DK1105466T3 - Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler - Google Patents

Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Info

Publication number: DK1105466T3
Authority: DK; Denmark
Prior art keywords: particles; human papillomavirus; papillomavirus virus; vlps; purifying human
Prior art date: 1998-08-14

Application number

DK99940950T

Other languages

English (en)

Inventor

James C Cook Iii

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-14

Filing date

1999-08-10

Publication date

2006-08-14

1999-08-10 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2006-08-14 Application granted granted Critical

2006-08-14 Publication of DK1105466T3 publication Critical patent/DK1105466T3/da

Links

238000000034 method Methods 0.000 title abstract 3
239000002245 particle Substances 0.000 title abstract 2
241000701806 Human papillomavirus Species 0.000 title 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
241001631646 Papillomaviridae Species 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
-1 phosphate anion Chemical class 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Microbiology (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
General Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK99940950T 1998-08-14 1999-08-10 Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler DK1105466T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9656898P	1998-08-14	1998-08-14

Publications (1)

Publication Number	Publication Date
DK1105466T3 true DK1105466T3 (da)	2006-08-14

Family

ID=22257989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99940950T DK1105466T3 (da)	1998-08-14	1999-08-10	Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Country Status (24)

Country	Link
US (1)	US6602697B1 (da)
EP (1)	EP1105466B1 (da)
JP (1)	JP4440471B2 (da)
KR (1)	KR20010072470A (da)
CN (1)	CN1354787A (da)
AT (1)	ATE324436T1 (da)
AU (1)	AU760633B2 (da)
BR (1)	BR9913026A (da)
CA (1)	CA2339034C (da)
CY (1)	CY1105084T1 (da)
CZ (1)	CZ2001570A3 (da)
DE (1)	DE69931053T2 (da)
DK (1)	DK1105466T3 (da)
EA (1)	EA200100236A1 (da)
ES (1)	ES2262333T3 (da)
HR (1)	HRP20010113A2 (da)
HU (1)	HUP0103091A3 (da)
IL (1)	IL141130A0 (da)
NZ (1)	NZ509610A (da)
PL (1)	PL347472A1 (da)
PT (1)	PT1105466E (da)
SI (1)	SI1105466T1 (da)
SK (1)	SK2232001A3 (da)
WO (1)	WO2000009671A1 (da)

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GB0206360D0 (en)	2002-03-18	2002-05-01	Glaxosmithkline Biolog Sa	Viral antigens
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MY139500A (en) *	2003-11-12	2009-10-30	Merck Sharp & Dohme	Optimized expression of hpv 58 l1 in yeast
US7479222B2 (en) *	2004-02-05	2009-01-20	Millipore Corporation	Porous adsorptive or chromatographic media
BRPI0509079B8 (pt) *	2004-03-24	2021-07-06	Merck & Co Inc	molécula de ácido nucléico, vetor, célula hospedeira, partículas tipo vírus, método para produzir vlps, vacina, composições farmacêuticas, e, métodos para evitar infecção por hpv e para induzir uma resposta imune em um animal
CA2579882C (en)	2004-09-10	2012-07-17	Asahi Glass Company, Limited	Edible vaccine
EP1736538A1 (en) *	2005-06-21	2006-12-27	Cytos Biotechnology AG	Process for the preparative purification of virus-like-particles (VLPs)
JP2010502425A (ja) *	2006-08-30	2010-01-28	ジーイー・ヘルスケア・バイオサイエンス・コーポレイション	膜を評価するシステム及び方法並びに膜濾過装置
ES2577833T3 (es) *	2006-09-29	2016-07-19	Takeda Vaccines, Inc.	Formulaciones de vacuna para norovirus
US8293876B2 (en) *	2007-02-22	2012-10-23	Baxter International Inc.	Method of purification of hydrophobic proteins
HUE028605T2 (en)	2007-03-14	2016-12-28	Takeda Vaccines Inc	Cleaning virus-like particles
DK2147926T3 (da)	2007-04-29	2016-11-28	Beijing Wantai Biological Pharmacy Entpr Co Ltd	Trunkerede humane papillomavirus type 18 L1 proteiner
US9428555B2 (en)	2007-04-29	2016-08-30	Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.	Truncated L1 protein of Human Papillomavirus type 16
US8748127B2 (en) *	2007-05-29	2014-06-10	Xiamen University	Truncated L1 protein of human papillomavirus type 6
US9433922B2 (en) *	2007-08-14	2016-09-06	Emd Millipore Corporation	Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20100266636A1 (en)	2007-09-18	2010-10-21	Ligocyte Pharmaceuticals, Inc.	Method of conferring a protective immune response to norovirus
SG10201601660YA (en)	2007-09-18	2016-04-28	Takeda Vaccines Inc	Method of conferring a protective immune response to norovirus
DE602007007927D1 (de) *	2007-11-05	2010-09-02	Agilent Technologies Inc	Einfrierung eines mikrofluidischen Chips
US20090130738A1 (en) *	2007-11-19	2009-05-21	Mikhail Kozlov	Media for membrane ion exchange chromatography
KR101793161B1 (ko)	2008-08-08	2017-11-03	다케다 백신즈 인코포레이티드	강화된 교차 반응성을 가진 복합체 캡시드 아미노산 서열들을 포함하는 바이러스-유사 입자들
JP5773454B2 (ja) *	2010-01-15	2015-09-02	バイオ−ラッドラボラトリーズインコーポレーティッド	アパタイトの表面中和方法
JP2013523175A (ja)	2010-04-14	2013-06-17	イーエムディー・ミリポア・コーポレーション	高力価、高純度のウイルスストックの作製方法及びその使用方法
US8895707B2 (en)	2010-08-18	2014-11-25	Bio-Rad Laboratories, Inc.	Elution of proteins from hydroxyapatite resins without resin deterioration
WO2012106449A1 (en)	2011-02-02	2012-08-09	Bio-Rad Laboratories, Inc.	Apatite surface neutralization with alkali solutions
EP3299030B1 (en)	2011-07-11	2022-06-08	Takeda Vaccines, Inc.	Parenteral norovirus vaccine formulations
MY184076A (en) *	2011-12-01	2021-03-17	Univ Cape Town	Hpv chimaeric particle
US9815695B2 (en)	2012-05-30	2017-11-14	Bio-Rad Laboratories, Inc.	In situ restoration of apatite-based chromatography resins
JOP20130186B1 (ar)	2012-06-22	2021-08-17	Takeda Vaccines Montana Inc	تنقية الجزيئات الشبيهة بالفيروسات
KR101559622B1 (ko)	2012-07-30	2015-10-13	중앙대학교 산학협력단	인유두종바이러스 바이러스 유사입자의 고효율 정제방법
JP6479305B2 (ja) *	2013-07-12	2019-03-06	株式会社Ｕｍｎファーマ	ウイルス様粒子の精製方法
US9802822B2 (en)	2014-06-23	2017-10-31	Bio-Rad Laboratories, Inc.	Apatite pretreatment
US10099157B2 (en)	2014-06-23	2018-10-16	Bio-Rad Laboratories, Inc.	Apatite in-situ restoration
CN105907729B (zh) *	2015-05-05	2019-08-16	广东东阳光药业有限公司	一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法
CN108524929B (zh) *	2017-03-06	2019-05-07	广州瑞贝斯药业有限公司	一种狂犬病疫苗的生产方法
CN110317832B (zh)	2018-03-28	2022-07-05	西比曼生物科技（香港）有限公司	Gmp级规模化制备重组慢病毒载体的纯化制剂的方法
JP6704074B2 (ja) *	2019-02-04	2020-06-03	株式会社Ｕｍｎファーマ	ウイルス様粒子の精製方法

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JPS6078999A (ja) *	1983-10-05	1985-05-04	Chemo Sero Therapeut Res Inst	ＨＢｓ抗原の精製方法
SE9000650L (sv)	1989-02-28	1990-08-29	Asahi Optical Co Ltd	Separation av celler eller virus
ATE328068T1 (de)	1994-05-16	2006-06-15	Merck & Co Inc	Papillomavirus vakzine
AU694269B2 (en) *	1994-09-22	1998-07-16	Merck Sharp & Dohme Corp.	Dna encoding human papillomavirus type 6a
AR004464A1 (es) *	1994-11-14	1998-12-16	Merck Sharp & Dohme	Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) *	1995-03-22	2005-11-20	Merck & Co Inc	Dna encoding human papillomavirus type 18
IL117591A0 (en) *	1995-03-30	1996-07-23	Merck & Co Inc	Synthetic DNA encoding human papillomavirus type 11 L1 protein
AU722196B2 (en)	1995-08-30	2000-07-27	Genzyme Corporation	Chromatographic purification of adenovirus and AAV

1999
- 1999-08-10 PL PL34747299A patent/PL347472A1/xx unknown
- 1999-08-10 AT AT99940950T patent/ATE324436T1/de active
- 1999-08-10 CN CN99811968A patent/CN1354787A/zh active Pending
- 1999-08-10 BR BR9913026A patent/BR9913026A/pt not_active Application Discontinuation
- 1999-08-10 HU HU0103091A patent/HUP0103091A3/hu unknown
- 1999-08-10 JP JP2000565108A patent/JP4440471B2/ja not_active Expired - Lifetime
- 1999-08-10 KR KR1020017001885A patent/KR20010072470A/ko not_active Withdrawn
- 1999-08-10 NZ NZ50961099A patent/NZ509610A/xx not_active IP Right Cessation
- 1999-08-10 DK DK99940950T patent/DK1105466T3/da active
- 1999-08-10 US US09/762,662 patent/US6602697B1/en not_active Expired - Lifetime
- 1999-08-10 IL IL14113099A patent/IL141130A0/xx unknown
- 1999-08-10 AU AU54698/99A patent/AU760633B2/en not_active Expired
- 1999-08-10 EP EP99940950A patent/EP1105466B1/en not_active Expired - Lifetime
- 1999-08-10 SI SI9930901T patent/SI1105466T1/sl unknown
- 1999-08-10 DE DE1999631053 patent/DE69931053T2/de not_active Expired - Lifetime
- 1999-08-10 CA CA 2339034 patent/CA2339034C/en not_active Expired - Lifetime
- 1999-08-10 WO PCT/US1999/017930 patent/WO2000009671A1/en not_active Ceased
- 1999-08-10 ES ES99940950T patent/ES2262333T3/es not_active Expired - Lifetime
- 1999-08-10 EA EA200100236A patent/EA200100236A1/ru unknown
- 1999-08-10 SK SK223-2001A patent/SK2232001A3/sk unknown
- 1999-08-10 CZ CZ2001570A patent/CZ2001570A3/cs unknown
- 1999-08-10 PT PT99940950T patent/PT1105466E/pt unknown
- 1999-08-10 HR HR20010113A patent/HRP20010113A2/hr not_active Application Discontinuation
2006
- 2006-07-11 CY CY20061100963T patent/CY1105084T1/el unknown

Also Published As

Publication number	Publication date
EP1105466A1 (en)	2001-06-13
PL347472A1 (en)	2002-04-08
DE69931053D1 (de)	2006-06-01
EP1105466A4 (en)	2002-05-15
SK2232001A3 (en)	2001-08-06
HUP0103091A2 (hu)	2001-12-28
NZ509610A (en)	2002-10-25
SI1105466T1 (sl)	2006-08-31
EA200100236A1 (ru)	2001-08-27
US6602697B1 (en)	2003-08-05
WO2000009671A1 (en)	2000-02-24
PT1105466E (pt)	2006-07-31
CA2339034C (en)	2010-10-12
HRP20010113A2 (en)	2002-02-28
AU5469899A (en)	2000-03-06
HUP0103091A3 (en)	2002-03-28
JP2003520188A (ja)	2003-07-02
DE69931053T2 (de)	2006-11-23
EP1105466B1 (en)	2006-04-26
CA2339034A1 (en)	2000-02-24
ATE324436T1 (de)	2006-05-15
IL141130A0 (en)	2002-02-10
BR9913026A (pt)	2001-09-25
CZ2001570A3 (cs)	2001-09-12
CY1105084T1 (el)	2009-11-04
ES2262333T3 (es)	2006-11-16
CN1354787A (zh)	2002-06-19
JP4440471B2 (ja)	2010-03-24
AU760633B2 (en)	2003-05-22
KR20010072470A (ko)	2001-07-31

Publication	Publication Date	Title
PL347472A1 (en)	2002-04-08	Process for purifying human papillomavirus virus-like particles
ATE332364T1 (de)	2006-07-15	Verfahren zur gewinnung von purifizierter virenzuammensetzung
LU91314I9 (da)	2019-01-30
DK1133283T3 (da)	2005-01-24	Fremgangsmåde til fremstilling af lægemiddelpartikler
NO972136L (no)	1998-11-10	FremgangsmÕte for fremstilling av uronsyreblokker fra alginat
FR11C0022I1 (da)	2011-05-08
AU2449500A (en)	2000-08-29	Preparation of iodixanol
DE3752362D1 (de)	2003-02-20	Optisch aktive Verbindungen
AR063314A2 (es)	2009-01-21	Metodos para purificar preparados de virus
IE890181L (en)	1989-07-22	Removal of steroids
FI962610A0 (fi)	1996-06-24	Menetelmä ksylitolin valmistamiseksi
DE59912722D1 (de)	2005-12-01	Kontinuierliches verfahren zur trennung von stoffen nach molekülgrösse
DE60042343D1 (de)	2009-07-16	Abtrennung von fibrinogen von plasmaproteasen
DK0833684T3 (da)	2001-10-08	Fremgangsmåde til fjernelse af organiske bestanddele fra en vandig strøm
ATE306564T1 (de)	2005-10-15	Verfahren zur aufreinigung von maltose
WO2002030983A3 (de)	2002-12-12	Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung
MXPA03007992A (es)	2004-09-29	Composicion farmaceutica de fragmentos f(ab)2 de anticuerpos y un proceso para su preparacion
WO2001046686A3 (de)	2001-12-06	Chromatographiematerial und verfahren unter verwendung desselben
ATE246250T1 (de)	2003-08-15	Immunogenes konstrukt, verfahren zu dessen herstellung und verwendung als vakzine
HUP0003671A1 (hu)	2001-02-28	Eljárás antitrombin III tisztítására
BR0213117A (pt)	2004-09-21	Conjugados peptìdeo angiotensina-veìculo e seus usos
DK1315757T3 (da)	2008-04-07	Fremgangsmåde til oprensning af EPI-HNE-proteiner
FI953493A0 (fi)	1995-07-19	Menetelmä molybdeenin talteen ottamiseksi lähtien epäpuhtaasta kalsiummolybdaatista, joka on saatu käsittelemällä uraanipitoisia malmeja
DE3677067D1 (de)	1991-02-28	Verfahren zur herstellung von heteropolysaccharidteilchen.
EP0955367A3 (en)	2001-06-13	Recombinant nucleoprotein of toscana virus