IS5910A - Afleiður ísósorbíðmónónítrats og notkun þeirra sem æðavíkarar með lága þolmynd - Google Patents

Afleiður ísósorbíðmónónítrats og notkun þeirra sem æðavíkarar með lága þolmynd

Info

Publication number: IS5910A
Authority: IS; Iceland
Prior art keywords: vasodilators; isosorbide mononitrate; low tolerance; mononitrate derivatives; derivatives
Prior art date: 1998-10-07

Application number

IS5910A

Other languages

English (en)

Other versions

IS2312B (is

Inventor

Repolles Moliner José

Pubill Coy Francisco

Cabeza Llorente Lydia

Carbo Banus Marcel.Li

Negrie Rofes Cristina

Antonio Cerda Riudavets Juan

Ferrer Siso Alicia

W. Radomski Marek

Salas Perez-Rasilla Eduardo

Martinez Bonnin Juan

Original Assignee

Lacer, S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-07

Filing date

2001-03-29

Publication date

2001-03-29

2001-03-29 Application filed by Lacer, S.A. filed Critical Lacer, S.A.

2001-03-29 Publication of IS5910A publication Critical patent/IS5910A/is

2007-11-15 Publication of IS2312B publication Critical patent/IS2312B/is

Links

YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical class [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 title 1
229940124549 vasodilator Drugs 0.000 title 1
239000003071 vasodilator agent Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)

IS5910A 1998-10-07 2001-03-29 Afleiður ísósorbíð einnítrats og notkun þeirra sem æðavíkkarar með lága þolmyndun IS2312B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009802076A ES2142773B1 (es)	1998-10-07	1998-10-07	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
PCT/ES1999/000316 WO2000020420A1 (es)	1998-10-07	1999-10-04	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida

Publications (2)

Publication Number	Publication Date
IS5910A true IS5910A (is)	2001-03-29
IS2312B IS2312B (is)	2007-11-15

Family

ID=8305360

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS5910A IS2312B (is)	1998-10-07	2001-03-29	Afleiður ísósorbíð einnítrats og notkun þeirra sem æðavíkkarar með lága þolmyndun

Country Status (40)

Country	Link
US (2)	US20010051735A1 (is)
EP (1)	EP1120419B1 (is)
JP (1)	JP4659214B2 (is)
KR (1)	KR100641801B1 (is)
CN (1)	CN1096465C (is)
AP (1)	AP1555A (is)
AR (1)	AR020538A1 (is)
AT (1)	ATE323707T1 (is)
AU (1)	AU762724B2 (is)
BG (1)	BG65135B1 (is)
BR (1)	BR9914355B1 (is)
CA (1)	CA2346010C (is)
CO (1)	CO5180544A1 (is)
CU (1)	CU23162A3 (is)
CZ (1)	CZ294551B6 (is)
DE (2)	DE69930949T2 (is)
DK (1)	DK1120419T3 (is)
EA (1)	EA003360B1 (is)
EE (1)	EE04374B1 (is)
ES (2)	ES2142773B1 (is)
GB (1)	GB2359810B (is)
GE (1)	GEP20043162B (is)
GT (1)	GT199900173A (is)
HR (1)	HRP20010256B1 (is)
HU (1)	HUP0103937A3 (is)
ID (1)	ID29946A (is)
IL (2)	IL142391A0 (is)
IS (1)	IS2312B (is)
NO (1)	NO328584B1 (is)
NZ (1)	NZ510855A (is)
OA (1)	OA11661A (is)
PA (1)	PA8483901A1 (is)
PE (1)	PE20001083A1 (is)
PL (1)	PL200028B1 (is)
PT (1)	PT1120419E (is)
RS (1)	RS50112B (is)
TR (1)	TR200100961T2 (is)
WO (1)	WO2000020420A1 (is)
YU (1)	YU25201A (is)
ZA (1)	ZA200102836B (is)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2258365B1 (es) *	2003-10-03	2007-12-01	Lacer, S.A.	Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) *	2006-12-28	2008-07-09	Lacer, S.A.	Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) *	2007-01-23	2010-10-21	Lacer, S.A.	Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en)	2007-12-21	2009-06-24	Trinity College Dublin	Efficient aspirin prodrugs
WO2009087379A2 (en)	2008-01-09	2009-07-16	Amura Therapeutics Limited	Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases
WO2009098113A1 (en) *	2008-02-07	2009-08-13	Nicox S.A.	Nitric oxide donor compounds
EP2149576A1 (en)	2008-07-22	2010-02-03	Lacer, S.A.	Isosorbide Nitrates having vasodilating activity
EP2149577B1 (en) *	2008-07-22	2011-04-27	Lacer, S.A.	New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2177216A1 (en) *	2008-10-13	2010-04-21	Lacer, S.A.	Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) *	2008-11-14	2010-05-20	Lacer, S.A.	New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) *	2008-12-19	2010-06-23	Lacer, S.A.	New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
ES2423939T3 (es) *	2009-09-10	2013-09-25	Cognis Ip Management Gmbh	Derivados de isosorburo gliceril éter y su empleo en aplicaciones de uso doméstico
US20130131161A1 (en)	2009-12-23	2013-05-23	Michael R. Bristow	Methods and compositions for cardiovascular diseases and conditions
CN102241687A (zh) *	2011-05-23	2011-11-16	中国人民解放军第四军医大学	抗缺血/再灌注损伤的药物
US9061962B2 (en)	2011-10-24	2015-06-23	Nicox Science Ireland	Quinone based nitric oxide donating compounds
CA2902009A1 (en) *	2013-03-05	2014-09-12	Archer Daniels Midland Company	Isohexide monotriflates and process for synthesis thereof
WO2014169976A1 (en)	2013-04-18	2014-10-23	Nicox Science Ireland	Quinone based nitric oxide donating compounds
CN104650108B (zh) *	2013-11-18	2017-05-24	富力	连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) *	2014-08-07	2017-05-24	富力	连翘脂素布洛芬酯、其制备及其应用

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FR1356374A (fr)	1963-02-12	1964-03-27		Machine à fonctions multiples pour le travail du bois
GB1356374A (en)	1971-04-29	1974-06-12	American Home Prod	Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
US3886196A (en)	1973-02-07	1975-05-27	Phillips Petroleum Co	Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles
DE3028289C2 (de)	1980-07-25	1986-11-27	Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe	2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE3248548A1 (de) *	1982-12-29	1984-07-05	Heinrich Mack Nachf., 7918 Illertissen	Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3421072A1 (de)	1984-06-06	1985-12-12	Heinrich Mack Nachf., 7918 Illertissen	1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3602067A1 (de)	1986-01-24	1987-07-30	Mack Chem Pharm	2,6-dioxabicyclo(3.3.0)octan-derivate, ihre herstellung und verwendung als arzneimittel
DE3606634A1 (de)	1986-02-28	1987-09-03	Mack Chem Pharm	Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1204571B (it) *	1987-05-08	1989-03-10	Chiesi Farma Spa	Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
DE3741005A1 (de)	1987-12-03	1989-06-15	Mack Chem Pharm	Aminopropanol-derivate von 1,4:3,6-dianhydro-hexit-nitraten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2628756B2 (ja) *	1988-09-15	1997-07-09	シュバルツファルマアクチェンゲゼルシャフト	新規有機ニトレート及びそれらの製造方法
US5428061A (en)	1988-09-15	1995-06-27	Schwarz Pharma Ag	Organic nitrates and method for their preparation
US4891373A (en) *	1988-11-23	1990-01-02	Pfizer Inc.	Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
CA2014520C (en)	1989-04-17	1996-07-16	Fumio Suzuki	Hexitol derivatives
NL9001955A (nl) *	1990-09-05	1992-04-01	Cedona Pharm Bv	Nieuwe thiazolidinederivaten.
FR2680173A1 (fr) *	1991-08-07	1993-02-12	Hoechst Lab	Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
ES2125342T3 (es) *	1992-07-30	1999-03-01	Cal Int Ltd	Esteres y combinaciones de un nitrato organico y de un salicilato.
IL120531A (en)	1997-03-26	2006-12-31	Yissum Res Dev Co	Nitric oxide donors and pharmaceutical compositions containing them

1998
- 1998-10-07 ES ES009802076A patent/ES2142773B1/es not_active Expired - Fee Related
1999
- 1999-09-30 AR ARP990104928A patent/AR020538A1/es active IP Right Grant
- 1999-10-04 JP JP2000574532A patent/JP4659214B2/ja not_active Expired - Fee Related
- 1999-10-04 DE DE69930949T patent/DE69930949T2/de not_active Expired - Lifetime
- 1999-10-04 AU AU62041/99A patent/AU762724B2/en not_active Ceased
- 1999-10-04 PL PL347030A patent/PL200028B1/pl not_active IP Right Cessation
- 1999-10-04 EE EEP200100207A patent/EE04374B1/xx not_active IP Right Cessation
- 1999-10-04 PE PE1999001005A patent/PE20001083A1/es not_active Application Discontinuation
- 1999-10-04 ID IDW00200101008A patent/ID29946A/id unknown
- 1999-10-04 OA OA1200100085A patent/OA11661A/en unknown
- 1999-10-04 DK DK99949015T patent/DK1120419T3/da active
- 1999-10-04 GB GB0111172A patent/GB2359810B/en not_active Expired - Fee Related
- 1999-10-04 CA CA002346010A patent/CA2346010C/en not_active Expired - Fee Related
- 1999-10-04 EA EA200100422A patent/EA003360B1/ru not_active IP Right Cessation
- 1999-10-04 WO PCT/ES1999/000316 patent/WO2000020420A1/es not_active Ceased
- 1999-10-04 CZ CZ20011257A patent/CZ294551B6/cs not_active IP Right Cessation
- 1999-10-04 AP APAP/P/2001/002128A patent/AP1555A/en active
- 1999-10-04 GE GEAP19995886A patent/GEP20043162B/en unknown
- 1999-10-04 HU HU0103937A patent/HUP0103937A3/hu unknown
- 1999-10-04 NZ NZ510855A patent/NZ510855A/xx not_active IP Right Cessation
- 1999-10-04 DE DE19983612T patent/DE19983612T1/de not_active Ceased
- 1999-10-04 KR KR1020017004374A patent/KR100641801B1/ko not_active Expired - Fee Related
- 1999-10-04 HR HR20010256A patent/HRP20010256B1/xx not_active IP Right Cessation
- 1999-10-04 RS YUP-252/01A patent/RS50112B/sr unknown
- 1999-10-04 AT AT99949015T patent/ATE323707T1/de not_active IP Right Cessation
- 1999-10-04 PT PT99949015T patent/PT1120419E/pt unknown
- 1999-10-04 TR TR2001/00961T patent/TR200100961T2/xx unknown
- 1999-10-04 BR BRPI9914355-0A patent/BR9914355B1/pt not_active IP Right Cessation
- 1999-10-04 IL IL14239199A patent/IL142391A0/xx active IP Right Grant
- 1999-10-04 YU YU25201A patent/YU25201A/sh unknown
- 1999-10-04 ES ES99949015T patent/ES2257871T3/es not_active Expired - Lifetime
- 1999-10-04 EP EP99949015A patent/EP1120419B1/en not_active Expired - Lifetime
- 1999-10-04 CN CN99811802A patent/CN1096465C/zh not_active Expired - Fee Related
- 1999-10-06 CO CO99063420A patent/CO5180544A1/es not_active Application Discontinuation
- 1999-10-07 PA PA19998483901A patent/PA8483901A1/es unknown
- 1999-10-07 GT GT199900173A patent/GT199900173A/es unknown
2001
- 2001-03-29 IS IS5910A patent/IS2312B/is unknown
- 2001-04-03 IL IL142391A patent/IL142391A/en not_active IP Right Cessation
- 2001-04-04 CU CU83A patent/CU23162A3/es not_active IP Right Cessation
- 2001-04-05 ZA ZA200102836A patent/ZA200102836B/xx unknown
- 2001-04-06 NO NO20011778A patent/NO328584B1/no not_active IP Right Cessation
- 2001-04-06 BG BG105417A patent/BG65135B1/bg unknown
- 2001-04-06 US US09/827,868 patent/US20010051735A1/en not_active Abandoned
2003
- 2003-04-28 US US10/424,828 patent/US6858632B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE19983612T1 (de)	2001-09-27
JP2002526544A (ja)	2002-08-20
US20010051735A1 (en)	2001-12-13
IS2312B (is)	2007-11-15
GB0111172D0 (en)	2001-06-27
IL142391A (en)	2007-07-24
NO328584B1 (no)	2010-03-22
EP1120419B1 (en)	2006-04-19
PE20001083A1 (es)	2000-11-28
DE69930949D1 (de)	2006-05-24
CO5180544A1 (es)	2002-07-30
KR100641801B1 (ko)	2006-11-02
GB2359810B (en)	2003-12-03
GEP20043162B (en)	2004-01-26
KR20010088848A (ko)	2001-09-28
CA2346010A1 (en)	2000-04-13
PL347030A1 (en)	2002-03-11
AP2001002128A0 (en)	2001-06-30
RS50112B (sr)	2009-03-25
PL200028B1 (pl)	2008-11-28
US6858632B2 (en)	2005-02-22
TR200100961T2 (tr)	2003-02-21
ES2257871T3 (es)	2006-08-01
HUP0103937A3 (en)	2003-11-28
NO20011778L (no)	2001-04-06
BR9914355A (pt)	2001-06-26
ZA200102836B (en)	2002-09-25
WO2000020420A1 (es)	2000-04-13
US20030225134A1 (en)	2003-12-04
GB2359810A (en)	2001-09-05
ES2142773B1 (es)	2001-01-01
PT1120419E (pt)	2006-07-31
CZ294551B6 (cs)	2005-01-12
BG65135B1 (bg)	2007-03-30
ATE323707T1 (de)	2006-05-15
AU762724B2 (en)	2003-07-03
DK1120419T3 (da)	2006-07-03
BR9914355B1 (pt)	2014-10-21
EA003360B1 (ru)	2003-04-24
ID29946A (id)	2001-10-25
IL142391A0 (en)	2002-03-10
JP4659214B2 (ja)	2011-03-30
DE69930949T2 (de)	2006-12-28
AU6204199A (en)	2000-04-26
AR020538A1 (es)	2002-05-15
NZ510855A (en)	2004-02-27
NO20011778D0 (no)	2001-04-06
CZ20011257A3 (cs)	2001-08-15
ES2142773A1 (es)	2000-04-16
HUP0103937A2 (hu)	2002-02-28
EA200100422A1 (ru)	2001-10-22
YU25201A (sh)	2003-04-30
BG105417A (en)	2001-12-29
CU23162A3 (es)	2006-07-18
PA8483901A1 (es)	2000-09-29
EE200100207A (et)	2002-06-17
CA2346010C (en)	2010-01-12
OA11661A (en)	2004-12-08
GT199900173A (es)	2001-03-30
EP1120419A1 (en)	2001-08-01
HRP20010256B1 (hr)	2009-08-31
CN1096465C (zh)	2002-12-18
CN1322205A (zh)	2001-11-14
EE04374B1 (et)	2004-10-15
HRP20010256A2 (en)	2002-04-30
AP1555A (en)	2006-01-18

Publication	Publication Date	Title
IS5910A (is)	2001-03-29	Afleiður ísósorbíðmónónítrats og notkun þeirra sem æðavíkarar með lága þolmynd
IS2594B (is)	2010-03-15	Arýlmetýl-kabónýlamínó-þíasólafleiður og notkun þeirra sem æxlishemjandi efni
IS5464A (is)	2000-04-19	Þíenópýrimidín og þíenópýridín afleiður nytsamlegar sem miðlar gegn krabbameini
DK1084104T3 (da)	2003-10-27	Nitrogenoxidsynthaseinhibitorer
PL366038A1 (en)	2005-01-24	Nucleoside compounds and uses thereof
DE60132732D1 (de)	2008-03-27	Primerzusammensetzung und Verbindungsverfahren
DE69908455D1 (de)	2003-07-10	Kuvertiervorrichtung
NO20010200D0 (no)	2001-01-12	Organiske fosforforbindelser og deres anvendelse
FR2804041B1 (fr)	2002-03-15	Structure de jouet souffle-bulle
IL139795A0 (en)	2002-02-10	Oxadiazoline derivatives and their use as insecticides
NO20011358L (no)	2001-04-17	Antivirale kombinasjoner
DE60117096D1 (de)	2006-04-20	Dihydroindol- und tetrahydrochinolinderivate
IT1302028B1 (it)	2000-07-20	Composizioni espandenti
DE60018144D1 (de)	2005-03-24	Wälzelement
DE60032911D1 (de)	2007-02-22	Rollendes spielzeug
IL166299A0 (en)	2006-01-15	Isosorbide mononitrate compositions and methods oftheir use
DE59908593D1 (de)	2004-03-25	Walzengruppe
HRP20020971A2 (en)	2005-02-28	4,5-dihydro-thiazo-2-ylamine derivatives and their use as no-inhibitors
PL358756A1 (en)	2004-08-23	Acetamide derivatives
IT246477Y1 (it)	2002-04-09	Attrezzo giocattolo gonfiabile
NO20011859D0 (no)	2001-04-11	Imidazoisokinolinforbindelser, deres sammensetninger og anvendelse
TR200000254A3 (tr)	2000-09-21	Antitümör ve antimetastaz maddeleri olarak O-ikameli hidroksikumaranon türevleri
DE69908456D1 (de)	2003-07-10	Kuvertiervorrichtung
ATA33798A (de)	2001-05-15	Postkarte
IL148951A0 (en)	2002-11-10	Slow combustion pyrotechnic composition