DK1120419T3 - Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance - Google Patents

Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance

Info

Publication number: DK1120419T3
Authority: DK; Denmark
Prior art keywords: vasodilators; isosorbide mononitrate; diminished; tolerance; mononitrate derivatives
Prior art date: 1998-10-07

Application number

DK99949015T

Other languages

English (en)

Inventor

Moliner Jose Repolles

Coy Francisco Pubill

Llorente Lydia Cabeza

Banus Marcel Li Carbo

Rofes Cristina Negrie

Perez-Rasilla Eduardo Salas

Siso Alicia Ferrer

Marek W Radomski

Bonnin Juan Martinez

Riudavets Juan Antonio Cerda

Original Assignee

Lacer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-07

Filing date

1999-10-04

Publication date

2006-07-03

1999-10-04 Application filed by Lacer Sa filed Critical Lacer Sa

2006-07-03 Application granted granted Critical

2006-07-03 Publication of DK1120419T3 publication Critical patent/DK1120419T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)

DK99949015T 1998-10-07 1999-10-04 Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance DK1120419T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES009802076A ES2142773B1 (es)	1998-10-07	1998-10-07	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.

Publications (1)

Publication Number	Publication Date
DK1120419T3 true DK1120419T3 (da)	2006-07-03

Family

ID=8305360

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99949015T DK1120419T3 (da)	1998-10-07	1999-10-04	Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance

Country Status (40)

Country	Link
US (2)	US20010051735A1 (da)
EP (1)	EP1120419B1 (da)
JP (1)	JP4659214B2 (da)
KR (1)	KR100641801B1 (da)
CN (1)	CN1096465C (da)
AP (1)	AP1555A (da)
AR (1)	AR020538A1 (da)
AT (1)	ATE323707T1 (da)
AU (1)	AU762724B2 (da)
BG (1)	BG65135B1 (da)
BR (1)	BR9914355B1 (da)
CA (1)	CA2346010C (da)
CO (1)	CO5180544A1 (da)
CU (1)	CU23162A3 (da)
CZ (1)	CZ294551B6 (da)
DE (2)	DE19983612T1 (da)
DK (1)	DK1120419T3 (da)
EA (1)	EA003360B1 (da)
EE (1)	EE04374B1 (da)
ES (2)	ES2142773B1 (da)
GB (1)	GB2359810B (da)
GE (1)	GEP20043162B (da)
GT (1)	GT199900173A (da)
HR (1)	HRP20010256B1 (da)
HU (1)	HUP0103937A3 (da)
ID (1)	ID29946A (da)
IL (2)	IL142391A0 (da)
IS (1)	IS2312B (da)
NO (1)	NO328584B1 (da)
NZ (1)	NZ510855A (da)
OA (1)	OA11661A (da)
PA (1)	PA8483901A1 (da)
PE (1)	PE20001083A1 (da)
PL (1)	PL200028B1 (da)
PT (1)	PT1120419E (da)
RS (1)	RS50112B (da)
TR (1)	TR200100961T2 (da)
WO (1)	WO2000020420A1 (da)
YU (1)	YU25201A (da)
ZA (1)	ZA200102836B (da)

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ES2258365B1 (es) *	2003-10-03	2007-12-01	Lacer, S.A.	Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) *	2006-12-28	2008-07-09	Lacer, S.A.	Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) *	2007-01-23	2010-10-21	Lacer, S.A.	Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en)	2007-12-21	2009-06-24	Trinity College Dublin	Efficient aspirin prodrugs
EP2240491B1 (en)	2008-01-09	2015-07-15	Amura Therapeutics Limited	TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES
US8003811B2 (en) *	2008-02-07	2011-08-23	Nicox S.A.	Nitric oxide donor compounds
EP2149577B1 (en) *	2008-07-22	2011-04-27	Lacer, S.A.	New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2149576A1 (en) *	2008-07-22	2010-02-03	Lacer, S.A.	Isosorbide Nitrates having vasodilating activity
EP2177216A1 (en)	2008-10-13	2010-04-21	Lacer, S.A.	Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) *	2008-11-14	2010-05-20	Lacer, S.A.	New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) *	2008-12-19	2010-06-23	Lacer, S.A.	New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
ES2423939T3 (es) *	2009-09-10	2013-09-25	Cognis Ip Management Gmbh	Derivados de isosorburo gliceril éter y su empleo en aplicaciones de uso doméstico
ES2587191T3 (es)	2009-12-23	2016-10-21	Arca Biopharma, Inc.	Métodos y composiciones para enfermedades y afecciones cardiovasculares
CN102241687A (zh) *	2011-05-23	2011-11-16	中国人民解放军第四军医大学	抗缺血/再灌注损伤的药物
EP2707354B1 (en)	2011-10-24	2015-04-29	Nicox Science Ireland	Quinone based nitric oxide donating compounds
RU2015139514A (ru) *	2013-03-05	2017-04-07	Арчер Дэниелс Мидлэнд Компани	Монотрифлаты изогексида и способ их синтеза
WO2014169976A1 (en)	2013-04-18	2014-10-23	Nicox Science Ireland	Quinone based nitric oxide donating compounds
CN104650108B (zh) *	2013-11-18	2017-05-24	富力	连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) *	2014-08-07	2017-05-24	富力	连翘脂素布洛芬酯、其制备及其应用
WO2026061429A1 (zh) *	2024-09-18	2026-03-26	南京宁丹新药技术股份有限公司	一类单硝酸异山梨酯衍生物的盐类化合物及其用途

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FR1356374A (fr)	1963-02-12	1964-03-27		Machine à fonctions multiples pour le travail du bois
AU465217B2 (en)	1971-04-29	1975-09-18	American Home Products Corporation	Mononitrte esters of 1,4:3, 6-dianhydro-d-glucitol
US3886196A (en)	1973-02-07	1975-05-27	Phillips Petroleum Co	Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles
DE3028289C2 (de)	1980-07-25	1986-11-27	Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe	2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE3248548A1 (de) *	1982-12-29	1984-07-05	Heinrich Mack Nachf., 7918 Illertissen	Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3421072A1 (de)	1984-06-06	1985-12-12	Heinrich Mack Nachf., 7918 Illertissen	1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3602067A1 (de)	1986-01-24	1987-07-30	Mack Chem Pharm	2,6-dioxabicyclo(3.3.0)octan-derivate, ihre herstellung und verwendung als arzneimittel
DE3606634A1 (de)	1986-02-28	1987-09-03	Mack Chem Pharm	Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1204571B (it) *	1987-05-08	1989-03-10	Chiesi Farma Spa	Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
DE3741005A1 (de)	1987-12-03	1989-06-15	Mack Chem Pharm	Aminopropanol-derivate von 1,4:3,6-dianhydro-hexit-nitraten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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WO1994003421A2 (en) *	1992-07-30	1994-02-17	Cal International Limited	Esters and combinations of an organic nitrate and a salicylate
IL120531A (en)	1997-03-26	2006-12-31	Yissum Res Dev Co	Nitric oxide donors and pharmaceutical compositions containing them

1998
- 1998-10-07 ES ES009802076A patent/ES2142773B1/es not_active Expired - Fee Related
1999
- 1999-09-30 AR ARP990104928A patent/AR020538A1/es active IP Right Grant
- 1999-10-04 ES ES99949015T patent/ES2257871T3/es not_active Expired - Lifetime
- 1999-10-04 OA OA1200100085A patent/OA11661A/en unknown
- 1999-10-04 EP EP99949015A patent/EP1120419B1/en not_active Expired - Lifetime
- 1999-10-04 NZ NZ510855A patent/NZ510855A/xx not_active IP Right Cessation
- 1999-10-04 CN CN99811802A patent/CN1096465C/zh not_active Expired - Fee Related
- 1999-10-04 DE DE19983612T patent/DE19983612T1/de not_active Ceased
- 1999-10-04 AP APAP/P/2001/002128A patent/AP1555A/en active
- 1999-10-04 YU YU25201A patent/YU25201A/sh unknown
- 1999-10-04 AU AU62041/99A patent/AU762724B2/en not_active Ceased
- 1999-10-04 KR KR1020017004374A patent/KR100641801B1/ko not_active Expired - Fee Related
- 1999-10-04 CZ CZ20011257A patent/CZ294551B6/cs not_active IP Right Cessation
- 1999-10-04 GB GB0111172A patent/GB2359810B/en not_active Expired - Fee Related
- 1999-10-04 DE DE69930949T patent/DE69930949T2/de not_active Expired - Lifetime
- 1999-10-04 EA EA200100422A patent/EA003360B1/ru not_active IP Right Cessation
- 1999-10-04 HU HU0103937A patent/HUP0103937A3/hu unknown
- 1999-10-04 GE GEAP19995886A patent/GEP20043162B/en unknown
- 1999-10-04 RS YUP-252/01A patent/RS50112B/sr unknown
- 1999-10-04 WO PCT/ES1999/000316 patent/WO2000020420A1/es not_active Ceased
- 1999-10-04 IL IL14239199A patent/IL142391A0/xx active IP Right Grant
- 1999-10-04 PT PT99949015T patent/PT1120419E/pt unknown
- 1999-10-04 ID IDW00200101008A patent/ID29946A/id unknown
- 1999-10-04 DK DK99949015T patent/DK1120419T3/da active
- 1999-10-04 EE EEP200100207A patent/EE04374B1/xx not_active IP Right Cessation
- 1999-10-04 PL PL347030A patent/PL200028B1/pl not_active IP Right Cessation
- 1999-10-04 TR TR2001/00961T patent/TR200100961T2/xx unknown
- 1999-10-04 JP JP2000574532A patent/JP4659214B2/ja not_active Expired - Fee Related
- 1999-10-04 BR BRPI9914355-0A patent/BR9914355B1/pt not_active IP Right Cessation
- 1999-10-04 HR HR20010256A patent/HRP20010256B1/xx not_active IP Right Cessation
- 1999-10-04 CA CA002346010A patent/CA2346010C/en not_active Expired - Fee Related
- 1999-10-04 PE PE1999001005A patent/PE20001083A1/es not_active Application Discontinuation
- 1999-10-04 AT AT99949015T patent/ATE323707T1/de not_active IP Right Cessation
- 1999-10-06 CO CO99063420A patent/CO5180544A1/es not_active Application Discontinuation
- 1999-10-07 PA PA19998483901A patent/PA8483901A1/es unknown
- 1999-10-07 GT GT199900173A patent/GT199900173A/es unknown
2001
- 2001-03-29 IS IS5910A patent/IS2312B/is unknown
- 2001-04-03 IL IL142391A patent/IL142391A/en not_active IP Right Cessation
- 2001-04-04 CU CU83A patent/CU23162A3/es not_active IP Right Cessation
- 2001-04-05 ZA ZA200102836A patent/ZA200102836B/xx unknown
- 2001-04-06 NO NO20011778A patent/NO328584B1/no not_active IP Right Cessation
- 2001-04-06 US US09/827,868 patent/US20010051735A1/en not_active Abandoned
- 2001-04-06 BG BG105417A patent/BG65135B1/bg unknown
2003
- 2003-04-28 US US10/424,828 patent/US6858632B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ510855A (en)	2004-02-27
NO20011778L (no)	2001-04-06
TR200100961T2 (tr)	2003-02-21
CZ20011257A3 (cs)	2001-08-15
NO20011778D0 (no)	2001-04-06
AP1555A (en)	2006-01-18
HRP20010256A2 (en)	2002-04-30
DE69930949T2 (de)	2006-12-28
IL142391A (en)	2007-07-24
ZA200102836B (en)	2002-09-25
IS2312B (is)	2007-11-15
YU25201A (sh)	2003-04-30
JP2002526544A (ja)	2002-08-20
GB2359810A (en)	2001-09-05
US20030225134A1 (en)	2003-12-04
GB0111172D0 (en)	2001-06-27
ES2142773B1 (es)	2001-01-01
BR9914355A (pt)	2001-06-26
US20010051735A1 (en)	2001-12-13
WO2000020420A1 (es)	2000-04-13
PL347030A1 (en)	2002-03-11
AU6204199A (en)	2000-04-26
GEP20043162B (en)	2004-01-26
IS5910A (is)	2001-03-29
ES2257871T3 (es)	2006-08-01
EE200100207A (et)	2002-06-17
CZ294551B6 (cs)	2005-01-12
EA003360B1 (ru)	2003-04-24
NO328584B1 (no)	2010-03-22
US6858632B2 (en)	2005-02-22
AR020538A1 (es)	2002-05-15
CU23162A3 (es)	2006-07-18
AU762724B2 (en)	2003-07-03
HUP0103937A2 (hu)	2002-02-28
ID29946A (id)	2001-10-25
CA2346010A1 (en)	2000-04-13
AP2001002128A0 (en)	2001-06-30
HUP0103937A3 (en)	2003-11-28
CN1322205A (zh)	2001-11-14
EA200100422A1 (ru)	2001-10-22
OA11661A (en)	2004-12-08
DE69930949D1 (de)	2006-05-24
JP4659214B2 (ja)	2011-03-30
PT1120419E (pt)	2006-07-31
CO5180544A1 (es)	2002-07-30
CA2346010C (en)	2010-01-12
GB2359810B (en)	2003-12-03
IL142391A0 (en)	2002-03-10
ES2142773A1 (es)	2000-04-16
CN1096465C (zh)	2002-12-18
GT199900173A (es)	2001-03-30
KR100641801B1 (ko)	2006-11-02
ATE323707T1 (de)	2006-05-15
DE19983612T1 (de)	2001-09-27
BG65135B1 (bg)	2007-03-30
BR9914355B1 (pt)	2014-10-21
RS50112B (sr)	2009-03-25
PE20001083A1 (es)	2000-11-28
EP1120419A1 (en)	2001-08-01
HRP20010256B1 (hr)	2009-08-31
EP1120419B1 (en)	2006-04-19
EE04374B1 (et)	2004-10-15
BG105417A (en)	2001-12-29
PL200028B1 (pl)	2008-11-28
KR20010088848A (ko)	2001-09-28
PA8483901A1 (es)	2000-09-29

Publication	Publication Date	Title
DK1120419T3 (da)	2006-07-03	Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance
NO20011956D0 (no)	2001-04-20	Substituerte fenylderivater, deres fremstilling og anvendelse
NO20024742L (no)	2002-11-25	Heterocykliske forbindelser, deres fremstilling og anvendelse
NO20015156L (no)	2001-12-18	5-pyridyl-1,3-azolforbindelser, deres fremstilling og anvendelse
NO20021253L (no)	2002-04-24	Kinolylpropylpiperidinderivater og deres anvendelse som antibakterielle midler
NO20014603L (no)	2001-11-26	Tienopyrimidinforbindelser, deres fremstilling og anvendelse
ATE314072T1 (de)	2006-01-15	Antivirale azaindolderivate
DK1498413T3 (da)	2011-12-05	4-aminopicolinater og deres anvendelse som herbicider
DK1198454T3 (da)	2006-06-12	Multilinderivater og deres anvendelse som antibakterielle midler
NO20030146L (no)	2003-01-10	Pyrimidin-derivater
NO20001079L (no)	2000-09-04	Kopolymerer og deres anvendelse som borehjelpemiddel
NO20026010D0 (no)	2002-12-13	Substituerte quinazolinderivater og deres anvendelse som inhibitorer
NO20025150L (no)	2002-12-16	2-acylindolderivater og deres anvendelse som antitumormidler
NO20000185D0 (no)	2000-01-14	Kondenserte 1,2,4-tiadiazinderivater, deres fremstilling og anvendelse
NO20005411D0 (no)	2000-10-27	Antipicornavirusforbindelser, deres fremstilling og anvendelse
DK1337521T3 (da)	2007-01-29	Salte af en isothiasol-4-carboxamid og deres anvendelse som antihyperproliferationsmiddel
DK1107980T3 (da)	2003-04-22	Krystallinske former af EtO2C-CH2-(R)Cgl-Aze-Pab-OH
DK0989121T3 (da)	2005-12-12	Substituerede benzamider og deres anvendelse som immunmodulatorer
NO995513L (no)	2000-01-12	N-triazolyl-2-indolkarboksamider og deres anvendelse som CCK-
ATE282038T1 (de)	2004-11-15	Kristallin form ii von cabergolin
DE60024023D1 (de)	2005-12-22	Nockenwellenversteller
DK1259515T3 (da)	2005-01-31	Thienopyridinderivater og deres anvendelse som antiinflammatoriske midler
NO20006479D0 (no)	2000-12-19	Tienopyridinforbindelser, deres fremstilling og anvendelse
NO20012802L (no)	2001-08-07	Benzofuranderivater, deres fremstilling og anvendelse
NO996156L (no)	2000-06-15	Substituerte cykloheptener, deres fremstilling og anvendelse