DK1028961T5 - Pleuromutilinderivater som antimikrobielle midler - Google Patents

Pleuromutilinderivater som antimikrobielle midler

Info

Publication number
DK1028961T5
DK1028961T5 DK98950202T DK98950202T DK1028961T5 DK 1028961 T5 DK1028961 T5 DK 1028961T5 DK 98950202 T DK98950202 T DK 98950202T DK 98950202 T DK98950202 T DK 98950202T DK 1028961 T5 DK1028961 T5 DK 1028961T5
Authority
DK
Denmark
Prior art keywords
antimicrobial agents
pleuromutiline
derivatives
pleuromutiline derivatives
antimicrobial
Prior art date
Application number
DK98950202T
Other languages
Danish (da)
English (en)
Other versions
DK1028961T3 (da
Inventor
Valerie Berry
Stephen Dabbs
Colin Henry Frydrych
Eric Hunt
Gary Woodnutt
Francis Dominic Sanderson
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26312507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1028961(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9722817.5A external-priority patent/GB9722817D0/en
Priority claimed from GBGB9813689.8A external-priority patent/GB9813689D0/en
Application filed by Smithkline Beecham Plc, Smithkline Beecham Corp filed Critical Smithkline Beecham Plc
Publication of DK1028961T3 publication Critical patent/DK1028961T3/da
Application granted granted Critical
Publication of DK1028961T5 publication Critical patent/DK1028961T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C271/36—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
DK98950202T 1997-10-29 1998-10-27 Pleuromutilinderivater som antimikrobielle midler DK1028961T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9722817.5A GB9722817D0 (en) 1997-10-29 1997-10-29 Novel compounds
GBGB9813689.8A GB9813689D0 (en) 1998-06-25 1998-06-25 Novel compounds
PCT/GB1998/003211 WO1999021855A1 (fr) 1997-10-29 1998-10-27 Derives de pleuromutiline utilises comme agents antimicrobiens

Publications (2)

Publication Number Publication Date
DK1028961T3 DK1028961T3 (da) 2005-01-03
DK1028961T5 true DK1028961T5 (da) 2009-03-09

Family

ID=26312507

Family Applications (2)

Application Number Title Priority Date Filing Date
DK98950202T DK1028961T5 (da) 1997-10-29 1998-10-27 Pleuromutilinderivater som antimikrobielle midler
DK08152170.0T DK1930330T3 (da) 1997-10-29 1998-10-27 Pleuromutilinderivater som antimikrobielle midler

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK08152170.0T DK1930330T3 (da) 1997-10-29 1998-10-27 Pleuromutilinderivater som antimikrobielle midler

Country Status (35)

Country Link
US (3) US6281226B1 (fr)
EP (3) EP1452534A1 (fr)
JP (2) JP4227729B2 (fr)
KR (1) KR100538721B1 (fr)
CN (1) CN1205211C (fr)
AR (1) AR015987A1 (fr)
AT (2) ATE277925T1 (fr)
AU (1) AU742167C (fr)
BR (1) BR9814747B1 (fr)
CA (1) CA2307551C (fr)
CO (1) CO5021129A1 (fr)
CY (2) CY2007028I2 (fr)
CZ (1) CZ298543B6 (fr)
DE (2) DE122007000076I2 (fr)
DK (2) DK1028961T5 (fr)
DZ (1) DZ2634A1 (fr)
EG (1) EG24177A (fr)
ES (2) ES2229538T7 (fr)
FR (1) FR07C0057I2 (fr)
HU (2) HU229792B1 (fr)
IL (2) IL135811A0 (fr)
LU (1) LU91372I2 (fr)
MY (1) MY130665A (fr)
NL (1) NL300304I2 (fr)
NO (3) NO327392B1 (fr)
NZ (1) NZ504203A (fr)
PE (1) PE123299A1 (fr)
PL (2) PL191927B1 (fr)
PT (2) PT1028961E (fr)
SI (2) SI1028961T1 (fr)
TR (1) TR200001203T2 (fr)
TW (1) TWI232861B (fr)
UY (1) UY25225A1 (fr)
WO (1) WO1999021855A1 (fr)
ZA (1) ZA989767B (fr)

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UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
WO2000027790A1 (fr) * 1998-11-11 2000-05-18 Smithkline Beecham P.L.C. Composes a base de mutiline
GB9912657D0 (en) * 1999-06-01 1999-07-28 Smithkline Beecham Plc Novel compounds
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB9919839D0 (en) * 1999-08-20 1999-10-27 Smithkline Beecham Plc Novel compounds
CN1210267C (zh) 2000-04-04 2005-07-13 史密斯克莱·比奇曼公司 用于抗菌的2－羟基－姆替林氨基甲酸酯衍生物
GB0017031D0 (en) 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
GB0017073D0 (en) * 2000-07-11 2000-08-30 Univ London Microorganism
PE20020676A1 (es) * 2000-09-13 2002-08-27 Biochemie Gmbh Compuestos de mutilina como antibacterianos
GB0024811D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
GB0027705D0 (en) * 2000-11-11 2000-12-27 S P A Novel compounds
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GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
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US20090234125A1 (en) * 2007-11-26 2009-09-17 Eli Lancry Amorphous retapamulin and processes for preparation thereof
WO2009075776A1 (fr) * 2007-12-05 2009-06-18 Teva Pharmaceutical Industries Ltd. Procédé pour préparer de la rétapamuline et ses intermédiaires
US8278313B2 (en) 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives
WO2010056855A1 (fr) * 2008-11-13 2010-05-20 Teva Pharmaceutical Industries Ltd. Préparation de rétapamuline par l'intermédiaire de son précurseur pleuromutiline-thiol
US20120107854A1 (en) * 2009-03-03 2012-05-03 National Institute Of Radiological Sciences Reagent for measurement of cholinesterase activity
JP5663572B2 (ja) 2009-07-14 2015-02-04 アルバニー モレキュラー リサーチ， インコーポレイテッド ５−ｈｔ３受容体モジュレーター、その作製方法、およびその使用
CN102344397B (zh) * 2011-08-23 2013-09-04 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的提纯方法
CN103626693B (zh) * 2012-08-28 2016-09-14 中国科学院上海药物研究所 一类截短侧耳素衍生物、其药物组合物及其合成方法与用途
CN103709093B (zh) * 2012-09-28 2016-06-08 山东亨利医药科技有限责任公司 含有并环的截短侧耳素类抗生素
JP2017527332A (ja) 2014-07-21 2017-09-21 エンドチョイス インコーポレイテッドＥｎｄｏｃｈｏｉｃｅ， Ｉｎｃ． 多焦点マルチカメラ内視鏡システム
CN113321672A (zh) * 2016-03-02 2021-08-31 比尔及梅琳达盖茨基金会 含硼小分子
US10611781B2 (en) 2016-03-02 2020-04-07 Bill And Melinda Gates Foundation Boron-containing small molecules
US10874679B2 (en) 2016-03-02 2020-12-29 Bill & Melinda Gates Foundation Boron-containing small molecules
CN106496085B (zh) * 2016-09-21 2018-01-26 盐城市舜宝化工有限公司 合成盐酸沃尼妙林的中间体化合物以及盐酸沃尼妙林的制备方法
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN111574395B (zh) * 2020-06-18 2021-07-02 华南农业大学 一种具有酰胺侧链的截短侧耳素衍生物及制备与应用
AT523646B1 (de) 2020-07-21 2021-10-15 Gerd Dr Ascher Pharmazeutische Verbindungen, ihre Anwendung alleine oder in Kombination, zur Prophylaxe und lokalen Initial-Therapie bei bakteriellen und viralen Infektionen, insbesondere Coronaviren
US11155514B1 (en) * 2020-12-19 2021-10-26 Shaanxi University Of Science And Technology Pleuromulin acitretin ester with antibacterial activity and a method of preparing the same
US11332430B1 (en) * 2021-01-25 2022-05-17 Xi'an Taikomed Pharmaceutical Technology Co., Ltd. Pleuromulin lauric acid ester with antibacterial activity and a method of preparing the same
CN112919463B (zh) * 2021-04-09 2021-10-26 南京理工大学 一种利用泰妙菌素废盐制备的活性炭及其制备方法
CN113121355B (zh) * 2021-04-13 2023-05-09 西安康诺化工有限公司 一种截短侧耳素大黄酸酯及其制备方法和应用
CN114736194A (zh) * 2022-03-29 2022-07-12 中牧实业股份有限公司 一种具有抗病原微生物活性的含吡啶季铵盐侧链的截短侧耳素衍生物及其制备方法与应用
CN119930551B (zh) * 2024-04-28 2026-04-07 徐士新 一种截短侧耳素衍生物及其制备方法与应用

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NO20002173D0 (no) 2000-04-27
UY25225A1 (es) 2000-12-29
IL135811A0 (en) 2001-05-20
NO20002173L (no) 2000-06-05
NO2009023I2 (no) 2012-12-03
PT1930330E (pt) 2011-10-31
DE122007000076I1 (de) 2008-02-14
CO5021129A1 (es) 2001-03-27
LU91372I9 (fr) 2019-01-02
PL340254A1 (en) 2001-01-29
SI1930330T1 (sl) 2011-12-30
DK1028961T3 (da) 2005-01-03
CZ298543B6 (cs) 2007-10-31
EG24177A (en) 2008-09-28
CY2007028I2 (el) 2009-11-04
ATE277925T1 (de) 2004-10-15
NL300304I2 (nl) 2008-03-03
HUS1400060I1 (hu) 2016-09-28
DE122007000076I2 (de) 2010-03-25
FR07C0057I2 (fr) 2008-05-16
MY130665A (en) 2007-07-31
DE69826704D1 (de) 2004-11-04
HUP0004040A3 (en) 2001-08-28
CA2307551C (fr) 2007-01-30
KR100538721B1 (ko) 2005-12-26
HUP0004040A1 (hu) 2001-05-28
CN1205211C (zh) 2005-06-08
ES2229538T7 (es) 2009-06-18
CY1112062T1 (el) 2015-11-04
US6281226B1 (en) 2001-08-28
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IL135811A (en) 2006-12-31
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DK1930330T3 (da) 2011-12-12
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AU742167C (en) 2003-08-07
HK1031376A1 (en) 2001-06-15
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