NO168767C - Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav - Google Patents

Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav

Info

Publication number: NO168767C
Authority: NO; Norway
Prior art keywords: sup; cyclopenta; procedures; preparing; pyrimidine derivatives
Prior art date: 1985-03-07

Application number

NO860852A

Other languages

English (en)

Norwegian (no)

Other versions

NO168767B (no

NO860852L (no

Inventor

Nobuyoshi Iwata

Kanichi Nakamura

Tomio Kimura

Isao Nakayama

Takashi Kobayashi

Original Assignee

Sankyo Co

Ube Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-07

Filing date

1986-03-07

Publication date

1992-04-01

1986-03-07 Application filed by Sankyo Co, Ube Industries filed Critical Sankyo Co

1986-09-08 Publication of NO860852L publication Critical patent/NO860852L/no

1991-12-23 Publication of NO168767B publication Critical patent/NO168767B/no

1992-04-01 Publication of NO168767C publication Critical patent/NO168767C/no

Links

238000000034 method Methods 0.000 title abstract 2
LTFBFZBWUKWXID-UHFFFAOYSA-N 1h-cyclopenta[d]pyrimidine Chemical class N1=CNC2=CC=CC2=C1 LTFBFZBWUKWXID-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
208000020401 Depressive disease Diseases 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
201000003102 mental depression Diseases 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Dental Preparations (AREA)
Saccharide Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Luminescent Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Soil Working Implements (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Eyeglasses (AREA)

NO860852A 1985-03-07 1986-03-07 Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav NO168767C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4362685		1985-03-07

Publications (3)

Publication Number	Publication Date
NO860852L NO860852L (no)	1986-09-08
NO168767B NO168767B (no)	1991-12-23
NO168767C true NO168767C (no)	1992-04-01

Family

ID=12669058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO860852A NO168767C (no)	1985-03-07	1986-03-07	Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav

Country Status (14)

Country	Link
US (1)	US4749704A (da)
EP (1)	EP0194161B1 (da)
JP (1)	JPS6270A (da)
KR (1)	KR890003839B1 (da)
AT (1)	ATE106077T1 (da)
AU (1)	AU580391B2 (da)
CA (1)	CA1273632A (da)
DE (1)	DE3689848T2 (da)
DK (1)	DK165109C (da)
ES (3)	ES8704905A1 (da)
FI (1)	FI88717C (da)
IE (1)	IE64504B1 (da)
NO (1)	NO168767C (da)
ZA (1)	ZA861708B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5037980A (en) *	1988-04-18	1991-08-06	American Cyanamid Company	Phenyl imidazo[1,2-a]pyrimidines
US5877178A (en) *	1991-04-08	1999-03-02	Duquesne University Of The Holy Ghost	Pyrimidine derivatives and methods of making and using these derivatives
US5234936A (en) *	1991-10-24	1993-08-10	American Home Products Corporation	Pyrimidocycloalkanes as a ii antagonists
JP2007501821A (ja) *	2003-08-12	2007-02-01	エフ．ホフマン−ラ　ロシュ　アーゲー	Ｃｆｒアンタゴニストとしてのテトラヒドロキナゾリン誘導体
WO2007049342A1 (ja)	2005-10-26	2007-05-03	Mitsubishi Denki Kabushiki Kaisha	エレベーター群管理制御装置
US8063050B2 (en)	2006-07-06	2011-11-22	Array Biopharma Inc.	Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2008006032A1 (en)	2006-07-06	2008-01-10	Array Biopharma Inc.	Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
CN101511842B (zh)	2006-07-06	2012-10-31	阵列生物制药公司	作为akt蛋白激酶抑制剂的二氢呋喃并嘧啶
ATE532789T1 (de)	2006-07-06	2011-11-15	Array Biopharma Inc	Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
WO2008021456A2 (en) *	2006-08-16	2008-02-21	Cytovia, Inc.	N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
SI2173723T1 (sl)	2007-07-05	2011-12-30	Array Biopharma Inc	Pirimidil ciklopentani kot inhibitorji AKT-protein-kinaze
US8618097B2 (en)	2007-07-05	2013-12-31	Array Biopharma, Inc.	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en)	2007-07-05	2014-09-30	Array Biopharma, Inc.	Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en)	2007-07-05	2016-08-09	Array Biopharma Inc.	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2240455B1 (en)	2008-01-09	2012-12-26	Array Biopharma, Inc.	Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
JP5346345B2 (ja)	2008-01-09	2013-11-20	アレイバイオファーマ、インコーポレイテッド	Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン類
WO2010047201A1 (ja)	2008-10-20	2010-04-29	三菱電機株式会社	エレベーター群管理装置
KR20140022053A (ko)	2011-04-01	2014-02-21	제넨테크, 인크.	Akt 및 mek 억제제 화합물의 조합물, 및 사용 방법
ES2620644T3 (es)	2011-04-01	2017-06-29	Genentech, Inc.	Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso
GB201121127D0 (en)	2011-12-08	2012-01-18	Dow Corning	Treatment of filler with silane
CN111303053B (zh) *	2020-03-16	2023-01-17	中国海洋大学	环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3470182A (en) *	1967-02-09	1969-09-30	Sandoz Ag	4-amino-substituted quinazolines
US3980650A (en) *	1972-05-05	1976-09-14	N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia	4-Amino-pyrimidine derivatives
US3915976A (en) *	1972-09-01	1975-10-28	Sandoz Ag	Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines
PH20344A (en) *	1981-01-29	1986-12-04	Sankyo Co	Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them
JPS57203072A (en) *	1981-06-05	1982-12-13	Sankyo Co Ltd	4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

1986
- 1986-03-06 JP JP61049238A patent/JPS6270A/ja not_active Withdrawn
- 1986-03-06 US US06/837,079 patent/US4749704A/en not_active Expired - Lifetime
- 1986-03-07 CA CA000503571A patent/CA1273632A/en not_active Expired - Lifetime
- 1986-03-07 EP EP86301660A patent/EP0194161B1/en not_active Expired - Lifetime
- 1986-03-07 FI FI860969A patent/FI88717C/fi not_active IP Right Cessation
- 1986-03-07 AU AU54481/86A patent/AU580391B2/en not_active Ceased
- 1986-03-07 KR KR1019860001624A patent/KR890003839B1/ko not_active Expired
- 1986-03-07 NO NO860852A patent/NO168767C/no unknown
- 1986-03-07 DK DK106586A patent/DK165109C/da not_active IP Right Cessation
- 1986-03-07 IE IE59786A patent/IE64504B1/en not_active IP Right Cessation
- 1986-03-07 ZA ZA861708A patent/ZA861708B/xx unknown
- 1986-03-07 DE DE3689848T patent/DE3689848T2/de not_active Expired - Fee Related
- 1986-03-07 AT AT86301660T patent/ATE106077T1/de not_active IP Right Cessation
- 1986-03-07 ES ES552796A patent/ES8704905A1/es not_active Expired
- 1986-11-14 ES ES557198A patent/ES8801221A1/es not_active Expired
- 1986-11-14 ES ES557199A patent/ES8801222A1/es not_active Expired

Also Published As

Publication number	Publication date
EP0194161A3 (en)	1987-09-02
AU580391B2 (en)	1989-01-12
IE860597L (en)	1986-09-07
CA1273632A (en)	1990-09-04
DE3689848T2 (de)	1995-01-12
ES8704905A1 (es)	1987-04-16
ES557198A0 (es)	1988-01-01
NO168767B (no)	1991-12-23
NO860852L (no)	1986-09-08
DK106586D0 (da)	1986-03-07
HK1005450A1 (en)	1999-01-08
DK165109C (da)	1993-03-01
KR860007221A (ko)	1986-10-08
ES8801222A1 (es)	1988-01-01
EP0194161B1 (en)	1994-05-25
KR890003839B1 (ko)	1989-10-05
ZA861708B (en)	1986-11-26
FI860969A0 (fi)	1986-03-07
ATE106077T1 (de)	1994-06-15
AU5448186A (en)	1986-09-11
ES8801221A1 (es)	1988-01-01
ES557199A0 (es)	1988-01-01
JPS6270A (ja)	1987-01-06
US4749704A (en)	1988-06-07
DK106586A (da)	1986-09-08
IE64504B1 (en)	1995-08-09
FI88717C (fi)	1993-06-28
DK165109B (da)	1992-10-12
EP0194161A2 (en)	1986-09-10
DE3689848D1 (de)	1994-06-30
ES552796A0 (es)	1987-04-16
FI88717B (fi)	1993-03-15
FI860969L (fi)	1986-09-08

Publication	Publication Date	Title
DK106586D0 (da)	1986-03-07	Cyklopenta(d)pyrimidinderivater samt deres fremstilling og anvendelse
EP0192060B1 (de)	1991-09-18	Heterocyclische Verbindungen
HUT41713A (en)	1987-05-28	Process for production of //arol-cyclobutyl/ alkyl/-amins and medical preparatives containing thereof
LV10422A (lv)	1995-02-20	Jaunie fluor-naftacendioni to glikozetie atvasinajumi un vinu razosanas panemiens
NZ219052A (en)	1988-11-29	Octahydroindolizine derivatives and pharmaceutical compositions
DK7286D0 (da)	1986-01-08	Octahydroindoliziner
JO1676B1 (en)	1992-08-09	Extra compounds indinol II
ATE32216T1 (de)	1988-02-15	Diphenylmethylimin-derivate.
PT82071B (pt)	1987-12-30	Processo para a preparacao de derivados de homocisteina tiolactona