2001-06-01
GR3035680T3 (en)	2001-06-29
IL115819A (en)	1998-10-30
CA2203661A1 (en)	1996-05-17
AU3924995A (en)	1996-05-31
AU704285B2 (en)	1999-04-15
KR100392060B1 (ko)	2003-11-28
HUT77408A (hu)	1998-04-28
NZ295656A (en)	1998-10-28
PL319939A1 (en)	1997-09-01
FI971854A0 (fi)	1997-04-30
TW349950B (en)	1999-01-11
SI0789701T1 (en)	2001-08-31
DE69520070T2 (de)	2001-09-13
TR199501356A2 (tr)	1996-06-21
NO972017D0 (no)	1997-04-30
DK0789701T3 (da)	2001-06-18

Legal Events

Date	Code	Title	Description
2008-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE191211T1 (de)	2000-04-15	3-pyrazolcarboxamidderivate mit cannabinoidrezeptor-affinität
DE69928945D1 (de)	2006-01-19	4,4-biarylpiperidinederivate mit opioid-receptor-wirkung
ITMI930699A0 (it)	1993-04-08	Nuovi derivati dell'indolo
FI944970A7 (fi)	1995-04-23	Trisyklisiä pyrrolijohdannaisia
FI953827L (fi)	1996-02-13	Trisyklisiä pyratsolijohdannaisia
DE69637369D1 (de)	2008-01-31	Trizyclische benzazepin-vasopressin-antagoniste
AP2000001784A0 (en)	2000-06-30	Halogen substituted tetracyclic tetrahydrofuran derivatives
NO304693B1 (no)	1999-02-01	Kinoksalinderivater med affinitet for quisqualatreseptorer
FI943941L (fi)	1994-10-26	CCK-reseptoriantagonisteina käyttökelpoiset bentsodiatsepiinijohdannaiset
FI940229A7 (fi)	1994-10-21	Trisykliset kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö
FI20002725A7 (fi)	2000-12-12	2,5-diokso-2,5-dihydro-1Hbents[b]atsepiinit NMDA-reseptorin antagonisteina
HU9300488D0 (en)	1993-05-28	Tricyclic benzodiazepine derivatives
NO982843D0 (no)	1998-06-19	2,7-Substituerte oktahydro-pyrrol£1,2-a\|pyrazin-derivater
DE69520070D1 (de)	2001-03-15	Substituierte tetracyclische azepinederivate mit 5-ht2 rezeptoraffinität
FI943808L (fi)	1994-10-24	Triatsolopyrimidiinijohdannaisia angiotensiini II:n reseptoreiden vastavaikuttajina
DE59803512D1 (de)	2002-05-02	Anhänger mit verriegelbarem bügel
FI971855A7 (fi)	1997-04-30	Substituoituja tetrasyklisiä oksatsepiini- ja tiatsepiinijohdannaisia, joilla on 5-HT2-reseptoraffineetti
FI961199A7 (fi)	1996-05-13	Substituoidut tiatsolo(3,2-alfa)atsepiinijohdannaiset
ITMI951669A1 (it)	1997-01-29	Derivati tetraciclici spiro-condensati
ITMI941649A0 (it)	1994-07-29	Derivati tetraciclici spiro-condensati
BR7600306U (pt)	1998-06-09	Pista tubular com looping vertical