NO168767C - Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav - Google Patents

Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav

Info

Publication number: NO168767C
Authority: NO; Norway
Prior art keywords: sup; cyclopenta; procedures; preparing; pyrimidine derivatives
Prior art date: 1985-03-07

Application number

NO860852A

Other languages

English (en)

Norwegian (no)

Other versions

NO168767B (no

NO860852L (no

Inventor

Nobuyoshi Iwata

Kanichi Nakamura

Tomio Kimura

Isao Nakayama

Takashi Kobayashi

Original Assignee

Sankyo Co

Ube Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-07

Filing date

1986-03-07

Publication date

1992-04-01

1986-03-07 Application filed by Sankyo Co, Ube Industries filed Critical Sankyo Co

1986-09-08 Publication of NO860852L publication Critical patent/NO860852L/no

1991-12-23 Publication of NO168767B publication Critical patent/NO168767B/no

1992-04-01 Publication of NO168767C publication Critical patent/NO168767C/no

Links

238000000034 method Methods 0.000 title abstract 2
LTFBFZBWUKWXID-UHFFFAOYSA-N 1h-cyclopenta[d]pyrimidine Chemical class N1=CNC2=CC=CC2=C1 LTFBFZBWUKWXID-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
208000020401 Depressive disease Diseases 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
201000003102 mental depression Diseases 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Dental Preparations (AREA)
Hydrogenated Pyridines (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Eyeglasses (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Soil Working Implements (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Luminescent Compositions (AREA)

NO860852A 1985-03-07 1986-03-07 Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav NO168767C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4362685		1985-03-07

Publications (3)

Publication Number	Publication Date
NO860852L NO860852L (no)	1986-09-08
NO168767B NO168767B (no)	1991-12-23
NO168767C true NO168767C (no)	1992-04-01

Family

ID=12669058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO860852A NO168767C (no)	1985-03-07	1986-03-07	Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav

Country Status (15)

Country	Link
US (1)	US4749704A (da)
EP (1)	EP0194161B1 (da)
JP (1)	JPS6270A (da)
KR (1)	KR890003839B1 (da)
AT (1)	ATE106077T1 (da)
AU (1)	AU580391B2 (da)
CA (1)	CA1273632A (da)
DE (1)	DE3689848T2 (da)
DK (1)	DK165109C (da)
ES (3)	ES8704905A1 (da)
FI (1)	FI88717C (da)
HK (1)	HK1005450A1 (da)
IE (1)	IE64504B1 (da)
NO (1)	NO168767C (da)
ZA (1)	ZA861708B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5037980A (en) *	1988-04-18	1991-08-06	American Cyanamid Company	Phenyl imidazo[1,2-a]pyrimidines
US5877178A (en) *	1991-04-08	1999-03-02	Duquesne University Of The Holy Ghost	Pyrimidine derivatives and methods of making and using these derivatives
US5234936A (en) *	1991-10-24	1993-08-10	American Home Products Corporation	Pyrimidocycloalkanes as a ii antagonists
CN100398524C (zh) *	2003-08-12	2008-07-02	弗·哈夫曼-拉罗切有限公司	作为crf拮抗剂的四氢喹唑啉衍生物
EP1942069A4 (en)	2005-10-26	2013-01-09	Mitsubishi Electric Corp	LIFT GROUP MANAGEMENT AND CONTROL DEVICE
RU2481336C2 (ru)	2006-07-06	2013-05-10	Эррэй Биофарма Инк.	Циклопента(d)пиримидины в качестве ингибиторов протеинкиназ акт
US8063050B2 (en)	2006-07-06	2011-11-22	Array Biopharma Inc.	Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
DE602007011628D1 (de)	2006-07-06	2011-02-10	Array Biopharma Inc	Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
WO2008006039A1 (en)	2006-07-06	2008-01-10	Array Biopharma Inc.	Dihydrothieno pyrimidines as akt protein kinase inhibitors
WO2008021456A2 (en) *	2006-08-16	2008-02-21	Cytovia, Inc.	N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
MX2009014013A (es)	2007-07-05	2010-01-28	Array Biopharma Inc	Pirimidil ciclopentanos como inhibidores de la proteina cinasa akt.
US9409886B2 (en)	2007-07-05	2016-08-09	Array Biopharma Inc.	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en)	2007-07-05	2014-09-30	Array Biopharma, Inc.	Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
CA2692502C (en)	2007-07-05	2016-03-01	Array Biopharma Inc.	Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8835434B2 (en)	2008-01-09	2014-09-16	Array Biopharma, Inc.	Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8853216B2 (en)	2008-01-09	2014-10-07	Array Biopharma, Inc.	Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
WO2010047201A1 (ja)	2008-10-20	2010-04-29	三菱電機株式会社	エレベーター群管理装置
TR201815685T4 (tr)	2011-04-01	2018-11-21	Genentech Inc	Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları.
FI2694072T4 (fi)	2011-04-01	2024-09-30	Genentech Inc	Akt-inhibiittoriyhdisteen ja abirateronin yhdistelmä käytettäväksi terapeuttisissa hoidoissa
GB201121127D0 (en)	2011-12-08	2012-01-18	Dow Corning	Treatment of filler with silane
CN111303053B (zh) *	2020-03-16	2023-01-17	中国海洋大学	环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3470182A (en) *	1967-02-09	1969-09-30	Sandoz Ag	4-amino-substituted quinazolines
US3980650A (en) *	1972-05-05	1976-09-14	N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia	4-Amino-pyrimidine derivatives
US3915976A (en) *	1972-09-01	1975-10-28	Sandoz Ag	Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines
PH20344A (en) *	1981-01-29	1986-12-04	Sankyo Co	Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them
JPS57203072A (en) *	1981-06-05	1982-12-13	Sankyo Co Ltd	4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

1986
- 1986-03-06 JP JP61049238A patent/JPS6270A/ja not_active Withdrawn
- 1986-03-06 US US06/837,079 patent/US4749704A/en not_active Expired - Lifetime
- 1986-03-07 IE IE59786A patent/IE64504B1/en not_active IP Right Cessation
- 1986-03-07 DK DK106586A patent/DK165109C/da not_active IP Right Cessation
- 1986-03-07 ES ES552796A patent/ES8704905A1/es not_active Expired
- 1986-03-07 ZA ZA861708A patent/ZA861708B/xx unknown
- 1986-03-07 FI FI860969A patent/FI88717C/fi not_active IP Right Cessation
- 1986-03-07 NO NO860852A patent/NO168767C/no unknown
- 1986-03-07 CA CA000503571A patent/CA1273632A/en not_active Expired - Lifetime
- 1986-03-07 AT AT86301660T patent/ATE106077T1/de not_active IP Right Cessation
- 1986-03-07 KR KR1019860001624A patent/KR890003839B1/ko not_active Expired
- 1986-03-07 AU AU54481/86A patent/AU580391B2/en not_active Ceased
- 1986-03-07 DE DE3689848T patent/DE3689848T2/de not_active Expired - Fee Related
- 1986-03-07 EP EP86301660A patent/EP0194161B1/en not_active Expired - Lifetime
- 1986-11-14 ES ES557198A patent/ES8801221A1/es not_active Expired
- 1986-11-14 ES ES557199A patent/ES8801222A1/es not_active Expired
1998
- 1998-05-27 HK HK98104569A patent/HK1005450A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US4749704A (en)	1988-06-07
DE3689848T2 (de)	1995-01-12
HK1005450A1 (en)	1999-01-08
ES8801222A1 (es)	1988-01-01
DK165109B (da)	1992-10-12
AU5448186A (en)	1986-09-11
FI88717C (fi)	1993-06-28
KR890003839B1 (ko)	1989-10-05
IE860597L (en)	1986-09-07
DE3689848D1 (de)	1994-06-30
NO168767B (no)	1991-12-23
FI88717B (fi)	1993-03-15
FI860969L (fi)	1986-09-08
EP0194161A2 (en)	1986-09-10
JPS6270A (ja)	1987-01-06
ZA861708B (en)	1986-11-26
DK165109C (da)	1993-03-01
DK106586D0 (da)	1986-03-07
ES8801221A1 (es)	1988-01-01
EP0194161B1 (en)	1994-05-25
AU580391B2 (en)	1989-01-12
NO860852L (no)	1986-09-08
CA1273632A (en)	1990-09-04
EP0194161A3 (en)	1987-09-02
ES557198A0 (es)	1988-01-01
ES8704905A1 (es)	1987-04-16
ES557199A0 (es)	1988-01-01
KR860007221A (ko)	1986-10-08
ATE106077T1 (de)	1994-06-15
FI860969A0 (fi)	1986-03-07
ES552796A0 (es)	1987-04-16
DK106586A (da)	1986-09-08
IE64504B1 (en)	1995-08-09

Publication	Publication Date	Title
AU580391B2 (en)	1989-01-12	Cyclopental ``d``pyrimidine derivatives, their preparation and use
AU584388B2 (en)	1989-05-25	Novel heterocyclic compounds
HUT41713A (en)	1987-05-28	Process for production of //arol-cyclobutyl/ alkyl/-amins and medical preparatives containing thereof
LV10422A (lv)	1995-02-20	Jaunie fluor-naftacendioni to glikozetie atvasinajumi un vinu razosanas panemiens
NZ219052A (en)	1988-11-29	Octahydroindolizine derivatives and pharmaceutical compositions
DK7286D0 (da)	1986-01-08	Octahydroindoliziner
JO1676B1 (en)	1992-08-09	Extra compounds indinol II
ATE32216T1 (de)	1988-02-15	Diphenylmethylimin-derivate.
PT82071B (pt)	1987-12-30	Processo para a preparacao de derivados de homocisteina tiolactona