DK1045691T3 - Kombinationer af statin-carboxylalkylether - Google Patents

Kombinationer af statin-carboxylalkylether

Info

Publication number: DK1045691T3
Authority: DK; Denmark
Prior art keywords: statin; combinations; alkyl ether; carboxyl alkyl; carboxyl
Prior art date: 1997-12-12

Application number

DK98960278T

Other languages

English (en)

Inventor

Charles Larry Bisgaier

Roger Schofield Newton

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-12

Filing date

1998-11-20

Publication date

2005-03-14

1998-11-20 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2005-03-14 Application granted granted Critical

2005-03-14 Publication of DK1045691T3 publication Critical patent/DK1045691T3/da

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
125000004181 carboxyalkyl group Chemical group 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

DK98960278T 1997-12-12 1998-11-20 Kombinationer af statin-carboxylalkylether DK1045691T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6937597P	1997-12-12	1997-12-12
PCT/US1998/024679 WO1999030704A1 (en)	1997-12-12	1998-11-20	Statin-carboxyalkylether combinations

Publications (1)

Publication Number	Publication Date
DK1045691T3 true DK1045691T3 (da)	2005-03-14

Family

ID=22088573

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98960278T DK1045691T3 (da)	1997-12-12	1998-11-20	Kombinationer af statin-carboxylalkylether

Country Status (30)

Country	Link
EP (1)	EP1045691B1 (da)
JP (1)	JP2002508320A (da)
KR (1)	KR20010033003A (da)
AR (1)	AR017851A1 (da)
AT (1)	ATE285762T1 (da)
AU (1)	AU754089B2 (da)
BR (1)	BR9813542A (da)
CA (1)	CA2304612A1 (da)
CO (1)	CO4970816A1 (da)
CR (1)	CR5926A (da)
CU (1)	CU20000140A7 (da)
DE (1)	DE69828442T2 (da)
DK (1)	DK1045691T3 (da)
ES (1)	ES2230733T3 (da)
GT (1)	GT199800196A (da)
HN (1)	HN1998000185A (da)
HU (1)	HUP0004547A3 (da)
IL (1)	IL135349A0 (da)
IS (1)	IS2150B (da)
MY (1)	MY118381A (da)
NO (1)	NO20002966L (da)
NZ (1)	NZ503982A (da)
PA (1)	PA8464601A1 (da)
PE (1)	PE20000017A1 (da)
PL (1)	PL341066A1 (da)
PT (1)	PT1045691E (da)
SV (1)	SV1998000146A (da)
UY (1)	UY25299A1 (da)
WO (1)	WO1999030704A1 (da)
ZA (1)	ZA9811348B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6861555B2 (en)	2000-01-25	2005-03-01	Warner-Lambert Company	Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
CA2299397A1 (en) *	1997-12-12	1999-06-24	Warner-Lambert Company	Antihyperlipidemic statin-lp(a) inhibitor combinations
US20030105154A1 (en)	2001-10-24	2003-06-05	Bisgaier Charles Larry	Statin-carboxyalkylether combinations
CZ20011035A3 (cs) *	1998-09-30	2001-10-17	Warner-Lambert Company	Léčivo pro prevenci nebo oddálení revaskularizace pomocí katetru u pacientů postiľených chorobou koronární artérie
US6562864B1 (en) *	1999-09-02	2003-05-13	Drake Larson	Catechin multimers as therapeutic drug delivery agents
IN191580B (da) *	1999-12-17	2003-12-06	Ranbaxy Lab Ltd
NZ519550A (en)	2000-01-25	2003-11-28	Warner Lambert Co	Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
AU2001256278A1 (en) *	2000-04-18	2001-10-30	Bayer Aktiengesellschaft	Use of cse inhibitors for treating heart failure
CZ20023459A3 (cs) *	2000-04-26	2003-05-14	Warner-Lambert Company	Antihypertensní činidla a jejich použití
US6689807B1 (en) *	2000-06-08	2004-02-10	Caritas St. Elizabeth's Medical Center Of Boston, Inc.	HMG CoA reductase inhibitors for promoting angiogenesis
CA2450820C (en) *	2001-08-16	2011-03-15	Teva Pharmaceutical Industries Ltd.	Processes for preparing calcium salt forms of statins
KR20040026705A (ko)	2001-08-16	2004-03-31	테바 파마슈티컬 인더스트리즈 리미티드	스타틴의 칼슘 염 형태의 제조 방법
US20050026979A1 (en) *	2003-07-31	2005-02-03	Maha Ghazzi	Methods for treating inflammation and inflammation-associated diseases with a statin and ether
JP6295205B2 (ja) *	2012-01-06	2018-03-14	ジェムファイアセラピューティクスインクＧｅｍｐｈｉｒｅＴｈｅｒａｐｅｕｔｉｃｓＩｎｃ．	心血管疾患のリスクを低減する方法
MX2018005096A (es) *	2015-11-06	2018-08-15	Gemphire Therapeutics Inc	Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5648387A (en) *	1995-03-24	1997-07-15	Warner-Lambert Company	Carboxyalkylethers, formulations, and treatment of vascular diseases

1998
- 1998-11-12 NZ NZ503982A patent/NZ503982A/en unknown
- 1998-11-20 JP JP2000538687A patent/JP2002508320A/ja active Pending
- 1998-11-20 EP EP98960278A patent/EP1045691B1/en not_active Expired - Lifetime
- 1998-11-20 HU HU0004547A patent/HUP0004547A3/hu unknown
- 1998-11-20 DE DE69828442T patent/DE69828442T2/de not_active Expired - Lifetime
- 1998-11-20 BR BR9813542-2A patent/BR9813542A/pt not_active Application Discontinuation
- 1998-11-20 DK DK98960278T patent/DK1045691T3/da active
- 1998-11-20 PT PT98960278T patent/PT1045691E/pt unknown
- 1998-11-20 PL PL98341066A patent/PL341066A1/xx unknown
- 1998-11-20 AT AT98960278T patent/ATE285762T1/de not_active IP Right Cessation
- 1998-11-20 CA CA002304612A patent/CA2304612A1/en not_active Abandoned
- 1998-11-20 ES ES98960278T patent/ES2230733T3/es not_active Expired - Lifetime
- 1998-11-20 AU AU15915/99A patent/AU754089B2/en not_active Ceased
- 1998-11-20 KR KR1020007006355A patent/KR20010033003A/ko not_active Ceased
- 1998-11-20 WO PCT/US1998/024679 patent/WO1999030704A1/en not_active Ceased
- 1998-11-20 IL IL13534998A patent/IL135349A0/xx unknown
- 1998-12-09 HN HN1998000185A patent/HN1998000185A/es unknown
- 1998-12-10 CR CR5926A patent/CR5926A/es not_active Application Discontinuation
- 1998-12-10 MY MYPI98005579A patent/MY118381A/en unknown
- 1998-12-10 ZA ZA9811348A patent/ZA9811348B/xx unknown
- 1998-12-11 CO CO98073828A patent/CO4970816A1/es unknown
- 1998-12-11 AR ARP980106321A patent/AR017851A1/es unknown
- 1998-12-11 PE PE1998001207A patent/PE20000017A1/es not_active Application Discontinuation
- 1998-12-11 SV SV1998000146A patent/SV1998000146A/es not_active Application Discontinuation
- 1998-12-11 GT GT199800196A patent/GT199800196A/es unknown
- 1998-12-11 PA PA19988464601A patent/PA8464601A1/es unknown
- 1998-12-11 UY UY25299A patent/UY25299A1/es not_active Application Discontinuation
2000
- 2000-04-14 IS IS5445A patent/IS2150B/is unknown
- 2000-06-09 NO NO20002966A patent/NO20002966L/no not_active Application Discontinuation
- 2000-06-09 CU CU20000140A patent/CU20000140A7/es unknown

Also Published As

Publication number	Publication date
NO20002966D0 (no)	2000-06-09
IL135349A0 (en)	2001-05-20
JP2002508320A (ja)	2002-03-19
EP1045691B1 (en)	2004-12-29
IS5445A (is)	2000-04-14
ES2230733T3 (es)	2005-05-01
GT199800196A (es)	2000-06-03
SV1998000146A (es)	1999-09-30
WO1999030704A1 (en)	1999-06-24
EP1045691A1 (en)	2000-10-25
HN1998000185A (es)	1999-06-02
CR5926A (es)	2000-03-06
DE69828442D1 (de)	2005-02-03
CA2304612A1 (en)	1999-06-24
KR20010033003A (ko)	2001-04-25
NO20002966L (no)	2000-06-09
BR9813542A (pt)	2000-10-10
AU1591599A (en)	1999-07-05
HUP0004547A3 (en)	2001-12-28
IS2150B (is)	2006-10-13
PA8464601A1 (es)	2001-12-14
MY118381A (en)	2004-10-30
CO4970816A1 (es)	2000-11-07
NZ503982A (en)	2002-03-28
PL341066A1 (en)	2001-03-26
AR017851A1 (es)	2001-10-24
ATE285762T1 (de)	2005-01-15
ZA9811348B (en)	1999-06-14
PT1045691E (pt)	2005-03-31
CU20000140A7 (es)	2005-10-19
HUP0004547A2 (hu)	2001-05-28
AU754089B2 (en)	2002-11-07
PE20000017A1 (es)	2000-01-20
DE69828442T2 (de)	2005-06-02
UY25299A1 (es)	2001-08-27

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EE200000365A (et)	2001-10-15	Bispidiini uued arütmiavastased ühendid
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ID24374A (id)	2000-07-13	Komposisi-komposisi parenteral alatrofloksasin
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BR9711363A (pt)	1999-08-17	Sintese de bis-indolilmaleimidas
ID21934A (id)	1999-08-12	Kertas berlapis banyak
IS5426A (is)	2000-03-31	Fjölbrigðaform af dófetilíði
DK0919547T3 (da)	2002-09-23	Fremstilling af polyenaldehyder
DK0996646T3 (da)	2003-10-06	Syntese af forgrenet polyolefin
DK0882722T3 (da)	2002-07-15	Fremstilling af alpha-tocopherol
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