DK1105466T3 - Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler - Google Patents

Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Info

Publication number: DK1105466T3
Authority: DK; Denmark
Prior art keywords: particles; human papillomavirus; papillomavirus virus; vlps; purifying human
Prior art date: 1998-08-14

Application number

DK99940950T

Other languages

English (en)

Inventor

James C Cook Iii

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-14

Filing date

1999-08-10

Publication date

2006-08-14

1999-08-10 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2006-08-14 Application granted granted Critical

2006-08-14 Publication of DK1105466T3 publication Critical patent/DK1105466T3/da

Links

238000000034 method Methods 0.000 title abstract 3
239000002245 particle Substances 0.000 title abstract 2
241000701806 Human papillomavirus Species 0.000 title 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
241001631646 Papillomaviridae Species 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
-1 phosphate anion Chemical class 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Microbiology (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Mycology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK99940950T 1998-08-14 1999-08-10 Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler DK1105466T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9656898P	1998-08-14	1998-08-14

Publications (1)

Publication Number	Publication Date
DK1105466T3 true DK1105466T3 (da)	2006-08-14

Family

ID=22257989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99940950T DK1105466T3 (da)	1998-08-14	1999-08-10	Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Country Status (24)

Country	Link
US (1)	US6602697B1 (da)
EP (1)	EP1105466B1 (da)
JP (1)	JP4440471B2 (da)
KR (1)	KR20010072470A (da)
CN (1)	CN1354787A (da)
AT (1)	ATE324436T1 (da)
AU (1)	AU760633B2 (da)
BR (1)	BR9913026A (da)
CA (1)	CA2339034C (da)
CY (1)	CY1105084T1 (da)
CZ (1)	CZ2001570A3 (da)
DE (1)	DE69931053T2 (da)
DK (1)	DK1105466T3 (da)
EA (1)	EA200100236A1 (da)
ES (1)	ES2262333T3 (da)
HR (1)	HRP20010113A2 (da)
HU (1)	HUP0103091A3 (da)
IL (1)	IL141130A0 (da)
NZ (1)	NZ509610A (da)
PL (1)	PL347472A1 (da)
PT (1)	PT1105466E (da)
SI (1)	SI1105466T1 (da)
SK (1)	SK2232001A3 (da)
WO (1)	WO2000009671A1 (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69935606T9 (de) *	1998-10-16	2021-03-11	Glaxosmithkline Biologicals S.A.	Adjuvanzsysteme und impfstoffe
JP2000262280A (ja) *	1999-03-18	2000-09-26	Asahi Optical Co Ltd	ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法
US6436402B1 (en) *	1999-10-15	2002-08-20	Merck & Co., Inc.	Process for making human papillomavirus virus-like particles with improved properties
GB0206360D0 (en) *	2002-03-18	2002-05-01	Glaxosmithkline Biolog Sa	Viral antigens
MY140664A (en) *	2003-09-29	2010-01-15	Merck Sharp & Dohme	Optimized expression of hpv 45 l1 in yeast
MY139500A (en) *	2003-11-12	2009-10-30	Merck Sharp & Dohme	Optimized expression of hpv 58 l1 in yeast
EP2821135A1 (en) *	2004-02-05	2015-01-07	EMD Millipore Corporation	Porous adsorptive or chromatographic media
EP1730175B1 (en) *	2004-03-24	2010-04-28	Merck Sharp & Dohme Corp.	Optimized expression of hpv 52 l1 in yeast
ATE474596T1 (de)	2004-09-10	2010-08-15	Asahi Glass Co Ltd	Impfstoff gegen humanes papillomavirus zur oralen verabreichung
EP1736538A1 (en) *	2005-06-21	2006-12-27	Cytos Biotechnology AG	Process for the preparative purification of virus-like-particles (VLPs)
WO2008027861A1 (en) *	2006-08-30	2008-03-06	Ge Healthcare Bio-Sciences Corp.	System and method for characterizing membranes and membrane filtration devices
SG10202012986SA (en)	2006-09-29	2021-01-28	Ligocyte Pharmaceuticals Inc	Norovirus vaccine formulations
WO2008101667A1 (en) *	2007-02-22	2008-08-28	Baxter International Inc.	Method of purification of hydrophobic proteins
DK2134360T3 (da) *	2007-03-14	2016-02-22	Takeda Vaccines Inc	Oprensning af viruslignende partikel
US9428555B2 (en)	2007-04-29	2016-08-30	Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.	Truncated L1 protein of Human Papillomavirus type 16
US9364529B2 (en)	2007-04-29	2016-06-14	Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.	Truncated L1 protein of human papillomavirus type 18
BRPI0810951B8 (pt) *	2007-05-29	2021-05-25	Beijing Wantai Biological Pharmacy Entpr Co Ltd	proteína l1 do hpv6, polinucleotídeo, vetor, célula, partícula semelhante ao vírus (vlp) hpv6, método para produzir a proteína hpv6 l1 truncada, vacina para prevenção de condiloma acuminado ou de infecções por hpv, uso da proteína hpv6 l1 truncada, método para prevenção de condiloma acuminado ou infecções por hpv, método para obter uma vlp de uma proteína l1 do hpv6 e método para produzir uma vacina para a prevenção de condiloma acuminado ou de infecções por hpv
US9433922B2 (en)	2007-08-14	2016-09-06	Emd Millipore Corporation	Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20100266636A1 (en) *	2007-09-18	2010-10-21	Ligocyte Pharmaceuticals, Inc.	Method of conferring a protective immune response to norovirus
JP2010539192A (ja)	2007-09-18	2010-12-16	リゴサイトファーマスーティカルズ，インコーポレイテッド	ノロウイルスに対して防御免疫応答を付与する方法
EP2011573B1 (en) *	2007-11-05	2010-07-21	Agilent Technologies, Inc.	Freezing a microfluidic chip
US20090130738A1 (en) *	2007-11-19	2009-05-21	Mikhail Kozlov	Media for membrane ion exchange chromatography
AU2009279456B2 (en)	2008-08-08	2015-02-05	Takeda Vaccines, Inc.	Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
WO2011088225A1 (en)	2010-01-15	2011-07-21	Bio-Rad Laboratories, Inc.	Surface neutralization of apatite
US9644187B2 (en)	2010-04-14	2017-05-09	Emd Millipore Corporation	Methods of producing high titer, high purity virus stocks and methods of use thereof
US8895707B2 (en)	2010-08-18	2014-11-25	Bio-Rad Laboratories, Inc.	Elution of proteins from hydroxyapatite resins without resin deterioration
JP5881744B2 (ja)	2011-02-02	2016-03-09	バイオ−ラッドラボラトリーズインコーポレーティッド	アルカリ溶液でのアパタイトの表面中和方法
CA2841356C (en)	2011-07-11	2022-03-01	Takeda Vaccines, Inc.	Parenteral norovirus vaccine formulations
SG11201401579UA (en) *	2011-12-01	2014-07-30	Univ Cape Town	Hpv chimaeric particle
US9815695B2 (en)	2012-05-30	2017-11-14	Bio-Rad Laboratories, Inc.	In situ restoration of apatite-based chromatography resins
JOP20130186B1 (ar)	2012-06-22	2021-08-17	Takeda Vaccines Montana Inc	تنقية الجزيئات الشبيهة بالفيروسات
KR101559622B1 (ko)	2012-07-30	2015-10-13	중앙대학교 산학협력단	인유두종바이러스 바이러스 유사입자의 고효율 정제방법
JP6479305B2 (ja) *	2013-07-12	2019-03-06	株式会社Ｕｍｎファーマ	ウイルス様粒子の精製方法
US10099157B2 (en)	2014-06-23	2018-10-16	Bio-Rad Laboratories, Inc.	Apatite in-situ restoration
CN105392569B (zh)	2014-06-23	2019-08-20	生物辐射实验室股份有限公司	磷灰石预处理
CN105907729B (zh) *	2015-05-05	2019-08-16	广东东阳光药业有限公司	一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法
CN108524929B (zh) *	2017-03-06	2019-05-07	广州瑞贝斯药业有限公司	一种狂犬病疫苗的生产方法
CN110317832B (zh)	2018-03-28	2022-07-05	西比曼生物科技（香港）有限公司	Gmp级规模化制备重组慢病毒载体的纯化制剂的方法
JP6704074B2 (ja) *	2019-02-04	2020-06-03	株式会社Ｕｍｎファーマ	ウイルス様粒子の精製方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6078999A (ja)	1983-10-05	1985-05-04	Chemo Sero Therapeut Res Inst	ＨＢｓ抗原の精製方法
SE9000650L (sv) *	1989-02-28	1990-08-29	Asahi Optical Co Ltd	Separation av celler eller virus
JP3863559B2 (ja) *	1994-05-16	2006-12-27	メルクエンドカンパニーインコーポレーテッド	乳頭腫ウィルスワクチン
NZ293461A (en) *	1994-09-22	1998-04-27	Merck & Co Inc	Dna encoding human papillomavirus type 6a, compounds derived therefrom
AR004464A1 (es) *	1994-11-14	1998-12-16	Merck Sharp & Dohme	Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) *	1995-03-22	2005-11-20	Merck & Co Inc	Dna encoding human papillomavirus type 18
IL117591A0 (en) *	1995-03-30	1996-07-23	Merck & Co Inc	Synthetic DNA encoding human papillomavirus type 11 L1 protein
AU722196B2 (en) *	1995-08-30	2000-07-27	Genzyme Corporation	Chromatographic purification of adenovirus and AAV

1999
- 1999-08-10 AU AU54698/99A patent/AU760633B2/en not_active Expired
- 1999-08-10 CA CA 2339034 patent/CA2339034C/en not_active Expired - Lifetime
- 1999-08-10 JP JP2000565108A patent/JP4440471B2/ja not_active Expired - Lifetime
- 1999-08-10 PT PT99940950T patent/PT1105466E/pt unknown
- 1999-08-10 WO PCT/US1999/017930 patent/WO2000009671A1/en not_active Ceased
- 1999-08-10 ES ES99940950T patent/ES2262333T3/es not_active Expired - Lifetime
- 1999-08-10 HU HU0103091A patent/HUP0103091A3/hu unknown
- 1999-08-10 AT AT99940950T patent/ATE324436T1/de active
- 1999-08-10 EA EA200100236A patent/EA200100236A1/ru unknown
- 1999-08-10 CN CN99811968A patent/CN1354787A/zh active Pending
- 1999-08-10 SK SK223-2001A patent/SK2232001A3/sk unknown
- 1999-08-10 IL IL14113099A patent/IL141130A0/xx unknown
- 1999-08-10 BR BR9913026A patent/BR9913026A/pt not_active Application Discontinuation
- 1999-08-10 DK DK99940950T patent/DK1105466T3/da active
- 1999-08-10 NZ NZ50961099A patent/NZ509610A/xx not_active IP Right Cessation
- 1999-08-10 SI SI9930901T patent/SI1105466T1/sl unknown
- 1999-08-10 CZ CZ2001570A patent/CZ2001570A3/cs unknown
- 1999-08-10 KR KR1020017001885A patent/KR20010072470A/ko not_active Withdrawn
- 1999-08-10 EP EP99940950A patent/EP1105466B1/en not_active Expired - Lifetime
- 1999-08-10 US US09/762,662 patent/US6602697B1/en not_active Expired - Lifetime
- 1999-08-10 PL PL34747299A patent/PL347472A1/xx unknown
- 1999-08-10 HR HR20010113A patent/HRP20010113A2/hr not_active Application Discontinuation
- 1999-08-10 DE DE1999631053 patent/DE69931053T2/de not_active Expired - Lifetime
2006
- 2006-07-11 CY CY20061100963T patent/CY1105084T1/el unknown

Also Published As

Publication number	Publication date
CY1105084T1 (el)	2009-11-04
EP1105466A4 (en)	2002-05-15
HUP0103091A2 (hu)	2001-12-28
NZ509610A (en)	2002-10-25
EA200100236A1 (ru)	2001-08-27
BR9913026A (pt)	2001-09-25
DE69931053T2 (de)	2006-11-23
SI1105466T1 (sl)	2006-08-31
EP1105466A1 (en)	2001-06-13
SK2232001A3 (en)	2001-08-06
HUP0103091A3 (en)	2002-03-28
HRP20010113A2 (en)	2002-02-28
ATE324436T1 (de)	2006-05-15
CA2339034C (en)	2010-10-12
US6602697B1 (en)	2003-08-05
WO2000009671A1 (en)	2000-02-24
KR20010072470A (ko)	2001-07-31
AU760633B2 (en)	2003-05-22
PT1105466E (pt)	2006-07-31
JP4440471B2 (ja)	2010-03-24
CA2339034A1 (en)	2000-02-24
AU5469899A (en)	2000-03-06
PL347472A1 (en)	2002-04-08
DE69931053D1 (de)	2006-06-01
ES2262333T3 (es)	2006-11-16
CN1354787A (zh)	2002-06-19
IL141130A0 (en)	2002-02-10
EP1105466B1 (en)	2006-04-26
CZ2001570A3 (cs)	2001-09-12
JP2003520188A (ja)	2003-07-02

Publication	Publication Date	Title
DK1105466T3 (da)	2006-08-14	Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler
ATE332364T1 (de)	2006-07-15	Verfahren zur gewinnung von purifizierter virenzuammensetzung
FR07C0012I1 (da)	2007-03-30
DK1133283T3 (da)	2005-01-24	Fremgangsmåde til fremstilling af lægemiddelpartikler
NO305033B1 (no)	1999-03-22	Fremgangsmate for fremstilling av uronsyreblokker fra alginat
ES2091069T3 (es)	1996-10-16	Procedimiento de purificacion de pentafluoroetano.
FR11C0022I1 (da)	2011-05-08
AU2449500A (en)	2000-08-29	Preparation of iodixanol
ATE231150T1 (de)	2003-02-15	Optisch aktive verbindungen
AR063314A2 (es)	2009-01-21	Metodos para purificar preparados de virus
IE890181L (en)	1989-07-22	Removal of steroids
AU3178997A (en)	1998-01-14	Method for producing xylitol
EP0416127A4 (en)	1991-10-02	Process for efficiently recovering adsorbable gas from gas which contains adsorbable gas at low concentration
DE60042343D1 (de)	2009-07-16	Abtrennung von fibrinogen von plasmaproteasen
EP0816374A3 (en)	2001-03-21	A method of preparing a composition containing a high proportion of ganglioside
WO2002030983A3 (de)	2002-12-12	Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung
MXPA03007992A (es)	2004-09-29	Composicion farmaceutica de fragmentos f(ab)2 de anticuerpos y un proceso para su preparacion
WO2001046686A3 (de)	2001-12-06	Chromatographiematerial und verfahren unter verwendung desselben
WO2002012533A3 (en)	2003-01-03	Fermentation and purification of mycolactones
ATE246250T1 (de)	2003-08-15	Immunogenes konstrukt, verfahren zu dessen herstellung und verwendung als vakzine
AU7652100A (en)	2001-04-30	Method for extracting bacterio-rhodopsin
DK1315757T3 (da)	2008-04-07	Fremgangsmåde til oprensning af EPI-HNE-proteiner
FI953493A0 (fi)	1995-07-19	Menetelmä molybdeenin talteen ottamiseksi lähtien epäpuhtaasta kalsiummolybdaatista, joka on saatu käsittelemällä uraanipitoisia malmeja
AU7707096A (en)	1997-06-27	Reversed phase chromatographic process
AU2003222305A1 (en)	2003-11-10	Separation process of 1,1,1,2-tetrafluoro-2-chloroethane (hcfc-124) from 1,1,2,2-tetrafluoro-1-chloroethane (hcfc-124a)