DK207688A - Quinolinderivater - Google Patents

Quinolinderivater

Info

Publication number
DK207688A
DK207688A DK207688A DK207688A DK207688A DK 207688 A DK207688 A DK 207688A DK 207688 A DK207688 A DK 207688A DK 207688 A DK207688 A DK 207688A DK 207688 A DK207688 A DK 207688A
Authority
DK
Denmark
Prior art keywords
quinoline
Prior art date
Application number
DK207688A
Other languages
English (en)
Other versions
DK170640B1 (da
DK207688D0 (da
Inventor
Hiraki Ueda
Hisashi Miyamoto
Hiroshi Yamashita
Hitoshi Tone
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of DK207688D0 publication Critical patent/DK207688D0/da
Publication of DK207688A publication Critical patent/DK207688A/da
Application granted granted Critical
Publication of DK170640B1 publication Critical patent/DK170640B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK207688A 1987-04-16 1988-04-15 Quinolinderivater DK170640B1 (da)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
JP9419887 1987-04-16
JP9419887 1987-04-16
JP10235187 1987-04-24
JP10235187 1987-04-24
JP10836187 1987-04-30
JP10836187 1987-04-30
JP12659887 1987-05-22
JP12659887 1987-05-22
JP14954487 1987-06-16
JP14954487 1987-06-16
JP17612687 1987-07-14
JP17612687 1987-07-14
JP28377687 1987-11-09
JP28377687 1987-11-09
JP28710887 1987-11-12
JP28710887 1987-11-12

Publications (3)

Publication Number Publication Date
DK207688D0 DK207688D0 (da) 1988-04-15
DK207688A true DK207688A (da) 1988-10-17
DK170640B1 DK170640B1 (da) 1995-11-20

Family

ID=27572879

Family Applications (2)

Application Number Title Priority Date Filing Date
DK207688A DK170640B1 (da) 1987-04-16 1988-04-15 Quinolinderivater
DK101492A DK171820B1 (da) 1987-04-16 1992-08-13 Quinolinderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK101492A DK171820B1 (da) 1987-04-16 1992-08-13 Quinolinderivater

Country Status (13)

Country Link
US (5) US5563138A (da)
EP (3) EP0287951B1 (da)
JP (2) JPH0696557B2 (da)
KR (2) KR940002113B1 (da)
CN (1) CN1053666C (da)
CY (1) CY2050B1 (da)
DE (4) DE19775083I2 (da)
DK (2) DK170640B1 (da)
ES (3) ES2172734T3 (da)
HK (1) HK128797A (da)
NL (1) NL980011I2 (da)
SA (1) SA97180461A (da)
SG (3) SG49836A1 (da)

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KR100204987B1 (ko) 1990-04-18 1999-06-15 제이코버스 코넬리스 레이서 항미생물성 퀴놀로닐 락탐
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
US5696132A (en) * 1991-05-28 1997-12-09 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
EP0688218B1 (en) * 1993-03-10 1999-11-17 Otsuka Pharmaceutical Co., Ltd. Interleukin-1 inhibitor
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
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DE4408212A1 (de) * 1994-03-11 1995-09-14 Bayer Ag 5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren
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EP0945435B1 (en) * 1996-11-28 2003-08-13 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient
DE19652239A1 (de) * 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
US6333431B1 (en) * 1998-09-14 2001-12-25 Otsuka Pharmaceutical Co., Ltd. Processes for the preparation of fluorinated benzoic acids
CA2344050A1 (en) * 1998-09-30 2000-04-06 Alcon Laboratories, Inc. Antibiotic compositions for treatment of the eye, ear and nose
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
DE19850788A1 (de) * 1998-11-04 2000-05-11 Clariant Gmbh Verfahren zur Herstellung von Trifluorbenzoesäuren
AU3192700A (en) 1999-03-17 2000-10-04 Daiichi Pharmaceutical Co., Ltd. Medicinal compositions
DE19962470A1 (de) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
WO2002041891A2 (en) * 2000-11-01 2002-05-30 The Procter & Gamble Company Hiv treatment with benzimidazoles
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
JP2005521712A (ja) * 2002-03-26 2005-07-21 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ 弱塩基の可溶化
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
EP2161258A3 (en) 2002-11-20 2010-04-07 Japan Tabacco Inc. 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
AU2003304460A1 (en) 2003-09-04 2005-03-29 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
CN100410249C (zh) * 2003-09-10 2008-08-13 杏林制药株式会社 7-(4-取代-3-环丙基氨基甲基-1-吡咯烷基)喹诺酮羧酸衍生物
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
IN2014CN00532A (da) 2006-03-06 2015-04-03 Japan Tobacco Inc
RS54047B1 (sr) 2006-03-06 2015-10-30 Japan Tobacco Inc. Postupak za dobijanje jedinjenja 4-oksohinolina
JP5199263B2 (ja) 2006-09-29 2013-05-15 シプラ・リミテッド テモゾロミドと類似体を調製するための改善された方法
CA2688008A1 (en) * 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
WO2009064836A2 (en) * 2007-11-15 2009-05-22 University Of Maryland, Baltimore Kynurenine-aminotransferase inhibitors
US20090270379A1 (en) * 2008-04-23 2009-10-29 Macielag Mark J Quinolone derivatives useful as antibacterial agents
CN106913569B (zh) * 2016-01-04 2022-04-22 广东工业大学 苯酞类化合物在制备抗耐药菌药物中的应用
CN112266326A (zh) * 2020-11-10 2021-01-26 杭州臻挚生物科技有限公司 二氯甲苯硝化物中间体的制备方法

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Also Published As

Publication number Publication date
US5591744A (en) 1997-01-07
JPH0696557B2 (ja) 1994-11-30
KR880012506A (ko) 1988-11-28
US5723648A (en) 1998-03-03
DE19775083I2 (de) 2001-06-13
SG101541A1 (en) 2004-01-30
SA97180461A (ar) 2005-12-03
EP0565132A2 (en) 1993-10-13
DK101492D0 (da) 1992-08-13
DE3855388T2 (de) 1997-02-13
DK170640B1 (da) 1995-11-20
SG49836A1 (en) 1998-06-15
HK128797A (en) 1997-09-19
KR940002113B1 (ko) 1994-03-17
CN1030237A (zh) 1989-01-11
NL980011I1 (nl) 1998-05-06
DK171820B1 (da) 1997-06-23
JPH01230558A (ja) 1989-09-14
EP0565132B1 (en) 2000-10-25
CN1053666C (zh) 2000-06-21
KR960006145B1 (ko) 1996-05-09
JPH07138232A (ja) 1995-05-30
ES2152936T3 (es) 2001-02-16
US5563138A (en) 1996-10-08
SG97777A1 (en) 2003-08-20
DE3856515D1 (de) 2002-03-21
EP0287951B1 (en) 1996-07-03
DK207688D0 (da) 1988-04-15
DE3855388D1 (de) 1996-08-08
ES2172734T3 (es) 2002-10-01
EP0287951A3 (en) 1990-06-13
EP0823413A2 (en) 1998-02-11
EP0823413A3 (en) 1998-12-09
JP2654537B2 (ja) 1997-09-17
EP0823413B1 (en) 2002-02-13
DE3856434D1 (de) 2000-11-30
EP0287951A2 (en) 1988-10-26
DK101492A (da) 1992-08-13
NL980011I2 (nl) 1998-10-01
DE3856434T2 (de) 2001-06-13
US5495020A (en) 1996-02-27
DE3856515T2 (de) 2002-08-14
US5811576A (en) 1998-09-22
EP0565132A3 (en) 1994-05-18
ES2091180T3 (es) 1996-11-01
CY2050B1 (en) 1998-04-30

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