DK0977577T3 - Præparater til behandling af ARDS eller IRDS indeholdende 3-(cyclopropylmethoxy)-N-(3,5-dichlor-4-pyridinyl)-4-(difluormethoxy)benzamid og lungesurfaktant - Google Patents

Præparater til behandling af ARDS eller IRDS indeholdende 3-(cyclopropylmethoxy)-N-(3,5-dichlor-4-pyridinyl)-4-(difluormethoxy)benzamid og lungesurfaktant

Info

Publication number
DK0977577T3
DK0977577T3 DK98910670T DK98910670T DK0977577T3 DK 0977577 T3 DK0977577 T3 DK 0977577T3 DK 98910670 T DK98910670 T DK 98910670T DK 98910670 T DK98910670 T DK 98910670T DK 0977577 T3 DK0977577 T3 DK 0977577T3
Authority
DK
Denmark
Prior art keywords
irds
cyclopropylmethoxy
ards
treatment
difluoromethoxy
Prior art date
Application number
DK98910670T
Other languages
Danish (da)
English (en)
Inventor
Ulrich Kilian
Rolf Beume
Uwe Krueger
Dietrich Haefner
Klaus Eistetter
Paul-Georg Germann
Hermann Amschler
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19705924A external-priority patent/DE19705924A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK0977577T3 publication Critical patent/DK0977577T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK98910670T 1997-02-17 1998-02-14 Præparater til behandling af ARDS eller IRDS indeholdende 3-(cyclopropylmethoxy)-N-(3,5-dichlor-4-pyridinyl)-4-(difluormethoxy)benzamid og lungesurfaktant DK0977577T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19705924A DE19705924A1 (de) 1997-02-17 1997-02-17 Neue Zusammensetzungen
EP97102639 1997-02-19

Publications (1)

Publication Number Publication Date
DK0977577T3 true DK0977577T3 (da) 2006-12-18

Family

ID=26033977

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98910670T DK0977577T3 (da) 1997-02-17 1998-02-14 Præparater til behandling af ARDS eller IRDS indeholdende 3-(cyclopropylmethoxy)-N-(3,5-dichlor-4-pyridinyl)-4-(difluormethoxy)benzamid og lungesurfaktant

Country Status (25)

Country Link
US (2) US6436970B1 (fr)
EP (1) EP0977577B1 (fr)
JP (1) JP4763104B2 (fr)
KR (1) KR100640025B1 (fr)
CN (1) CN1123345C (fr)
AT (1) ATE336254T1 (fr)
AU (1) AU734122B2 (fr)
BR (1) BR9807399B1 (fr)
CA (1) CA2276429C (fr)
CZ (1) CZ293871B6 (fr)
DE (1) DE69835594T2 (fr)
DK (1) DK0977577T3 (fr)
EA (1) EA001758B1 (fr)
EE (1) EE04094B1 (fr)
ES (1) ES2271990T3 (fr)
HU (1) HU227520B1 (fr)
IL (1) IL130658A (fr)
NO (1) NO323594B1 (fr)
NZ (1) NZ336569A (fr)
PL (1) PL190775B1 (fr)
PT (1) PT977577E (fr)
SI (1) SI0977577T1 (fr)
TR (1) TR199901772T2 (fr)
UA (1) UA50808C2 (fr)
WO (1) WO1998035683A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69835594T2 (de) * 1997-02-17 2007-08-16 Altana Pharma Ag Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten
JP2001081031A (ja) * 1999-08-30 2001-03-27 Schering Ag 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤
AU6083899A (en) 1999-09-16 2001-04-17 Aventis Behring Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
AU2001261962B2 (en) * 2000-05-25 2005-04-21 Merck Frosst Canada Ltd Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
EP1397359B1 (fr) 2001-05-24 2005-08-31 Merck Frosst Canada & Co. Inhibiteurs de 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4
US20030099601A1 (en) * 2001-11-27 2003-05-29 Gordon Marc S. Inhalation lung surfactant therapy
US6998384B2 (en) * 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US6822114B1 (en) 2002-10-08 2004-11-23 Albemarle Corporation Process for production of fluoroalkoxy-substituted benzamides and their intermediates
KR20050094810A (ko) * 2002-11-27 2005-09-28 알타나 파마 아게 로플루미래스트와 ｒ,ｒ-포르모테롤을 포함하는 상승작용성조합물
BR0316451A (pt) * 2002-11-27 2005-10-11 Altana Pharma Ag Combinação sinergìstica compreendendo roflumilast e formoterol
DK1606261T3 (da) 2003-03-10 2010-01-18 Nycomed Gmbh Hidtil ukendt fremgangsmåde til fremstilling af roflumilast
WO2004110450A1 (fr) * 2003-06-16 2004-12-23 Altana Pharma Ag Composition comprenant un surfactant pulmonaire et un inhibiteur des pde5 pour le traitement de maladies pulmonaires
JP5108515B2 (ja) * 2004-08-06 2012-12-26 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺サーファクタント及びｔｎｆ由来ペプチドを含有する組成物
AU2006224619B2 (en) * 2005-03-16 2012-06-07 Takeda Gmbh Taste masked dosage form containing roflumilast
US20100098641A1 (en) * 2006-12-13 2010-04-22 William Baker Monophosphates as Mutual Prodrugs of Anti-Inflammatory Signal Transduction Modulators (AISTM's) and Beta-Agonists for the Treatment of Pulmonary Inflammation and Bronchoconstriction
WO2009055788A1 (fr) * 2007-10-26 2009-04-30 Aeris Therapeutics, Inc. Traitement de pneumoréduction et compositions utiles pour celui-ci
WO2015016761A2 (fr) * 2013-08-01 2015-02-05 Isletone Ab Cellules souches mésenchymateuses dans le traitement de maladies inflammatoires pulmonaires
CN104800214A (zh) * 2014-01-27 2015-07-29 成都英诺新科技有限公司 一种罗氟司特吸入气雾剂复方及制备方法
RU2728821C1 (ru) * 2020-05-13 2020-07-31 Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства" (ФГБУН НЦБМТ ФМБА России) Способ лечения острого респираторного дистресс-синдрома даларгином и легочным сурфактантом

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223040A (en) * 1974-11-26 1980-09-16 Carroll John M Lauric acid for the prevention and treatment of mycobacterial diseases
JPS5795920A (en) * 1980-12-04 1982-06-15 Teijin Ltd Remedy for respiratory disease
JPS5845299A (ja) * 1981-09-10 1983-03-16 東京田辺製薬株式会社 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤
ES8601918A1 (es) * 1983-05-11 1985-12-01 Byk Gulden Lomberg Chem Fab Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
DE59410119D1 (de) * 1993-07-02 2002-06-20 Byk Gulden Lomberg Chem Fab Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren
US5856196A (en) * 1993-10-25 1999-01-05 Beth Israel Hospital Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor
GB9401460D0 (en) 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
DE4434629C1 (de) * 1994-09-28 1996-06-27 Byk Gulden Lomberg Chem Fab Zusammensetzungen zur Behandlung von IRDS und ARDS
US5531219A (en) * 1994-11-04 1996-07-02 Alliance Pharmaceutical Corp. Use of liquid fluorocarbons to facilitate pulmonary drug delivery
US5698537A (en) * 1996-06-18 1997-12-16 Clarion Pharmaceuticals Inc. Method of lowering the viscosity of mucus
DE69835594T2 (de) * 1997-02-17 2007-08-16 Altana Pharma Ag Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten
US6180142B1 (en) * 1998-08-21 2001-01-30 The Regents Of The University Of California Reduction of surfactant inactivation in pulmonary surfactant therapy
WO2001000338A1 (fr) * 1999-06-29 2001-01-04 L-Tech Corporation Nettoyage et sechage de film chimique

Also Published As

Publication number Publication date
EP0977577B1 (fr) 2006-08-16
IL130658A0 (en) 2000-06-01
JP2001512452A (ja) 2001-08-21
CZ291499A3 (cs) 2000-02-16
PL335134A1 (en) 2000-04-10
CZ293871B6 (cs) 2004-08-18
UA50808C2 (uk) 2002-11-15
KR20000071112A (ko) 2000-11-25
JP4763104B2 (ja) 2011-08-31
HUP0001043A2 (hu) 2000-09-28
CA2276429C (fr) 2007-06-19
EP0977577A1 (fr) 2000-02-09
ES2271990T3 (es) 2007-04-16
EA001758B1 (ru) 2001-08-27
EA199900645A1 (ru) 2000-04-24
CN1248169A (zh) 2000-03-22
HK1026145A1 (en) 2000-12-08
US6436970B1 (en) 2002-08-20
NO323594B1 (no) 2007-06-11
DE69835594T2 (de) 2007-08-16
KR100640025B1 (ko) 2006-10-31
AU734122B2 (en) 2001-06-07
US6998410B2 (en) 2006-02-14
PL190775B1 (pl) 2006-01-31
US20020132835A1 (en) 2002-09-19
NO993875L (no) 1999-08-11
HUP0001043A3 (en) 2002-12-28
BR9807399B1 (pt) 2011-04-19
CA2276429A1 (fr) 1998-08-20
EE9900279A (et) 2000-02-15
DE69835594D1 (de) 2006-09-28
PT977577E (pt) 2007-02-28
SI0977577T1 (sl) 2007-02-28
EE04094B1 (et) 2003-08-15
AU6497398A (en) 1998-09-08
NZ336569A (en) 2001-04-27
HU227520B1 (hu) 2011-07-28
ATE336254T1 (de) 2006-09-15
TR199901772T2 (fr) 1999-09-21
NO993875D0 (no) 1999-08-11
WO1998035683A1 (fr) 1998-08-20
CN1123345C (zh) 2003-10-08
IL130658A (en) 2004-07-25
BR9807399A (pt) 2000-03-14

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