DK1144436T3 - Fremgangsmåde til fremstilling af bicykliske forbindelser og anvendelse af denne fremgangsmåde til fremstilling af en ICE-inhiberende forbindelse - Google Patents

Fremgangsmåde til fremstilling af bicykliske forbindelser og anvendelse af denne fremgangsmåde til fremstilling af en ICE-inhiberende forbindelse

Info

Publication number: DK1144436T3
Authority: DK; Denmark
Prior art keywords: preparing; inhibitory compound; bicyclic compounds; compound; formula
Prior art date: 1999-01-12

Application number

DK00900552T

Other languages

English (en)

Inventor

Veronique Crocq

Patrick Roussel

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-12

Filing date

2000-01-11

Publication date

2004-08-02

2000-01-11 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2004-08-02 Application granted granted Critical

2004-08-02 Publication of DK1144436T3 publication Critical patent/DK1144436T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 4
230000002401 inhibitory effect Effects 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 2
125000002619 bicyclic group Chemical group 0.000 title 1
238000000034 method Methods 0.000 abstract 2
LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000003777 Interleukin-1 beta Human genes 0.000 abstract 1
108090000193 Interleukin-1 beta Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000003007 phosphonic acid derivatives Chemical class 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK00900552T 1999-01-12 2000-01-11 Fremgangsmåde til fremstilling af bicykliske forbindelser og anvendelse af denne fremgangsmåde til fremstilling af en ICE-inhiberende forbindelse DK1144436T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9900227A FR2788276B1 (fr)	1999-01-12	1999-01-12	NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice)
PCT/FR2000/000041 WO2000042061A1 (fr)	1999-01-12	2000-01-11	Procede de preparation de composes bicycliques et l'application de ce procede pour la preparation d'un compose inhibiteur de ice

Publications (1)

Publication Number	Publication Date
DK1144436T3 true DK1144436T3 (da)	2004-08-02

Family

ID=9540778

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00900552T DK1144436T3 (da)	1999-01-12	2000-01-11	Fremgangsmåde til fremstilling af bicykliske forbindelser og anvendelse af denne fremgangsmåde til fremstilling af en ICE-inhiberende forbindelse

Country Status (24)

Country	Link
US (1)	US6512111B1 (da)
EP (1)	EP1144436B1 (da)
JP (1)	JP4601826B2 (da)
KR (1)	KR100797349B1 (da)
CN (1)	CN1240710C (da)
AT (1)	ATE263780T1 (da)
AU (1)	AU774752B2 (da)
BR (1)	BR0007810B1 (da)
CA (1)	CA2359964C (da)
DE (1)	DE60009658T2 (da)
DK (1)	DK1144436T3 (da)
ES (1)	ES2215020T3 (da)
FR (1)	FR2788276B1 (da)
HK (1)	HK1045316B (da)
HU (1)	HU230062B1 (da)
IL (2)	IL144227A0 (da)
NO (1)	NO328110B1 (da)
NZ (1)	NZ512908A (da)
PL (1)	PL196993B1 (da)
PT (1)	PT1144436E (da)
SI (1)	SI1144436T1 (da)
TW (1)	TWI222443B (da)
WO (1)	WO2000042061A1 (da)
ZA (1)	ZA200105550B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6703500B2 (en)	1998-08-19	2004-03-09	Vertex Pharmaceuticals, Incorporated	Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en)	1998-08-19	2003-05-06	Vertex Pharmaceuticals Incorporated	Method for synthesizing caspase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ204130A (en) *	1982-05-12	1986-03-14	Hoffmann La Roche	Bicyclic heterocyclic compounds and pharmaceutical compositions
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds

1999
- 1999-01-12 FR FR9900227A patent/FR2788276B1/fr not_active Expired - Fee Related
- 1999-12-10 TW TW088121699A patent/TWI222443B/zh not_active IP Right Cessation
2000
- 2000-01-11 BR BRPI0007810-7A patent/BR0007810B1/pt not_active IP Right Cessation
- 2000-01-11 AT AT00900552T patent/ATE263780T1/de active
- 2000-01-11 IL IL14422700A patent/IL144227A0/xx active IP Right Grant
- 2000-01-11 ES ES00900552T patent/ES2215020T3/es not_active Expired - Lifetime
- 2000-01-11 AU AU30524/00A patent/AU774752B2/en not_active Ceased
- 2000-01-11 JP JP2000593628A patent/JP4601826B2/ja not_active Expired - Fee Related
- 2000-01-11 CA CA2359964A patent/CA2359964C/fr not_active Expired - Fee Related
- 2000-01-11 WO PCT/FR2000/000041 patent/WO2000042061A1/fr not_active Ceased
- 2000-01-11 NZ NZ512908A patent/NZ512908A/en not_active IP Right Cessation
- 2000-01-11 US US09/869,950 patent/US6512111B1/en not_active Expired - Lifetime
- 2000-01-11 DE DE60009658T patent/DE60009658T2/de not_active Expired - Lifetime
- 2000-01-11 HU HU0202665A patent/HU230062B1/hu not_active IP Right Cessation
- 2000-01-11 SI SI200030348T patent/SI1144436T1/xx unknown
- 2000-01-11 PL PL348919A patent/PL196993B1/pl unknown
- 2000-01-11 PT PT00900552T patent/PT1144436E/pt unknown
- 2000-01-11 CN CNB008048320A patent/CN1240710C/zh not_active Expired - Fee Related
- 2000-01-11 KR KR1020017008755A patent/KR100797349B1/ko not_active Expired - Fee Related
- 2000-01-11 EP EP00900552A patent/EP1144436B1/fr not_active Expired - Lifetime
- 2000-01-11 HK HK02106828.3A patent/HK1045316B/zh not_active IP Right Cessation
- 2000-01-11 DK DK00900552T patent/DK1144436T3/da active
2001
- 2001-07-05 ZA ZA200105550A patent/ZA200105550B/en unknown
- 2001-07-10 IL IL144227A patent/IL144227A/en not_active IP Right Cessation
- 2001-07-11 NO NO20013435A patent/NO328110B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60009658D1 (de)	2004-05-13
CN1343218A (zh)	2002-04-03
EP1144436B1 (fr)	2004-04-07
JP4601826B2 (ja)	2010-12-22
HU230062B1 (hu)	2015-06-29
AU774752B2 (en)	2004-07-08
HUP0202665A2 (hu)	2002-12-28
FR2788276A1 (fr)	2000-07-13
HK1045316B (zh)	2006-09-29
FR2788276B1 (fr)	2001-02-16
SI1144436T1 (en)	2004-06-30
KR20010101468A (ko)	2001-11-14
US6512111B1 (en)	2003-01-28
ZA200105550B (en)	2002-07-25
JP2002534533A (ja)	2002-10-15
EP1144436A1 (fr)	2001-10-17
DE60009658T2 (de)	2005-03-24
PT1144436E (pt)	2004-08-31
BR0007810A (pt)	2001-11-06
WO2000042061A1 (fr)	2000-07-20
CA2359964A1 (fr)	2000-07-20
IL144227A0 (en)	2002-05-23
IL144227A (en)	2006-12-31
CA2359964C (fr)	2010-04-20
BR0007810B1 (pt)	2011-08-23
NO20013435L (no)	2001-08-27
HUP0202665A3 (en)	2004-12-28
NO20013435D0 (no)	2001-07-11
PL196993B1 (pl)	2008-02-29
HK1045316A1 (en)	2002-11-22
ES2215020T3 (es)	2004-10-01
ATE263780T1 (de)	2004-04-15
NZ512908A (en)	2003-07-25
CN1240710C (zh)	2006-02-08
PL348919A1 (en)	2002-06-17
TWI222443B (en)	2004-10-21
AU3052400A (en)	2000-08-01
NO328110B1 (no)	2009-12-07
KR100797349B1 (ko)	2008-01-22

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