NO20032731L - Fremgangsmåte for fremstilling av sulfonamid-substituerte imidazotriazinoner - Google Patents

Fremgangsmåte for fremstilling av sulfonamid-substituerte imidazotriazinoner

Info

Publication number
NO20032731L
NO20032731L NO20032731A NO20032731A NO20032731L NO 20032731 L NO20032731 L NO 20032731L NO 20032731 A NO20032731 A NO 20032731A NO 20032731 A NO20032731 A NO 20032731A NO 20032731 L NO20032731 L NO 20032731L
Authority
NO
Norway
Prior art keywords
sulfonamide
preparation
substituted imidazotriazinones
reacted
imidazotriazinones
Prior art date
Application number
NO20032731A
Other languages
English (en)
Other versions
NO20032731D0 (no
NO325398B1 (no
Inventor
Marc Nowakowski
Reinhold Gehring
Werner Heilmann
Karl-Heinz Wahl
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO20032731D0 publication Critical patent/NO20032731D0/no
Publication of NO20032731L publication Critical patent/NO20032731L/no
Publication of NO325398B1 publication Critical patent/NO325398B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Abstract

Det er beskrevet en fremgangsmåte for fremstilling av sulfonamid-substituerte imidazotriazinoner med generell formel (I), som er kjennetegnet ved at forbindelser med formel (II) omsettes med svovelsyre og de oppnådde produktene omsettes deretter med tionylklorid og in situ i et inert oppløsningsmiddel med et amin til forbindelsen ifølge oppfinnelsen, samt eventuelt til de tilsvarende saltene, hydratene eller N-oksidene.
NO20032731A 2000-12-18 2003-06-16 Fremgangsmate for fremstilling av sulfonamid-substituerte imidazotriazinoner NO325398B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10063108A DE10063108A1 (de) 2000-12-18 2000-12-18 Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
PCT/EP2001/014239 WO2002050076A2 (de) 2000-12-18 2001-12-05 Verfahren zur herstellung von sulfonamid-substituierten imidazotriazinonen

Publications (3)

Publication Number Publication Date
NO20032731D0 NO20032731D0 (no) 2003-06-16
NO20032731L true NO20032731L (no) 2003-06-16
NO325398B1 NO325398B1 (no) 2008-04-21

Family

ID=7667666

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032731A NO325398B1 (no) 2000-12-18 2003-06-16 Fremgangsmate for fremstilling av sulfonamid-substituerte imidazotriazinoner

Country Status (42)

Country Link
US (3) US6777551B2 (no)
EP (1) EP1345939B1 (no)
JP (1) JP4441175B2 (no)
KR (1) KR100787288B1 (no)
CN (1) CN1227253C (no)
AR (1) AR032775A1 (no)
AT (1) ATE328885T1 (no)
AU (2) AU1708902A (no)
BG (1) BG66142B1 (no)
BR (1) BRPI0116227B8 (no)
CA (1) CA2431933C (no)
CU (2) CU23341B7 (no)
CY (1) CY1105197T1 (no)
CZ (1) CZ297005B6 (no)
DE (2) DE10063108A1 (no)
DK (1) DK1345939T3 (no)
DO (1) DOP2001000295A (no)
EC (1) ECSP034657A (no)
EE (1) EE05308B1 (no)
ES (1) ES2266098T3 (no)
GT (1) GT200100251A (no)
HN (1) HN2001000278A (no)
HR (1) HRP20030583B1 (no)
HU (1) HU229296B1 (no)
IL (2) IL156278A0 (no)
MA (1) MA25927A1 (no)
MX (1) MXPA03005429A (no)
MY (1) MY126689A (no)
NO (1) NO325398B1 (no)
NZ (1) NZ526477A (no)
PE (1) PE20020590A1 (no)
PL (1) PL207294B1 (no)
PT (1) PT1345939E (no)
RU (1) RU2299211C2 (no)
SI (1) SI1345939T1 (no)
SK (1) SK286894B6 (no)
SV (1) SV2003000766A (no)
TW (1) TWI289562B (no)
UA (1) UA75109C2 (no)
UY (2) UY27070A1 (no)
WO (1) WO2002050076A2 (no)
ZA (1) ZA200304705B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE202004006552U1 (de) * 2004-04-26 2004-07-08 Knürr AG Kühlungssystem für Geräte- und Netzwerkschränke
DE102004023069A1 (de) 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
US7977478B2 (en) * 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil
CN101965348B (zh) * 2007-09-06 2013-11-13 上海特化医药科技有限公司 伐地那非的制备方法及其中间体
PL2228370T3 (pl) 2007-12-28 2012-10-31 Topharman Shanghai Co Ltd N-{1-[3-(2-etoksy-5-(4-etylopiperazynylo)benzenosulfonylo)-4,5-dihydro-5-okso-1,2,4-triazyn-6-yl]etylo}butyroamid, sposób jego wytwarzania i zastosowanie
AU2010280358A1 (en) 2009-08-07 2012-03-08 Ranbaxy Laboratories Limited Processes for the preparation of vardenafil
PL390079A1 (pl) * 2009-12-30 2011-07-04 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
CN102134242B (zh) 2011-01-21 2013-08-28 浙江大德药业集团有限公司 一种用于治疗阳痿的快速长效的化合物
CZ2011767A3 (cs) * 2011-11-24 2013-06-05 Zentiva, K.S. Zpusob prípravy a izolace solí vardenafilu s kyselinami
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
PL223869B1 (pl) 2013-12-16 2016-11-30 Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna Sposób otrzymywania wardenafilu i jego soli
CN107383020A (zh) * 2017-07-29 2017-11-24 合肥创新医药技术有限公司 一种伐地那非杂质的制备方法
MX2020005890A (es) 2017-12-20 2020-10-19 Klaria Pharma Holding Ab Formulacion de pelicula que comprende vardenafil, metodo para su preparacion y uso de la misma.
CN115043757B (zh) * 2022-07-27 2023-08-08 南京桦冠生物技术有限公司 一种连续化制备苄脒盐酸盐的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
CA2395558C (en) * 1997-11-12 2007-07-17 Bayer Aktiengesellschaft Intermediates for 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone

Also Published As

Publication number Publication date
CU23873B1 (es) 2013-04-19
CZ20031692A3 (cs) 2003-10-15
IL156278A0 (en) 2004-01-04
CA2431933C (en) 2009-12-01
HUP0302467A3 (en) 2004-11-29
DK1345939T3 (da) 2006-09-25
HN2001000278A (es) 2002-01-30
PL207294B1 (pl) 2010-11-30
ZA200304705B (en) 2004-08-12
KR100787288B1 (ko) 2007-12-20
NO20032731D0 (no) 2003-06-16
US6777551B2 (en) 2004-08-17
SI1345939T1 (sl) 2006-10-31
CA2431933A1 (en) 2002-06-27
EE05308B1 (et) 2010-06-15
HK1063799A1 (en) 2005-01-14
AR032775A1 (es) 2003-11-26
EE200300294A (et) 2003-10-15
US20050014756A1 (en) 2005-01-20
UY27070A1 (es) 2002-07-31
WO2002050076A3 (de) 2002-08-29
BR0116227B1 (pt) 2014-08-26
MA25927A1 (fr) 2003-10-01
UY37172A (es) 2017-06-30
SK286894B6 (sk) 2009-07-06
CN1481386A (zh) 2004-03-10
PT1345939E (pt) 2006-08-31
DE10063108A1 (de) 2002-06-20
CZ297005B6 (cs) 2006-08-16
CU23341B7 (es) 2009-02-20
DOP2001000295A (es) 2002-12-15
HRP20030583B1 (hr) 2011-09-30
BR0116227A (pt) 2003-12-30
PL365310A1 (en) 2004-12-27
CU20080213A7 (es) 2012-06-21
UA75109C2 (en) 2006-03-15
US20020137930A1 (en) 2002-09-26
PE20020590A1 (es) 2002-07-13
BG107892A (bg) 2004-08-31
HUP0302467A2 (hu) 2003-11-28
JP2004517849A (ja) 2004-06-17
CN1227253C (zh) 2005-11-16
GT200100251A (es) 2002-10-01
EP1345939A2 (de) 2003-09-24
CY1105197T1 (el) 2010-03-03
NO325398B1 (no) 2008-04-21
ATE328885T1 (de) 2006-06-15
ECSP034657A (es) 2003-07-25
BG66142B1 (bg) 2011-07-29
IL156278A (en) 2009-06-15
HU229296B1 (en) 2013-10-28
SK7502003A3 (en) 2003-10-07
RU2299211C2 (ru) 2007-05-20
AU1708902A (en) 2002-07-01
DE50110080D1 (de) 2006-07-20
SV2003000766A (es) 2003-01-13
MXPA03005429A (es) 2004-05-04
ES2266098T3 (es) 2007-03-01
JP4441175B2 (ja) 2010-03-31
EP1345939B1 (de) 2006-06-07
BRPI0116227B8 (pt) 2021-05-25
TWI289562B (en) 2007-11-11
US20050203298A1 (en) 2005-09-15
AU2002217089B2 (en) 2006-01-12
US6998483B2 (en) 2006-02-14
MY126689A (en) 2006-10-31
KR20030063430A (ko) 2003-07-28
HRP20030583A2 (en) 2005-06-30
WO2002050076A2 (de) 2002-06-27
NZ526477A (en) 2004-12-24

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Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

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