DK0960944T3 - Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter - Google Patents

Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter

Info

Publication number: DK0960944T3
Authority: DK; Denmark
Prior art keywords: taxanes; taxol; taxus species; cell cultures; improved production
Prior art date: 1992-02-20

Application number

DK99202507T

Other languages

Danish (da)

English (en)

Inventor

Christopher L Prince

Eugene J Kane

Braden Roach

Prakash G Kadkade

Barry F Schubmehl

Venkataraman Bringi

Original Assignee

Phyton Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-20

Filing date

1993-02-22

Publication date

2004-04-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27126086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0960944(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-02-22 Application filed by Phyton Inc filed Critical Phyton Inc

2004-04-05 Application granted granted Critical

2004-04-05 Publication of DK0960944T3 publication Critical patent/DK0960944T3/da

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 3
229940123237 Taxane Drugs 0.000 title abstract 3
241001116500 Taxus Species 0.000 title abstract 3
238000004113 cell culture Methods 0.000 title abstract 3
229960001592 paclitaxel Drugs 0.000 title abstract 3
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 3
238000004114 suspension culture Methods 0.000 abstract 2
206010020649 Hyperkeratosis Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
235000015097 nutrients Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0025—Culture media for plant cell or plant tissue culture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues

Landscapes

Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Botany (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK99202507T 1992-02-20 1993-02-22 Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter DK0960944T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83914492A	1992-02-20	1992-02-20
US07/874,344 US5407816A (en)	1992-02-20	1992-04-24	Enhanced production of taxol and taxanes by cell cultures of taxus species

Publications (1)

Publication Number	Publication Date
DK0960944T3 true DK0960944T3 (da)	2004-04-05

Family

ID=27126086

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99202507T DK0960944T3 (da)	1992-02-20	1993-02-22	Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter
DK93906156T DK0672162T3 (da)	1992-02-20	1993-02-22	Forøget produktion af taxol og taxaner ved hjælp af cellekulturer af Taxus-arter

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK93906156T DK0672162T3 (da)	1992-02-20	1993-02-22	Forøget produktion af taxol og taxaner ved hjælp af cellekulturer af Taxus-arter

Country Status (15)

Country	Link
US (1)	US5407816A (ja)
EP (3)	EP1378574B1 (ja)
JP (5)	JP3513151B2 (ja)
KR (6)	KR20040000390A (ja)
AT (3)	ATE256197T1 (ja)
AU (1)	AU672194B2 (ja)
CA (1)	CA2130745C (ja)
DE (3)	DE69333358T2 (ja)
DK (2)	DK0960944T3 (ja)
ES (3)	ES2213328T3 (ja)
GR (1)	GR3034722T3 (ja)
NZ (1)	NZ249734A (ja)
PT (2)	PT672162E (ja)
SG (1)	SG46427A1 (ja)
WO (1)	WO1993017121A1 (ja)

Families Citing this family (58)

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US7264951B1 (en)	1992-02-20	2007-09-04	Phyton, Inc.	Enhanced production of taxol and taxanes by cell cultures of Taxus species
US5407816A (en) *	1992-02-20	1995-04-18	Phyton Catalytic, Inc.	Enhanced production of taxol and taxanes by cell cultures of taxus species
US5850032A (en) *	1992-04-01	1998-12-15	Union Camp Corporation	Method for production of plant biological products in precocious neomorphic embryoids
CA2434692A1 (en) *	1992-04-07	1993-10-08	Paul M. Cino	Callus cell induction and the preparation of taxanes
JPH08500973A (ja) *	1992-05-21	1996-02-06	ザペンステイトリサーチファウンデーション	タキソール、関連タキサン及び他の新規な抗癌／抗ウイルス性化合物原料としてのイチイ培養組織
JP2967532B2 (ja) *	1992-06-11	1999-10-25	日石三菱株式会社	タキサン類化合物の製造方法
US5981568A (en)	1993-01-28	1999-11-09	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
KR950005081B1 (ko) *	1993-07-06	1995-05-18	산림청임목육종연구소	주목 종자의 씨눈 유래의 체세포배 및 체세포배성세포 혹은 그 배양배지로부터 택솔(Taxol) 및 그 유도체를 생산하는 방법
DE69431135T2 (de)	1993-11-15	2003-03-27	Mitsui Chemicals, Inc.	Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen
IL113447A (en) *	1994-04-22	1999-01-26	Us Agriculture	Attractant for controlling insects and apparatus containing the same
CA2163614C (en) *	1994-11-25	2002-12-31	Yukihito Yukimune	Method of producing a taxane-type diterpene
US6248572B1 (en) *	1995-04-27	2001-06-19	Samyang, Genex, Corporation	Production of taxol from taxus plant cell culture adding silver nitrate
KR960037826A (ko) *	1995-04-27	1996-11-19	김경환	택서스속 식물세포의 반연속식 배양방법
US5900367A (en) *	1995-04-29	1999-05-04	Samyang Genex Co., Ltd.	Method for purifying taxol from taxus biomass
AU2435695A (en) *	1995-05-05	1996-11-21	Union Camp Corporation	Method for production of plant biological products in precoc ious neomorphic embryoids
JPH11505422A (ja) *	1995-05-19	1999-05-21	フィテラインク．	植物細胞培養物および植物組織培養物の処理方法
HUP9901788A3 (en) *	1996-05-24	2002-07-29	Phyton Inc Ithaca	Enhanced production of taxanes by cell cultures of taxus species
WO1998043618A2 (en)	1997-03-31	1998-10-08	Neorx Corporation	Use of cytoskeletal inhibitors for the prevention of restenosis
US5801193A (en) *	1997-04-15	1998-09-01	Immune Modulation, Inc.	Compositions and methods for immunosuppressing
KR100287465B1 (ko)	1997-06-25	2001-05-02	나까니시 히로유끼	탁산형 디테르펜의 제조방법
KR100266448B1 (ko) *	1997-06-26	2000-09-15	박종헌	식물세포 배양 중의 온도변화에 의한 택솔의 대량생산 방법
ES2178369T3 (es)	1998-01-14	2002-12-16	Bristol Myers Squibb Co	Nuevos complejos cristalinos dce baccatina iii con imidazol, 2-metilimidazol o isopropanol.
US6093422A (en) *	1998-01-23	2000-07-25	Zodiac Pool Care, Inc.	Biocidal compositions for treating water
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
FR2800740B1 (fr) *	1999-11-08	2002-10-11	Lorraine Inst Nat Polytech	Procede de production de metabolites a partir de vegetaux en culture hors sol
CA2410632A1 (en)	2000-06-22	2001-12-27	David S. Garvey	Nitrosated and nitrosylated taxanes, compositions and methods of use
WO2002040633A2 (en) *	2000-11-14	2002-05-23	Regents Of The University Of California	Optimized antitrypsin expression in rice cell culture
US6365407B1 (en) *	2001-03-05	2002-04-02	Council Of Scientific & Industrial Research	Culture medium composition useful for induction and proliferation of Taxus calli
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
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US20030124205A1 (en) *	2001-12-28	2003-07-03	Avon Products, Inc.	Topical cosmetic composition having a natural plant active ingredient and method of using same
TW200304947A (en) *	2002-02-08	2003-10-16	Bristol Myers Squibb Co	Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
CN101421392A (zh) *	2004-02-13	2009-04-29	菲托生物技术公司	茚满酰酰胺在刺激紫杉属次生代谢中的应用
US8936940B2 (en)	2005-06-03	2015-01-20	Samyang Biopharmaceuticals Corporation	Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medium
EP2386626B1 (en) *	2005-10-31	2016-10-26	Unhwa Corporation	Stability of secondary metabolite mass production through syncronized plant cell cultures
US8053238B2 (en) *	2005-10-31	2011-11-08	Unhwa Corporation	Isolated population of plant single cells and method of preparing the same
GB0605900D0 (en) *	2006-03-23	2006-05-03	Lipigen As	Modulators of nuclear receptors
NZ598285A (en)	2007-01-30	2013-10-25	Syngenta Participations Ag	Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
KR101064518B1 (ko) *	2007-09-21	2011-09-19	주식회사 운화	저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법
AU2008202078B2 (en) *	2007-10-10	2012-05-31	Wellkey Holdings Limited	Stability of secondary metabolite mass production through synchronized plant cell cultures
KR101100867B1 (ko) *	2008-05-14	2012-01-02	주식회사 운화	주목의 형성층 또는 전형성층 유래 식물줄기세포주를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물
US8713329B2 (en) *	2009-02-26	2014-04-29	Red Hat, Inc.	Authenticated secret sharing
EP2414509B1 (en)	2009-04-03	2015-09-23	DianaPlantSciences S.A.S.	Production and extraction of procyanidins from plant cell cultures
US9167840B2 (en)	2009-04-03	2015-10-27	DianaPlantScience, Inc.	Production and extraction of procyanidins from plant cell cultures
KR101212032B1 (ko) *	2009-05-26	2012-12-12	주식회사 운화	국화과의 형성층 유래 식물줄기세포 및 이의 분리배양방법
WO2010137879A2 (ko) *	2009-05-26	2010-12-02	주식회사 운화	버드나무과의 형성층 유래 식물줄기세포 및 이의 분리배양방법
CN102459573A (zh) *	2009-05-28	2012-05-16	云火公司	茄科的形成层来源的植物干细胞及其分离培养方法
CN101671319B (zh) *	2009-09-18	2012-02-29	应成杰	红豆杉无毒提取物的提取工艺
JP2012217441A (ja) *	2011-04-14	2012-11-12	Housetec Inc	タキサン類の生産方法、およびカルス誘導方法
CN102715085B (zh) *	2012-06-19	2014-04-16	湖南农业大学	一种诱导红豆杉种子种胚获得愈伤组织和悬浮细胞的方法
CN102715086B (zh) *	2012-06-19	2014-04-16	湖南农业大学	一种红豆杉试管苗诱导获得愈伤组织和悬浮细胞的方法
CN103058961B (zh) *	2013-01-28	2015-04-29	普洱市红宝生物科技有限公司	从云南红豆杉中提取紫杉醇的方法
CN103570647A (zh) *	2013-11-06	2014-02-12	湖南农业大学	从红豆杉细胞培养液中制备高纯度紫杉醇的方法
KR101603539B1 (ko) *	2014-08-11	2016-03-15	영남대학교 산학협력단	택솔을 생산하는 콜레토트리쿰 데마티움 균주 및 그 용도
KR101786448B1 (ko)	2015-08-24	2017-10-18	영남대학교 산학협력단	택솔을 생산하는 트라이코더마 비리데슨스 tx1 균주 및 이의 용도
CN109022510A (zh) *	2018-08-23	2018-12-18	吉首大学	一种利用南方红豆杉菌根菌与活组织细胞共培养生产紫杉醇及10-dabⅲ的方法
CN110441439B (zh) *	2019-07-01	2022-03-01	杭州师范大学	区分密叶红豆杉和云南红豆杉的代谢标志物及其检测方法
EP4284939A1 (en) *	2021-01-28	2023-12-06	Phyto-Technics BV	Production of taxol from taxus cuttings

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5019504A (en) *	1989-03-23	1991-05-28	The United States Of America As Represented By The Secretary Of Agriculture	Production of taxol or taxol-like compounds in cell culture
JPH03216123A (ja) *	1990-01-17	1991-09-24	Nitsusen Kagaku Kogyo Kk	培養植物体の増殖促進方法
EP0529083B1 (en) *	1991-02-12	1996-12-18	Nippon Steel Corporation	Process for producing taxol by cell culture of taxus species
US5407816A (en) *	1992-02-20	1995-04-18	Phyton Catalytic, Inc.	Enhanced production of taxol and taxanes by cell cultures of taxus species

1992
- 1992-04-24 US US07/874,344 patent/US5407816A/en not_active Expired - Lifetime
1993
- 1993-02-22 DK DK99202507T patent/DK0960944T3/da active
- 1993-02-22 AT AT99202507T patent/ATE256197T1/de not_active IP Right Cessation
- 1993-02-22 EP EP03021426A patent/EP1378574B1/en not_active Revoked
- 1993-02-22 EP EP93906156A patent/EP0672162B1/en not_active Revoked
- 1993-02-22 AT AT93906156T patent/ATE195146T1/de not_active IP Right Cessation
- 1993-02-22 ES ES99202507T patent/ES2213328T3/es not_active Expired - Lifetime
- 1993-02-22 PT PT93906156T patent/PT672162E/pt unknown
- 1993-02-22 DE DE69333358T patent/DE69333358T2/de not_active Expired - Lifetime
- 1993-02-22 ES ES03021426T patent/ES2361150T3/es not_active Expired - Lifetime
- 1993-02-22 NZ NZ249734A patent/NZ249734A/en not_active IP Right Cessation
- 1993-02-22 KR KR10-2003-7001795A patent/KR20040000390A/ko not_active Ceased
- 1993-02-22 DE DE69334352T patent/DE69334352D1/de not_active Expired - Lifetime
- 1993-02-22 KR KR1020077022817A patent/KR20070104684A/ko not_active Ceased
- 1993-02-22 KR KR1019940702908A patent/KR100285788B1/ko not_active Expired - Lifetime
- 1993-02-22 PT PT99202507T patent/PT960944E/pt unknown
- 1993-02-22 WO PCT/US1993/001576 patent/WO1993017121A1/en not_active Ceased
- 1993-02-22 KR KR10-2000-7011030A patent/KR100392036B1/ko not_active Ceased
- 1993-02-22 KR KR1020097019012A patent/KR20090116792A/ko not_active Ceased
- 1993-02-22 AT AT03021426T patent/ATE504659T1/de not_active IP Right Cessation
- 1993-02-22 SG SG1996004612A patent/SG46427A1/en unknown
- 1993-02-22 EP EP99202507A patent/EP0960944B1/en not_active Revoked
- 1993-02-22 DK DK93906156T patent/DK0672162T3/da active
- 1993-02-22 AU AU37291/93A patent/AU672194B2/en not_active Expired
- 1993-02-22 KR KR1020117014841A patent/KR20110079863A/ko not_active Withdrawn
- 1993-02-22 DE DE69329154T patent/DE69329154T2/de not_active Revoked
- 1993-02-22 CA CA002130745A patent/CA2130745C/en not_active Expired - Lifetime
- 1993-02-22 JP JP51501693A patent/JP3513151B2/ja not_active Expired - Lifetime
- 1993-02-22 ES ES93906156T patent/ES2150938T3/es not_active Expired - Lifetime
2000
- 2000-10-30 GR GR20000402411T patent/GR3034722T3/el not_active IP Right Cessation
2003
- 2003-09-10 JP JP2003318959A patent/JP2004000285A/ja active Pending
2005
- 2005-09-09 JP JP2005262536A patent/JP2005348751A/ja active Pending
2008
- 2008-02-12 JP JP2008031160A patent/JP2008131955A/ja active Pending
2009
- 2009-05-25 JP JP2009125857A patent/JP2009183305A/ja active Pending

Also Published As

Publication number	Publication date
DE69329154D1 (de)	2000-09-07
DE69333358D1 (de)	2004-01-22
KR20040000390A (ko)	2004-01-03
WO1993017121A1 (en)	1993-09-02
JP2008131955A (ja)	2008-06-12
HK1003718A1 (en)	1998-11-06
CA2130745C (en)	2008-01-22
PT960944E (pt)	2004-04-30
ES2213328T3 (es)	2004-08-16
DE69333358T2 (de)	2004-08-19
ES2150938T3 (es)	2000-12-16
KR100392036B1 (ko)	2003-07-16
GR3034722T3 (en)	2001-01-31
KR20110079863A (ko)	2011-07-08
EP0672162A1 (en)	1995-09-20
EP0960944B1 (en)	2003-12-10
DE69329154T2 (de)	2001-06-07
ES2361150T3 (es)	2011-06-14
DE69334352D1 (de)	2011-05-19
PT672162E (pt)	2001-01-31
ATE195146T1 (de)	2000-08-15
EP0672162B1 (en)	2000-08-02
CA2130745A1 (en)	1993-09-02
KR20090116792A (ko)	2009-11-11
JP2005348751A (ja)	2005-12-22
NZ249734A (en)	1996-08-27
JP2004000285A (ja)	2004-01-08
JP2009183305A (ja)	2009-08-20
JPH07506721A (ja)	1995-07-27
JP3513151B2 (ja)	2004-03-31
EP1378574A1 (en)	2004-01-07
EP1378574B1 (en)	2011-04-06
KR20070104684A (ko)	2007-10-26
EP0672162A4 (en)	1995-11-29
HK1024936A1 (en)	2000-10-27
EP0960944A1 (en)	1999-12-01
US5407816A (en)	1995-04-18
SG46427A1 (en)	1998-02-20
AU3729193A (en)	1993-09-13
DK0672162T3 (da)	2000-12-18
ATE256197T1 (de)	2003-12-15
ATE504659T1 (de)	2011-04-15
KR950700996A (ko)	1995-02-20
AU672194B2 (en)	1996-09-26
KR100285788B1 (ko)	2001-05-02

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BR9709361A (pt)	1999-08-10	Produção aumentada de taxanos por culturas de espécie taxus
DE60130737T8 (de)	2008-10-30	Verstaerkte produktion von lipiden enthaltend mehrfachungesaettigte fettsaeuren durch hochdichte kulturen von eukariotischen mikroben in gaervorrichtungen
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EA199700004A1 (ru)	1997-09-30	Усиленная аккумуляция трегалозы в растениях
ATE231729T1 (de)	2003-02-15	Verfahren zur industriellen herstellung eines japanischen enkephalitis impfstoffes, und so erhaltener impfstoff
DK0568821T3 (da)	2000-03-06	Calluscelleinduktion og fremstilling af taxaner
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PT1212448E (pt)	2004-03-31	Processo de producao de exopolissacaridos
ATE502101T1 (de)	2011-04-15	Neues candida tropicalis cj-fid(kctc 10457bp) und herstellungsverfahren für xylitol damit
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