DK1065196T3 - Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf - Google Patents

Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf

Info

Publication number: DK1065196T3
Authority: DK; Denmark
Prior art keywords: acid; esters; eicosan; purification; selective separation
Prior art date: 1999-06-28

Application number

DK00113020T

Other languages

Danish (da)

English (en)

Inventor

Satoshi Kiyohara

Shiro Nisshin Fujita

Original Assignee

Nisshin Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-28

Filing date

2000-06-21

Publication date

2003-09-22

2000-06-21 Application filed by Nisshin Pharma Inc filed Critical Nisshin Pharma Inc

2003-09-22 Application granted granted Critical

2003-09-22 Publication of DK1065196T3 publication Critical patent/DK1065196T3/da

Links

235000020669 docosahexaenoic acid Nutrition 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 title 2
229940090949 docosahexaenoic acid Drugs 0.000 title 1
YIYBQIKDCADOSF-UHFFFAOYSA-N pent-2-enoic acid Chemical compound CCC=CC(O)=O YIYBQIKDCADOSF-UHFFFAOYSA-N 0.000 title 1
238000000746 purification Methods 0.000 title 1
238000000926 separation method Methods 0.000 title 1
239000005909 Kieselgur Substances 0.000 abstract 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 2
GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
235000021122 unsaturated fatty acids Nutrition 0.000 abstract 2
150000004670 unsaturated fatty acids Chemical class 0.000 abstract 2
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical class [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
DVSZKTAMJJTWFG-UHFFFAOYSA-N docosa-2,4,6,8,10,12-hexaenoic acid Chemical class CCCCCCCCCC=CC=CC=CC=CC=CC=CC(O)=O DVSZKTAMJJTWFG-UHFFFAOYSA-N 0.000 abstract 1
235000020673 eicosapentaenoic acid Nutrition 0.000 abstract 1
229910052709 silver Inorganic materials 0.000 abstract 1
239000004332 silver Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Fats And Perfumes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK00113020T 1999-06-28 2000-06-21 Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf DK1065196T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP18140799		1999-06-28

Publications (1)

Publication Number	Publication Date
DK1065196T3 true DK1065196T3 (da)	2003-09-22

Family

ID=16100230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00113020T DK1065196T3 (da)	1999-06-28	2000-06-21	Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf

Country Status (7)

Country	Link
US (1)	US6313330B1 (de)
EP (1)	EP1065196B1 (de)
AT (1)	ATE241584T1 (de)
CA (1)	CA2311974A1 (de)
DE (1)	DE60002952T2 (de)
DK (1)	DK1065196T3 (de)
NO (1)	NO321273B1 (de)

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KR101167331B1 (ko)	2003-12-30	2012-07-19	디에스엠 아이피 어셋츠 비.브이.	탈기 방법
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JP5503856B2 (ja)	2008-09-10	2014-05-28	キユーピー株式会社	高度不飽和脂肪酸誘導体の取得方法
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US20110071176A1 (en)	2009-09-23	2011-03-24	Amarin Pharma, Inc.	Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
PE20130491A1 (es) *	2009-12-30	2013-05-02	Basf Pharma Callanish Ltd	Proceso simulado de separacion cromatografica de lecho movil para la purificacion de acidos grasos poliinsaturados
NZ778131A (en)	2010-11-29	2023-03-31	Amarin Pharmaceuticals Ie Ltd	Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11712429B2 (en)	2010-11-29	2023-08-01	Amarin Pharmaceuticals Ireland Limited	Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
GB201111589D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New modified process
GB201111591D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	Further new process
GB201111595D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	Improved process
GB201111594D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New improved process
GB201111601D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New process
US11291643B2 (en)	2011-11-07	2022-04-05	Amarin Pharmaceuticals Ireland Limited	Methods of treating hypertriglyceridemia
EP2775837A4 (de)	2011-11-07	2015-10-28	Amarin Pharmaceuticals Ie Ltd	Verfahren zur behandlung von hypertriglyceridämie
ES2891473T3 (es)	2012-01-06	2022-01-28	Amarin Pharmaceuticals Ie Ltd	Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto
EP4338805B1 (de)	2012-06-29	2025-06-04	Amarin Pharmaceuticals Ireland Limited	Eicosapentaensäureethylester zur verwendung bei der verringerung des risikos eines nicht-fatalen herzinfarktes bei einer person in statin-therapie
WO2014074552A2 (en)	2012-11-06	2014-05-15	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US9814733B2 (en)	2012-12-31	2017-11-14	A,arin Pharmaceuticals Ireland Limited	Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en)	2012-12-31	2014-07-03	Amarin Pharmaceuticals Ireland Limited	Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
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US9452151B2 (en)	2013-02-06	2016-09-27	Amarin Pharmaceuticals Ireland Limited	Methods of reducing apolipoprotein C-III
US9624492B2 (en)	2013-02-13	2017-04-18	Amarin Pharmaceuticals Ireland Limited	Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en)	2013-02-19	2017-05-30	The Regents Of The University Of Colorado	Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en)	2013-03-14	2016-03-15	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en)	2013-03-15	2014-09-18	Amarin Pharmaceuticals Ireland Limited	Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US9428711B2 (en)	2013-05-07	2016-08-30	Groupe Novasep	Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en)	2013-05-07	2014-08-12	Group Novasep	Chromatographic process for the production of highly purified polyunsaturated fatty acids
US10966968B2 (en)	2013-06-06	2021-04-06	Amarin Pharmaceuticals Ireland Limited	Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en)	2013-09-04	2015-03-05	Amarin Pharmaceuticals Ireland Limited	Methods of treating or preventing prostate cancer
US9585859B2 (en)	2013-10-10	2017-03-07	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103962091B (zh) *	2013-11-28	2017-01-25	大连工业大学	一种银离子改性氨基硅胶分离epa和dha的方法
EP2883860B1 (de)	2013-12-11	2016-08-24	Novasep Process	Chromatografisches Verfahren zur Herstellung von mehrfach ungesättigten Fettsäuren
JP6303017B2 (ja)	2014-01-07	2018-03-28	ノヴァセププロセスＮｏｖａｓｅｐＰｒｏｃｅｓｓ	芳香族アミノ酸を精製する方法
US10561631B2 (en)	2014-06-11	2020-02-18	Amarin Pharmaceuticals Ireland Limited	Methods of reducing RLP-C
WO2015195662A1 (en)	2014-06-16	2015-12-23	Amarin Pharmaceuticals Ireland Limited	Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
US10406130B2 (en)	2016-03-15	2019-09-10	Amarin Pharmaceuticals Ireland Limited	Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
WO2018213663A1 (en)	2017-05-19	2018-11-22	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en)	2018-03-02	2021-07-13	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
KR20210110890A (ko)	2018-09-24	2021-09-09	애머린 파마슈티칼스 아일랜드 리미티드	대상체에서 심혈관 사건의 위험도를 감소시키는 방법
JP7528054B2 (ja) *	2019-03-26	2024-08-05	日清ファルマ株式会社	エイコサペンタエン酸アルキルエステル含有組成物の製造方法
CN109912403A (zh) *	2019-04-18	2019-06-21	南京市第一医院	一种Omega-3制备大电导钙激活钾通道开放剂的方法
US12427134B2 (en)	2019-11-12	2025-09-30	Amarin Pharmaceuticals Ireland Limited	Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter
AU2022263358A1 (en)	2021-04-21	2023-11-30	Amarin Pharmaceuticals Ireland Limited	Methods of reducing the risk of heart failure

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EP0347509A1 (de) *	1988-06-21	1989-12-27	Century Laboratories Inc.	Verfahren zur Extraktion und Reinigung von polyungesättigten Fettsäuren aus Naturquellen
JPH028298A (ja) *	1988-06-17	1990-01-11	Agency Of Ind Science & Technol	イカ内臓からドコサヘキサエン酸及びエイコサペンタエン酸を選択的に分離精製する方法
JPH07242895A (ja) *	1993-03-16	1995-09-19	Ikeda Shiyotsuken Kk	高純度エイコサペンタエン酸又はその低級アルコールエステルの分離精製法
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2000
- 2000-06-19 CA CA002311974A patent/CA2311974A1/en not_active Abandoned
- 2000-06-21 AT AT00113020T patent/ATE241584T1/de not_active IP Right Cessation
- 2000-06-21 DK DK00113020T patent/DK1065196T3/da active
- 2000-06-21 DE DE60002952T patent/DE60002952T2/de not_active Expired - Fee Related
- 2000-06-21 EP EP00113020A patent/EP1065196B1/de not_active Expired - Lifetime
- 2000-06-26 NO NO20003335A patent/NO321273B1/no unknown
- 2000-06-28 US US09/604,766 patent/US6313330B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1065196B1 (de)	2003-05-28
EP1065196A1 (de)	2001-01-03
NO20003335L (no)	2000-12-29
NO321273B1 (no)	2006-04-10
ATE241584T1 (de)	2003-06-15
US6313330B1 (en)	2001-11-06
DE60002952D1 (de)	2003-07-03
CA2311974A1 (en)	2000-12-28
DE60002952T2 (de)	2004-03-11
NO20003335D0 (no)	2000-06-26

Publication	Publication Date	Title
DK1065196T3 (da)	2003-09-22	Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf
JP5951764B2 (ja)	2016-07-13	魚油から高純度のｅｐａを生成するためのｓｍｂ方法
JP5990580B2 (ja)	2016-09-14	新規なｓｍｂ方法
DK0658164T3 (da)	2001-06-18	Fremgangsmåde til chromatografisk oprensning og adskillelse af nukleinsyreblandinger
JP5946833B2 (ja)	2016-07-06	ω３脂肪酸を濃縮する方法
IS1928B (is)	2004-05-18	Hreinsun á fjölómettuðum fitusýruglýseríðum
ATE406345T1 (de)	2008-09-15	Reinigung von aminosäuren durch chromatographische simulierte wanderbetttrennung
ES2097047T3 (es)	1997-03-16	Procedimientos para el fraccionamiento cromatografico de acidos grasos y sus derivados.
JP2014518312A (ja)	2014-07-28	Ｓｍｂ方法
DK1877769T3 (da)	2011-03-28	Fremgangsmåde og anordning til kromatografisk oprensning
Lembke	2012	Production techniques for omega-3 concentrates
ATE8785T1 (de)	1984-08-15	Kohlstoff-koffein-trennung.
DE502006008403D1 (de)	2011-01-05	Verfahren zur abtrennung von säuren aus chemischen reaktionsgemischen mit hilfe unpolarer tertiärer amine
JPH08218091A (ja)	1996-08-27	高純度の高度不飽和脂肪酸およびその誘導体の製造方法
BR9913720A (pt)	2001-12-04	Processo de purificação por cristalização ourecristalização de ácidos carboxìlicos
WO2016194359A1 (ja)	2016-12-08	高純度・高収率な高度不飽和脂肪酸の製造方法
DK1192204T3 (da)	2006-02-20	Fremgangsmåde til oprensning af aldehyd-urenheder
DK0780374T3 (da)	2002-07-29	Fremgangsmåde til reduktion af indholdet af vand og polære urenheder i imidoalkanpercarboxylsyre
BR9914302A (pt)	2001-06-26	Método para a recuperação de acetato de metila e ácido acético residual
EP1918270A4 (de)	2009-04-22	Verfahren zur aufreinigung von ubiquinon-10
DE68928249D1 (de)	1997-09-18	Verfahren zur Trennung von Methylester von alpha-L-aspartyl-L-phenylalaninen
JPS5786254A (en)	1982-05-29	Healthful food
DE602004026048D1 (de)	2010-04-29	Verfahren zur reinigung des modifizierten hauptallergens von milben
PL363073A1 (pl)	2004-11-15	Sposób regenerowania kwasów z wodnego roztworu zawierającego metale przez ekstrakcję w układzie ciecz/ciecz
JPS528007A (en)	1977-01-21	Fractionation of oil and fat