DK1018513T3 - 8-(2,2,2-trifluorethyl)-8-azabicyclo[3,2,1]octan-3-on anvendeligt som mellemprodukt til serotonin-4-receptor-stimulerende quinolincarboxylsyrederivater - Google Patents

8-(2,2,2-trifluorethyl)-8-azabicyclo[3,2,1]octan-3-on anvendeligt som mellemprodukt til serotonin-4-receptor-stimulerende quinolincarboxylsyrederivater

Info

Publication number: DK1018513T3
Authority: DK; Denmark
Prior art keywords: useful; octan; azabicyclo; serotonin; trifluoroethyl
Prior art date: 1994-05-18

Application number

DK99123695T

Other languages

Danish (da)

English (en)

Inventor

Yutaka Ohuchi

Masaji Suzuki

Hajime Asanuma

Sadakazu Yokomori

Katsuo Hatayama

Original Assignee

Syngenta Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-18

Filing date

1995-05-18

Publication date

2006-04-03

1995-05-18 Application filed by Syngenta Ltd filed Critical Syngenta Ltd

2006-04-03 Application granted granted Critical

2006-04-03 Publication of DK1018513T3 publication Critical patent/DK1018513T3/da

Links

PFWHBGBCEGCDJT-UHFFFAOYSA-N 8-(2,2,2-trifluoroethyl)-8-azabicyclo[3.2.1]octan-3-one Chemical compound C1C(=O)CC2CCC1N2CC(F)(F)F PFWHBGBCEGCDJT-UHFFFAOYSA-N 0.000 title 1
LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
239000003905 agrochemical Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

DK99123695T 1994-05-18 1995-05-18 8-(2,2,2-trifluorethyl)-8-azabicyclo[3,2,1]octan-3-on anvendeligt som mellemprodukt til serotonin-4-receptor-stimulerende quinolincarboxylsyrederivater DK1018513T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP10317794		1994-05-18
EP95918742A EP0710662B1 (de)	1994-05-18	1995-05-18	Chinolincarbonsäure-derivate

Publications (1)

Publication Number	Publication Date
DK1018513T3 true DK1018513T3 (da)	2006-04-03

Family

ID=14347238

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99123695T DK1018513T3 (da)	1994-05-18	1995-05-18	8-(2,2,2-trifluorethyl)-8-azabicyclo[3,2,1]octan-3-on anvendeligt som mellemprodukt til serotonin-4-receptor-stimulerende quinolincarboxylsyrederivater

Country Status (11)

Country	Link
US (1)	US5753673A (de)
EP (2)	EP0710662B1 (de)
JP (1)	JP3829879B2 (de)
KR (1)	KR960703907A (de)
AT (2)	ATE316970T1 (de)
AU (1)	AU685632B2 (de)
CA (1)	CA2167055A1 (de)
DE (2)	DE69520545T2 (de)
DK (1)	DK1018513T3 (de)
ES (1)	ES2252907T3 (de)
WO (1)	WO1995031455A1 (de)

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KR970701191A (ko) *	1994-02-28	1997-03-17	우에하라 아키라	복소환 화합물
US6054465A (en) *	1995-11-13	2000-04-25	Smithkline Beecham Corporation	Hemoregulatory compounds
US6451813B1 (en)	2001-01-26	2002-09-17	R. T. Alamo Ventures I, Llc	Treatment of gastroparesis in certain patient groups
US20050222175A1 (en) *	2004-03-31	2005-10-06	Dhanoa Dale S	New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7612078B2 (en)	2003-03-31	2009-11-03	Epix Delaware, Inc.	Piperidinylamino-thieno[2,3-D] pyrimidine compounds
ES2338882T3 (es) *	2003-11-24	2010-05-13	Pfizer, Inc.	Compuestos de acido quinolona-carboxilico que tienen actividad agonista del receptor 5-ht4.
TW200533348A (en) *	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) *	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en)	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7488736B2 (en)	2004-05-17	2009-02-10	Epix Delaware, Inc.	Thienopyridinone compounds and methods of treatment
US7407966B2 (en)	2004-10-07	2008-08-05	Epix Delaware, Inc.	Thienopyridinone compounds and methods of treatment
US7576211B2 (en)	2004-09-30	2009-08-18	Epix Delaware, Inc.	Synthesis of thienopyridinone compounds and related intermediates
US7598265B2 (en) *	2004-09-30	2009-10-06	Epix Delaware, Inc.	Compositions and methods for treating CNS disorders
DE602005016446D1 (de) *	2004-11-05	2009-10-15	Theravance Inc	5-HT4-Rezeptoragonistenverbindungen
DE602005014566D1 (de) *	2004-11-05	2009-07-02	Theravance Inc	Chinolinon-carboxamid-verbindungen
ATE469897T1 (de) *	2004-12-22	2010-06-15	Theravance Inc	Indazolcarbonsäureamidverbindungen
US20060183901A1 (en) *	2005-02-17	2006-08-17	Theravance, Inc.	Crystalline form of an indazole-carboxamide compound
BRPI0608392A2 (pt) *	2005-03-02	2009-12-29	Theravance Inc	compostos de quinolinona como agonistas do receptor 5-ht4
TWI377206B (en) *	2005-04-06	2012-11-21	Theravance Inc	Crystalline form of a quinolinone-carboxamide compound
US7317022B2 (en) *	2005-06-07	2008-01-08	Theravance, Inc.	Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists
MY143574A (en) *	2005-11-22	2011-05-31	Theravance Inc	Carbamate compounds as 5-ht4 receptor agonists
US7487406B2 (en) *	2005-11-29	2009-02-03	International Business Machines Corporation	Systems, methods, and media for managing software defects
US7671198B2 (en) *	2006-02-16	2010-03-02	Theravance, Inc.	Process for preparing intermediates to 5-HT4 receptor agonist compounds
TWI415850B (zh)	2007-07-20	2013-11-21	Theravance Inc	製備ｍｕ類鴉片受體拮抗劑之中間物的方法
WO2010065743A2 (en)	2008-12-03	2010-06-10	Nanotherapeutics, Inc.	Bicyclic compounds and methods of making and using same
AR079493A1 (es)	2009-12-21	2012-02-01	Nippon Soda Co	Compuesto de amina ciclica y acaricida
AR081721A1 (es)	2010-02-25	2012-10-17	Nippon Soda Co	Compuesto de amina ciclica y acaricida
CN102333775A (zh) *	2010-03-22	2012-01-25	北京世纪迈劲生物科技有限公司	制备二苯乙醇酸去甲托品酯和其盐的方法及其中所用的中间体
JP5767099B2 (ja) *	2011-06-16	2015-08-19	日本曹達株式会社	環状アミン化合物および有害生物防除剤
AU2019412747B8 (en) *	2018-12-27	2025-04-24	F. Hoffmann-La Roche Ag	Process for the preparation exo-tert-butyl N-(3-azabicyclo[3.2.1]octan-8-yl)carbamate

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IT1228293B (it) *	1989-02-06	1991-06-07	Angeli Inst Spa	Benzoderivati di composti eterociclici contenenti azoto.
JP3122671B2 (ja) *	1990-05-23	2001-01-09	協和醗酵工業株式会社	複素環式化合物
DE69113284T2 (de) *	1990-12-28	1996-02-22	Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo	Chinolinderivat.
WO1994012497A1 (fr) *	1992-11-20	1994-06-09	Taisho Pharmaceutical Co., Ltd.	Compose heterocyclique

1995
- 1995-05-17 JP JP11879495A patent/JP3829879B2/ja not_active Expired - Fee Related
- 1995-05-18 US US08/578,532 patent/US5753673A/en not_active Expired - Fee Related
- 1995-05-18 EP EP95918742A patent/EP0710662B1/de not_active Expired - Lifetime
- 1995-05-18 DK DK99123695T patent/DK1018513T3/da active
- 1995-05-18 EP EP99123695A patent/EP1018513B1/de not_active Expired - Lifetime
- 1995-05-18 DE DE69520545T patent/DE69520545T2/de not_active Expired - Fee Related
- 1995-05-18 AT AT99123695T patent/ATE316970T1/de not_active IP Right Cessation
- 1995-05-18 AT AT95918742T patent/ATE200286T1/de active
- 1995-05-18 KR KR1019960700086A patent/KR960703907A/ko not_active Withdrawn
- 1995-05-18 CA CA002167055A patent/CA2167055A1/en not_active Abandoned
- 1995-05-18 ES ES99123695T patent/ES2252907T3/es not_active Expired - Lifetime
- 1995-05-18 DE DE69534768T patent/DE69534768T2/de not_active Expired - Fee Related
- 1995-05-18 AU AU24548/95A patent/AU685632B2/en not_active Ceased
- 1995-05-18 WO PCT/JP1995/000954 patent/WO1995031455A1/ja not_active Ceased

Also Published As

Publication number	Publication date
EP1018513A2 (de)	2000-07-12
ES2252907T3 (es)	2006-05-16
EP1018513A3 (de)	2004-07-21
ATE200286T1 (de)	2001-04-15
DE69534768D1 (de)	2006-04-13
DE69520545T2 (de)	2001-08-09
WO1995031455A1 (en)	1995-11-23
EP0710662B1 (de)	2001-04-04
EP0710662A1 (de)	1996-05-08
DE69520545D1 (de)	2001-05-10
CA2167055A1 (en)	1995-11-23
DE69534768T2 (de)	2007-02-01
AU685632B2 (en)	1998-01-22
AU2454895A (en)	1995-12-05
EP1018513B1 (de)	2006-02-01
JPH0834784A (ja)	1996-02-06
KR960703907A (ko)	1996-08-31
EP0710662A4 (de)	1996-09-18
US5753673A (en)	1998-05-19
ATE316970T1 (de)	2006-02-15
JP3829879B2 (ja)	2006-10-04

Publication	Publication Date	Title
ATE316970T1 (de)	2006-02-15	8-(2,2,2-trifluoroethyl)-8-azabicyclo(3.2.1)oct n-3-on verwendbar als zwischenprodukt für serotonin-4-rezeptor stimulierende chinolincarbonsäure- derivate
ES2101960T3 (es)	1997-07-16	Lactamas benzo-condensadas.
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KR930703312A (ko)	1993-11-29	아자비사이클로 [2.2.2]옥탄-3-이민의 제조방법 및 그의 제조용 중간체
DE68917853D1 (de)	1994-10-06	Herstellung von 1,4-Diazabicyclo[3.2.2]nonanen.
ATE9225T1 (de)	1984-09-15	Derivate des 5-hydroxy-tetrahydro-2-furanons.
DE68901582D1 (de)	1992-06-25	Enantiomere glutaramide als harntreibende verbindungen.
ES2016017A6 (es)	1990-10-01	Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
GR3023381T3 (en)	1997-08-29	Process for preparing trans-piperidine-2,5-dicarboxylates
FI896251A0 (fi)	1989-12-22	Menetelmä uusien terapeuttisesti käyttökelpoisten pyratsolopyridiinijohdannaisten valmistamiseksi
ES8304971A1 (es)	1983-03-16	Un procedimiento para la preparacion de derivados de tiocarbapenem 3-sustituidos.
ATE82291T1 (de)	1992-11-15	Clavamderivate, herstellung und zwischenprodukte.
AU4006893A (en)	1993-12-16	Arylpiperidine and arylpiperazine alkylbenzyl alcohol derivatives as antipsychotics
DE69319955D1 (de)	1998-09-03	Kristalline Formen von Endo-2,3-Dihydro-N-(8-Methyl-8-Azabicyclo(3.2.1)Oct-3-yl)-2-Oxo-1H-Benzimidazol-1-Carboxamid Hydrochlorid Monohydrat und von Endo-3-Ethyl-2,3-Dihydro-N-(8-Methyl-8-Azabicyclo(3.2.1)Oct-3-yl)-2-Oxo-1H-Benzimidazol-1-Carboxamid Hydrochlorid Monohydrat als 5-HT Antagonisten
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KR930017901A (ko)	1993-09-20	카바세펨의 제조를 위한 신규한 방법 및 화합물