DK101492A - Quinolinderivater - Google Patents

Quinolinderivater Download PDF

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Publication number
DK101492A
DK101492A DK101492A DK101492A DK101492A DK 101492 A DK101492 A DK 101492A DK 101492 A DK101492 A DK 101492A DK 101492 A DK101492 A DK 101492A DK 101492 A DK101492 A DK 101492A
Authority
DK
Denmark
Prior art keywords
quinoline
Prior art date
Application number
DK101492A
Other languages
English (en)
Other versions
DK171820B1 (da
DK101492D0 (da
Inventor
Hiraki Ueda
Hisashi Miyamoto
Hiroshi Yamashita
Hitoshi Tone
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of DK101492D0 publication Critical patent/DK101492D0/da
Publication of DK101492A publication Critical patent/DK101492A/da
Application granted granted Critical
Publication of DK171820B1 publication Critical patent/DK171820B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
DK101492A 1987-04-16 1992-08-13 Quinolinderivater DK171820B1 (da)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
JP9419887 1987-04-16
JP9419887 1987-04-16
JP10235187 1987-04-24
JP10235187 1987-04-24
JP10836187 1987-04-30
JP10836187 1987-04-30
JP12659887 1987-05-22
JP12659887 1987-05-22
JP14954487 1987-06-16
JP14954487 1987-06-16
JP17612687 1987-07-14
JP17612687 1987-07-14
JP28377687 1987-11-09
JP28377687 1987-11-09
JP28710887 1987-11-12
JP28710887 1987-11-12

Publications (3)

Publication Number Publication Date
DK101492D0 DK101492D0 (da) 1992-08-13
DK101492A true DK101492A (da) 1992-08-13
DK171820B1 DK171820B1 (da) 1997-06-23

Family

ID=27572879

Family Applications (2)

Application Number Title Priority Date Filing Date
DK207688A DK170640B1 (da) 1987-04-16 1988-04-15 Quinolinderivater
DK101492A DK171820B1 (da) 1987-04-16 1992-08-13 Quinolinderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK207688A DK170640B1 (da) 1987-04-16 1988-04-15 Quinolinderivater

Country Status (13)

Country Link
US (5) US5591744A (da)
EP (3) EP0565132B1 (da)
JP (2) JPH0696557B2 (da)
KR (2) KR940002113B1 (da)
CN (1) CN1053666C (da)
CY (1) CY2050B1 (da)
DE (4) DE19775083I2 (da)
DK (2) DK170640B1 (da)
ES (3) ES2152936T3 (da)
HK (1) HK128797A (da)
NL (1) NL980011I2 (da)
SA (1) SA97180461A (da)
SG (3) SG101541A1 (da)

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US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
FI901201A7 (fi) * 1989-03-13 1990-09-14 Bristol Myers Squibb Co Antibakteeriset 5-substituoidut 1,4-dihydro-4-oksonaftyridiini-3-karboksylaattijohdannaiset ja niiden valmistus
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
CA2078444A1 (en) 1990-04-18 1991-10-19 Thomas P. Demuth, Jr. Antimicrobial quinolonyl lactams
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US5696132A (en) * 1991-05-28 1997-12-09 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
EP0688218B1 (en) * 1993-03-10 1999-11-17 Otsuka Pharmaceutical Co., Ltd. Interleukin-1 inhibitor
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
CA2175351A1 (en) * 1993-10-28 1995-05-04 Jun Nakano Quinolinecarboxylic acid derivative and salt thereof
DE4408212A1 (de) * 1994-03-11 1995-09-14 Bayer Ag 5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren
DE4431821A1 (de) * 1994-09-07 1996-03-14 Bayer Ag Verfahren zur Herstellung von N-Arylaminoacrylsäurederivaten und die Verwendung so hergestellter N-Arylaminoacrylsäurederivate zur Herstellung von 4-Chinolon-3-carbonsäurederivaten
CA2210007A1 (en) * 1995-01-24 1996-08-01 Yasuo Ito Quinoline carboxylic acid
JP3448305B2 (ja) * 1996-11-28 2003-09-22 湧永製薬株式会社 新規ピリドンカルボン酸誘導体又はその塩及びこれを有効成分とする医薬
DE19652239A1 (de) * 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
JP4305597B2 (ja) * 1998-09-14 2009-07-29 大塚製薬株式会社 弗素置換安息香酸の製造法
BR9914158A (pt) * 1998-09-30 2001-06-26 Alcon Lab Inc Composição antibiótica para o tratamento dos olhos, ouvidos e nariz
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
DE19850788A1 (de) * 1998-11-04 2000-05-11 Clariant Gmbh Verfahren zur Herstellung von Trifluorbenzoesäuren
EP2275141A1 (en) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Tastemasked pharmaceutical compositions
DE19962470A1 (de) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
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US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
WO2003082273A1 (en) * 2002-03-26 2003-10-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Solubilization of weak bases
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
KR100665919B1 (ko) * 2002-11-20 2007-03-08 니뽄 다바코 산교 가부시키가이샤 4-옥소퀴놀린 화합물 및 ｈｉｖ 인테그라제 저해제로서의그의 용도
EP1660495B1 (en) 2003-09-04 2007-07-11 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
BRPI0413964B8 (pt) * 2003-09-10 2021-05-25 Kyorin Seiyaku Kk ácido derivado do ácido carboxílico quinolona, sua composição e agente antibacterial
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
WO2007102512A1 (ja) 2006-03-06 2007-09-13 Japan Tobacco Inc. ４－オキソキノリン化合物の製造方法
IN2014CN00532A (da) 2006-03-06 2015-04-03 Japan Tobacco Inc
US8258294B2 (en) 2006-09-29 2012-09-04 Cipla Limited Process for the preparation of temozolomide and analogs
CA2688008A1 (en) * 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
US20100273787A1 (en) * 2007-11-15 2010-10-28 Robert Schwarcz Kynurenine-aminotransferase inhibitors
US20090270379A1 (en) * 2008-04-23 2009-10-29 Macielag Mark J Quinolone derivatives useful as antibacterial agents
CN106913569B (zh) * 2016-01-04 2022-04-22 广东工业大学 苯酞类化合物在制备抗耐药菌药物中的应用
CN112266326A (zh) * 2020-11-10 2021-01-26 杭州臻挚生物科技有限公司 二氯甲苯硝化物中间体的制备方法

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Also Published As

Publication number Publication date
HK128797A (en) 1997-09-19
JPH0696557B2 (ja) 1994-11-30
DK171820B1 (da) 1997-06-23
US5591744A (en) 1997-01-07
US5495020A (en) 1996-02-27
US5563138A (en) 1996-10-08
DE3855388D1 (de) 1996-08-08
ES2172734T3 (es) 2002-10-01
SG97777A1 (en) 2003-08-20
KR960006145B1 (ko) 1996-05-09
SG49836A1 (en) 1998-06-15
ES2152936T3 (es) 2001-02-16
SA97180461A (ar) 2005-12-03
EP0823413B1 (en) 2002-02-13
EP0287951B1 (en) 1996-07-03
KR880012506A (ko) 1988-11-28
SG101541A1 (en) 2004-01-30
DK207688A (da) 1988-10-17
DK207688D0 (da) 1988-04-15
EP0823413A3 (en) 1998-12-09
DE3855388T2 (de) 1997-02-13
JPH01230558A (ja) 1989-09-14
DE3856515D1 (de) 2002-03-21
KR940002113B1 (ko) 1994-03-17
ES2091180T3 (es) 1996-11-01
US5723648A (en) 1998-03-03
DK101492D0 (da) 1992-08-13
CY2050B1 (en) 1998-04-30
EP0287951A2 (en) 1988-10-26
DE3856515T2 (de) 2002-08-14
US5811576A (en) 1998-09-22
CN1053666C (zh) 2000-06-21
NL980011I1 (nl) 1998-05-06
EP0823413A2 (en) 1998-02-11
DE19775083I2 (de) 2001-06-13
EP0565132A2 (en) 1993-10-13
DK170640B1 (da) 1995-11-20
DE3856434D1 (de) 2000-11-30
DE3856434T2 (de) 2001-06-13
JP2654537B2 (ja) 1997-09-17
NL980011I2 (nl) 1998-10-01
EP0565132A3 (en) 1994-05-18
EP0287951A3 (en) 1990-06-13
CN1030237A (zh) 1989-01-11
EP0565132B1 (en) 2000-10-25
JPH07138232A (ja) 1995-05-30

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