DK1082337T3 - 17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber - Google Patents

17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber

Info

Publication number: DK1082337T3
Authority: DK; Denmark
Prior art keywords: beta; hydroxylamino; agonistic; antagonistic; derivatives
Prior art date: 1998-05-29

Application number

DK99924207T

Other languages

Danish (da)

English (en)

Inventor

John A Kepler

C Edgar Cook

Gary S Bartley

Rupa S Shetty

Original Assignee

Res Triangle Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-29

Filing date

1999-05-28

Publication date

2006-12-04

1999-05-28 Application filed by Res Triangle Inst filed Critical Res Triangle Inst

2006-12-04 Application granted granted Critical

2006-12-04 Publication of DK1082337T3 publication Critical patent/DK1082337T3/da

Links

230000001270 agonistic effect Effects 0.000 title 1
230000003042 antagnostic effect Effects 0.000 title 1
-1 aryl steroids Chemical class 0.000 title 1
230000003054 hormonal effect Effects 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
230000001911 anti-progestational effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK99924207T 1998-05-29 1999-05-28 17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber DK1082337T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/086,560 US6262042B1 (en)	1998-05-29	1998-05-29	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties

Publications (1)

Publication Number	Publication Date
DK1082337T3 true DK1082337T3 (da)	2006-12-04

Family

ID=22199388

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99924207T DK1082337T3 (da)	1998-05-29	1999-05-28	17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber

Country Status (24)

Country	Link
US (3)	US6262042B1 (cs)
EP (1)	EP1082337B1 (cs)
JP (1)	JP4545929B2 (cs)
KR (1)	KR100611289B1 (cs)
CN (1)	CN100357311C (cs)
AT (1)	ATE333462T1 (cs)
AU (1)	AU753382B2 (cs)
BR (1)	BR9910794A (cs)
CA (1)	CA2333669C (cs)
CY (1)	CY1106443T1 (cs)
CZ (1)	CZ300313B6 (cs)
DE (1)	DE69932432T8 (cs)
DK (1)	DK1082337T3 (cs)
ES (1)	ES2270596T3 (cs)
HU (1)	HU228770B1 (cs)
ID (1)	ID26885A (cs)
IL (1)	IL139861A (cs)
NO (1)	NO317988B1 (cs)
NZ (1)	NZ507985A (cs)
PL (1)	PL198055B1 (cs)
PT (1)	PT1082337E (cs)
RU (1)	RU2238943C2 (cs)
SK (1)	SK285748B6 (cs)
WO (1)	WO1999062928A1 (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6262042B1 (en) *	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6982251B2 (en) *	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
HU230253B1 (hu)	2001-01-26	2015-11-30	Merck Sharp & Dohme Corp	Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
DK1355644T3 (da)	2001-01-26	2006-10-23	Schering Corp	Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
JP2005504091A (ja)	2001-09-21	2005-02-10	シェーリング　コーポレイション	ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
ES2190373B1 (es) *	2001-12-07	2004-10-16	J. URIACH & CIA, S.A.	Uso del acido 2-hidroxi- o 2-acetiloxi-4-trifluorometilbenzoico como agente para el tratamiento y prevencion del deterioro cognitivo ligero.
WO2004043457A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2517571C (en)	2003-03-07	2011-07-05	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2006519869A (ja)	2003-03-07	2006-08-31	シェーリング　コーポレイション	置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
JP4589919B2 (ja)	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US8097606B2 (en) *	2003-07-23	2012-01-17	Corcept Therapeutics, Inc.	Antiglucocorticoids for the treatment of catatonia
US20070249573A1 (en) *	2006-04-13	2007-10-25	Gerd Schubert	17alpha-substituted 4-(3-oxoestra-4,9-dien-11beta-yl)-benzoic acid, its derivatives and process for its production
US9517240B2 (en)	2006-09-26	2016-12-13	The Regents Of The University Of California	Methods and compositions for cancer prevention and treatment
WO2008039482A2 (en) *	2006-09-26	2008-04-03	The Regents Of The University Of California	Methods and compositions for cancer prevention and treatment
US8299050B2 (en) *	2008-01-29	2012-10-30	Laboratoire Hra-Pharma	Method for treating uterine fibroids
US8778969B2 (en) *	2009-11-07	2014-07-15	Peter H Proctor	Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines
US9096641B2 (en) *	2013-06-05	2015-08-04	Evestra, Inc.	Imidazolyl progesterone antagonists

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE289539C (cs)
DE290198C (cs)
DE287510C (cs)
US3187022A (en) *	1964-01-31	1965-06-01	Parke Davis & Co	17beta-amino-17alpha-pregnen-20-one compounds and the production thereof
US4686085A (en) *	1980-04-14	1987-08-11	Thomas Jefferson University	Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
ZA8231B (en)	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr)	1982-03-01	1986-02-14	Roussel Uclaf	Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
EP0116974B1 (de)	1983-02-18	1986-10-29	Schering Aktiengesellschaft	11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE3306121A1 (de) *	1983-02-18	1984-09-06	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-spirolaktone in der steroidreihe, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische praeparate
ES533260A0 (es) *	1983-06-15	1985-02-01	Schering Ag	Procedimiento para la preparacion de 13a-alquilgonanos
DE3347126A1 (de)	1983-12-22	1985-07-11	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
US4481144A (en)	1984-02-03	1984-11-06	E. R. Squibb & Sons, Inc.	17-Substituted thia-17-alkyl(or alkenyl or alkynyl)androstenes
US4529548A (en)	1984-05-07	1985-07-16	E. R. Squibb & Sons, Inc.	17β-(substituted thio)androstenes
AU580843B2 (en)	1985-02-07	1989-02-02	Schering Aktiengesellschaft	11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3506785A1 (de)	1985-02-22	1986-08-28	Schering AG, Berlin und Bergkamen, 1000 Berlin	11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2596395B1 (fr)	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
FR2598421B1 (fr)	1986-05-06	1988-08-19	Roussel Uclaf	Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3625315A1 (de)	1986-07-25	1988-01-28	Schering Ag	11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate
US4861763A (en)	1986-09-17	1989-08-29	Research Triangle Institute	17 α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and their progestational use
US4774236A (en)	1986-09-17	1988-09-27	Research Triangle Institute	17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
DE3702383A1 (de)	1987-01-23	1988-08-04	Schering Ag	11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
IE60780B1 (en)	1987-01-23	1994-08-10	Akzo Nv	New 11-aryl steroid derivatives
FR2610933B1 (fr)	1987-02-18	1989-06-09	Roussel Uclaf	Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
EP0289073B1 (en)	1987-04-24	1991-11-27	Akzo N.V.	Novel 11-aryloestrane and 11-arylpregnane derivatives
FR2618783B1 (fr)	1987-07-30	1991-02-01	Roussel Uclaf	Nouveaux 17-aryle steroides, leurs procedes et des intermediaires de preparation comme medicaments et les compositions pharmaceutiques les renfermant
ES2053714T3 (es) *	1987-12-12	1994-08-01	Akzo Nv	Proceso para la preparacion de 11-arilesteroides.
US4954490A (en)	1988-06-23	1990-09-04	Research Triangle Institute	11 β-substituted progesterone analogs
DE3822770A1 (de)	1988-07-01	1990-01-04	Schering Ag	13-alkyl-11ss-phenylgonane
FR2643638B1 (fr)	1989-02-24	1991-06-14	Roussel Uclaf	Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
DE69026538T2 (de)	1989-06-20	1996-11-21	Philips Electronics Nv	Signalverarbeitungseinrichtungen vor und nach Übertragung und/oder Speicherung mit Datenflussverminderung, und Verfahren zur Übertragung und/oder Speicherung von Signalen mit solchen Einrichtungen
DE3921059A1 (de)	1989-06-23	1991-01-10	Schering Ag	11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
ATE172469T1 (de)	1989-08-04	1998-11-15	Schering Ag	11 beta-aryl-gona-4,9-dien-3-one
DE4042005A1 (de)	1990-12-22	1992-06-25	Schering Ag	D-homo-(16-en)-11(beta)-aryl-4-estrene
ZA929315B (en)	1991-12-20	1993-05-24	Akzo Nv	17-spirofuran-3'-ylidene steroids.
MX9301121A (es)	1992-03-02	1993-09-01	Schering Ag	Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
WO1993021926A1 (en)	1992-05-06	1993-11-11	Medical College Of Hampton Roads	Minimizing progestin associated breakthrough bleeding
US5929262A (en)	1995-03-30	1999-07-27	The United States Of America As Represented By The Department Of Health And Human Services	Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates
AU710139B2 (en)	1996-05-01	1999-09-16	Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The	21-substituted progesterone derivatives as new antiprogestational agents
US6020328A (en)	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en)	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en)	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6172052B1 (en)	1998-12-04	2001-01-09	Research Triangle Institute	17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6043235A (en)	1999-07-21	2000-03-28	Research Triangle Institute	11β-aryl-17, 17-spirothiolane-substituted steroids

1998
- 1998-05-29 US US09/086,560 patent/US6262042B1/en not_active Expired - Lifetime
1999
- 1999-05-28 CN CNB998068012A patent/CN100357311C/zh not_active Expired - Lifetime
- 1999-05-28 WO PCT/US1999/010480 patent/WO1999062928A1/en not_active Ceased
- 1999-05-28 JP JP2000552138A patent/JP4545929B2/ja not_active Expired - Lifetime
- 1999-05-28 EP EP99924207A patent/EP1082337B1/en not_active Expired - Lifetime
- 1999-05-28 DE DE69932432T patent/DE69932432T8/de active Active
- 1999-05-28 SK SK1809-2000A patent/SK285748B6/sk not_active IP Right Cessation
- 1999-05-28 NZ NZ507985A patent/NZ507985A/en not_active IP Right Cessation
- 1999-05-28 BR BR9910794-5A patent/BR9910794A/pt not_active Application Discontinuation
- 1999-05-28 DK DK99924207T patent/DK1082337T3/da active
- 1999-05-28 PL PL344413A patent/PL198055B1/pl unknown
- 1999-05-28 AT AT99924207T patent/ATE333462T1/de active
- 1999-05-28 ID IDW20002450A patent/ID26885A/id unknown
- 1999-05-28 AU AU40761/99A patent/AU753382B2/en not_active Expired
- 1999-05-28 RU RU2000133319A patent/RU2238943C2/ru active
- 1999-05-28 PT PT99924207T patent/PT1082337E/pt unknown
- 1999-05-28 KR KR1020007013416A patent/KR100611289B1/ko not_active Expired - Lifetime
- 1999-05-28 CZ CZ20004446A patent/CZ300313B6/cs not_active IP Right Cessation
- 1999-05-28 ES ES99924207T patent/ES2270596T3/es not_active Expired - Lifetime
- 1999-05-28 IL IL13986199A patent/IL139861A/xx not_active IP Right Cessation
- 1999-05-28 CA CA002333669A patent/CA2333669C/en not_active Expired - Lifetime
- 1999-05-28 HU HU0103109A patent/HU228770B1/hu unknown
2000
- 2000-11-27 NO NO20005989A patent/NO317988B1/no not_active IP Right Cessation
2001
- 2001-07-02 US US09/895,395 patent/US6620801B2/en not_active Expired - Lifetime
2003
- 2003-07-02 US US10/611,785 patent/US7018991B2/en not_active Expired - Lifetime
2006
- 2006-10-12 CY CY20061101454T patent/CY1106443T1/el unknown

Also Published As

Publication number	Publication date
SK18092000A3 (sk)	2001-04-09
US6620801B2 (en)	2003-09-16
ID26885A (id)	2001-02-15
US6262042B1 (en)	2001-07-17
PT1082337E (pt)	2006-11-30
EP1082337B1 (en)	2006-07-19
CA2333669A1 (en)	1999-12-09
PL344413A1 (en)	2001-11-05
HK1035196A1 (en)	2001-11-16
US7018991B2 (en)	2006-03-28
CN100357311C (zh)	2007-12-26
US20020065257A1 (en)	2002-05-30
CN1303391A (zh)	2001-07-11
IL139861A (en)	2005-09-25
CZ300313B6 (cs)	2009-04-15
CZ20004446A3 (cs)	2001-04-11
WO1999062928A1 (en)	1999-12-09
DE69932432D1 (de)	2006-08-31
JP2002531381A (ja)	2002-09-24
KR20010052427A (ko)	2001-06-25
NZ507985A (en)	2003-11-28
DE69932432T2 (de)	2007-03-15
CA2333669C (en)	2008-08-26
BR9910794A (pt)	2001-02-13
AU4076199A (en)	1999-12-20
HUP0103109A2 (hu)	2002-01-28
KR100611289B1 (ko)	2006-08-10
JP4545929B2 (ja)	2010-09-15
PL198055B1 (pl)	2008-05-30
IL139861A0 (en)	2002-02-10
SK285748B6 (sk)	2007-07-06
NO20005989D0 (no)	2000-11-27
HUP0103109A3 (en)	2002-09-30
AU753382B2 (en)	2002-10-17
DE69932432T8 (de)	2007-08-23
ATE333462T1 (de)	2006-08-15
EP1082337A1 (en)	2001-03-14
RU2238943C2 (ru)	2004-10-27
ES2270596T3 (es)	2007-04-01
EP1082337A4 (en)	2004-12-29
US20040023936A1 (en)	2004-02-05
NO20005989L (no)	2000-11-27
HU228770B1 (en)	2013-05-28
NO317988B1 (no)	2005-01-17
CY1106443T1 (el)	2011-10-12

Publication	Publication Date	Title
DK1082337T3 (da)	2006-12-04	17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber
MXPA00008738A (es)	2004-05-21	20-ceto-1 1b-arilesteroides y sus derivados teniendo propiedades agonistas o antagonistas hormonales.
DK1135403T3 (da)	2003-11-24	17beta-acyl-17alfa-propynyl-11beta-arylsteroider og deres derivater med agonistiske eller antagonistiske hormonale egenskaber
NO20042811L (no)	2004-07-05	Substituerte henzoksazoler og analoger som estrogene midler
DK1097173T3 (da)	2008-09-01	Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
EP2298354A3 (en)	2011-06-08	Remodelling and glycoconjugation of interferon-beta
NO993003L (no)	1999-06-18	Sulfonamid-derivater, fremgangsmÕte for deres fremstilling og deres anvendelse som medikamenter
NO20013003L (no)	2001-07-25	Kinolin-derivater
NO20041503L (no)	2004-05-13	Pyrimidinoner som melanin konsentrerende hormon reseptor 1
DE69840603D1 (de)	2009-04-09	Alpha-ketoamidhaltige multikatalytische protease inhibitoren
CY1108453T1 (el)	2014-04-09	Διαδικασια για την παρασκευη επλερενονης
NO20050083L (no)	2005-03-23	Ghrelin analoger
MXPA03010158A (es)	2004-03-10	Sulfonamidas.
NO20023643L (no)	2002-09-30	Forbindelser som har antitumoraktivitet, fremgangsmåte for deres fremstilling og farmasöytiske sammensetninger som inneholderdem
NO20021037D0 (no)	2002-03-01	17<beta>-acyl-17<alfa> -propynyl-11<beta>-(cyklisk amino)arylsteroider og deres derivater som har hormonelleantagonistegenskaper
CY1109995T1 (el)	2014-09-10	Συνθεσεις περιεχουσες προϊοντα σογιας
DK1383742T3 (da)	2011-02-14	Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater
DK1355906T3 (da)	2005-05-30	2H-1-benzopyranderivater, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger indeholdende dem
BR0013292A (pt)	2002-04-02	Derivados de benzenamina como anti-coagulantes
MXPA05012742A (es)	2006-02-13	Composiciones de tratamiento para el cabello.
DE60134702D1 (de)	2008-08-21	Mischungen von Isoflavonen und Flavonen
SE0100374D0 (sv)	2001-02-07	Novel compositions of potassium channel openers and protein kinase c inhibitors and use thereof
ATE377020T1 (de)	2007-11-15	Kristallines gamma-lacton der17beta-hydroxy-
DE502004012272D1 (de)	2011-04-14	Kosmetisches oder therapeutisches kombinationspraparat
WO2004043368A3 (en)	2004-07-22	Sulfonamides