DK1117403T3 - MGLUR5-antagonister til behandling af smerte og angst - Google Patents

MGLUR5-antagonister til behandling af smerte og angst

Info

Publication number: DK1117403T3
Authority: DK; Denmark
Prior art keywords: pain; treatment; anxiety; antagonists; mglur5 antagonists
Prior art date: 1998-10-02

Application number

DK99948905T

Other languages

Danish (da)

English (en)

Inventor

Hans Allgeier

Nicholas David Cosford

Fabrizio Gasparini

Conrad Gentsch

Stephen D Hess

Edwin Carl Johnson

Rainer Kuhn

Laszlo Urban

Mark Andrew Varney

Elebi Goenuel Veli

Katharine Walker

Peter Josef Flor

Mark Tricklebank

Original Assignee

Sibia Neurosciences Inc

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-02

Filing date

1999-09-30

Publication date

2004-04-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314451&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1117403(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-10-02 Priority claimed from GBGB9821503.1A external-priority patent/GB9821503D0/en

1999-09-30 Application filed by Sibia Neurosciences Inc, Novartis Ag filed Critical Sibia Neurosciences Inc

2004-04-13 Application granted granted Critical

2004-04-13 Publication of DK1117403T3 publication Critical patent/DK1117403T3/da

Links

239000005557 antagonist Substances 0.000 title abstract 3
208000019901 Anxiety disease Diseases 0.000 title abstract 2
230000036506 anxiety Effects 0.000 title abstract 2
101150087728 Grm5 gene Proteins 0.000 title 1
102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 1
108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 1
102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
229940124807 mGLUR antagonist Drugs 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)

DK99948905T 1998-10-02 1999-09-30 MGLUR5-antagonister til behandling af smerte og angst DK1117403T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9821503.1A GB9821503D0 (en)	1998-10-02	1998-10-02	Organic compounds
US22081398A	1998-12-23	1998-12-23
PCT/EP1999/007239 WO2000020001A1 (en)	1998-10-02	1999-09-30	Mglur5 antagonists for the treatment of pain and anxiety

Publications (1)

Publication Number	Publication Date
DK1117403T3 true DK1117403T3 (da)	2004-04-13

Family

ID=26314451

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99948905T DK1117403T3 (da)	1998-10-02	1999-09-30	MGLUR5-antagonister til behandling af smerte og angst

Country Status (21)

Country	Link
EP (1)	EP1117403B1 (pl)
JP (1)	JP2002526408A (pl)
KR (1)	KR20010088832A (pl)
CN (1)	CN1187048C (pl)
AT (1)	ATE255894T1 (pl)
AU (1)	AU765644B2 (pl)
BR (1)	BR9914215A (pl)
CA (1)	CA2345137A1 (pl)
DE (1)	DE69913548T2 (pl)
DK (1)	DK1117403T3 (pl)
ES (1)	ES2213389T3 (pl)
HU (1)	HUP0200553A3 (pl)
ID (1)	ID29095A (pl)
IL (2)	IL142047A0 (pl)
NO (1)	NO20011440L (pl)
NZ (1)	NZ510743A (pl)
PL (1)	PL202906B1 (pl)
PT (1)	PT1117403E (pl)
RU (1)	RU2232017C2 (pl)
SK (1)	SK4382001A3 (pl)
WO (1)	WO2000020001A1 (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0005700D0 (en) *	2000-03-09	2000-05-03	Glaxo Group Ltd	Therapy
CA2432077C (en) *	2000-12-22	2011-01-18	F. Hoffmann-La Roche Ag	Tetrahydro-(benzo or thieno)-azepine-pyrazine and triazine derivatives as mglur 1 antagonists
GB0128996D0 (en)	2001-12-04	2002-01-23	Novartis Ag	Organic compounds
SE0303419D0 (sv) *	2003-12-17	2003-12-17	Astrazeneca Ab	New use 11
SE0303418D0 (sv) *	2003-12-17	2003-12-17	Astrazeneca Ab	New use 1
FR2883180B1 (fr) *	2005-03-18	2007-05-25	Pierre Fabre Medicament Sa	Utilisation de l'acetyl-leucine pour la preparation d'un medicament destine au traitement de troubles de l'equilibre
GB0525068D0 (en)	2005-12-08	2006-01-18	Novartis Ag	Organic compounds
DE102005062985A1 (de) *	2005-12-28	2007-07-05	Grünenthal GmbH	Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln
PL2083811T3 (pl)	2006-11-22	2017-05-31	Clinical Research Associates, Llc	Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu
US8349852B2 (en)	2009-01-13	2013-01-08	Novartis Ag	Quinazolinone derivatives useful as vanilloid antagonists
US8586581B2 (en) *	2009-12-17	2013-11-19	Hoffmann-La Roche Inc	Ethynyl compounds useful for treatment of CNS disorders
AR080055A1 (es)	2010-02-01	2012-03-07	Novartis Ag	Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
WO2011092293A2 (en)	2010-02-01	2011-08-04	Novartis Ag	Cyclohexyl amide derivatives as crf receptor antagonists
ES2527849T3 (es)	2010-02-02	2015-01-30	Novartis Ag	Derivados de ciclohexilamida como antagonistas del receptor de CRF
US20130058915A1 (en)	2010-03-02	2013-03-07	Children's Medica Center Corporation	Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110294879A1 (en)	2010-05-28	2011-12-01	Xenoport, Inc.	Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders
WO2012009646A1 (en)	2010-07-15	2012-01-19	Xenoport, Inc.	Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
WO2012054724A1 (en)	2010-10-21	2012-04-26	Massachusetts Institute Of Technology	Methods of treating seizure disorders
AR086554A1 (es)	2011-05-27	2014-01-08	Novartis Ag	Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina
EP2557183A1 (de)	2011-08-12	2013-02-13	Siemens Aktiengesellschaft	Verfahren zum Betrieb einer Konti-Glühe für die Verarbeitung eines Walzguts
JP2015525202A (ja)	2012-05-03	2015-09-03	ノバルティスアーゲー	グレリン受容体アゴニストとしての２，７−ジアザ−スピロ［４，５］デカ−７−イル誘導体のｌ−リンゴ酸塩およびその結晶形態
HRP20200638T1 (hr)	2015-06-03	2020-07-10	F. Hoffmann - La Roche Ag	Derivati etinila
EP3661500B1 (en)	2017-07-31	2026-01-07	Novartis AG	Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use
EP3459939A1 (en)	2017-09-26	2019-03-27	Pragma Therapeutics	Novel heterocyclic compounds as modulators of mglur7
KR102027368B1 (ko) *	2018-05-29	2019-10-01	서울대학교산학협력단	통증의 강도를 측정하는 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0334119B1 (en) *	1988-03-21	1993-06-16	Boehringer Ingelheim Pharmaceuticals Inc.	Compounds for inhibiting the biosynthesis of lipoxygenase-derived metabolites of arachidonic acid
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives

1999
- 1999-09-30 NZ NZ510743A patent/NZ510743A/en unknown
- 1999-09-30 PT PT99948905T patent/PT1117403E/pt unknown
- 1999-09-30 IL IL14204799A patent/IL142047A0/xx active IP Right Grant
- 1999-09-30 AT AT99948905T patent/ATE255894T1/de active
- 1999-09-30 PL PL346876A patent/PL202906B1/pl not_active IP Right Cessation
- 1999-09-30 EP EP99948905A patent/EP1117403B1/en not_active Revoked
- 1999-09-30 ID IDW20010730A patent/ID29095A/id unknown
- 1999-09-30 SK SK438-2001A patent/SK4382001A3/sk unknown
- 1999-09-30 ES ES99948905T patent/ES2213389T3/es not_active Expired - Lifetime
- 1999-09-30 WO PCT/EP1999/007239 patent/WO2000020001A1/en not_active Ceased
- 1999-09-30 BR BR9914215-5A patent/BR9914215A/pt not_active Application Discontinuation
- 1999-09-30 RU RU2001111868/14A patent/RU2232017C2/ru not_active IP Right Cessation
- 1999-09-30 KR KR1020017004152A patent/KR20010088832A/ko not_active Ceased
- 1999-09-30 DE DE69913548T patent/DE69913548T2/de not_active Revoked
- 1999-09-30 JP JP2000573360A patent/JP2002526408A/ja active Pending
- 1999-09-30 CN CNB998117110A patent/CN1187048C/zh not_active Expired - Fee Related
- 1999-09-30 DK DK99948905T patent/DK1117403T3/da active
- 1999-09-30 CA CA002345137A patent/CA2345137A1/en not_active Abandoned
- 1999-09-30 AU AU61984/99A patent/AU765644B2/en not_active Ceased
- 1999-09-30 HU HU0200553A patent/HUP0200553A3/hu unknown
2001
- 2001-03-15 IL IL142047A patent/IL142047A/en not_active IP Right Cessation
- 2001-03-21 NO NO20011440A patent/NO20011440L/no unknown

Also Published As

Publication number	Publication date
ID29095A (id)	2001-07-26
IL142047A (en)	2007-09-20
PL202906B1 (pl)	2009-08-31
NZ510743A (en)	2003-10-31
EP1117403A1 (en)	2001-07-25
NO20011440D0 (no)	2001-03-21
BR9914215A (pt)	2001-07-03
AU6198499A (en)	2000-04-26
DE69913548D1 (de)	2004-01-22
CN1321087A (zh)	2001-11-07
ATE255894T1 (de)	2003-12-15
PT1117403E (pt)	2004-04-30
PL346876A1 (en)	2002-03-11
HUP0200553A3 (en)	2002-11-28
JP2002526408A (ja)	2002-08-20
CA2345137A1 (en)	2000-04-13
RU2232017C2 (ru)	2004-07-10
EP1117403B1 (en)	2003-12-10
CN1187048C (zh)	2005-02-02
NO20011440L (no)	2001-05-15
SK4382001A3 (en)	2001-08-06
IL142047A0 (en)	2002-03-10
HUP0200553A2 (hu)	2002-07-29
WO2000020001A1 (en)	2000-04-13
ES2213389T3 (es)	2004-08-16
KR20010088832A (ko)	2001-09-28
AU765644B2 (en)	2003-09-25
DE69913548T2 (de)	2004-09-23

Publication	Publication Date	Title
NO20011440D0 (no)	2001-03-21	mGluR5-antagonister for behandling av smerte og angst
DK1196172T3 (da)	2006-06-19	(S,S)-reboxetin til behandling af kronisk smerte
TR200200408T2 (tr)	2002-06-21	Yeni spiro bileşikleri
NO20004935D0 (no)	2000-09-29	Anordning til den transdermale avleveringen av diklofenak
IS2494B (is)	2009-02-15	Notkun á morfólínóli til meðhöndlunar á kynferðislegri vanvirkni
EP1129089A4 (en)	2003-01-22	SPIRO-INDOLE AS Y5 RECEPTOR ANTAGONISTS
ATE322258T1 (de)	2006-04-15	Methoden und zusammensetzungen zur modulation der aktivität der alpha-adrenergen rezeptoren
DK1562932T3 (da)	2007-08-13	4 tetrazolyl-4-phenylpiperidinderivater til behandling af smerter
DK1063990T3 (da)	2007-05-21	Anvendelse af Biochanin-beriget ekstrakt til behandling af östrogen-associerede lidelser
CY1107531T1 (el)	2013-03-13	Χρηση αναστολεων πρωτεασομης για την αγωγη των διαταραχων ξηρου οφθαλμου
DE60108857D1 (de)	2005-03-17	Methoden und zusammensetzungen zur modulierung der aktivität von alpha-adrenergen rezeptoren
DK1282616T3 (da)	2004-09-20	Hydroxyphenylpiperidin-4-ylidenmethylbenzamidderivater til behandling af smerter
DE60136477D1 (de)	2008-12-18	Retinoide zur behandlung von emphysem
ATE370728T1 (de)	2007-09-15	Antagonisten des gardos-kanals
ATE266420T1 (de)	2004-05-15	Kombinationspräparat, das selektive nmda nr2b- antagonisten und cox-2 inhibitoren enthält
DK1200081T3 (da)	2006-12-27	Anvendelse af escitalopram til behandling af generaliseret angstlidelse
DE50114605D1 (de)	2009-02-05	No-thien-2-yl-essigsaure-derivate und ihre verwendung zur behandlung von migraine bzw. schmerz
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DE60016047D1 (de)	2004-12-23	Dihydrobenzopyrane, dihydrobenzothiopyrane und tetrahydrochinoline zur behandlung cox-2-abhängiger krankheiten
NO20024777D0 (no)	2002-10-03	Kinolinyl-piperidin-4-yliden-metyl-benzamidderivater til behandling av smerte
BR0314139A (pt)	2005-07-12	Derivados de 1,4-pirazina substituìdos
DE60127712D1 (de)	2007-05-16	Selektive dopamin-d4-rezeptoragonisten zur behandlung von sexuellen dysfunktionen
NO20005548D0 (no)	2000-11-03	Mykobakterieinhibitorer
DK1455770T3 (da)	2007-10-08	Anvendelse af norepinephringenoptagelsesinhibitorer til behandling af tic lidelser
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