DK0828749T3 - Fremgangsmåder til syntese af organophosphorderivater - Google Patents

Fremgangsmåder til syntese af organophosphorderivater

Info

Publication number
DK0828749T3
DK0828749T3 DK96917829T DK96917829T DK0828749T3 DK 0828749 T3 DK0828749 T3 DK 0828749T3 DK 96917829 T DK96917829 T DK 96917829T DK 96917829 T DK96917829 T DK 96917829T DK 0828749 T3 DK0828749 T3 DK 0828749T3
Authority
DK
Denmark
Prior art keywords
synthesis
organophosphorus
derivatives
methods
mononucleoside
Prior art date
Application number
DK96917829T
Other languages
Danish (da)
English (en)
Inventor
Wojciech J Stec
Lucyna Wozniak
Timothy Riley
Original Assignee
Genta Inc
Polska Akademia Nauk Instytut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL30880395A external-priority patent/PL181682B1/pl
Priority claimed from PL31024895A external-priority patent/PL181746B1/pl
Priority claimed from PL96312934A external-priority patent/PL184377B1/pl
Application filed by Genta Inc, Polska Akademia Nauk Instytut filed Critical Genta Inc
Application granted granted Critical
Publication of DK0828749T3 publication Critical patent/DK0828749T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
DK96917829T 1995-05-26 1996-05-24 Fremgangsmåder til syntese af organophosphorderivater DK0828749T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PL30880395A PL181682B1 (pl) 1995-05-26 1995-05-26 Sposób wytwarzania modyfikowanych P-chiralnych analogów nukleotydów
PL31024895A PL181746B1 (pl) 1995-09-01 1995-09-01 Sposób wytwarzania modyfikowanych P-chiralnych analogów nukleotydów
PL96312934A PL184377B1 (pl) 1996-02-26 1996-02-26 Nowe pochodne fosforoorganiczne i sposób ich wytwarzania
PCT/US1996/007639 WO1996037503A1 (en) 1995-05-26 1996-05-24 Compositions and methods for the synthesis of organophosphorus derivatives

Publications (1)

Publication Number Publication Date
DK0828749T3 true DK0828749T3 (da) 2003-10-27

Family

ID=27354078

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96917829T DK0828749T3 (da) 1995-05-26 1996-05-24 Fremgangsmåder til syntese af organophosphorderivater

Country Status (10)

Country Link
EP (2) EP1323727A3 (de)
JP (1) JP2002500617A (de)
AT (1) ATE245161T1 (de)
AU (1) AU707369B2 (de)
CA (1) CA2222048A1 (de)
DE (1) DE69629112T2 (de)
DK (1) DK0828749T3 (de)
ES (1) ES2202447T3 (de)
PT (1) PT828749E (de)
WO (1) WO1996037503A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852188A (en) 1990-01-11 1998-12-22 Isis Pharmaceuticals, Inc. Oligonucleotides having chiral phosphorus linkages
DE69232699T2 (de) 1991-10-15 2003-02-06 Isis Pharmaceutical, Inc. Über chirale phosphoratome gebundene oligonukleotide
PL184612B1 (pl) * 1997-04-25 2002-11-29 Pan Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
US20020119443A1 (en) 2000-07-21 2002-08-29 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
WO2024228396A1 (ja) * 2023-05-01 2024-11-07 株式会社ナティアス オリゴヌクレオチド合成用の高脂溶性ヌクレオチドビルディングブロックおよびこれを用いたオリゴヌクレオチドの合成

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3332068A1 (de) * 1983-09-06 1985-03-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
ATE221079T1 (de) * 1995-09-01 2002-08-15 Polska Akad Nauk Centrum Zusammensetzungen und verfahrenen zur synthese von organophosphorus derivaten

Also Published As

Publication number Publication date
EP0828749A4 (de) 1998-11-04
AU707369B2 (en) 1999-07-08
CA2222048A1 (en) 1996-11-28
EP1323727A2 (de) 2003-07-02
EP0828749B1 (de) 2003-07-16
DE69629112D1 (de) 2003-08-21
WO1996037503A1 (en) 1996-11-28
EP0828749A1 (de) 1998-03-18
PT828749E (pt) 2003-11-28
JP2002500617A (ja) 2002-01-08
ATE245161T1 (de) 2003-08-15
ES2202447T3 (es) 2004-04-01
DE69629112T2 (de) 2004-04-22
EP1323727A3 (de) 2003-09-10
AU6024096A (en) 1996-12-11

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