DK1163264T3 - Nye LHRH-antagonister med forbedrede oplöselighedsegenskaber - Google Patents

Nye LHRH-antagonister med forbedrede oplöselighedsegenskaber

Info

Publication number
DK1163264T3
DK1163264T3 DK00910816T DK00910816T DK1163264T3 DK 1163264 T3 DK1163264 T3 DK 1163264T3 DK 00910816 T DK00910816 T DK 00910816T DK 00910816 T DK00910816 T DK 00910816T DK 1163264 T3 DK1163264 T3 DK 1163264T3
Authority
DK
Denmark
Prior art keywords
improved solubility
solubility properties
lhrh antagonists
new lhrh
new
Prior art date
Application number
DK00910816T
Other languages
Danish (da)
English (en)
Inventor
Bernhard Kutscher
Michael Bernd
Eckhard Guenther
Peter Romeis
Thomas Reissmann
Thomas Beckers
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Application granted granted Critical
Publication of DK1163264T3 publication Critical patent/DK1163264T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00910816T 1999-03-17 2000-03-11 Nye LHRH-antagonister med forbedrede oplöselighedsegenskaber DK1163264T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19911771A DE19911771B4 (de) 1999-03-17 1999-03-17 LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
EP00910816A EP1163264B1 (de) 1999-03-17 2000-03-11 Neue lhrh-antagonisten mit verbesserten löslichkeitseigenschaften
PCT/EP2000/002165 WO2000055190A1 (de) 1999-03-17 2000-03-11 Neue lhrh-antagonisten mit verbesserten löslichkeitseigenschaften

Publications (1)

Publication Number Publication Date
DK1163264T3 true DK1163264T3 (da) 2004-12-06

Family

ID=7901213

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00910816T DK1163264T3 (da) 1999-03-17 2000-03-11 Nye LHRH-antagonister med forbedrede oplöselighedsegenskaber

Country Status (33)

Country Link
US (3) US6627609B1 (ko)
EP (1) EP1163264B1 (ko)
JP (1) JP3801867B2 (ko)
KR (1) KR100569623B1 (ko)
CN (1) CN1185251C (ko)
AR (1) AR022970A1 (ko)
AT (1) ATE277077T1 (ko)
AU (1) AU759442B2 (ko)
BG (1) BG65283B1 (ko)
BR (1) BR0009472A (ko)
CA (1) CA2381461C (ko)
CO (1) CO5150192A1 (ko)
CZ (1) CZ301696B6 (ko)
DE (2) DE19911771B4 (ko)
DK (1) DK1163264T3 (ko)
ES (1) ES2225103T3 (ko)
HK (1) HK1045531B (ko)
HU (1) HU229672B1 (ko)
IL (3) IL145484A0 (ko)
MX (1) MXPA01010052A (ko)
NO (1) NO327753B1 (ko)
NZ (1) NZ514830A (ko)
PL (1) PL200647B1 (ko)
PT (1) PT1163264E (ko)
RU (1) RU2227145C2 (ko)
SI (2) SI1163264T1 (ko)
SK (1) SK287880B6 (ko)
TR (1) TR200103339T2 (ko)
TW (1) TWI243179B (ko)
UA (1) UA70997C2 (ko)
WO (1) WO2000055190A1 (ko)
YU (1) YU68702A (ko)
ZA (1) ZA200107753B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US5677184A (en) * 1994-04-19 1997-10-14 Takeda Chemical Industries, Ltd. CHO cells that express human LH-RH receptor
DE19911771B4 (de) 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
US7005418B1 (en) 1999-09-23 2006-02-28 Zentaris Gmbh Method for the therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction
AU769482B2 (en) * 1999-09-23 2004-01-29 Zentaris Gmbh Method for the therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction
CN100500692C (zh) 2000-03-14 2009-06-17 赞塔里斯有限公司 新型lhrh拮抗剂,其制备方法和药物用途
DE10024451A1 (de) * 2000-05-18 2001-11-29 Asta Medica Ag Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung
SK14512003A3 (sk) 2001-04-30 2004-08-03 Zentaris Gmbh Spôsob liečenia demencie a neurodegeneratívnych chorôb strednými dávkami LHRH antagonistov
SE0104462D0 (sv) * 2001-12-29 2001-12-29 Carlbiotech Ltd As Peptide purifcation (Peptidrening)
BRPI0314546B8 (pt) 2002-09-27 2021-05-25 Zentaris Gmbh composição de gel farmacêutico compreendendo peptídeos farmaceuticamente atvos com liberação sustentada, método para a produção dos mesmos kit.
CN100340572C (zh) * 2004-12-01 2007-10-03 中国人民解放军军事医学科学院毒物药物研究所 新的lhrh拮抗剂
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
EP1891964A1 (en) * 2006-08-08 2008-02-27 AEterna Zentaris GmbH Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits
CN101597321B (zh) * 2008-06-03 2013-04-24 中国人民解放军军事医学科学院毒物药物研究所 长效低组胺释放副作用的lhrh拮抗剂
WO2012050892A2 (en) * 2010-09-29 2012-04-19 Esperance Pharmaceuticals, Inc. Methods for stimulating, increasing or enhancing killing of a cell that expresses luteinizing hormone releasing hormone (lhrh) receptors
CN102584945A (zh) * 2012-02-09 2012-07-18 深圳翰宇药业股份有限公司 一种醋酸加尼瑞克的制备方法
CN103524599B (zh) * 2012-07-05 2016-04-20 中国人民解放军军事医学科学院毒物药物研究所 环肽lhrh拮抗剂衍生物及其药物用途
CN104231055A (zh) 2013-06-18 2014-12-24 深圳翰宇药业股份有限公司 加尼瑞克前体以及由其制备醋酸加尼瑞克的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
DE3467173D1 (en) * 1983-08-16 1987-12-10 Akzo Nv Lh- rh antagonists
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US5140009A (en) 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5300492A (en) * 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs
DE68928278T2 (de) * 1988-02-10 1998-03-12 Tap Pharmaceuticals Inc Lhrh-analog
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
CN1036343C (zh) * 1990-11-10 1997-11-05 天津市计划生育研究所 新促黄体生成素释放激素拮抗类似物的制备方法
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
JPH08510260A (ja) * 1993-05-20 1996-10-29 バイオテック・オーストラリア・プロプライエタリー・リミテッド Ｌｈｒｈ拮抗剤
RU2074191C1 (ru) * 1994-06-08 1997-02-27 Российско-германское совместное предприятие "Константа" Способ синтеза дез-гли 10, /d-лей 6/ lh-rh-этиламида
US5942493A (en) * 1995-11-28 1999-08-24 Asta Medica Aktiengesellschaft LH-RH antagonists having improved action
DE19544212A1 (de) * 1995-11-28 1997-06-05 Asta Medica Ag Neue LH-RH-Antagonisten mit verbesserter Wirkung
US6054432A (en) * 1996-09-12 2000-04-25 Asta Medica Aktiengesellschaft Means for treating prostate hypertrophy and prostate cancer
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19911771B4 (de) * 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
US6586403B1 (en) * 2000-07-20 2003-07-01 Salpep Biotechnology, Inc. Treating allergic reactions and inflammatory responses with tri-and dipeptides
KR100876538B1 (ko) * 2000-08-17 2008-12-31 아에테르나 젠타리스 게엠베하 Ｌｈｒｈ 길항제의 염의 제조방법

Also Published As

Publication number Publication date
HK1045531B (zh) 2005-05-20
NZ514830A (en) 2003-05-30
PT1163264E (pt) 2004-12-31
AR022970A1 (es) 2002-09-04
US20060281685A1 (en) 2006-12-14
AU759442B2 (en) 2003-04-17
US7148195B2 (en) 2006-12-12
US6627609B1 (en) 2003-09-30
IL145484A (en) 2006-12-31
HK1045531A1 (en) 2002-11-29
WO2000055190A1 (de) 2000-09-21
DE19911771B4 (de) 2006-03-30
YU68702A (sh) 2006-01-16
BR0009472A (pt) 2001-11-27
DE19911771A1 (de) 2000-09-28
UA70997C2 (uk) 2004-11-15
US20040266695A1 (en) 2004-12-30
EP1163264B1 (de) 2004-09-22
SI1163264T1 (en) 2004-12-31
TWI243179B (en) 2005-11-11
TR200103339T2 (tr) 2002-04-22
IL145484A0 (en) 2002-06-30
ES2225103T3 (es) 2005-03-16
HU229672B1 (en) 2014-04-28
HUP0200363A2 (en) 2002-06-28
CO5150192A1 (es) 2002-04-29
IL151647A (en) 2009-08-03
EP1163264A1 (de) 2001-12-19
ATE277077T1 (de) 2004-10-15
CA2381461A1 (en) 2000-09-21
BG65283B1 (bg) 2007-11-30
JP3801867B2 (ja) 2006-07-26
JP2002543045A (ja) 2002-12-17
RU2227145C2 (ru) 2004-04-20
SK287880B6 (sk) 2012-02-03
AU3288700A (en) 2000-10-04
CN1348462A (zh) 2002-05-08
NO20014486L (no) 2001-11-02
SK13232001A3 (sk) 2002-05-09
NO20014486D0 (no) 2001-09-14
CZ20013318A3 (cs) 2002-05-15
CZ301696B6 (cs) 2010-05-26
ZA200107753B (en) 2002-05-13
PL351792A1 (en) 2003-06-16
CN1185251C (zh) 2005-01-19
CA2381461C (en) 2011-01-04
NO327753B1 (no) 2009-09-14
MXPA01010052A (es) 2003-07-14
HUP0200363A3 (en) 2002-09-30
PL200647B1 (pl) 2009-01-30
US7732412B2 (en) 2010-06-08
BG106008A (en) 2002-06-28
SI1268522T1 (sl) 2009-02-28
KR100569623B1 (ko) 2006-04-11
DE50007905D1 (de) 2004-10-28
KR20020002482A (ko) 2002-01-09

Similar Documents

Publication Publication Date Title
DE60026169D1 (de) Selektive neurokinin-antagonisten
DK1676845T3 (da) Nye quinazolinderivater
DK1163264T3 (da) Nye LHRH-antagonister med forbedrede oplöselighedsegenskaber
DE50013910D1 (de) Horizontalspritzgiessmaschine
NO20032596D0 (no) Heterosykliske etersubstituerte imidazokinoliner
NO20032909L (no) Glukopyranosyloksypyrazolderivater samt medikamentell anvendelse derav
DK1163237T3 (da) Amidderivater
NO20021116L (no) Nye sammensetninger
DE60010586D1 (de) Verbesserungen bezüglich injektionsvorrichtungen
NO20020810D0 (no) Nye fenylpiperaziner
EE200200490A (et) Kinoliini derivaadid alfa-2 antagonistidena
NO20015074L (no) Nye sammensetninger
DK1237857T3 (da) Nye Phenalkyloxyphenylderivater
DE60118569D1 (de) 4-phenylpyridin-derivate als neurokinin-1-rezeptor-antagonisten
EE200200204A (et) Asendatud bensimidasooli preparaat
EE200200135A (et) D4 antagonistidena toimivad tienoisoksasolüül- jatienüülpürrasolüülfenoksü-asendatud propüülderivaadid
DE60003893D1 (de) 2-aminopyridine mit kondensierten ringsubstituenten
DE60009931D1 (de) Muscarin-antagonisten
NO20004892D0 (no) Kinolin-4-yl-derivater I
DE60018760D1 (de) Schiebernadel
NO20015237D0 (no) Integrinreseptor-antagonister
DK1088818T3 (da) Quinolin-4-yl-derivater
NO20014127D0 (no) 5-HT1F agonister
NO20013601D0 (no) Nye morfolinobenzamidsalter
DE60012953D1 (de) 3-amino-2-phenylpiperidinderivate als substanz p antagonisten