ATE287393T1 - Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
ATE287393T1
ATE287393T1 AT99907879T AT99907879T ATE287393T1 AT E287393 T1 ATE287393 T1 AT E287393T1 AT 99907879 T AT99907879 T AT 99907879T AT 99907879 T AT99907879 T AT 99907879T AT E287393 T1 ATE287393 T1 AT E287393T1
Authority
AT
Austria
Prior art keywords
substituents
hydrocarbon group
group optionally
aliphatic hydrocarbon
hydrogen atom
Prior art date
Application number
AT99907879T
Other languages
English (en)
Inventor
Yuzo Ichimori
Masayuki Ii
Katsumi Itoh
Tomoyuki Kitazaki
Junji Yamada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE287393T1 publication Critical patent/ATE287393T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Silicon Compounds (AREA)
AT99907879T 1998-03-09 1999-03-08 Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung ATE287393T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5649298 1998-03-09
JP28436298 1998-10-06
PCT/JP1999/001103 WO1999046242A1 (en) 1998-03-09 1999-03-08 Cycloalkene derivatives, process for producing the same, and use

Publications (1)

Publication Number Publication Date
ATE287393T1 true ATE287393T1 (de) 2005-02-15

Family

ID=26397446

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99907879T ATE287393T1 (de) 1998-03-09 1999-03-08 Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung

Country Status (19)

Country Link
US (1) US6495604B1 (de)
EP (2) EP1063228B1 (de)
JP (2) JP3665712B2 (de)
KR (4) KR100577044B1 (de)
CN (1) CN100432049C (de)
AT (1) ATE287393T1 (de)
AU (1) AU747521B2 (de)
BR (1) BR9908610A (de)
CA (1) CA2320467C (de)
DE (1) DE69923300T2 (de)
DK (1) DK1063228T5 (de)
ES (1) ES2232114T3 (de)
HU (1) HU230061B1 (de)
ID (1) ID25649A (de)
NO (1) NO326426B1 (de)
NZ (1) NZ505874A (de)
PT (1) PT1063228E (de)
RU (1) RU2214398C2 (de)
WO (1) WO1999046242A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1063228T5 (da) 1998-03-09 2009-06-15 Takeda Pharmaceutical Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf
US20040220103A1 (en) 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
WO2001010826A1 (en) 1999-08-06 2001-02-15 Takeda Chemical Industries, Ltd. Substituted aromatic-ring compounds, process for producing the same, and use
WO2001040498A1 (en) * 1999-11-29 2001-06-07 Takeda Chemical Industries, Ltd. Process for the production of optically active cyclohexene derivatives and intermediates therefor
CN1416341B (zh) * 2000-02-04 2010-05-05 武田药品工业株式会社 稳定的乳液组合物
JP4863553B2 (ja) * 2000-02-04 2012-01-25 武田薬品工業株式会社 安定な乳化組成物
CA2685447C (en) 2000-08-10 2013-05-28 Takeda Pharmaceutical Company Limited Pharmaceutical composition
JP4922507B2 (ja) * 2000-08-10 2012-04-25 武田薬品工業株式会社 医薬組成物
KR100821546B1 (ko) 2000-10-18 2008-04-11 다케다 야쿠힌 고교 가부시키가이샤 광학 활성 술폰아미드의 제조 방법 및 그의 합성용 중간체
AU2002221099A1 (en) * 2000-12-08 2002-06-18 Takeda Chemical Industries Ltd. Combination drugs
JP4278384B2 (ja) 2001-03-21 2009-06-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 ビタミンｂ２還元体を含む医薬
JP5137289B2 (ja) * 2001-08-03 2013-02-06 武田薬品工業株式会社 安定な乳化組成物
EP1495756A4 (de) * 2002-04-08 2009-10-28 Takeda Pharmaceutical Therapeutikum zur prävention schwerer sepsis
US7511042B2 (en) 2003-12-03 2009-03-31 Boehringer Ingelheim Pharmaceuticals, Inc. Triazole compounds
MY147790A (en) * 2005-04-28 2013-01-31 Takeda Pharmaceutical Stable emulsion composition
US7935835B2 (en) * 2005-09-14 2011-05-03 Daiichi Sankyo Company, Limited Substituted cycloalkene derivative
EP1997902B1 (de) 2006-03-30 2013-09-18 Hiroshima University Screening-verfahren
JPWO2007123186A1 (ja) 2006-04-20 2009-09-03 武田薬品工業株式会社 医薬
JPWO2007132825A1 (ja) 2006-05-15 2009-09-24 武田薬品工業株式会社 医薬
US20090209585A1 (en) * 2006-07-07 2009-08-20 Takashi Ichikawa Cycloalkene derivatives, process for production of the derivatives, and use of the same
JP2008260760A (ja) * 2007-03-12 2008-10-30 Daiichi Sankyo Co Ltd 置換シクロアルケン誘導体を含有する医薬組成物
SG10201503402XA (en) 2010-01-27 2015-06-29 Takeda Pharmaceutical Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent
WO2012039447A1 (ja) 2010-09-24 2012-03-29 第一三共株式会社 置換シクロアルケン誘導体の結晶
EP2866565A4 (de) * 2012-07-03 2016-04-13 Jay Pravda Verfahren zur behandlung, diagnose und/oder überwachung der progression von oxo-assoziierten zuständen
WO2014050910A1 (ja) 2012-09-26 2014-04-03 武田薬品工業株式会社 固体粒子の製造方法
US9611244B2 (en) * 2015-05-08 2017-04-04 Takeda Pharmaceutical Company Limited Cyclic compounds
RU2742337C2 (ru) 2016-09-09 2021-02-04 Такеда Фармасьютикал Компани Лимитед Циклическое соединение
CN110352189A (zh) * 2017-02-24 2019-10-18 景凯生物科技股份有限公司 用于预防及/或治疗自体免疫、发炎或感染相关障碍的磺酰胺或酰胺化合物、组合物与方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2095627C (en) 1990-11-06 1999-01-05 Junzo Seki Stable lyophilized fatty emulsions and a process for the production thereof
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5576016A (en) 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
CA2182698A1 (en) 1994-02-25 1995-08-31 Jun Sato Injectable emulsions containing antifungal triazole derivatives
JPH08109165A (ja) * 1994-08-18 1996-04-30 Chugai Pharmaceut Co Ltd 一酸化窒素合成酵素阻害作用を有するアミノ酸誘導体
AU3230895A (en) * 1994-08-18 1996-03-14 Chugai Seiyaku Kabushiki Kaisha Amino acid derivative having nitrogen monoxide synthetase inhibitor activity
DK1063228T5 (da) 1998-03-09 2009-06-15 Takeda Pharmaceutical Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf
CN1416341B (zh) 2000-02-04 2010-05-05 武田药品工业株式会社 稳定的乳液组合物

Also Published As

Publication number Publication date
HU230061B1 (hu) 2015-06-29
HK1031723A1 (en) 2001-06-22
CN100432049C (zh) 2008-11-12
CA2320467C (en) 2010-05-04
EP1063228A1 (de) 2000-12-27
WO1999046242A1 (en) 1999-09-16
AU2746499A (en) 1999-09-27
KR20050026075A (ko) 2005-03-14
JP3665712B2 (ja) 2005-06-29
DE69923300D1 (de) 2005-02-24
KR100492098B1 (ko) 2005-06-01
ID25649A (id) 2000-10-19
PT1063228E (pt) 2005-05-31
CN1291184A (zh) 2001-04-11
US6495604B1 (en) 2002-12-17
CA2320467A1 (en) 1999-09-16
JP2000178246A (ja) 2000-06-27
KR20010034555A (ko) 2001-04-25
DE69923300T2 (de) 2006-01-05
KR20060017921A (ko) 2006-02-27
NO20004485L (no) 2000-09-08
EP1063228B1 (de) 2005-01-19
EP1063228A4 (de) 2001-08-08
KR20050071719A (ko) 2005-07-07
DK1063228T5 (da) 2009-06-15
KR100779889B1 (ko) 2007-11-28
BR9908610A (pt) 2000-12-05
RU2214398C2 (ru) 2003-10-20
PL342826A1 (en) 2001-07-02
JP2005232168A (ja) 2005-09-02
AU747521B2 (en) 2002-05-16
JP4342453B2 (ja) 2009-10-14
KR100577044B1 (ko) 2006-05-08
AU747521C (en) 1999-09-27
NO326426B1 (no) 2008-12-01
NZ505874A (en) 2003-09-26
HUP0101192A2 (hu) 2001-08-28
NO20004485D0 (no) 2000-09-08
DK1063228T3 (da) 2005-04-25
ES2232114T3 (es) 2005-05-16
EP1524263A1 (de) 2005-04-20
HUP0101192A3 (en) 2003-09-29

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